CN103717308B - 微芯片和微粒分析装置 - Google Patents

微芯片和微粒分析装置 Download PDF

Info

Publication number
CN103717308B
CN103717308B CN201280037611.2A CN201280037611A CN103717308B CN 103717308 B CN103717308 B CN 103717308B CN 201280037611 A CN201280037611 A CN 201280037611A CN 103717308 B CN103717308 B CN 103717308B
Authority
CN
China
Prior art keywords
microchip
opening
basalis
hole
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201280037611.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN103717308A (zh
Inventor
秋山雄治
秋山昭次
山崎刚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sony Corp
Original Assignee
Sony Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sony Corp filed Critical Sony Corp
Publication of CN103717308A publication Critical patent/CN103717308A/zh
Application granted granted Critical
Publication of CN103717308B publication Critical patent/CN103717308B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201280037611.2A 2011-08-03 2012-06-29 微芯片和微粒分析装置 Active CN103717308B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011-169726 2011-08-03
JP2011169726A JP6003020B2 (ja) 2011-08-03 2011-08-03 マイクロチップ及び微小粒子分析装置
PCT/JP2012/004215 WO2013018273A1 (en) 2011-08-03 2012-06-29 Microchip and particle analyzing apparatus

Publications (2)

Publication Number Publication Date
CN103717308A CN103717308A (zh) 2014-04-09
CN103717308B true CN103717308B (zh) 2015-07-08

Family

ID=46598898

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280037611.2A Active CN103717308B (zh) 2011-08-03 2012-06-29 微芯片和微粒分析装置

Country Status (5)

Country Link
US (2) US9459182B2 (enExample)
EP (1) EP2739396B1 (enExample)
JP (1) JP6003020B2 (enExample)
CN (1) CN103717308B (enExample)
WO (1) WO2013018273A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
JP6003020B2 (ja) * 2011-08-03 2016-10-05 ソニー株式会社 マイクロチップ及び微小粒子分析装置
CN103547907B (zh) * 2012-03-30 2016-08-17 索尼公司 微粒分选装置和用于控制微粒分选装置中的位置的方法
JP5924077B2 (ja) 2012-03-30 2016-05-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取装置における軌道方向判定方法
US9087371B2 (en) 2012-03-30 2015-07-21 Sony Corporation Microparticle sorting device and method of optimizing fluid stream therein
US10379029B2 (en) 2012-09-18 2019-08-13 Cytonome/St, Llc Flow cell
WO2014093080A1 (en) * 2012-12-11 2014-06-19 The Regents Of The University Of California Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging
EP3910318B1 (en) 2013-01-28 2024-06-12 Sony Group Corporation Microparticle sorting device, and method and program for sorting microparticles
JP5991236B2 (ja) * 2013-03-13 2016-09-14 ソニー株式会社 分取装置
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
EP3035030B1 (en) 2013-10-16 2019-07-10 Sony Corporation Particle fractionation device, particle fractionation method, and program
CN115266543A (zh) 2013-10-30 2022-11-01 Abs全球公司 识别对象的装置及相关方法
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
CN105980831B (zh) 2014-02-13 2021-01-12 索尼公司 粒子分捡装置、粒子分捡方法、程序以及粒子分捡系统
JP6657625B2 (ja) 2014-09-05 2020-03-04 ソニー株式会社 液滴分取装置、液滴分取方法及びプログラム
WO2016122554A1 (en) 2015-01-30 2016-08-04 Hewlett-Packard Development Company, L.P. Microfluidic flow control
JP2018509615A (ja) 2015-02-19 2018-04-05 プレミアム ジェネティクス （ユーケー） リミテッド 走査型赤外線測定システム
EP3271127B1 (en) * 2015-03-17 2020-11-18 President and Fellows of Harvard College Method for automated membrane fabrication
GB201509640D0 (en) * 2015-06-03 2015-07-15 Sphere Fluidics Ltd Systems and methods
EP3343200B1 (en) 2015-10-19 2021-12-15 Sony Group Corporation Image processing device, microparticle separation device, and image processing method
KR102501627B1 (ko) * 2016-04-15 2023-02-21 벡톤 디킨슨 앤드 컴퍼니 밀폐형 액적 분류기 및 이의 사용 방법
JP6919215B2 (ja) 2017-02-17 2021-08-18 ソニーグループ株式会社 マイクロチップ及び微小粒子分取装置
JP6922281B2 (ja) * 2017-03-14 2021-08-18 ソニーグループ株式会社 マイクロチップ、及び微小粒子測定装置
ES2774703T3 (es) * 2017-06-27 2020-07-22 Univ Graz Medizinische Método y dispositivo para analizar una muestra fluídica con partículas dispersadas
US11666900B2 (en) 2018-01-24 2023-06-06 Sniper (Suzhou) Life Technology Co. Motion controlling mechanism, liquid discharging nozzle, microdroplet generating device and method, liquid driving mechanism and method, microdroplet generating method, and surface processing method of liquid discharging nozzle
WO2019144905A1 (zh) 2018-01-24 2019-08-01 北京光阱管理咨询合伙企业（有限合伙） 微液滴容器、微液滴容器制备方法、微液滴平铺方法、微液滴生成试剂盒、温控装置、微液滴生成用油相组合物及其处理方法
WO2019195836A1 (en) * 2018-04-07 2019-10-10 Lumacyte, LLC Fluidic autosampler and incubator
BR112020023607A2 (pt) 2018-05-23 2021-02-17 Abs Global, Inc. sistemas e métodos para focalização de partículas em microcanais
EP3851829B1 (en) * 2018-09-10 2024-05-29 Sony Group Corporation Channel unit for fine particle isolation and fine particle isolation device
JP7495400B2 (ja) * 2018-10-30 2024-06-04 ベクトン・ディキンソン・アンド・カンパニー アライメント窓を有する粒子選別モジュール、システム、およびその使用方法
US10795413B1 (en) 2019-04-03 2020-10-06 Manufacturing Resources International, Inc. Electronic display assembly with a channel for ambient air in an access panel
CN117413819A (zh) 2019-04-18 2024-01-19 艾步思国际有限责任公司 用于连续添加冷冻保护剂的系统和工艺
CN114901395B (zh) * 2019-11-27 2024-11-05 10X基因组学有限公司 用于产生液滴的装置、系统和方法
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
CN116368237A (zh) 2020-10-21 2023-06-30 Abs全球股份有限公司 用于处理遗传样本以确定特性或检测污染的方法及系统
WO2022108840A1 (en) 2020-11-23 2022-05-27 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2370519A (en) * 2000-11-13 2002-07-03 Agilent Technologies Inc Micro-device with electro-spray emitter
CN1601115A (zh) * 2004-10-25 2005-03-30 北京大学 微型射流泵及其制备方法
CN101609088A (zh) * 2008-06-16 2009-12-23 索尼株式会社 微流控芯片和微流控芯片中的送流方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03164256A (ja) * 1989-11-24 1991-07-16 Canon Inc インクジェットヘッド
JPH0985156A (ja) * 1995-09-21 1997-03-31 Dainippon Screen Mfg Co Ltd 回転式基板塗布装置
JP2003334760A (ja) * 2002-05-15 2003-11-25 Asahi Diamond Industrial Co Ltd ノズル
JP2004069499A (ja) * 2002-08-06 2004-03-04 Canon Inc 液体搬送装置およびそれを用いた化学分析装置
SE0300454D0 (sv) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
US7651665B2 (en) * 2004-09-07 2010-01-26 Hewlett-Packard Development Company, L.P. Microtray for handling biosubstances
US20060060769A1 (en) * 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
JP2006192622A (ja) * 2005-01-12 2006-07-27 Sony Corp 液体吐出ヘッド、液体吐出装置、及び液体吐出ヘッドの製造方法
JP2010038866A (ja) * 2008-08-08 2010-02-18 Sony Corp マイクロチップ、微小粒子分取装置及び送流方法
JP5487638B2 (ja) * 2009-02-17 2014-05-07 ソニー株式会社 微小粒子分取のための装置及びマイクロチップ
JP5691195B2 (ja) * 2010-03-01 2015-04-01 ソニー株式会社 マイクロチップ及び微小粒子分析装置
USD704580S1 (en) * 2012-03-08 2014-05-13 Sony Corporation Micro flow channel chip for flow cytometer
JP2011237201A (ja) * 2010-05-06 2011-11-24 Sony Corp 微小粒子分取装置、マイクロチップ及びマイクロチップモジュール
JP6003020B2 (ja) * 2011-08-03 2016-10-05 ソニー株式会社 マイクロチップ及び微小粒子分析装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2370519A (en) * 2000-11-13 2002-07-03 Agilent Technologies Inc Micro-device with electro-spray emitter
CN1601115A (zh) * 2004-10-25 2005-03-30 北京大学 微型射流泵及其制备方法
CN101609088A (zh) * 2008-06-16 2009-12-23 索尼株式会社 微流控芯片和微流控芯片中的送流方法

