CN104970987A - Preparation method of lipidosome repairing damaged skin after allergy - Google Patents
Preparation method of lipidosome repairing damaged skin after allergy Download PDFInfo
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Abstract
The invention relates to a preparation method of lipidosome repairing damaged skin after allergy, which is characterized by comprising the following steps: A. weighing octyl dodecyl alcohol, extract of peanut seed coat and extract of roots of stephania tetrandra, heating the mixture to 75-85 DEG C, and mixing and stirring the mixture until the mixture is dissolved completely; B. weighing polyglycerol esters, sorbitan esters, dicetyl phosphate, sucrose polycottonseedate and pine tree sterol, heating the mixture to 75-85 DEG C, and mixing and stirring the mixture uniformly; C. weighing deionized water and an extract from bark of mangnolia officinalis and heating the mixture to 75-85 DEG C; D. weighing the mixtures prepared in the steps A, B and C respectively and mixing the three mixtures with uniform stirring to obtain a pre-mixed solution; and E. cyclically homogenizing the pre-mixed solution through a high-pressure homogenizer by 8-15 times, and cooling the solution to room temperature to obtain the lipidosome repairing damaged skin after allergy. The lipidosome is good in an effect of repairing damaged skin after allergy, is high in bioavailability and is good in skin permeability.
Description
Technical field
The invention belongs to cosmetic technical field, particularly a kind of preparation method of repairing the liposome of irritated rear impaired skin.
Background technology
Environmental pollution is serious, and the result caused is exactly that the responsive number of skin gets more and more.Anaphylactogen impels parts of skin cell to discharge histamine, the materials such as interleukin, causes capillary permeability increase, mucosa glandular secretion increases, skin produces redness, pruritus, speckle, occurs the external sensitivity of skin or allergic symptom.Cosmetics use glycyrrhizic acid dipotassium usually, allantoin, the antiallergic materials such as bisabolol, though can eliminate condition susceptible, there is no and repair the function of impaired skin because of sensitivity.After irritated disappearance, skin is impaired not to be recovered completely, and concrete impaired Symptoms is that keratodermatitis is thinning, and skin barrier function weakens, and dermal furrow destroys.Therefore, cosmetic industry repairs composition after needing a kind of suitable allergy, after allergic symptom disappears, repairs the skin damage symptom occurred afterwards due to allergy.
Summary of the invention
The technical problem to be solved in the present invention is, a kind of preparation method of repairing the liposome of irritated rear impaired skin is provided, the method can wrap up peanut seed capsule extract, Radix stephaniae tetrandrae root extract, sucrose polycottonseedate oleate, pinaster sterol, Magnolia bark extract simultaneously, prepared by the method can repair irritated after the liposome mean diameter of impaired skin can control between 50nm – 200nm, bioavailability is high, promote Cutaneous permeation, can arbitrary proportion aqueous dispersion, conveniently add use.
For solving the problems of the technologies described above, the present invention by the following technical solutions: a kind of repair irritated after the preparation method of liposome of impaired skin, it is characterized in that: comprise the following steps:
A: be that 5 ~ 10:1 ~ 3:1 takes octyldodecanol, peanut seed capsule extract, Radix stephaniae tetrandrae root extract in mass ratio, be heated to 75 ~ 85 DEG C, mix and blend is to dissolving completely;
B: be that 2 ~ 5:1 ~ 3:3 ~ 5:1 ~ 2:1 takes polyglycereol esters, arlacels, Dihexadecylphosphate, sucrose polycottonseedate oleate, pinaster sterol in mass ratio, be heated to 75 ~ 85 DEG C, mixing and stirring;
C: be that 10 ~ 50:1 takes deionized water, Magnolia bark extract in mass ratio, after mixing, be heated to 75 ~ 85 DEG C;
D: in mass ratio for 1:2 ~ 5:10 ~ 30 take the mixture prepared by step A, the mixture prepared by step B, the active matter prepared by step C respectively, be heated to 75 ~ 85 DEG C, stir, obtain aqueous premix;
E: by aqueous premix under 80 ~ 150MPa pressure, 75 ~ 90 DEG C of temperature conditions, by high pressure homogenizer circulation homogenizing 8 ~ 15 times, chiller is used in high pressure homogenizer outlet, ensure that high pressure homogenizer outlet section mixeding liquid temperature is no more than 90 DEG C, after homogenizing completes, be cooled to room temperature, the liposome of irritated rear impaired skin must be repaired.
