KR20140057286A - 리파아제를 이용해 베타-락톤에서 l-카르니틴을 제조하는 방법 - Google Patents

리파아제를 이용해 베타-락톤에서 l-카르니틴을 제조하는 방법 Download PDF

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Publication number
KR20140057286A
KR20140057286A KR1020147004878A KR20147004878A KR20140057286A KR 20140057286 A KR20140057286 A KR 20140057286A KR 1020147004878 A KR1020147004878 A KR 1020147004878A KR 20147004878 A KR20147004878 A KR 20147004878A KR 20140057286 A KR20140057286 A KR 20140057286A
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KR
South Korea
Prior art keywords
halo
hydroxybutyric acid
lactone
carnitine
lipase
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Ceased
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KR1020147004878A
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English (en)
Korean (ko)
Inventor
마누엘라 아비
엘렌 클레그라프
Original Assignee
론자 아게 (론자 엘티디.)
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Publication date
Application filed by 론자 아게 (론자 엘티디.) filed Critical 론자 아게 (론자 엘티디.)
Publication of KR20140057286A publication Critical patent/KR20140057286A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020147004878A 2011-07-27 2012-07-25 리파아제를 이용해 베타-락톤에서 l-카르니틴을 제조하는 방법 Ceased KR20140057286A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161512032P 2011-07-27 2011-07-27
EP11006163.7 2011-07-27
EP11006163A EP2551350A1 (en) 2011-07-27 2011-07-27 Process for producing L-carnitine from ß-lactones employing lipases
US61/512,032 2011-07-27
PCT/EP2012/064575 WO2013014179A1 (en) 2011-07-27 2012-07-25 Process for producing l-carnitine from beta-lactones employing lipases

Publications (1)

Publication Number Publication Date
KR20140057286A true KR20140057286A (ko) 2014-05-12

Family

ID=44508594

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147004878A Ceased KR20140057286A (ko) 2011-07-27 2012-07-25 리파아제를 이용해 베타-락톤에서 l-카르니틴을 제조하는 방법

Country Status (8)

Country Link
US (1) US9523106B2 (enExample)
EP (2) EP2551350A1 (enExample)
JP (2) JP2014521325A (enExample)
KR (1) KR20140057286A (enExample)
CN (1) CN103703138A (enExample)
AR (1) AR087317A1 (enExample)
TW (1) TWI595093B (enExample)
WO (1) WO2013014179A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103497978B (zh) * 2013-09-06 2017-12-26 蚌埠丰原医药科技发展有限公司 一种高光学纯l‑肉碱的制备方法
CN110372525A (zh) * 2019-07-25 2019-10-25 抚顺顺能化工有限公司 一种以r-(-)-环氧氯丙烷为起始原料合成l-肉碱的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH680588A5 (en) 1990-03-01 1992-09-30 Lonza Ag Prepn. of optically active 2-oxetanone derivs. - by hydrodechlorination of 4-(tri:, di: or mono:chloromethyl)-2-oxetanone(s) using tri: N-butyl tin hydride
US5473104A (en) 1994-09-13 1995-12-05 Neurocrine Biosciences, Inc. Process for the preparation of L-carnitine
DE102004037700A1 (de) 2004-08-02 2006-03-16 Basf Ag Verfahren zur enantioselektiven Öffnung von Oxetan-2-onen
JP2006063001A (ja) 2004-08-25 2006-03-09 Takasago Internatl Corp 光学活性β−ブチロラクトンの製造方法
US7569709B2 (en) 2006-03-10 2009-08-04 Cornell Research Foundation, Inc. Low pressure carbonylation of heterocycles
KR100893763B1 (ko) * 2007-08-29 2009-04-20 한국화학연구원 광학활성 알킬 3-하이드록시부타노에이트 유도체의 제조방법
TWI400223B (zh) * 2007-11-16 2013-07-01 Lonza Ag 製備甜菜鹼的方法

Also Published As

Publication number Publication date
EP2551350A1 (en) 2013-01-30
EP2737074B1 (en) 2016-06-01
TWI595093B (zh) 2017-08-11
US9523106B2 (en) 2016-12-20
TW201305345A (zh) 2013-02-01
CN103703138A (zh) 2014-04-02
WO2013014179A1 (en) 2013-01-31
JP2014521325A (ja) 2014-08-28
US20130034885A1 (en) 2013-02-07
EP2737074A1 (en) 2014-06-04
JP6169812B2 (ja) 2017-07-26
AR087317A1 (es) 2014-03-12
JP2017108745A (ja) 2017-06-22

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