IL267593B2 - Coagulogen-free amebocyte lysate from Limulus manuliferus - Google Patents
Coagulogen-free amebocyte lysate from Limulus manuliferusInfo
- Publication number
- IL267593B2 IL267593B2 IL267593A IL26759319A IL267593B2 IL 267593 B2 IL267593 B2 IL 267593B2 IL 267593 A IL267593 A IL 267593A IL 26759319 A IL26759319 A IL 26759319A IL 267593 B2 IL267593 B2 IL 267593B2
- Authority
- IL
- Israel
- Prior art keywords
- lal
- clarified
- coagulogen
- composition
- sample
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/50—Lipopolysaccharides; LPS
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762445136P | 2017-01-11 | 2017-01-11 | |
| PCT/US2018/013310 WO2018132562A1 (en) | 2017-01-11 | 2018-01-11 | Coagulogen-free clarified limulus amebocyte lysate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL267593A IL267593A (en) | 2019-08-29 |
| IL267593B1 IL267593B1 (en) | 2024-12-01 |
| IL267593B2 true IL267593B2 (en) | 2025-04-01 |
Family
ID=61249697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL267593A IL267593B2 (en) | 2017-01-11 | 2018-01-11 | Coagulogen-free amebocyte lysate from Limulus manuliferus |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11352656B2 (enExample) |
| EP (1) | EP3552021B1 (enExample) |
| JP (2) | JP7507560B2 (enExample) |
| KR (1) | KR102545029B1 (enExample) |
| CN (1) | CN110192110B (enExample) |
| IL (1) | IL267593B2 (enExample) |
| WO (1) | WO2018132562A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL264464B2 (en) | 2016-08-03 | 2024-02-01 | Lonza Walkersville Inc | A method for detecting endotoxin using Limulus extract of amoeba, which is mainly free of coagulogen |
| US11352656B2 (en) | 2017-01-11 | 2022-06-07 | Lonza Walkersville, Inc. | Coagulogen-free clarified limulus amebocyte lysate and chromogenic assay of endotoxin |
| WO2025090132A2 (en) * | 2023-05-12 | 2025-05-01 | Life Technolohgies Corporation | Methods and kits for detecting endotoxin |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0141685B1 (ko) * | 1988-09-01 | 1998-07-01 | 야마따니 와따루 | 참게 아메보사이트 라이세이트 g 인자 활성화 저해제 |
| ATE148230T1 (de) * | 1989-10-30 | 1997-02-15 | Biowhittaker Inc | Kinetische bestimmungsmethode für endotoxin unter verwendung von limulus-amoebocyten-lysat und chromogenem substrat |
| JP3122454B2 (ja) * | 1990-09-27 | 2001-01-09 | 生化学工業株式会社 | カブトガニ・アメボサイト・ライセートの調製法 |
| US5208148A (en) | 1990-12-07 | 1993-05-04 | Molecular Probes, Inc. | Lipophilic fluorescent glycosidase substrates |
| ATE180018T1 (de) | 1991-08-23 | 1999-05-15 | Molecular Probes Inc | Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellen |
| US5242805A (en) | 1991-08-23 | 1993-09-07 | Molecular Probes, Inc. | Long wavelength lipophilic fluorogenic glycosidase substrates |
| US5576424A (en) | 1991-08-23 | 1996-11-19 | Molecular Probes, Inc. | Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells |
| JP3242733B2 (ja) * | 1993-02-26 | 2001-12-25 | 生化学工業株式会社 | エンドトキシン特異的測定剤 |
| US5830912A (en) | 1996-11-15 | 1998-11-03 | Molecular Probes, Inc. | Derivatives of 6,8-difluoro-7-hydroxycoumarin |
| US5773236A (en) | 1997-04-25 | 1998-06-30 | Molecule Probes, Inc. | Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules |
| US20100203071A1 (en) * | 2007-03-21 | 2010-08-12 | Norman Blais | Chimeric antigens |
| CN101855539B (zh) | 2007-11-12 | 2012-08-22 | 国立大学法人广岛大学 | 内毒素浓度测定方法及浓度测定用试剂盒 |
| US7846678B2 (en) | 2008-08-18 | 2010-12-07 | BioDtech, Inc. | Enhancing endotoxin detection |
