CN103562724B - 用于测量内毒素的试剂 - Google Patents

用于测量内毒素的试剂 Download PDF

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Publication number
CN103562724B
CN103562724B CN201280010708.4A CN201280010708A CN103562724B CN 103562724 B CN103562724 B CN 103562724B CN 201280010708 A CN201280010708 A CN 201280010708A CN 103562724 B CN103562724 B CN 103562724B
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factor
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val
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CN103562724A (zh
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水村光
相泽真纪
小田俊男
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Seikagaku Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43508—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from crustaceans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
    • G01N2333/96405—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
    • G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
    • G01N2333/96411—Serine endopeptidases (3.4.21)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/50—Lipopolysaccharides; LPS
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201280010708.4A 2011-02-28 2012-02-28 用于测量内毒素的试剂 Active CN103562724B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610799888.9A CN106432457A (zh) 2011-02-28 2012-02-28 用于测量内毒素的试剂

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161447556P 2011-02-28 2011-02-28
US61/447556 2011-02-28
US61/447,556 2011-02-28
PCT/JP2012/055728 WO2012118226A1 (en) 2011-02-28 2012-02-28 An agent for measuring endotoxin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610799888.9A Division CN106432457A (zh) 2011-02-28 2012-02-28 用于测量内毒素的试剂

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CN103562724A CN103562724A (zh) 2014-02-05
CN103562724B true CN103562724B (zh) 2016-10-05

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US (5) US20140024062A1 (enExample)
EP (3) EP2681564B1 (enExample)
JP (5) JP2014510898A (enExample)
CN (2) CN103562724B (enExample)
ES (2) ES2650170T3 (enExample)
SG (3) SG10202110031YA (enExample)
WO (1) WO2012118226A1 (enExample)

Families Citing this family (18)

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Publication number Priority date Publication date Assignee Title
EP2740791A1 (en) * 2012-12-05 2014-06-11 MicroCoat Biotechnologie GmbH Method for recombinant production of horseshoe crab Factor C protein in protozoa
ES2784510T3 (es) * 2012-12-10 2020-09-28 Seikagaku Kogyo Co Ltd Método para producir un nuevo Factor C recombinante, método para mitigar la inhibición de la reacción en ensayos de endotoxina, y método para medir endotoxina
CN104884952A (zh) 2012-12-28 2015-09-02 生化学工业株式会社 付之鲎试验的抗凝血酶iii用的前处理剂及前处理方法
JP6562765B2 (ja) * 2015-08-13 2019-08-21 大日本印刷株式会社 電気化学式エンドトキシン濃度検出用容器、電極チップおよびエンドトキシンの検出方法
JP6557090B2 (ja) * 2015-08-13 2019-08-07 大日本印刷株式会社 電極チップおよび電極チップの製造方法
GB2562439B (en) * 2016-01-28 2022-04-13 Kimberly Clark Co Adherent composition for RNA viruses and method of removing RNA viruses from a surface
EP3418730A4 (en) 2016-02-16 2019-10-30 Seikagaku Corporation ELECTROCHEMICAL MEASUREMENT USING A PHENYLENEDIAMINE DERIVATIVE
CN105866080B (zh) * 2016-04-05 2019-11-12 中国科学院苏州生物医学工程技术研究所 重组鲎三因子试剂及其检测内毒素的方法
JP6927993B2 (ja) * 2016-10-18 2021-09-01 生化学工業株式会社 リムルス属由来の組換え蛋白質及びこれをコードするｄｎａ
ES2967126T3 (es) 2017-03-01 2024-04-26 Seikagaku Kogyo Co Ltd Variante del factor B del cangrejo de herradura
CN108913707B (zh) * 2018-07-23 2021-06-15 广东医科大学 一种特异性检测内毒素的试剂及其制备方法
EP4488372A3 (en) 2018-10-03 2025-03-19 Seikagaku Corporation Method for enhancing sensitivity of endotoxin measuring agent
JPWO2021210669A1 (enExample) 2020-04-16 2021-10-21
FR3125336B1 (fr) * 2021-07-19 2023-07-14 Biomerieux Sa Procédé de quantification d'endotoxines d'un échantillon biologique
US20250044296A1 (en) 2021-08-04 2025-02-06 Seikagaku Corporation Reagent for measuring b-glucan, method for producing same and use thereof
CN114317504B (zh) * 2021-12-28 2023-07-25 健帆生物科技集团股份有限公司 一种鲎因子c截短蛋白及其制备方法和应用
WO2024254215A1 (en) * 2023-06-05 2024-12-12 Charles River Laboratories, Inc. Recombinant amebocyte clotting factors and uses thereof
CN118581071B (zh) * 2024-06-05 2025-10-10 郑州伊美诺生物技术有限公司 一种重组鲎试剂及其制备方法、应用

Citations (7)

