JP2019526052A5 - - Google Patents
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- Publication number
- JP2019526052A5 JP2019526052A5 JP2019504062A JP2019504062A JP2019526052A5 JP 2019526052 A5 JP2019526052 A5 JP 2019526052A5 JP 2019504062 A JP2019504062 A JP 2019504062A JP 2019504062 A JP2019504062 A JP 2019504062A JP 2019526052 A5 JP2019526052 A5 JP 2019526052A5
- Authority
- JP
- Japan
- Prior art keywords
- lal
- coagulogen
- sample
- substrate
- chromogenic substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- 239000003593 chromogenic compound Substances 0.000 claims 7
- 108010045487 coagulogen Proteins 0.000 claims 7
- 239000002158 endotoxin Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 241000239218 Limulus Species 0.000 claims 5
- 238000009295 crossflow filtration Methods 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 238000004040 coloring Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 238000006911 enzymatic reaction Methods 0.000 claims 2
- 239000004695 Polyether sulfone Substances 0.000 claims 1
- 238000002835 absorbance Methods 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229960000074 biopharmaceutical Drugs 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000006201 parenteral dosage form Substances 0.000 claims 1
- 229920006393 polyether sulfone Polymers 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- -1 vaccines Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662370493P | 2016-08-03 | 2016-08-03 | |
| US62/370,493 | 2016-08-03 | ||
| PCT/US2017/045137 WO2018026941A1 (en) | 2016-08-03 | 2017-08-02 | Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526052A JP2019526052A (ja) | 2019-09-12 |
| JP2019526052A5 true JP2019526052A5 (enExample) | 2020-09-10 |
| JP7044222B2 JP7044222B2 (ja) | 2022-03-30 |
Family
ID=61069187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504062A Active JP7044222B2 (ja) | 2016-08-03 | 2017-08-02 | 実質的にコアギュローゲンを含まないリムルスアメボサイトライセートを使用してエンドトキシンを検出する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11156614B2 (enExample) |
| EP (2) | EP3943608B1 (enExample) |
| JP (1) | JP7044222B2 (enExample) |
| KR (1) | KR102561368B1 (enExample) |
| CN (1) | CN109790561B (enExample) |
| IL (1) | IL264464B2 (enExample) |
| SG (1) | SG11201900767VA (enExample) |
| WO (1) | WO2018026941A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| IL264464B2 (en) | 2016-08-03 | 2024-02-01 | Lonza Walkersville Inc | A method for detecting endotoxin using Limulus extract of amoeba, which is mainly free of coagulogen |
| CN110494543A (zh) | 2016-10-19 | 2019-11-22 | 弗洛设计声能学公司 | 通过声学的亲和细胞提取 |
| US11352656B2 (en) | 2017-01-11 | 2022-06-07 | Lonza Walkersville, Inc. | Coagulogen-free clarified limulus amebocyte lysate and chromogenic assay of endotoxin |
| KR20220066413A (ko) | 2017-12-14 | 2022-05-24 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4322217A (en) | 1980-06-27 | 1982-03-30 | Mallinckrodt, Inc. | Process for preparing Limulus lysate |
| ATE148230T1 (de) * | 1989-10-30 | 1997-02-15 | Biowhittaker Inc | Kinetische bestimmungsmethode für endotoxin unter verwendung von limulus-amoebocyten-lysat und chromogenem substrat |
| JP3122454B2 (ja) | 1990-09-27 | 2001-01-09 | 生化学工業株式会社 | カブトガニ・アメボサイト・ライセートの調製法 |
| US5208148A (en) | 1990-12-07 | 1993-05-04 | Molecular Probes, Inc. | Lipophilic fluorescent glycosidase substrates |
| US5576424A (en) | 1991-08-23 | 1996-11-19 | Molecular Probes, Inc. | Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells |
| ATE180018T1 (de) | 1991-08-23 | 1999-05-15 | Molecular Probes Inc | Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellen |
| US5242805A (en) | 1991-08-23 | 1993-09-07 | Molecular Probes, Inc. | Long wavelength lipophilic fluorogenic glycosidase substrates |
| JP3242733B2 (ja) | 1993-02-26 | 2001-12-25 | 生化学工業株式会社 | エンドトキシン特異的測定剤 |
| US5830912A (en) | 1996-11-15 | 1998-11-03 | Molecular Probes, Inc. | Derivatives of 6,8-difluoro-7-hydroxycoumarin |
| US5773236A (en) | 1997-04-25 | 1998-06-30 | Molecule Probes, Inc. | Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules |
| US20100203071A1 (en) | 2007-03-21 | 2010-08-12 | Norman Blais | Chimeric antigens |
| CN101855539B (zh) | 2007-11-12 | 2012-08-22 | 国立大学法人广岛大学 | 内毒素浓度测定方法及浓度测定用试剂盒 |
| US7846678B2 (en) * | 2008-08-18 | 2010-12-07 | BioDtech, Inc. | Enhancing endotoxin detection |
| MY155541A (en) | 2010-10-29 | 2015-10-30 | Universiti Malaysia Terengganu | Process for the preparation of amoebocyte lysate from the haemolymph of the horseshoe crab |
| CN102305788A (zh) | 2010-11-22 | 2012-01-04 | 天津市一瑞生物工程有限公司 | 革兰阴性菌脂多糖(内毒素)比色检测试剂盒的制备及其使用方法 |
| IL264464B2 (en) | 2016-08-03 | 2024-02-01 | Lonza Walkersville Inc | A method for detecting endotoxin using Limulus extract of amoeba, which is mainly free of coagulogen |
| US11352656B2 (en) * | 2017-01-11 | 2022-06-07 | Lonza Walkersville, Inc. | Coagulogen-free clarified limulus amebocyte lysate and chromogenic assay of endotoxin |
| US20190001330A1 (en) * | 2017-06-28 | 2019-01-03 | Lonza Walkersville, Inc. | Cartridge for endotoxin detection |
-
2017
- 2017-08-02 IL IL264464A patent/IL264464B2/en unknown
- 2017-08-02 JP JP2019504062A patent/JP7044222B2/ja active Active
- 2017-08-02 WO PCT/US2017/045137 patent/WO2018026941A1/en not_active Ceased
- 2017-08-02 EP EP21183657.2A patent/EP3943608B1/en active Active
- 2017-08-02 EP EP17837616.6A patent/EP3494226B1/en active Active
- 2017-08-02 SG SG11201900767VA patent/SG11201900767VA/en unknown
- 2017-08-02 CN CN201780048853.4A patent/CN109790561B/zh active Active
- 2017-08-02 KR KR1020197005917A patent/KR102561368B1/ko active Active
- 2017-08-03 US US15/668,101 patent/US11156614B2/en active Active
-
2021
- 2021-09-23 US US17/482,918 patent/US11906521B2/en active Active
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