Further, described polyglycereol esters is a kind of in polyglycereol ~ 10 cetylate (INCI title: POLYGLYCERYL ~ 10 PALMITATE), polyglycereol ~ 10 laurate (INCI title: POLYGLYCERYL ~ 10 LAURATE), polyglycereol ~ 10 oleate (INCI title: POLYGLYCERYL ~ 10 OLEATE) or their mixture.
Further, described arlacels is a kind of in the smooth cetylate of Pyrusussuriensis (INCI title: SORBITAN PALMITATE), the smooth oleate of Pyrusussuriensis (INCI title: SORBITAN OLEATE) or their mixture.
The liposome of impaired skin after the reparation allergy prepared by the inventive method, at rotating speed be in the centrifuge of 10000 turns per minute centrifugal 30 minutes not stratified; Not stratified, invariant color in three months is preserved under 45 DEG C of environment; Normal temperature storage 3 years is not stratified, has good stability.
Repair the liposome of irritated rear impaired skin
the evaluation of Cutaneous permeation facilitation effect
Adopt modified Franz diffusion cells (Modified Franz diffusion cell) using luteolin as Testing index, skin repairing effect liposome-skin infiltration facilitation effect after allergy is evaluated.The skin membrane used is the human body skin (stripping subcutaneous fat) obtained when female chest is performed the operation, and liquid nitrogen is sealed up for safekeeping, ~ 80 DEG C of storages, carries out recover (skin membrane is in 60 DEG C of 2min that thaw) before experiment.The liposome (sample 1) prepared with embodiment four contrasts with the aqueous solution (sample 2) containing mutually commensurability peanut seed capsule extract.Gather 5 hours by micropipette pipe (Micropipette) in the mode of every 1 hour accurate acquisition 1ml, detected the concentration of luteolin by HPLC, experimental results as shown in Figure 1.
As can be seen from the permeability test result of luteolin, after allergy prepared by the present invention, skin repairing effect liposome rapid osmotic can be impregnated into skin, after skin application 5h, skin infiltration rate is about about 3.5 times of control sample, illustrate that the liposome prepared by the present invention is a kind of effective active matter transmission system, active matter can be helped better to be less readily available for absorption by the skin and to utilize.
The liposome of irritated rear impaired skin can be repaired to the evaluation of skin barrier repairing effect:
0th day transepidermal water loss value TEWL is determined to the volar forearm skin of the test group membership of 48 dry skins (skin hydration instrument value <60), adopts the Tewameter TM210 of German CK company to measure; Skin hydration adopts the Corneometer CM825 PC of German CK company to measure; Rubescent situation adopts the Chromameter CR300 of Japanese Minolta company to measure.Afterwards, smear 2% sodium lauryl sulphate (SDS) and close the damage of 24 hours initiation skin barriers, wipe unnecessary solution after 24 hours, dry by soft paper gentleness after tap water.Record the TWEL value of skin after 4 ~ 6 hours, skin hydration and skin rubefaction value (representative value TEWL:18 ~ 20g/cm
2; Hydration value: 37 ~ 41 unit values; Rubescent value a*:12 ~ 14; ), the test result of 48 test group memberships is: the meansigma methods of TEWL is 30g/cm
2, the meansigma methods of hydration value is 28 unit values, and the meansigma methods a* of rubescent value is 22.After test, 48 test group memberships are divided into 6 groups, often organize 8, and in 3 days under connecing, every day smears sample (2mg/cm sooner or later
2), morning next day test experiments data.Test the TWEL value of every group membership's skin, skin hydration and skin rubefaction value, average.Experimental data is as shown in the table:
Note: A, only interpolation mass fraction are the liposomal samples of 8.93% peanut seed capsule extract;
B, only add mass fraction be 8.93% Radix stephaniae tetrandrae root extract liposomal samples;
c,only add mass fraction be 8.93% sucrose polycottonseedate oleate liposomal samples;
D, only interpolation mass fraction are the liposomal samples of 8.93% pinaster sterol;
E, only interpolation mass fraction are the liposomal samples of 8.93% Magnolia bark extract;
The liposomal samples (adding peanut seed capsule extract, the Radix stephaniae tetrandrae root extract of mass fraction 0.65%, the sucrose polycottonseedate oleate of mass fraction 3.06%, the pinaster sterol of mass fraction 1.53%, the Magnolia bark extract of mass fraction 1.74% of mass fraction 1.95%) of F, embodiment four preparation.
