CN103608334B - 咪唑衍生物的制备方法 - Google Patents

咪唑衍生物的制备方法 Download PDF

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Publication number
CN103608334B
CN103608334B CN201280029606.7A CN201280029606A CN103608334B CN 103608334 B CN103608334 B CN 103608334B CN 201280029606 A CN201280029606 A CN 201280029606A CN 103608334 B CN103608334 B CN 103608334B
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China
Prior art keywords
compound
added
mixture
general formula
stirred
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Expired - Fee Related
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CN201280029606.7A
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English (en)
Chinese (zh)
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CN103608334A (zh
Inventor
川端洋一
泽井泰宏
菅野和明
泽田直隆
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Takeda Pharmaceutical Co Ltd
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Takeda Chemical Industries Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201280029606.7A 2011-06-15 2012-06-14 咪唑衍生物的制备方法 Expired - Fee Related CN103608334B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011-133712 2011-06-15
JP2011133712 2011-06-15
PCT/JP2012/065795 WO2012173280A1 (en) 2011-06-15 2012-06-14 Production method of imidazole derivatives

Publications (2)

Publication Number Publication Date
CN103608334A CN103608334A (zh) 2014-02-26
CN103608334B true CN103608334B (zh) 2015-12-23

Family

ID=46458578

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280029606.7A Expired - Fee Related CN103608334B (zh) 2011-06-15 2012-06-14 咪唑衍生物的制备方法

Country Status (27)

Country Link
US (2) US9278938B2 (enExample)
EP (1) EP2721010B1 (enExample)
JP (1) JP6082353B2 (enExample)
KR (1) KR20140028069A (enExample)
CN (1) CN103608334B (enExample)
AR (1) AR086926A1 (enExample)
AU (1) AU2012270496A1 (enExample)
BR (1) BR112013030888A2 (enExample)
CA (1) CA2838971C (enExample)
CL (1) CL2013003492A1 (enExample)
CO (1) CO6852075A2 (enExample)
CR (1) CR20130655A (enExample)
DO (1) DOP2013000287A (enExample)
EA (1) EA201490019A1 (enExample)
EC (1) ECSP14013128A (enExample)
ES (1) ES2554454T3 (enExample)
IL (1) IL229566A0 (enExample)
MA (1) MA35809B1 (enExample)
MX (1) MX2013014009A (enExample)
PE (1) PE20141326A1 (enExample)
PH (1) PH12013502567A1 (enExample)
SG (1) SG195036A1 (enExample)
TN (1) TN2013000481A1 (enExample)
TW (1) TW201307295A (enExample)
UY (1) UY34130A (enExample)
WO (1) WO2012173280A1 (enExample)
ZA (1) ZA201308884B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10864460B2 (en) * 2014-09-30 2020-12-15 Unm Rainforest Innovations Graphene-based inorganic-organic hybrid materials and separation of racemic mixtures
US20200033307A1 (en) * 2018-07-25 2020-01-30 Honeywell International Inc. Method of determining an amount of water in a sample using a derivative of imidazole and a hydrogen halide donor
KR102253950B1 (ko) * 2019-07-24 2021-05-20 (주)에니켐텍 신규한 메데토미딘 제조방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1639130A (zh) * 2002-01-10 2005-07-13 武田药品工业株式会社 制备稠合咪唑化合物的方法、稳定形式的里福马斯基试剂及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5832880A (ja) * 1981-08-24 1983-02-25 Isukura Sangyo Kk ハリントニンの部分合成方法
US6713632B1 (en) 1999-06-22 2004-03-30 Takeda Chemical Industries, Ltd. Process for the preparation of imidazole derivatives
PE20010781A1 (es) 1999-10-22 2001-08-08 Takeda Chemical Industries Ltd Compuestos 1-(1h-imidazol-4-il)-1-(naftil-2-sustituido)etanol, su produccion y utilizacion
DE10031604A1 (de) * 2000-06-29 2002-01-17 Consortium Elektrochem Ind Verfahren zur Herstellung von beta-Hydroxy- und beta-Aminocarbonylverbindungen
EP1681290B9 (en) 2000-11-17 2013-06-19 Takeda Pharmaceutical Company Limited Imidazole derivatives, production method thereof and use thereof
WO2003059839A1 (en) 2002-01-04 2003-07-24 Koninklijke Philips Electronics N.V. Sintered body and electric lamp
EP1394140A1 (de) * 2002-08-14 2004-03-03 Consortium für elektrochemische Industrie GmbH Enantioselektives Reformatsky-Verfahren zur Herstellung von optisch aktiven Alkoholen, Aminen und deren Derivaten
EP2164409B1 (en) 2007-06-29 2018-08-08 Atheromed, Inc. Atherectomy system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1639130A (zh) * 2002-01-10 2005-07-13 武田药品工业株式会社 制备稠合咪唑化合物的方法、稳定形式的里福马斯基试剂及其制备方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Highly Functionalized Organomagnesium Reagents Prepared through Halogen-Metal Exchange;Paul Knochel et al;《ANGEWANDTE CHEMIE INTERNATIONAL EDITION》;20030922;第42卷(第36期);4302-4320 *
Non-cryogenic metalation of aryl bromides bearing proton donating groups：formation of a stable magnesio-intermediate;Shinji Kato et al;《Tetrahedron Letters》;20021007;第43卷;7315-7317 *
Selective Halogen-Magnesium Exchange Reaction via Organomagnesium Ate Complex;Atsushi Inoue et al;《Journal of Organic Chemistry》;20010512;第66卷;4333-4339 *

Also Published As

Publication number Publication date
JP6082353B2 (ja) 2017-02-15
CA2838971A1 (en) 2012-12-20
TW201307295A (zh) 2013-02-16
MA35809B1 (fr) 2014-12-01
CL2013003492A1 (es) 2014-07-18
CR20130655A (es) 2014-03-03
CA2838971C (en) 2019-07-30
CN103608334A (zh) 2014-02-26
MX2013014009A (es) 2014-03-12
IL229566A0 (en) 2014-01-30
ECSP14013128A (es) 2014-02-28
TN2013000481A1 (en) 2015-03-30
ES2554454T3 (es) 2015-12-21
SG195036A1 (en) 2013-12-30
CO6852075A2 (es) 2014-01-30
UY34130A (es) 2013-01-31
US9278938B2 (en) 2016-03-08
BR112013030888A2 (pt) 2017-03-21
PE20141326A1 (es) 2014-10-16
JP2014520066A (ja) 2014-08-21
PH12013502567A1 (en) 2014-01-27
AU2012270496A1 (en) 2013-12-19
US10005780B2 (en) 2018-06-26
EP2721010B1 (en) 2015-09-09
EP2721010A1 (en) 2014-04-23
US20140100373A1 (en) 2014-04-10
EA201490019A1 (ru) 2014-04-30
DOP2013000287A (es) 2014-02-16
US20160244454A1 (en) 2016-08-25
WO2012173280A1 (en) 2012-12-20
AR086926A1 (es) 2014-01-29
ZA201308884B (en) 2015-02-25
KR20140028069A (ko) 2014-03-07

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