CN103703138A - 采用脂肪酶自β-内酯产生L-肉碱的方法 - Google Patents

采用脂肪酶自β-内酯产生L-肉碱的方法 Download PDF

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Publication number
CN103703138A
CN103703138A CN201280036473.6A CN201280036473A CN103703138A CN 103703138 A CN103703138 A CN 103703138A CN 201280036473 A CN201280036473 A CN 201280036473A CN 103703138 A CN103703138 A CN 103703138A
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CN
China
Prior art keywords
halo
lactone
hydroxybutyrate
aforementioned
lipase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201280036473.6A
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English (en)
Chinese (zh)
Inventor
M·阿维
E·克莱格拉夫
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Lonza AG
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Lonza AG
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Publication date
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Publication of CN103703138A publication Critical patent/CN103703138A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201280036473.6A 2011-07-27 2012-07-25 采用脂肪酶自β-内酯产生L-肉碱的方法 Pending CN103703138A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161512032P 2011-07-27 2011-07-27
EP11006163.7 2011-07-27
EP11006163A EP2551350A1 (en) 2011-07-27 2011-07-27 Process for producing L-carnitine from ß-lactones employing lipases
US61/512,032 2011-07-27
PCT/EP2012/064575 WO2013014179A1 (en) 2011-07-27 2012-07-25 Process for producing l-carnitine from beta-lactones employing lipases

Publications (1)

Publication Number Publication Date
CN103703138A true CN103703138A (zh) 2014-04-02

Family

ID=44508594

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280036473.6A Pending CN103703138A (zh) 2011-07-27 2012-07-25 采用脂肪酶自β-内酯产生L-肉碱的方法

Country Status (8)

Country Link
US (1) US9523106B2 (enExample)
EP (2) EP2551350A1 (enExample)
JP (2) JP2014521325A (enExample)
KR (1) KR20140057286A (enExample)
CN (1) CN103703138A (enExample)
AR (1) AR087317A1 (enExample)
TW (1) TWI595093B (enExample)
WO (1) WO2013014179A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110372525A (zh) * 2019-07-25 2019-10-25 抚顺顺能化工有限公司 一种以r-(-)-环氧氯丙烷为起始原料合成l-肉碱的制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103497978B (zh) * 2013-09-06 2017-12-26 蚌埠丰原医药科技发展有限公司 一种高光学纯l‑肉碱的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH680588A5 (en) * 1990-03-01 1992-09-30 Lonza Ag Prepn. of optically active 2-oxetanone derivs. - by hydrodechlorination of 4-(tri:, di: or mono:chloromethyl)-2-oxetanone(s) using tri: N-butyl tin hydride
KR20090022032A (ko) * 2007-08-29 2009-03-04 한국화학연구원 광학활성 알킬 3-하이드록시부타노에이트 유도체의제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5473104A (en) 1994-09-13 1995-12-05 Neurocrine Biosciences, Inc. Process for the preparation of L-carnitine
DE102004037700A1 (de) 2004-08-02 2006-03-16 Basf Ag Verfahren zur enantioselektiven Öffnung von Oxetan-2-onen
JP2006063001A (ja) 2004-08-25 2006-03-09 Takasago Internatl Corp 光学活性β−ブチロラクトンの製造方法
US7569709B2 (en) 2006-03-10 2009-08-04 Cornell Research Foundation, Inc. Low pressure carbonylation of heterocycles
TWI400223B (zh) * 2007-11-16 2013-07-01 Lonza Ag 製備甜菜鹼的方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH680588A5 (en) * 1990-03-01 1992-09-30 Lonza Ag Prepn. of optically active 2-oxetanone derivs. - by hydrodechlorination of 4-(tri:, di: or mono:chloromethyl)-2-oxetanone(s) using tri: N-butyl tin hydride
KR20090022032A (ko) * 2007-08-29 2009-03-04 한국화학연구원 광학활성 알킬 3-하이드록시부타노에이트 유도체의제조방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHOONG EUI SONG ET AL: "New Method for the Preparation of (R)-Carnitine", 《TETRAHEDRON: ASYMMETRY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110372525A (zh) * 2019-07-25 2019-10-25 抚顺顺能化工有限公司 一种以r-(-)-环氧氯丙烷为起始原料合成l-肉碱的制备方法

Also Published As

Publication number Publication date
EP2551350A1 (en) 2013-01-30
EP2737074B1 (en) 2016-06-01
TWI595093B (zh) 2017-08-11
US9523106B2 (en) 2016-12-20
TW201305345A (zh) 2013-02-01
WO2013014179A1 (en) 2013-01-31
JP2014521325A (ja) 2014-08-28
KR20140057286A (ko) 2014-05-12
US20130034885A1 (en) 2013-02-07
EP2737074A1 (en) 2014-06-04
JP6169812B2 (ja) 2017-07-26
AR087317A1 (es) 2014-03-12
JP2017108745A (ja) 2017-06-22

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