As can be seen from experimental result, use the TEWL value after F group sample progressively to reduce, be 18,16,15 respectively, be starkly lower than other group, illustrate that effect that F group sample reduces transepidermal water lost is obvious; Use the hydration value value after F group sample progressively to raise, be 45,58,65 respectively, apparently higher than other groups, illustrate that F group sample replenishing water and preserving moisture effect is obvious; Use the rubescent value value after F group sample progressively to reduce, be 14,12,12 respectively, and be starkly lower than other groups, illustrate that F group sample reparation skin rubefaction effect is obvious.From above-mentioned test result, peanut seed capsule extract, Radix stephaniae tetrandrae root extract, sucrose polycottonseedate oleate, pinaster sterol, Magnolia bark extract five kinds of active compounds are worked in coordination with and are compositely prepared into liposome, than being used alone wherein any one, better skin barrier repairing effect can be reached.
Peanut seed capsule extract, its INCI is called ARACHIS HYPOGAEA (PEANUT) SEEDCOAT EXTRACT, main active substances is luteolin, there is analgesia, the function of anti-inflammatory, by Hangzhou, Tian Cao Science and Technology Ltd. has commercially available prod to produce, and content of luteolin is greater than 80%; Radix stephaniae tetrandrae root extract, its INCI is called Radix stephaniae tetrandrae (STEPHANIA TETRANDA) root extract, and main active is tetrandrine, can promote that epidermal wound heals, and produced by Qing Teng bio tech ltd, Xi'an, tetrandrine content is greater than 50%; Sucrose polycottonseedate oleate, its INCI title: SUCROSE POLYCOTTONSEEDATE, has the fabulous compatibility with skin, can be combined thus pin moisture, moisturizing by moisture in skin, repairing skin barrier, produced, without purity requirement by CRODA company of Britain; Pinaster sterol, its INCI title: PHYTOSTEROLS, pinaster is originated, its main active is β ~ sitosterol, produced by Danisco company of Finland, commodity are called PinVita, have and increase cutaneous nerve amide content, recover the effect of skin barrier function, wherein β ~ sitosterol content is greater than 80%.Magnolia bark extract MAGNOLIA OFFICINALIS BARK EXTRACT possesses the effect of skin pressure of releiving, containing honokiol (INCI title: HONOKIOL) and isomers magnolol (INCI title: MAGNOLOL) thereof, extract the bark from plant Cortex Magnoliae Officinalis, honokiol and magnolol add up to purity to be greater than 98%, are produced for this Chinese mugwort traditional Chinese medicine technology institute company by Nanjing.The present invention selects specific five kinds of active matters, repairs from many approach impaired skin, and five kinds of active matter Synergistics strengthen the skin after to allergy and repair effect.Experiment proof, five kinds of collaborative uses of active matters, than being used alone wherein any one, can reach better irritated rear skin repairing effect.Test proof simultaneously, use nanometer liposome as active matter transmission system, then active matter can be helped better to be less readily available for absorption by the skin and to utilize, better effects if.
