CN103687594A - 眼科治疗 - Google Patents

眼科治疗 Download PDF

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Publication number
CN103687594A
CN103687594A CN201280025096.6A CN201280025096A CN103687594A CN 103687594 A CN103687594 A CN 103687594A CN 201280025096 A CN201280025096 A CN 201280025096A CN 103687594 A CN103687594 A CN 103687594A
Authority
CN
China
Prior art keywords
eye
compositions
composition
opioid
tramadol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280025096.6A
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English (en)
Chinese (zh)
Inventor
安纳特·夏尔马
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
O F Toso J Research & Development Ltd
Original Assignee
Optosolve Research and Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1105731.2A external-priority patent/GB201105731D0/en
Priority claimed from GBGB1105732.0A external-priority patent/GB201105732D0/en
Application filed by Optosolve Research and Development Ltd filed Critical Optosolve Research and Development Ltd
Priority to CN201711200533.4A priority Critical patent/CN107982211A/zh
Publication of CN103687594A publication Critical patent/CN103687594A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280025096.6A 2011-04-05 2012-04-05 眼科治疗 Pending CN103687594A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711200533.4A CN107982211A (zh) 2011-04-05 2012-04-05 眼科治疗

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1105731.2A GB201105731D0 (en) 2011-04-05 2011-04-05 Topical analgesics
GB1105732.0 2011-04-05
GBGB1105732.0A GB201105732D0 (en) 2011-04-05 2011-04-05 Ophthalmic lubricants
GB1105731.2 2011-04-05
PCT/GB2012/000330 WO2012136969A2 (en) 2011-04-05 2012-04-05 Ophthalmic treatments

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201711200533.4A Division CN107982211A (zh) 2011-04-05 2012-04-05 眼科治疗

Publications (1)

Publication Number Publication Date
CN103687594A true CN103687594A (zh) 2014-03-26

Family

ID=46086008

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201280025096.6A Pending CN103687594A (zh) 2011-04-05 2012-04-05 眼科治疗
CN201711200533.4A Pending CN107982211A (zh) 2011-04-05 2012-04-05 眼科治疗

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201711200533.4A Pending CN107982211A (zh) 2011-04-05 2012-04-05 眼科治疗

Country Status (12)

Country Link
US (2) US20140088199A1 (https=)
EP (2) EP3799866A1 (https=)
JP (2) JP6148664B2 (https=)
KR (2) KR20140145948A (https=)
CN (2) CN103687594A (https=)
BR (1) BR112013025493A2 (https=)
CA (1) CA2869280C (https=)
ES (1) ES2836808T3 (https=)
HK (1) HK1254720A1 (https=)
MA (1) MA35070B1 (https=)
MX (1) MX346312B (https=)
WO (1) WO2012136969A2 (https=)

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CN105232449A (zh) * 2015-10-30 2016-01-13 上海昊海生物科技股份有限公司 盐酸莫西沙星透明质酸钠缓释纳米凝胶及其制备方法
CN110996954A (zh) * 2017-06-08 2020-04-10 眼科治疗有限责任公司 低剂量的溴莫尼定组合及其用途
CN111655241A (zh) * 2017-12-15 2020-09-11 塔苏斯制药有限公司 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法
CN112007028A (zh) * 2020-09-03 2020-12-01 北京博纳致恒科技有限责任公司 一种复合睫状肌松弛剂的人工泪液及用途
CN113577097A (zh) * 2015-09-24 2021-11-02 基质生物研究所 高弹性透明质酸组合物及其使用方法
US12257263B2 (en) 2014-08-04 2025-03-25 Tarsus Pharmaceuticals, Inc. Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations

