CN103732597B - 三环杂环化合物和jak抑制剂 - Google Patents

三环杂环化合物和jak抑制剂 Download PDF

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Publication number
CN103732597B
CN103732597B CN201280039516.6A CN201280039516A CN103732597B CN 103732597 B CN103732597 B CN 103732597B CN 201280039516 A CN201280039516 A CN 201280039516A CN 103732597 B CN103732597 B CN 103732597B
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group
alkyl
unsubstituted
phenyl
aromatic heterocyclic
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CN103732597A (zh
Inventor
林圭史
渡边恒夫
外山公二
加门淳司
南昌孝
宇仁巳由纪
奈须麻莉子
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Misao Kusano
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Nissan Chemical Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • C07D498/14—Ortho-condensed systems
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Dermatology (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
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  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280039516.6A 2011-08-12 2012-08-10 三环杂环化合物和jak抑制剂 Expired - Fee Related CN103732597B (zh)

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CN201510345134.1A CN105001226B (zh) 2011-08-12 2012-08-10 三环杂环化合物和jak抑制剂

Applications Claiming Priority (11)

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JP2011-177289 2011-08-12
JP2011177270 2011-08-12
JP2011177289 2011-08-12
JP2011-177270 2011-08-12
JP2012097073 2012-04-20
JP2012-097073 2012-04-20
JP2012103516 2012-04-27
JP2012-103516 2012-04-27
JP2012-103517 2012-04-27
JP2012103517 2012-04-27
PCT/JP2012/070876 WO2013024895A1 (en) 2011-08-12 2012-08-10 Tricyclic heterocyclic compounds and jak inhibitors

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US (2) US9216999B2 (https=)
EP (2) EP3112370A1 (https=)
JP (2) JP6123804B2 (https=)
KR (1) KR102021159B1 (https=)
CN (2) CN103732597B (https=)
AU (1) AU2012295802B2 (https=)
BR (1) BR112014002472A2 (https=)
CA (1) CA2841458C (https=)
IL (2) IL230812A0 (https=)
IN (1) IN2014MN00228A (https=)
MX (1) MX365311B (https=)
MY (2) MY166970A (https=)
PH (1) PH12013502670A1 (https=)
RU (1) RU2632870C2 (https=)
TW (1) TWI601727B (https=)
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