GB2499681B - Atmospheric pressure ion source by interacting high velocity spray with a target - Google Patents

Atmospheric pressure ion source by interacting high velocity spray with a target

Info

Publication number
GB2499681B
GB2499681B GB1207004.1A GB201207004A GB2499681B GB 2499681 B GB2499681 B GB 2499681B GB 201207004 A GB201207004 A GB 201207004A GB 2499681 B GB2499681 B GB 2499681B
Authority
GB
United Kingdom
Prior art keywords
target
atmospheric pressure
ion source
high velocity
pressure ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1207004.1A
Other languages
English (en)
Other versions
GB2499681A (en
GB201207004D0 (en
Inventor
Stevan Bajic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1106694.1A external-priority patent/GB201106694D0/en
Priority claimed from GBGB1204937.5A external-priority patent/GB201204937D0/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of GB201207004D0 publication Critical patent/GB201207004D0/en
Publication of GB2499681A publication Critical patent/GB2499681A/en
Application granted granted Critical
Publication of GB2499681B publication Critical patent/GB2499681B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/7273—Desolvation chambers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/061—Ion deflecting means, e.g. ion gates
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/142—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using a solid target which is not previously vapourised
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/24—Vacuum systems, e.g. maintaining desired pressures
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
GB1207004.1A 2011-04-20 2012-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target Active GB2499681B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1106694.1A GB201106694D0 (en) 2011-04-20 2011-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target
GBGB1204937.5A GB201204937D0 (en) 2012-03-21 2012-03-21 Atomspheric pressure ion source by interacting high velocity spray with a target

Publications (3)

Publication Number Publication Date
GB201207004D0 GB201207004D0 (en) 2012-06-06
GB2499681A GB2499681A (en) 2013-08-28
GB2499681B true GB2499681B (en) 2016-02-10

Family

ID=46261648

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1207004.1A Active GB2499681B (en) 2011-04-20 2012-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target

Country Status (7)

Country Link
US (3) US8809777B2 (https=)
EP (2) EP2700086B1 (https=)
JP (1) JP6080311B2 (https=)
CN (1) CN103597574B (https=)
CA (1) CA2833675C (https=)
GB (1) GB2499681B (https=)
WO (1) WO2012143737A1 (https=)

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US10429366B2 (en) 2014-05-28 2019-10-01 Dionex Corporation Methods and systems for detection of non-volatile solutes