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GB201217522D0 (en) * 2012-10-01 2012-11-14 Sharma Anant ophthalmic therapy
AU2014252808A1 (en) * 2013-04-09 2015-11-12 Cresset Biomolecular Discovery Ltd The treatment of inflammatory disorders
ES2540151B1 (es) * 2013-10-11 2016-02-29 Farmalider S.A. Composición farmacéutica de ibuprofeno y tramadol para uso oftálmico
RU2549472C1 (ru) * 2013-12-26 2015-04-27 Илья Александрович Марков Фармацевтическая композиция в форме капель для профилактики и лечения аллергических заболеваний глаз
US9913849B2 (en) * 2014-01-10 2018-03-13 Manistee Partners Llc Treatment of migraines
WO2016172712A2 (en) 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
KR20170132725A (ko) * 2015-02-24 2017-12-04 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 안구 건조 질환 및 다른 안과 질환을 치료하기 위한 방법 및 조성물
US9877964B2 (en) 2015-02-24 2018-01-30 Ocugen, Inc. Methods and compositions for treating dry eye disease and other eye disorders
HK1248570A1 (zh) 2015-05-29 2018-10-19 西德奈克西斯公司 D2o稳定化的药物制剂
ES2604816B1 (es) * 2015-09-09 2018-01-29 Farmalider, S.A. Composición farmacéutica de tramadol para uso oftálmico
EP3355874A4 (en) * 2015-09-30 2019-06-12 George Edward Hoag TOPICAL ANALGETIC FORMULATIONS, MANUFACTURE AND METHOD FOR USE THEREOF
CN110114119B (zh) * 2016-10-12 2022-05-31 Ps治疗有限公司 人工泪液、隐形眼镜和药物载体组合物及其使用方法
EP3624773A4 (en) 2017-05-19 2021-04-07 Ocugen, Inc. OPHTHALMIC COMPOSITIONS AND METHOD OF USE
WO2019122982A1 (en) 2017-12-21 2019-06-27 Grünenthal GmbH Pharmaceutical combination in a bilayer tablet form comprising ketorolac tromethamine and tramadol hydrochloride, and its use in pain treatment
JP7370316B2 (ja) * 2018-03-13 2023-10-27 参天製薬株式会社 点眼型洗眼薬用組成物
FR3096890B1 (fr) * 2019-06-07 2021-05-14 H4 Orphan Pharma Utilisation d’une molécule opioïde pour traiter l’œil sec et l’œil allergique.
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US20230077811A1 (en) * 2020-02-11 2023-03-16 Tufts Medical Center, Inc. Activation of neuropeptide receptors on plasmacytoid dendritic cells to treat or prevent ocular diseases associated with neovascularization and inflammation
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JP2024509372A (ja) * 2021-02-26 2024-03-01 ヴァイルマ インコーポレイテッド ガバペンチノイドの局所投与のための方法及び製剤
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WO2024010040A1 (ja) * 2022-07-06 2024-01-11 ロート製薬株式会社 眼科組成物
WO2024010045A1 (ja) * 2022-07-06 2024-01-11 学校法人金沢医科大学 疼痛抑制剤
JPWO2024010044A1 (https=) * 2022-07-06 2024-01-11
TW202408472A (zh) * 2022-07-06 2024-03-01 日商樂敦製藥股份有限公司 眼科組成物
WO2025146828A1 (ja) * 2024-01-05 2025-07-10 ロート製薬株式会社 眼科組成物
WO2025159099A1 (ja) * 2024-01-24 2025-07-31 国立大学法人北海道大学 医薬組成物、眼瞼けいれん処置薬、知覚過敏またはジストニア処置薬、および症状モデルマウス

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12257263B2 (en) 2014-08-04 2025-03-25 Tarsus Pharmaceuticals, Inc. Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
CN113577097A (zh) * 2015-09-24 2021-11-02 基质生物研究所 高弹性透明质酸组合物及其使用方法
CN105232449A (zh) * 2015-10-30 2016-01-13 上海昊海生物科技股份有限公司 盐酸莫西沙星透明质酸钠缓释纳米凝胶及其制备方法
CN105232449B (zh) * 2015-10-30 2019-04-09 上海昊海生物科技股份有限公司 盐酸莫西沙星透明质酸钠缓释纳米凝胶及其制备方法
CN110996954A (zh) * 2017-06-08 2020-04-10 眼科治疗有限责任公司 低剂量的溴莫尼定组合及其用途
CN111655241A (zh) * 2017-12-15 2020-09-11 塔苏斯制药有限公司 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法
US12213964B2 (en) 2017-12-15 2025-02-04 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations
US12364685B2 (en) 2017-12-15 2025-07-22 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
CN112007028A (zh) * 2020-09-03 2020-12-01 北京博纳致恒科技有限责任公司 一种复合睫状肌松弛剂的人工泪液及用途

Also Published As

Publication number Publication date
JP2014513073A (ja) 2014-05-29
HK1254720A1 (zh) 2019-07-26
MA35070B1 (fr) 2014-04-03
US9913813B2 (en) 2018-03-13
US20160199320A1 (en) 2016-07-14
CN107982211A (zh) 2018-05-04
KR20190004815A (ko) 2019-01-14
EP2694048A2 (en) 2014-02-12
KR102165246B1 (ko) 2020-10-13
WO2012136969A2 (en) 2012-10-11
JP2017141243A (ja) 2017-08-17
ES2836808T3 (es) 2021-06-28
MX346312B (es) 2017-03-15
US20140088199A1 (en) 2014-03-27
JP6148664B2 (ja) 2017-06-14
CA2869280A1 (en) 2012-10-11
WO2012136969A3 (en) 2013-01-03
BR112013025493A2 (pt) 2017-03-01
EP2694048B1 (en) 2020-10-07
EP3799866A1 (en) 2021-04-07
MX2013011314A (es) 2014-03-27
JP6419876B2 (ja) 2018-11-07
KR20140145948A (ko) 2014-12-24
CA2869280C (en) 2020-03-10

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