CN103597574B - 通过高速喷雾与靶材互相作用的大气压离子源 - Google Patents

通过高速喷雾与靶材互相作用的大气压离子源 Download PDF

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Publication number
CN103597574B
CN103597574B CN201280027496.0A CN201280027496A CN103597574B CN 103597574 B CN103597574 B CN 103597574B CN 201280027496 A CN201280027496 A CN 201280027496A CN 103597574 B CN103597574 B CN 103597574B
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China
Prior art keywords
ion
target
droplet
capillary
guns according
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CN201280027496.0A
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English (en)
Chinese (zh)
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CN103597574A (zh
Inventor
斯特万·巴伊奇
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Micromass UK Ltd
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Micromass UK Ltd
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Priority claimed from GBGB1106694.1A external-priority patent/GB201106694D0/en
Priority claimed from GBGB1204937.5A external-priority patent/GB201204937D0/en
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Publication of CN103597574A publication Critical patent/CN103597574A/zh
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/7273—Desolvation chambers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/061—Ion deflecting means, e.g. ion gates
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/142—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using a solid target which is not previously vapourised
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/24—Vacuum systems, e.g. maintaining desired pressures
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CN201280027496.0A 2011-04-20 2012-04-20 通过高速喷雾与靶材互相作用的大气压离子源 Active CN103597574B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB1106694.1 2011-04-20
GBGB1106694.1A GB201106694D0 (en) 2011-04-20 2011-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target
US201161478725P 2011-04-25 2011-04-25
US61/478,725 2011-04-25
GBGB1204937.5A GB201204937D0 (en) 2012-03-21 2012-03-21 Atomspheric pressure ion source by interacting high velocity spray with a target
GB1204937.5 2012-03-21
US201261614734P 2012-03-23 2012-03-23
US61/614,734 2012-03-23
PCT/GB2012/050888 WO2012143737A1 (en) 2011-04-20 2012-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target

Publications (2)

Publication Number Publication Date
CN103597574A CN103597574A (zh) 2014-02-19
CN103597574B true CN103597574B (zh) 2016-09-07

Family

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CN201280027496.0A Active CN103597574B (zh) 2011-04-20 2012-04-20 通过高速喷雾与靶材互相作用的大气压离子源

Country Status (7)

Country Link
US (3) US8809777B2 (https=)
EP (2) EP2700086B1 (https=)
JP (1) JP6080311B2 (https=)
CN (1) CN103597574B (https=)
CA (1) CA2833675C (https=)
GB (1) GB2499681B (https=)
WO (1) WO2012143737A1 (https=)

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US11139156B2 (en) * 2015-03-06 2021-10-05 Micromass Uk Limited In vivo endoscopic tissue identification tool
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GB2554181B (en) 2015-03-06 2021-09-08 Micromass Ltd Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("REIMS") device
DE102016007402A1 (de) * 2015-06-23 2016-12-29 Dionex Corporation Verfahren und systeme zur erkennung von nichtflüchtigen gelösten stoffen
GB201517195D0 (en) 2015-09-29 2015-11-11 Micromass Ltd Capacitively coupled reims technique and optically transparent counter electrode
EP3443354B1 (en) 2016-04-14 2025-08-20 Micromass UK Limited Spectrometric analysis of plants
GB2563194B (en) 2016-04-21 2020-08-05 Waters Technologies Corp Dual mode ionization device
GB2567793B (en) 2017-04-13 2023-03-22 Micromass Ltd A method of fragmenting and charge reducing biomolecules
GB201721700D0 (en) * 2017-12-22 2018-02-07 Micromass Ltd Ion source
GB201807914D0 (en) * 2018-05-16 2018-06-27 Micromass Ltd Impactor spray or electrospray ionisation ion source
WO2020241098A1 (ja) 2019-05-24 2020-12-03 国立研究開発法人産業技術総合研究所 スプレーイオン化装置、分析装置および表面塗布装置
JP7186471B2 (ja) 2019-07-31 2022-12-09 国立研究開発法人産業技術総合研究所 スプレーイオン化装置、分析装置および表面塗布装置
GB201915843D0 (en) * 2019-10-31 2019-12-18 Micromass Ltd Ion source
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CN113217247B (zh) * 2021-06-01 2022-04-29 哈尔滨工程大学 一种柴油机多次喷射喷雾贯穿距预测方法

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Also Published As

Publication number Publication date
US20140339420A1 (en) 2014-11-20
GB2499681B (en) 2016-02-10
US8921777B2 (en) 2014-12-30
GB2499681A (en) 2013-08-28
US9082603B2 (en) 2015-07-14
GB201207004D0 (en) 2012-06-06
US20150155151A1 (en) 2015-06-04
CA2833675A1 (en) 2012-10-26
EP2700086A1 (en) 2014-02-26
EP3582251A1 (en) 2019-12-18
JP2014515831A (ja) 2014-07-03
US20140151547A1 (en) 2014-06-05
EP3582251B1 (en) 2020-12-16
WO2012143737A1 (en) 2012-10-26
EP2700086B1 (en) 2019-09-11
CN103597574A (zh) 2014-02-19
CA2833675C (en) 2019-01-15
US8809777B2 (en) 2014-08-19
JP6080311B2 (ja) 2017-02-15

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