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US9768004B2 (en) * 2013-11-26 2017-09-19 Waters Technologies Corporation Systems, devices, and methods for connecting a chromatography system to a mass spectrometer
WO2015128652A2 (en) 2014-02-26 2015-09-03 Micromass Uk Limited Impactor spray atmospheric pressure ion source with target paddle
WO2015128661A1 (en) * 2014-02-26 2015-09-03 Micromass Uk Limited Ambient ionisation with an impactor spray source
GB201403370D0 (en) * 2014-02-26 2014-04-09 Micromass Ltd Impactor spray atmospheric pressure ion source with target paddle
US20160372313A1 (en) * 2014-03-04 2016-12-22 Micromass Uk Limited Sample Introduction System for Spectrometers
JP6368254B2 (ja) * 2015-01-28 2018-08-01 花王株式会社 脂質の網羅的解析方法
GB2554206B (en) 2015-03-06 2021-03-24 Micromass Ltd Spectrometric analysis of microbes
EP3741303A3 (en) 2015-03-06 2020-12-30 Micromass UK Limited Chemically guided ambient ionisation mass spectrometry
WO2016142692A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Spectrometric analysis
EP3726562B1 (en) 2015-03-06 2023-12-20 Micromass UK Limited Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue
CA2978042A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
KR101956496B1 (ko) 2015-03-06 2019-03-08 마이크로매스 유케이 리미티드 전기수술 응용분야에 대한 액체 트랩 또는 세퍼레이터
US11139156B2 (en) * 2015-03-06 2021-10-05 Micromass Uk Limited In vivo endoscopic tissue identification tool
WO2016142685A1 (en) * 2015-03-06 2016-09-15 Micromass Uk Limited Collision surface for improved ionisation
CN112964625B (zh) 2015-03-06 2024-06-07 英国质谱公司 细胞群体分析
EP3265818B1 (en) * 2015-03-06 2020-02-12 Micromass UK Limited Imaging guided ambient ionisation mass spectrometry
CA2978165A1 (en) * 2015-03-06 2016-09-15 Micromass Uk Limited Improved ionisation of gaseous samples
DE202016008460U1 (de) 2015-03-06 2018-01-22 Micromass Uk Limited Zellpopulationsanalyse
GB2552602B (en) 2015-03-06 2020-12-30 Micromass Ltd Desorption electrospray ionisation mass spectrometry ("DESI-MS") analysis of swabs
GB2554181B (en) 2015-03-06 2021-09-08 Micromass Ltd Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("REIMS") device
GB201517195D0 (en) 2015-09-29 2015-11-11 Micromass Ltd Capacitively coupled reims technique and optically transparent counter electrode
EP3443354B1 (en) 2016-04-14 2025-08-20 Micromass UK Limited Spectrometric analysis of plants
GB2563194B (en) 2016-04-21 2020-08-05 Waters Technologies Corp Dual mode ionization device
GB2567793B (en) 2017-04-13 2023-03-22 Micromass Ltd A method of fragmenting and charge reducing biomolecules
GB201721700D0 (en) * 2017-12-22 2018-02-07 Micromass Ltd Ion source
GB201807914D0 (en) * 2018-05-16 2018-06-27 Micromass Ltd Impactor spray or electrospray ionisation ion source
WO2020241098A1 (ja) 2019-05-24 2020-12-03 国立研究開発法人産業技術総合研究所 スプレーイオン化装置、分析装置および表面塗布装置
JP7186471B2 (ja) 2019-07-31 2022-12-09 国立研究開発法人産業技術総合研究所 スプレーイオン化装置、分析装置および表面塗布装置
GB201915843D0 (en) * 2019-10-31 2019-12-18 Micromass Ltd Ion source
EP4082669B1 (en) 2020-02-03 2024-11-27 National Institute Of Advanced Industrial Science and Technology Spray ionization device
WO2021181892A1 (ja) 2020-03-11 2021-09-16 国立研究開発法人産業技術総合研究所 スプレーイオン化装置、分析装置および表面塗布装置
CN113217247B (zh) * 2021-06-01 2022-04-29 哈尔滨工程大学 一种柴油机多次喷射喷雾贯穿距预测方法

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JPS59153164A (ja) * 1983-02-21 1984-09-01 Jeol Ltd 液体クロマトグラフ質量分析装置
JPH10267806A (ja) * 1997-03-27 1998-10-09 Jeol Ltd 超音波霧化装置
JPH1151902A (ja) * 1997-08-05 1999-02-26 Jeol Ltd Ｌｃ／ｍｓインターフェイス
JP2002190272A (ja) * 2000-12-21 2002-07-05 Jeol Ltd エレクトロスプレー・イオン源
US20030119193A1 (en) * 2001-04-25 2003-06-26 Robert Hess System and method for high throughput screening of droplets
GB2394830A (en) * 2002-08-19 2004-05-05 Jeol Ltd Electrospray mass spectrometer
US20060145089A1 (en) * 2002-10-10 2006-07-06 Universita' Degli Studi Di Milano Ionization source for mass spectrometry analysis
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10429366B2 (en) 2014-05-28 2019-10-01 Dionex Corporation Methods and systems for detection of non-volatile solutes

Also Published As

Publication number Publication date
US20140339420A1 (en) 2014-11-20
US8921777B2 (en) 2014-12-30
GB2499681A (en) 2013-08-28
US9082603B2 (en) 2015-07-14
GB201207004D0 (en) 2012-06-06
US20150155151A1 (en) 2015-06-04
CA2833675A1 (en) 2012-10-26
EP2700086A1 (en) 2014-02-26
EP3582251A1 (en) 2019-12-18
JP2014515831A (ja) 2014-07-03
US20140151547A1 (en) 2014-06-05
EP3582251B1 (en) 2020-12-16
WO2012143737A1 (en) 2012-10-26
EP2700086B1 (en) 2019-09-11
CN103597574A (zh) 2014-02-19
CA2833675C (en) 2019-01-15
US8809777B2 (en) 2014-08-19
JP6080311B2 (ja) 2017-02-15
CN103597574B (zh) 2016-09-07

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