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CN1030138A (zh) * 1987-05-20 1989-01-04 雷夫·贝克 一种测定样品中内毒素存在的方法
CN1091832A (zh) * 1992-09-14 1994-09-07 生化学工业株式会社 特异地检测内毒素的试剂
CN1105757A (zh) * 1993-02-26 1995-07-26 生化学工业株式会社 用于内毒素测定的试剂以及使用该试剂进行测定的方法
CN1126838A (zh) * 1993-09-30 1996-07-17 生化学工业株式会社 用于内毒素特异性鉴别的试剂
WO1999015676A1 (en) * 1997-09-19 1999-04-01 National University Of Singapore A novel generation of cloned horseshoe crab recombinant factor c for detection and removal of endotoxin
CN1529711A (zh) * 2001-06-28 2004-09-15 ά 检测内毒素的方法和试剂
CN101454448A (zh) * 2006-07-07 2009-06-10 生化学工业株式会社 凝固酶原以及使用所述酶检测内毒素或(1→3)-β-D-葡聚糖的方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1030138A (zh) * 1987-05-20 1989-01-04 雷夫·贝克 一种测定样品中内毒素存在的方法
CN1091832A (zh) * 1992-09-14 1994-09-07 生化学工业株式会社 特异地检测内毒素的试剂
CN1105757A (zh) * 1993-02-26 1995-07-26 生化学工业株式会社 用于内毒素测定的试剂以及使用该试剂进行测定的方法
CN1126838A (zh) * 1993-09-30 1996-07-17 生化学工业株式会社 用于内毒素特异性鉴别的试剂
WO1999015676A1 (en) * 1997-09-19 1999-04-01 National University Of Singapore A novel generation of cloned horseshoe crab recombinant factor c for detection and removal of endotoxin
CN1529711A (zh) * 2001-06-28 2004-09-15 ά 检测内毒素的方法和试剂
CN101454448A (zh) * 2006-07-07 2009-06-10 生化学工业株式会社 凝固酶原以及使用所述酶检测内毒素或(1→3)-β-D-葡聚糖的方法

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Title
Functional expression of full length Limulus Factor C in stably transformed Sf9 cells;Jing Wang et al.;《Biotechnology Letters》;20010101;第23卷;71-76 *
Horseshoe Crab Coagulation Factor B A UNIQUE SERINE PROTEASE ZYMOGEN ACTIVATED BY CLEAVAGE OF AN ILE-ILE BOND;Tatsushi Mut et al.;《THE JOURNAL BIOLOGICAL CHEMISTRY》;19931005;第268卷(第28期);2138-21388 *
Limulus Factor C AN ENDOTOXIN-SENSITIVE SERINE PROTEASE ZYMOGEN WITH A MOSAIC STRUCTURE OF COMPLEMENT-LIKE, EPIDERMAL GROWTH FACTOR-LIKE, AND LECTIN-LIKE DOMAINS;Tatsushi Muta et al.;《THE JOURNAL OF BIOLOGICAL CHEMISTR》;19910405;第266卷(第10期);6554-6561 *
Proclotting Enzyme from Horseshoe Crab Hemocytes cDNA CLONING, DISULFIDE LOCATIONS, AND SUBCELLULAR LOCALIZATION;atsushi Mutat et al.;《THE JOURNAL OP BIOLOGICAL CHEMISTRY》;19901225;第265卷(第36期);22426-22433 *
一种更敏感专一的重新组合鲎凝固酶原BC因子;吴伟洪和罗希远;《现代应用药学》;19871231;第4卷(第6期);1-4 *
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US20150252405A1 (en) 2015-09-10
SG10201601351WA (en) 2016-03-30
EP2681564A1 (en) 2014-01-08
JP2024010024A (ja) 2024-01-23
US20180259527A1 (en) 2018-09-13
US20140024062A1 (en) 2014-01-23
JP7590530B2 (ja) 2024-11-26
EP2681564B1 (en) 2017-10-25
EP3273244B1 (en) 2019-09-25
ES2650170T3 (es) 2018-01-17
WO2012118226A1 (en) 2012-09-07
EP3517962A1 (en) 2019-07-31
CN103562724A (zh) 2014-02-05
EP3273244A1 (en) 2018-01-24
US20220018841A1 (en) 2022-01-20
JP2014510898A (ja) 2014-05-01
SG10202110031YA (en) 2021-10-28
JP7372392B2 (ja) 2023-10-31
CN106432457A (zh) 2017-02-22
JP6640267B2 (ja) 2020-02-05
ES2763089T3 (es) 2020-05-27
US20170138945A1 (en) 2017-05-18
JP2020100622A (ja) 2020-07-02
SG192578A1 (en) 2013-09-30
JP2018141797A (ja) 2018-09-13
US11162949B2 (en) 2021-11-02
JP2022119887A (ja) 2022-08-17

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