JP2020505007A5 - - Google Patents
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- Publication number
- JP2020505007A5 JP2020505007A5 JP2019536071A JP2019536071A JP2020505007A5 JP 2020505007 A5 JP2020505007 A5 JP 2020505007A5 JP 2019536071 A JP2019536071 A JP 2019536071A JP 2019536071 A JP2019536071 A JP 2019536071A JP 2020505007 A5 JP2020505007 A5 JP 2020505007A5
- Authority
- JP
- Japan
- Prior art keywords
- lal
- clarified
- sample
- pna
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 19
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 7
- 239000002158 endotoxin Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 239000003593 chromogenic compound Substances 0.000 claims 5
- 108010045487 coagulogen Proteins 0.000 claims 5
- 241000239218 Limulus Species 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 3
- 238000005119 centrifugation Methods 0.000 claims 3
- 238000005352 clarification Methods 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 3
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims 3
- 238000010186 staining Methods 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 238000002835 absorbance Methods 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 238000009295 crossflow filtration Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 241000239220 Limulus polyphemus Species 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000004040 coloring Methods 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000006166 lysate Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000006201 parenteral dosage form Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 239000012465 retentate Substances 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- -1 vaccines Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022166858A JP7724762B2 (ja) | 2017-01-11 | 2022-10-18 | コアギュローゲンを含まない、清澄化リムルスアメボサイトライセート |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762445136P | 2017-01-11 | 2017-01-11 | |
| US62/445,136 | 2017-01-11 | ||
| PCT/US2018/013310 WO2018132562A1 (en) | 2017-01-11 | 2018-01-11 | Coagulogen-free clarified limulus amebocyte lysate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022166858A Division JP7724762B2 (ja) | 2017-01-11 | 2022-10-18 | コアギュローゲンを含まない、清澄化リムルスアメボサイトライセート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505007A JP2020505007A (ja) | 2020-02-20 |
| JP2020505007A5 true JP2020505007A5 (enExample) | 2021-02-12 |
| JP7507560B2 JP7507560B2 (ja) | 2024-06-28 |
Family
ID=61249697
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019536071A Active JP7507560B2 (ja) | 2017-01-11 | 2018-01-11 | コアギュローゲンを含まない、清澄化リムルスアメボサイトライセート |
| JP2022166858A Active JP7724762B2 (ja) | 2017-01-11 | 2022-10-18 | コアギュローゲンを含まない、清澄化リムルスアメボサイトライセート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022166858A Active JP7724762B2 (ja) | 2017-01-11 | 2022-10-18 | コアギュローゲンを含まない、清澄化リムルスアメボサイトライセート |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11352656B2 (enExample) |
| EP (1) | EP3552021B1 (enExample) |
| JP (2) | JP7507560B2 (enExample) |
| KR (1) | KR102545029B1 (enExample) |
| CN (1) | CN110192110B (enExample) |
| IL (1) | IL267593B2 (enExample) |
| WO (1) | WO2018132562A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL264464B2 (en) | 2016-08-03 | 2024-02-01 | Lonza Walkersville Inc | A method for detecting endotoxin using Limulus extract of amoeba, which is mainly free of coagulogen |
| US11352656B2 (en) | 2017-01-11 | 2022-06-07 | Lonza Walkersville, Inc. | Coagulogen-free clarified limulus amebocyte lysate and chromogenic assay of endotoxin |
| WO2025090132A2 (en) * | 2023-05-12 | 2025-05-01 | Life Technolohgies Corporation | Methods and kits for detecting endotoxin |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0141685B1 (ko) * | 1988-09-01 | 1998-07-01 | 야마따니 와따루 | 참게 아메보사이트 라이세이트 g 인자 활성화 저해제 |
| ATE148230T1 (de) * | 1989-10-30 | 1997-02-15 | Biowhittaker Inc | Kinetische bestimmungsmethode für endotoxin unter verwendung von limulus-amoebocyten-lysat und chromogenem substrat |
| JP3122454B2 (ja) * | 1990-09-27 | 2001-01-09 | 生化学工業株式会社 | カブトガニ・アメボサイト・ライセートの調製法 |
| US5208148A (en) | 1990-12-07 | 1993-05-04 | Molecular Probes, Inc. | Lipophilic fluorescent glycosidase substrates |
| ATE180018T1 (de) | 1991-08-23 | 1999-05-15 | Molecular Probes Inc | Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellen |
| US5242805A (en) | 1991-08-23 | 1993-09-07 | Molecular Probes, Inc. | Long wavelength lipophilic fluorogenic glycosidase substrates |
| US5576424A (en) | 1991-08-23 | 1996-11-19 | Molecular Probes, Inc. | Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells |
| JP3242733B2 (ja) * | 1993-02-26 | 2001-12-25 | 生化学工業株式会社 | エンドトキシン特異的測定剤 |
| US5830912A (en) | 1996-11-15 | 1998-11-03 | Molecular Probes, Inc. | Derivatives of 6,8-difluoro-7-hydroxycoumarin |
| US5773236A (en) | 1997-04-25 | 1998-06-30 | Molecule Probes, Inc. | Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules |
| US20100203071A1 (en) * | 2007-03-21 | 2010-08-12 | Norman Blais | Chimeric antigens |
| CN101855539B (zh) | 2007-11-12 | 2012-08-22 | 国立大学法人广岛大学 | 内毒素浓度测定方法及浓度测定用试剂盒 |
| US7846678B2 (en) | 2008-08-18 | 2010-12-07 | BioDtech, Inc. | Enhancing endotoxin detection |
| MY155541A (en) | 2010-10-29 | 2015-10-30 | Universiti Malaysia Terengganu | Process for the preparation of amoebocyte lysate from the haemolymph of the horseshoe crab |
| CN102305788A (zh) * | 2010-11-22 | 2012-01-04 | 天津市一瑞生物工程有限公司 | 革兰阴性菌脂多糖(内毒素)比色检测试剂盒的制备及其使用方法 |
| IL264464B2 (en) | 2016-08-03 | 2024-02-01 | Lonza Walkersville Inc | A method for detecting endotoxin using Limulus extract of amoeba, which is mainly free of coagulogen |
| US11352656B2 (en) | 2017-01-11 | 2022-06-07 | Lonza Walkersville, Inc. | Coagulogen-free clarified limulus amebocyte lysate and chromogenic assay of endotoxin |
| US20190001330A1 (en) | 2017-06-28 | 2019-01-03 | Lonza Walkersville, Inc. | Cartridge for endotoxin detection |
-
2018
- 2018-01-11 US US15/868,318 patent/US11352656B2/en active Active
- 2018-01-11 JP JP2019536071A patent/JP7507560B2/ja active Active
- 2018-01-11 WO PCT/US2018/013310 patent/WO2018132562A1/en not_active Ceased
- 2018-01-11 KR KR1020197023341A patent/KR102545029B1/ko active Active
- 2018-01-11 IL IL267593A patent/IL267593B2/en unknown
- 2018-01-11 CN CN201880006683.8A patent/CN110192110B/zh active Active
- 2018-01-11 EP EP18706328.4A patent/EP3552021B1/en active Active
-
2022
- 2022-05-05 US US17/737,578 patent/US12359241B2/en active Active
- 2022-10-18 JP JP2022166858A patent/JP7724762B2/ja active Active
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