The present invention, by nano-lipid body technique, improves the bioavailability of active component, promotes Cutaneous permeation, improves the percutaneous passage of bioactive molecule through keratodermatitis, plays the skin-care effect of active matter better.
The liposome of impaired skin after the reparation allergy prepared by the inventive method, its mean diameter is between 50nm – 200nm, and bioavailability is high, can promote Cutaneous permeation, can arbitrary proportion aqueous dispersion, conveniently adds use.
In sum, the liposome of impaired skin after reparation allergy prepared by the present invention, good to skin repairing effect after allergy, bioavailability is high, can promote Cutaneous permeation, can arbitrary proportion aqueous dispersion, conveniently adds use.
Accompanying drawing explanation
Fig. 1 is the permeability test interpretation of result figure of luteolin.
Detailed description of the invention
embodiment 1:
Repair a preparation method for the liposome of irritated rear impaired skin, comprise the following steps:
A: in mass ratio for 5:1:1 takes 5.49g octyldodecanol, 1.1g peanut seed capsule extract, 1.1g Radix stephaniae tetrandrae root extract, be heated to 75 DEG C, mix and blend is to dissolving completely;
B: in mass ratio for 2:1:3:1:1 takes 3.86g polyglycereol ~ 10 cetylate, the smooth cetylate of 1.92g Pyrusussuriensis, 5.76g Dihexadecylphosphate, 1.92g sucrose polycottonseedate oleate, 1.92g pinaster sterol, be heated to 85 DEG C, mixing and stirring; C: in mass ratio for 10:1 takes 69.93g deionized water, 7.0g Magnolia bark extract, after mixing, be heated to 85 DEG C; D: in mass ratio for 1:2:10 takes the mixture prepared by step A, the mixture prepared by step B, the active matter prepared by step C respectively, be heated to 85 DEG C, stir, obtain aqueous premix;
E: by aqueous premix under 80MPa pressure, 80 DEG C of temperature conditions, by Microfluidics high pressure homogenizer circulation homogenizing 8 times, chiller is used in high pressure homogenizer outlet, ensure that high pressure homogenizer outlet section mixeding liquid temperature is no more than 90 DEG C, after homogenizing completes, be cooled to room temperature, irritated rear help must occur and repair impaired skin lipids body, mean diameter 80nm.
embodiment 2:
Repair a preparation method for the liposome of irritated rear impaired skin, comprise the following steps:
A: in mass ratio for 5:2:1 takes 2.61g octyldodecanol, 1.04g peanut seed capsule extract, 0.52g Radix stephaniae tetrandrae root extract, be heated to 85 DEG C, mix and blend is to dissolving completely;
B: in mass ratio for 3:2:4:1:1 takes 3.43g polyglycereol ~ 10 laurate, the smooth cetylate of 2.27g Pyrusussuriensis, 4.54g Dihexadecylphosphate, 1.13g sucrose polycottonseedate oleate, 1.13g pinaster sterol, be heated to 80 DEG C, mixing and stirring;
C: in mass ratio for 20:1 takes 79.16g deionized water, 4.17g Magnolia bark extract, after mixing, be heated to 80 DEG C;
D: in mass ratio for 1:3:20 takes the mixture prepared by step A, the mixture prepared by step B, the active matter prepared by step C respectively, be heated to 75 DEG C, stir, obtain aqueous premix;
E: by aqueous premix under 100MPa pressure, 75 DEG C of temperature conditions, by Microfluidics high pressure homogenizer circulation homogenizing 10 times, chiller is used in high pressure homogenizer outlet, ensure that high pressure homogenizer outlet section mixeding liquid temperature is no more than 90 DEG C, after homogenizing completes, be cooled to room temperature, irritated rear help must occur and repair impaired skin lipids body, mean diameter 100nm.