Also Published As

Publication number Publication date
JP2013032994A (ja) 2013-02-14
JP6003020B2 (ja) 2016-10-05
EP2739396B1 (en) 2020-01-01
US9459182B2 (en) 2016-10-04
WO2013018273A1 (en) 2013-02-07
US20140174206A1 (en) 2014-06-26
EP2739396A1 (en) 2014-06-11
CN103717308A (zh) 2014-04-09
US10315194B2 (en) 2019-06-11
US20170028398A1 (en) 2017-02-02

Similar Documents

Publication Publication Date Title
CN103717308B (zh) 微芯片和微粒分析装置
KR101850548B1 (ko) 미소 입자 분류 장치, 마이크로칩 모듈 및 미소 입자들의 분류 방법
JP4572973B2 (ja) マイクロチップ及びマイクロチップにおける送流方法
JP4661942B2 (ja) マイクロチップとその流路構造
JP5487638B2 (ja) 微小粒子分取のための装置及びマイクロチップ
JP6922281B2 (ja) マイクロチップ、及び微小粒子測定装置
CN103547907A (zh) 微粒分选装置和用于控制微粒分选装置中的位置的方法
WO2014017186A1 (ja) 微小粒子測定装置及び微小粒子測定装置における送液方法
JP5316530B2 (ja) マイクロチップとその流路構造
CN105126940B (zh) 复合结构体和用于分析微粒子的微芯片
JP5092881B2 (ja) 流路構造及びマイクロチップ
JP2013250229A (ja) 微小粒子分取用マイクロチップ、該微小粒子分取用マイクロチップが搭載された微小粒子分取装置、並びに微小粒子の分取方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant