CN103642902B - 遗传分析系统和方法 - Google Patents
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Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8340950B2 (en) | 2006-02-10 | 2012-12-25 | Affymetrix, Inc. | Direct to consumer genotype-based products and services |
US20080131887A1 (en) | 2006-11-30 | 2008-06-05 | Stephan Dietrich A | Genetic Analysis Systems and Methods |
WO2008103299A2 (en) | 2007-02-16 | 2008-08-28 | Massachusetts Eye & Ear Infirmary | Methods and compositions for prognosing, detecting, and treating age-related macular degeneration |
US7844609B2 (en) | 2007-03-16 | 2010-11-30 | Expanse Networks, Inc. | Attribute combination discovery |
FR2934698B1 (fr) * | 2008-08-01 | 2011-11-18 | Commissariat Energie Atomique | Procede de prediction pour le pronostic ou le diagnostic ou la reponse therapeutique d'une maladie et notamment du cancer de la prostate et dispositif permettant la mise en oeuvre du procede. |
WO2010017520A1 (en) * | 2008-08-08 | 2010-02-11 | Navigenics, Inc. | Methods and systems for personalized action plans |
BRPI0918889A2 (pt) * | 2008-09-12 | 2015-12-01 | Navigenics Inc | método para gerar uma pontuação de um índice composto genético ambiental (egci) para uma doença ou condição de um indivíduo |
NZ572036A (en) | 2008-10-15 | 2010-03-26 | Nikola Kirilov Kasabov | Data analysis and predictive systems and related methodologies |
WO2010067381A1 (en) * | 2008-12-12 | 2010-06-17 | Decode Genetics Ehf | Genetic variants as markers for use in diagnosis, prognosis and treatment of eosinophilia, asthma, and myocardial infarction |
US8108406B2 (en) | 2008-12-30 | 2012-01-31 | Expanse Networks, Inc. | Pangenetic web user behavior prediction system |
EP3276526A1 (en) | 2008-12-31 | 2018-01-31 | 23Andme, Inc. | Finding relatives in a database |
AU2010242073C1 (en) | 2009-04-30 | 2015-12-24 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
AU2010256343B2 (en) * | 2009-06-01 | 2014-01-30 | Genetic Technologies Limited | Methods for breast cancer risk assessment |
DE102010013114B4 (de) * | 2010-03-26 | 2012-02-16 | Rüdiger Lawaczeck | Prädiagnostisches Sicherheitssystem |
KR20110136638A (ko) * | 2010-06-15 | 2011-12-21 | 재단법인 게놈연구재단 | 게놈정보를 이용하여 온라인 상의 사회적 네트워크를 형성하는 시스템 및 그 형성방법 |
WO2012006669A1 (en) * | 2010-07-13 | 2012-01-19 | Fitgenes Pty Ltd | System and method for determining personal health intervention |
WO2012030967A1 (en) * | 2010-08-31 | 2012-03-08 | Knome, Inc. | Personal genome indexer |
US20120309641A1 (en) | 2010-10-19 | 2012-12-06 | Medtronic, Inc. | Diagnostic kits, genetic markers, and methods for scd or sca therapy selection |
EP2636003B1 (en) * | 2010-11-01 | 2019-08-14 | Koninklijke Philips N.V. | In vitro diagnostic testing including automated brokering of royalty payments for proprietary tests |
US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
US8718950B2 (en) | 2011-07-08 | 2014-05-06 | The Medical College Of Wisconsin, Inc. | Methods and apparatus for identification of disease associated mutations |
CA2812342C (en) * | 2011-09-26 | 2015-04-07 | John TRAKADIS | Method and system for genetic trait search based on the phenotype and the genome of a human subject |
US10378060B2 (en) | 2011-10-14 | 2019-08-13 | Dana-Farber Cancer Institute, Inc. | ZNF365/ZFP365 biomarker predictive of anti-cancer response |
KR101295785B1 (ko) * | 2011-10-31 | 2013-08-12 | 삼성에스디에스 주식회사 | 유전변이 데이터 베이스 구축 장치 및 방법 |
US10437858B2 (en) | 2011-11-23 | 2019-10-08 | 23Andme, Inc. | Database and data processing system for use with a network-based personal genetics services platform |
US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
KR20140009854A (ko) * | 2012-07-13 | 2014-01-23 | 삼성전자주식회사 | 치료제 선정을 위한 유전 정보의 분석 방법 및 장치 |
KR101967248B1 (ko) * | 2012-08-16 | 2019-04-10 | 삼성전자주식회사 | 개인의 유전 정보를 분석하는 방법 및 장치 |
JP5844715B2 (ja) | 2012-11-07 | 2016-01-20 | 学校法人沖縄科学技術大学院大学学園 | データ通信システム、データ解析装置、データ通信方法、および、プログラム |
KR101533395B1 (ko) * | 2013-01-21 | 2015-07-08 | 이상열 | 단일 염기 다형성을 이용한 개체간의 유사도 산출 방법 및 시스템 |
WO2014119914A1 (ko) * | 2013-02-01 | 2014-08-07 | 에스케이텔레콤 주식회사 | 유전자 서열 기반 개인 마커에 관한 정보를 제공하는 방법 및 이를 이용한 장치 |
EP2971159B1 (en) | 2013-03-14 | 2019-05-08 | Molecular Loop Biosolutions, LLC | Methods for analyzing nucleic acids |
US20140274763A1 (en) * | 2013-03-15 | 2014-09-18 | Pathway Genomics Corporation | Method and system to predict response to pain treatments |
US9192647B2 (en) | 2013-10-04 | 2015-11-24 | Hans-Michael Dosch | Method for reversing recent-onset type 1 diabetes (T1D) by administering substance P (sP) |
US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
TW201516725A (zh) * | 2013-10-18 | 2015-05-01 | Tci Gene Inc | 單一核苷酸多型性疾病發生率預測系統 |
FI20136079A (fi) * | 2013-11-04 | 2015-05-05 | Medisapiens Oy | Menetelmä ja järjestelmä geeniperimän terveyden arvioimiseksi |
DE202014010499U1 (de) | 2013-12-17 | 2015-10-20 | Kymab Limited | Targeting von humaner PCSK9 zur Cholesterinbehandlung |
KR101400946B1 (ko) * | 2013-12-27 | 2014-05-29 | 한국과학기술정보연구원 | 생물학적 네트워크 분석 장치 및 방법 |
KR102131973B1 (ko) * | 2013-12-30 | 2020-07-08 | 주식회사 케이티 | 개인 건강관리 방법 및 시스템 |
CN106460062A (zh) | 2014-05-05 | 2017-02-22 | 美敦力公司 | 用于scd、crt、crt‑d或sca治疗识别和/或选择的方法和组合物 |
US11053548B2 (en) | 2014-05-12 | 2021-07-06 | Good Start Genetics, Inc. | Methods for detecting aneuploidy |
EP3332790A1 (en) | 2014-07-15 | 2018-06-13 | Kymab Limited | Antibodies for use in treating conditions related to specific pcsk9 variants in specific patients populations |
EP4328245A3 (en) | 2014-07-15 | 2024-06-05 | Kymab Ltd. | Antibodies for use in treating conditions related to specific pcsk9 variants in specific patients populations |
DE202015009002U1 (de) | 2014-07-15 | 2016-08-18 | Kymab Limited | Targeting von humaner PCSK9 zur Cholesterinbehandlung |
WO2016023916A1 (en) | 2014-08-12 | 2016-02-18 | Kymab Limited | Treatment of disease using ligand binding to targets of interest |
US20180032673A1 (en) * | 2014-09-03 | 2018-02-01 | Otsuka Pharmaceutical Co., Ltd. | Pathology determination assistance device, method and storage medium |
US11408024B2 (en) | 2014-09-10 | 2022-08-09 | Molecular Loop Biosciences, Inc. | Methods for selectively suppressing non-target sequences |
EP3224595A4 (en) | 2014-09-24 | 2018-06-13 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
WO2016071701A1 (en) | 2014-11-07 | 2016-05-12 | Kymab Limited | Treatment of disease using ligand binding to targets of interest |
WO2016112073A1 (en) | 2015-01-06 | 2016-07-14 | Good Start Genetics, Inc. | Screening for structural variants |
CA2974199A1 (en) | 2015-01-20 | 2016-07-28 | Nantomics, Llc | Systems and methods for response prediction to chemotherapy in high grade bladder cancer |
EP3256606B1 (en) * | 2015-02-09 | 2019-05-22 | 10X Genomics, Inc. | Systems and methods for determining structural variation |
CA2978708A1 (en) * | 2015-03-03 | 2016-09-09 | Nantomics, Llc | Ensemble-based research recommendation systems and methods |
KR102508971B1 (ko) * | 2015-07-22 | 2023-03-09 | 주식회사 케이티 | 질병 위험도 예측 방법 및 이를 수행하는 장치 |
WO2017048945A1 (en) * | 2015-09-16 | 2017-03-23 | Good Start Genetics, Inc. | Systems and methods for medical genetic testing |
AU2016324166A1 (en) * | 2015-09-18 | 2018-05-10 | Omicia, Inc. | Predicting disease burden from genome variants |
KR101795662B1 (ko) * | 2015-11-19 | 2017-11-13 | 연세대학교 산학협력단 | 대사 이상 질환 진단 장치 및 그 방법 |
FR3045874B1 (fr) * | 2015-12-18 | 2019-06-14 | Axlr, Satt Du Languedoc Roussillon | Architecture pour l'analyse de donnees genomiques |
JP6776576B2 (ja) * | 2016-03-28 | 2020-10-28 | 富士通株式会社 | データベース処理プログラム、データベース処理装置及びデータベース処理方法 |
KR101991007B1 (ko) * | 2016-05-27 | 2019-06-20 | (주)메디젠휴먼케어 | Snp를 이용한 질병 관련 유전체 분석 시스템 및 장치 |
EP3479272A1 (en) * | 2016-06-29 | 2019-05-08 | Koninklijke Philips N.V. | Disease-oriented genomic anonymization |
KR101815529B1 (ko) | 2016-07-29 | 2018-01-30 | (주)신테카바이오 | 휴먼 하플로타이핑 시스템 및 방법 |
WO2018042185A1 (en) * | 2016-09-02 | 2018-03-08 | Imperial Innovations Ltd | Methods, systems and apparatus for identifying pathogenic gene variants |
CN106778083A (zh) * | 2016-11-28 | 2017-05-31 | 墨宝股份有限公司 | 一种自动生成基因检测报告的方法及装置 |
EP3553737A4 (en) * | 2016-12-12 | 2019-11-06 | Nec Corporation | INFORMATION PROCESSING DEVICE, METHOD FOR GENETIC INFORMATION AND PROGRAM GENERATION |
WO2018168986A1 (ja) * | 2017-03-15 | 2018-09-20 | 東洋紡株式会社 | 遺伝子検査方法及び遺伝子検査キット |
CN108629153A (zh) * | 2017-03-23 | 2018-10-09 | 广州康昕瑞基因健康科技有限公司 | 医学基因分析方法和系统 |
US20200174021A1 (en) * | 2017-08-08 | 2020-06-04 | Queensland University Of Technology | Methods for diagnosis of early stage heart failure |
KR102073590B1 (ko) * | 2017-08-17 | 2020-02-06 | (주)에이엔티홀딩스 | 유전자 정보에 기초하여 서비스를 제공하기 위한 방법, 시스템 및 비일시성의 컴퓨터 판독 가능 기록 매체 |
KR102097540B1 (ko) * | 2017-12-26 | 2020-04-07 | 주식회사 클리노믹스 | 질병 및 표현형 위험도 예측 장치 및 방법 |
CN108549795A (zh) * | 2018-03-13 | 2018-09-18 | 刘吟 | 基于家系图框架的遗传咨询信息系统 |
GB201810897D0 (en) * | 2018-07-03 | 2018-08-15 | Chronomics Ltd | Phenotype prediction |
CN109355368A (zh) * | 2018-10-22 | 2019-02-19 | 江苏美因康生物科技有限公司 | 一种快速检测高血压个体化用药基因多态性的试剂盒及方法 |
US10896742B2 (en) | 2018-10-31 | 2021-01-19 | Ancestry.Com Dna, Llc | Estimation of phenotypes using DNA, pedigree, and historical data |
GB2578727A (en) * | 2018-11-05 | 2020-05-27 | Earlham Inst | Genomic analysis |
WO2020132456A1 (en) * | 2018-12-20 | 2020-06-25 | The Johns Hopkins University | Treating type 1 diabetes, other autoimmune diseases |
JP7137520B2 (ja) * | 2019-04-23 | 2022-09-14 | ジェネシスヘルスケア株式会社 | 膵炎のリスクを判定する方法 |
JP7137522B2 (ja) * | 2019-04-24 | 2022-09-14 | ジェネシスヘルスケア株式会社 | 脊椎側弯症のリスクを判定する方法 |
JP7137521B2 (ja) * | 2019-04-24 | 2022-09-14 | ジェネシスヘルスケア株式会社 | 乾癬のリスクを判定する方法 |
JP7137525B2 (ja) * | 2019-04-24 | 2022-09-14 | ジェネシスヘルスケア株式会社 | 接触性皮膚炎のリスクを判定する方法 |
JP7137523B2 (ja) * | 2019-04-24 | 2022-09-14 | ジェネシスヘルスケア株式会社 | じんましんのリスクを判定する方法 |
JP7137526B2 (ja) * | 2019-04-24 | 2022-09-14 | ジェネシスヘルスケア株式会社 | アトピー性皮膚炎のリスクを判定する方法 |
JP7137524B2 (ja) * | 2019-04-24 | 2022-09-14 | ジェネシスヘルスケア株式会社 | 変形性膝関節症のリスクを判定する方法 |
KR102357453B1 (ko) * | 2019-06-24 | 2022-02-04 | (주) 아이크로진 | 유전 정보를 이용한 시각화 방법 및 시각화 서비스 플랫폼 |
KR102091790B1 (ko) * | 2019-09-02 | 2020-03-20 | 주식회사 클리노믹스 | 피검사자와 생물체 간의 유전자 정보를 이용한 유전적 띠 제공 시스템 및 그 방법 |
KR102151716B1 (ko) * | 2019-12-06 | 2020-09-04 | 주식회사 클리노믹스 | 게놈 정보를 이용한 유전적 성씨 정보 제공 시스템 및 방법 |
KR102179850B1 (ko) * | 2019-12-06 | 2020-11-17 | 주식회사 클리노믹스 | 구강 내 미생물 분석장치를 이용한 건강 예측 시스템 및 방법 |
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CN113921143B (zh) * | 2021-10-08 | 2024-04-16 | 天津金域医学检验实验室有限公司 | 一种共分离分析中Bayes因子的个性化估算方法及系统 |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1849401A (zh) * | 2003-09-17 | 2006-10-18 | 新加坡科技研究局 | 基因鉴定特征(gis)分析的方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000067139A (ja) * | 1998-08-25 | 2000-03-03 | Hitachi Ltd | 電子カルテシステム |
AU785341B2 (en) * | 1999-08-27 | 2007-01-25 | Iris Biotechnologies Inc. | Artificial intelligence system for genetic analysis |
WO2001026029A2 (en) * | 1999-10-01 | 2001-04-12 | Orchid Biosciences, Inc. | Method and system for providing genotype clinical information over a computer network |
US20020019746A1 (en) * | 2000-03-16 | 2002-02-14 | Rienhoff Hugh Y. | Aggregating persons with a select profile for further medical characterization |
JP2002107366A (ja) * | 2000-10-02 | 2002-04-10 | Hitachi Ltd | 診断支援システム |
AU2001297684A1 (en) * | 2000-12-04 | 2002-08-19 | Genaissance Pharmaceuticals, Inc. | System and method for the management of genomic data |
US20020128860A1 (en) * | 2001-01-04 | 2002-09-12 | Leveque Joseph A. | Collecting and managing clinical information |
US20020187483A1 (en) * | 2001-04-20 | 2002-12-12 | Cerner Corporation | Computer system for providing information about the risk of an atypical clinical event based upon genetic information |
US7461006B2 (en) * | 2001-08-29 | 2008-12-02 | Victor Gogolak | Method and system for the analysis and association of patient-specific and population-based genomic data with drug safety adverse event data |
US20030104453A1 (en) * | 2001-11-06 | 2003-06-05 | David Pickar | System for pharmacogenetics of adverse drug events |
US20040053263A1 (en) * | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
WO2004109551A1 (ja) * | 2003-06-05 | 2004-12-16 | Hitachi High-Technologies Corporation | 塩基配列関連情報を用いた情報提供システム及びプログラム |
GB0313964D0 (en) * | 2003-06-16 | 2003-07-23 | Mars Inc | Genotype test |
US7084264B2 (en) * | 2003-07-16 | 2006-08-01 | Chau-Ting Yeh | Viral sequences |
CN1867922A (zh) * | 2003-10-15 | 2006-11-22 | 株式会社西格恩波斯特 | 疾病危险度判定用基因多态的确定方法、疾病危险度判定方法及判定用阵列 |
US20050214811A1 (en) * | 2003-12-12 | 2005-09-29 | Margulies David M | Processing and managing genetic information |
US7127355B2 (en) * | 2004-03-05 | 2006-10-24 | Perlegen Sciences, Inc. | Methods for genetic analysis |
US20070265217A1 (en) * | 2004-07-16 | 2007-11-15 | Bayer Healthcare Ag | Single Nucleotide Polymorphisms as Prognostic Tool to Diagnose Adverse Drug Reactions (Adr) and Drug Efficacy |
EP1824996A2 (en) * | 2004-11-19 | 2007-08-29 | Oy Jurilab Ltd | Method and kit for detecting a risk of essential arterial hypertension |
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CN103642902A (zh) | 2014-03-19 |
AU2007325021B2 (en) | 2013-05-09 |
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CA2671267A1 (en) | 2008-06-05 |
GB2444410A (en) | 2008-06-04 |
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