| MY155541A (en) | 2010-10-29 | 2015-10-30 | Universiti Malaysia Terengganu | Process for the preparation of amoebocyte lysate from the haemolymph of the horseshoe crab |
| CN102305788A (zh) * | 2010-11-22 | 2012-01-04 | 天津市一瑞生物工程有限公司 | 革兰阴性菌脂多糖(内毒素)比色检测试剂盒的制备及其使用方法 |
| IL264464B2 (en) | 2016-08-03 | 2024-02-01 | Lonza Walkersville Inc | A method for detecting endotoxin using Limulus extract of amoeba, which is mainly free of coagulogen |
| US11352656B2 (en) | 2017-01-11 | 2022-06-07 | Lonza Walkersville, Inc. | Coagulogen-free clarified limulus amebocyte lysate and chromogenic assay of endotoxin |
| US20190001330A1 (en) | 2017-06-28 | 2019-01-03 | Lonza Walkersville, Inc. | Cartridge for endotoxin detection |
-
2018
- 2018-01-11 US US15/868,318 patent/US11352656B2/en active Active
- 2018-01-11 JP JP2019536071A patent/JP7507560B2/ja active Active
- 2018-01-11 WO PCT/US2018/013310 patent/WO2018132562A1/en not_active Ceased
- 2018-01-11 KR KR1020197023341A patent/KR102545029B1/ko active Active
- 2018-01-11 IL IL267593A patent/IL267593B2/en unknown
- 2018-01-11 CN CN201880006683.8A patent/CN110192110B/zh active Active
- 2018-01-11 EP EP18706328.4A patent/EP3552021B1/en active Active
-
2022
- 2022-05-05 US US17/737,578 patent/US12359241B2/en active Active
- 2022-10-18 JP JP2022166858A patent/JP7724762B2/ja active Active
Non-Patent Citations (1)
| Title |
|---|
| NAKAMURA S ET AL., " FRACTIONATION OF LIMULUS AMEBOCYTE LYSATE - CHARACTERIZATION OF ACTIVATION OF THE PROCLOTTING ENZYME BY AN ENDOTOXIN-MEDIATED ACTIVATOR", 5 October 1982 (1982-10-05) * |
Also Published As
| Publication number | Publication date |
|---|---|
| US12359241B2 (en) | 2025-07-15 |
| JP2020505007A (ja) | 2020-02-20 |
| KR20190104387A (ko) | 2019-09-09 |
| EP3552021B1 (en) | 2022-10-26 |
| KR102545029B1 (ko) | 2023-06-19 |
| JP2023002669A (ja) | 2023-01-10 |
| IL267593A (en) | 2019-08-29 |
| IL267593B1 (en) | 2024-12-01 |
| JP7507560B2 (ja) | 2024-06-28 |
| CN110192110A (zh) | 2019-08-30 |
| JP7724762B2 (ja) | 2025-08-18 |
| US11352656B2 (en) | 2022-06-07 |
| WO2018132562A1 (en) | 2018-07-19 |
| EP3552021A1 (en) | 2019-10-16 |
| US20220267824A1 (en) | 2022-08-25 |
| CN110192110B (zh) | 2023-01-10 |
| US20180208964A1 (en) | 2018-07-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL264464B2 (en) | A method for detecting endotoxin using Limulus extract of amoeba, which is mainly free of coagulogen | |
| US12359241B2 (en) | Coagulogen-free clarified limulus amebocyte lysate | |
| EP1606414B1 (en) | Methods and compositions for the detection of microbial contaminants | |
| Sheraba et al. | Advanced approaches for endotoxin detection and removal from snake antivenoms | |
| HK40007693B (en) | Coagulogen-free clarified limulus amebocyte lysate | |
| HK40007693A (en) | Coagulogen-free clarified limulus amebocyte lysate | |
| IL305093A (en) | Hybrid amebocyte lysate and uses thereof | |
| HK40006346A (en) | Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogen | |
| HK40006346B (zh) | 利用基本上不含凝固蛋白原的鲎阿米巴样细胞溶解物检测内毒素的方法 | |
| KR20200121096A (ko) | 리포폴리사카라이드 추출용 용매 및 이를 이용한 리포폴리사카라이드 추출 방법 | |
| Al-Saffar et al. | Quantitative Detection of the Partially Purified Endotoxin Extracted from the Locally Isolated Salmonella typhimurium A3 | |
| Kabanov et al. | Effects of surface proteins of human erythrocyte membrane on the interaction with lipopolysaccharides from Escherichia coli O55: B5 |