KR102545029B1 - 맑고 밝게된 무-코아굴로겐 리물루스 아메바세포 용해물 - Google Patents

맑고 밝게된 무-코아굴로겐 리물루스 아메바세포 용해물 Download PDF

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KR102545029B1
KR102545029B1 KR1020197023341A KR20197023341A KR102545029B1 KR 102545029 B1 KR102545029 B1 KR 102545029B1 KR 1020197023341 A KR1020197023341 A KR 1020197023341A KR 20197023341 A KR20197023341 A KR 20197023341A KR 102545029 B1 KR102545029 B1 KR 102545029B1
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KR20190104387A (ko
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캔디스 스텀보흐
레벤 타데쎄
카렌 린
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론자 워커스빌 아이엔씨.
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/50Lipopolysaccharides; LPS
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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KR1020197023341A 2017-01-11 2018-01-11 맑고 밝게된 무-코아굴로겐 리물루스 아메바세포 용해물 Active KR102545029B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762445136P 2017-01-11 2017-01-11
US62/445,136 2017-01-11
PCT/US2018/013310 WO2018132562A1 (en) 2017-01-11 2018-01-11 Coagulogen-free clarified limulus amebocyte lysate

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KR20190104387A KR20190104387A (ko) 2019-09-09
KR102545029B1 true KR102545029B1 (ko) 2023-06-19

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US (2) US11352656B2 (enExample)
EP (1) EP3552021B1 (enExample)
JP (2) JP7507560B2 (enExample)
KR (1) KR102545029B1 (enExample)
CN (1) CN110192110B (enExample)
IL (1) IL267593B2 (enExample)
WO (1) WO2018132562A1 (enExample)

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Publication number Priority date Publication date Assignee Title
IL264464B2 (en) 2016-08-03 2024-02-01 Lonza Walkersville Inc A method for detecting endotoxin using Limulus extract of amoeba, which is mainly free of coagulogen
US11352656B2 (en) 2017-01-11 2022-06-07 Lonza Walkersville, Inc. Coagulogen-free clarified limulus amebocyte lysate and chromogenic assay of endotoxin
WO2025090132A2 (en) * 2023-05-12 2025-05-01 Life Technolohgies Corporation Methods and kits for detecting endotoxin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012057609A1 (en) 2010-10-29 2012-05-03 Universiti Malaysia Terengganu Process for the preparation of amoebocyte lysate from the haemolymph of the horseshoe crab
JP2019526052A (ja) 2016-08-03 2019-09-12 ロンザ ウォーカーズヴィル,インコーポレーテッド 実質的にコアギュローゲンを含まないリムルスアメボサイトライセートを使用してエンドトキシンを検出する方法

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KR0141685B1 (ko) * 1988-09-01 1998-07-01 야마따니 와따루 참게 아메보사이트 라이세이트 g 인자 활성화 저해제
ATE148230T1 (de) * 1989-10-30 1997-02-15 Biowhittaker Inc Kinetische bestimmungsmethode für endotoxin unter verwendung von limulus-amoebocyten-lysat und chromogenem substrat
JP3122454B2 (ja) * 1990-09-27 2001-01-09 生化学工業株式会社 カブトガニ・アメボサイト・ライセートの調製法
US5208148A (en) 1990-12-07 1993-05-04 Molecular Probes, Inc. Lipophilic fluorescent glycosidase substrates
ATE180018T1 (de) 1991-08-23 1999-05-15 Molecular Probes Inc Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellen
US5242805A (en) 1991-08-23 1993-09-07 Molecular Probes, Inc. Long wavelength lipophilic fluorogenic glycosidase substrates
US5576424A (en) 1991-08-23 1996-11-19 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
JP3242733B2 (ja) * 1993-02-26 2001-12-25 生化学工業株式会社 エンドトキシン特異的測定剤
US5830912A (en) 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
US5773236A (en) 1997-04-25 1998-06-30 Molecule Probes, Inc. Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules
US20100203071A1 (en) * 2007-03-21 2010-08-12 Norman Blais Chimeric antigens
CN101855539B (zh) 2007-11-12 2012-08-22 国立大学法人广岛大学 内毒素浓度测定方法及浓度测定用试剂盒
US7846678B2 (en) 2008-08-18 2010-12-07 BioDtech, Inc. Enhancing endotoxin detection
CN102305788A (zh) * 2010-11-22 2012-01-04 天津市一瑞生物工程有限公司 革兰阴性菌脂多糖(内毒素)比色检测试剂盒的制备及其使用方法
US11352656B2 (en) 2017-01-11 2022-06-07 Lonza Walkersville, Inc. Coagulogen-free clarified limulus amebocyte lysate and chromogenic assay of endotoxin
US20190001330A1 (en) 2017-06-28 2019-01-03 Lonza Walkersville, Inc. Cartridge for endotoxin detection

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012057609A1 (en) 2010-10-29 2012-05-03 Universiti Malaysia Terengganu Process for the preparation of amoebocyte lysate from the haemolymph of the horseshoe crab
JP2019526052A (ja) 2016-08-03 2019-09-12 ロンザ ウォーカーズヴィル,インコーポレーテッド 実質的にコアギュローゲンを含まないリムルスアメボサイトライセートを使用してエンドトキシンを検出する方法

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US12359241B2 (en) 2025-07-15
JP2020505007A (ja) 2020-02-20
KR20190104387A (ko) 2019-09-09
EP3552021B1 (en) 2022-10-26
JP2023002669A (ja) 2023-01-10
IL267593A (en) 2019-08-29
IL267593B1 (en) 2024-12-01
JP7507560B2 (ja) 2024-06-28
CN110192110A (zh) 2019-08-30
JP7724762B2 (ja) 2025-08-18
US11352656B2 (en) 2022-06-07
IL267593B2 (en) 2025-04-01
WO2018132562A1 (en) 2018-07-19
EP3552021A1 (en) 2019-10-16
US20220267824A1 (en) 2022-08-25
CN110192110B (zh) 2023-01-10
US20180208964A1 (en) 2018-07-26

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