embodiment 3:
Repair a preparation method for the liposome of irritated rear impaired skin, comprise the following steps:
A: in mass ratio for 7:1:1 takes 2.16g octyldodecanol, 0.31g peanut seed capsule extract, 0.31g Radix stephaniae tetrandrae root extract, be heated to 80 DEG C, mix and blend is to dissolving completely;
B: in mass ratio for 4:1:5:2:1 takes 4.27g polyglycereol ~ 10 oleate, the smooth oleate of 1.07g Pyrusussuriensis, 5.35g Dihexadecylphosphate, 2.13g sucrose polycottonseedate oleate, 1.07g pinaster sterol, be heated to 80 DEG C, mixing and stirring;
C: in mass ratio for 30:1 takes 80.64g deionized water, 2.69g Magnolia bark extract, after mixing, be heated to 85 DEG C;
D: in mass ratio for 1:5:30 takes the mixture prepared by step A, the mixture prepared by step B, the active matter prepared by step C respectively, be heated to 75 ~ 85 DEG C, stir, obtain aqueous premix;
E: by aqueous premix under 150MPa pressure, 85 DEG C of temperature conditions, by Microfluidics high pressure homogenizer circulation homogenizing 15 times, chiller is used in high pressure homogenizer outlet, ensure that high pressure homogenizer outlet section mixeding liquid temperature is no more than 90 DEG C, after homogenizing completes, be cooled to room temperature, irritated rear help must occur and repair impaired skin lipids body, mean diameter 50nm.
embodiment 4:
Repair a preparation method for the liposome of irritated rear impaired skin, comprise the following steps:
A: in mass ratio for 7:3:1 takes 4.54g octyldodecanol, 1.95g peanut seed capsule extract, 0.65g Radix stephaniae tetrandrae root extract, be heated to 85 DEG C, mix and blend is to dissolving completely;
B: in mass ratio for 5:3:3:2:1 takes 7.66g polyglycereol esters ((polyglycereol ~ 10 cetylate: polyglycereol ~ 10 laurate=1:2)), the smooth oleate of 4.59g Pyrusussuriensis, 4.59g Dihexadecylphosphate, 3.06g sucrose polycottonseedate oleate, 1.53g pinaster sterol, be heated to 75 DEG C, mixing and stirring;
C: in mass ratio for 40:1 takes 49.69g deionized water, 1.74g Magnolia bark extract, after mixing, be heated to 80 DEG C;
D: in mass ratio for 1:3:10 takes the mixture prepared by step A, the mixture prepared by step B, the active matter prepared by step C respectively, be heated to 80 DEG C, stir, obtain aqueous premix;
E: by aqueous premix under 120MPa pressure, 90 DEG C of temperature conditions, by Microfluidics high pressure homogenizer circulation homogenizing 10 times, chiller is used in high pressure homogenizer outlet, ensure that high pressure homogenizer outlet section mixeding liquid temperature is no more than 90 DEG C, after homogenizing completes, be cooled to room temperature, irritated rear help must occur and repair impaired skin lipids body, mean diameter 120nm.
embodiment 5:
Repair a preparation method for the liposome of irritated rear impaired skin, comprise the following steps:
A: in mass ratio for 10:3:1 takes 2.75g octyldodecanol, 0.825 peanut seed capsule extract, 0.275g Radix stephaniae tetrandrae root extract, be heated to 80 DEG C, mix and blend is to dissolving completely;
B: in mass ratio for 5:1:4:2:1 takes 7.39g polyglycereol esters (polyglycereol ~ 10 laurate: polyglycereol ~ 10 oleate=2:3), 1.48g arlacels (the smooth cetylate of Pyrusussuriensis: the smooth oleate=1:2 of Pyrusussuriensis), 5.92g Dihexadecylphosphate, 2.96g sucrose polycottonseedate oleate, 1.48g pinaster sterol, be heated to 85 DEG C, mixing and stirring;
C: in mass ratio for 50:1 takes 75.41g deionized water, 1.51g Magnolia bark extract, after mixing, be heated to 85 DEG C;
D: in mass ratio for 1:5:20 takes the mixture prepared by step A, the mixture prepared by step B, the active matter prepared by step C respectively, be heated to 85 DEG C, stir, obtain aqueous premix;
E: by aqueous premix under 80MPa pressure, 90 DEG C of temperature conditions, by Microfluidics high pressure homogenizer circulation homogenizing 8 times, chiller is used in high pressure homogenizer outlet, ensure that high pressure homogenizer outlet section mixeding liquid temperature is no more than 90 DEG C, after homogenizing completes, be cooled to room temperature, irritated rear help must occur and repair impaired skin lipids body, mean diameter 200nm.
Claims (3)
1. repair a preparation method for the liposome of irritated rear impaired skin, it is characterized in that: comprise the following steps:
A: be that 5 ~ 10:1 ~ 3:1 takes octyldodecanol, peanut seed capsule extract, Radix stephaniae tetrandrae root extract in mass ratio, be heated to 75 ~ 85 DEG C, mix and blend is to dissolving completely;
B: be that 2 ~ 5:1 ~ 3:3 ~ 5:1 ~ 2:1 takes polyglycereol esters, arlacels, Dihexadecylphosphate (CAS:2197 ~ 63 ~ 9), sucrose polycottonseedate oleate, pinaster sterol in mass ratio, be heated to 75 ~ 85 DEG C, mixing and stirring;
C: be that 10 ~ 50:1 takes deionized water, Magnolia bark extract in mass ratio, after mixing, be heated to 75 ~ 85 DEG C;
D: in mass ratio for 1:2 ~ 5:10 ~ 30 take the mixture prepared by step A, the mixture prepared by step B, the active matter prepared by step C respectively, be heated to 75 ~ 85 DEG C, stir, obtain aqueous premix;
E: by aqueous premix under 80 ~ 150MPa pressure, 75 ~ 90 DEG C of temperature conditions, by high pressure homogenizer circulation homogenizing 8 ~ 15 times, chiller is used in high pressure homogenizer outlet, ensure that high pressure homogenizer outlet section mixeding liquid temperature is no more than 90 DEG C, after homogenizing completes, be cooled to room temperature, obtain the liposome repairing irritated rear impaired skin.
2. according to claim 1 repair irritated after the preparation method of liposome of impaired skin, it is characterized in that: described polyglycereol esters is a kind of in polyglycereol ~ 10 cetylate, polyglycereol ~ 10 laurate, polyglycereol ~ 10 oleate or their mixture.
3. according to claim 1 repair irritated after the preparation method of liposome of impaired skin, it is characterized in that: described arlacels is a kind of in the smooth cetylate of Pyrusussuriensis, the smooth oleate of Pyrusussuriensis or their mixture.
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| CN108514520A (en) * | 2018-05-03 | 2018-09-11 | 上海璞萃生物科技有限公司 | A kind of antiallergic composition and its application |
| CN111450003A (en) * | 2020-04-21 | 2020-07-28 | 圣迪斯哥(深圳)生物科技有限公司 | Anti-aging and beautifying nutrient containing golden fragrant willow extract, preparation method thereof, essence and extraction method of golden fragrant willow extract |
| CN112353735A (en) * | 2020-08-21 | 2021-02-12 | 广州澳梓美生物科技有限公司 | Composition with repairing and relieving effects and preparation and application thereof |
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| CN112353735A (en) * | 2020-08-21 | 2021-02-12 | 广州澳梓美生物科技有限公司 | Composition with repairing and relieving effects and preparation and application thereof |
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| Publication number | Publication date |
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| CN104970987B (en) | 2018-01-19 |
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