CN105277698B - 一种用于胃病检测的试剂盒 - Google Patents
一种用于胃病检测的试剂盒 Download PDFInfo
- Publication number
- CN105277698B CN105277698B CN201510849189.6A CN201510849189A CN105277698B CN 105277698 B CN105277698 B CN 105277698B CN 201510849189 A CN201510849189 A CN 201510849189A CN 105277698 B CN105277698 B CN 105277698B
- Authority
- CN
- China
- Prior art keywords
- detection
- aptamer
- pgii
- pepsinogen
- test kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96472—Aspartic endopeptidases (3.4.23)
- G01N2333/96475—Aspartic endopeptidases (3.4.23) with definite EC number
- G01N2333/96477—Pepsin (3.4.23.1; 3.4.23.2; 3.4.23.3)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/062—Gastritis or peptic ulcer disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
名称 | 解离常数Kd(单位nM) |
PGII -1 | 8.9 |
PGII -2 | 8.8 |
PGII -3 | 8.7 |
PGII -4 | 8.9 |
PGII -5 | 8.3 |
PGII -6 | 8.0 |
PGII -7 | 8.4 |
PGII -8 | 7.9 |
PGII -9 | 8.6 |
PGII -10 | 8.3 |
PGII -11 | 8.7 |
PGII -12 | 8.6 |
PGII -13 | 8.4 |
PGII -14 | 8.6 |
PBS空白对照 | 无结合能力 |
Claims (1)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610504404.3A CN106405083A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504868.4A CN105911280A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610497173.8A CN106153914A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201510849189.6A CN105277698B (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610503246.XA CN106053809A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610505390.7A CN105929161A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610503443.1A CN106198975A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504436.3A CN106153915A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610505427.6A CN106153916A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504405.8A CN105891479A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610503444.6A CN105891478A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504437.8A CN105929160A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504439.7A CN106198977A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504850.4A CN105891480A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510849189.6A CN105277698B (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
Related Child Applications (13)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610504436.3A Division CN106153915A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504404.3A Division CN106405083A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504850.4A Division CN105891480A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610505390.7A Division CN105929161A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504439.7A Division CN106198977A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504405.8A Division CN105891479A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610503444.6A Division CN105891478A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610503443.1A Division CN106198975A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610497173.8A Division CN106153914A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504868.4A Division CN105911280A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610505427.6A Division CN106153916A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610503246.XA Division CN106053809A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504437.8A Division CN105929160A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
Publications (2)
Publication Number | Publication Date |
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CN105277698A CN105277698A (zh) | 2016-01-27 |
CN105277698B true CN105277698B (zh) | 2016-09-21 |
Family
ID=55147066
Family Applications (14)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610503444.6A Pending CN105891478A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504437.8A Pending CN105929160A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504404.3A Withdrawn CN106405083A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610505390.7A Pending CN105929161A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504436.3A Withdrawn CN106153915A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610503443.1A Withdrawn CN106198975A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504405.8A Pending CN105891479A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504868.4A Pending CN105911280A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610505427.6A Withdrawn CN106153916A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504439.7A Withdrawn CN106198977A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504850.4A Pending CN105891480A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610503246.XA Pending CN106053809A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610497173.8A Withdrawn CN106153914A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201510849189.6A Expired - Fee Related CN105277698B (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
Family Applications Before (13)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610503444.6A Pending CN105891478A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504437.8A Pending CN105929160A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504404.3A Withdrawn CN106405083A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610505390.7A Pending CN105929161A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504436.3A Withdrawn CN106153915A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610503443.1A Withdrawn CN106198975A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504405.8A Pending CN105891479A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504868.4A Pending CN105911280A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610505427.6A Withdrawn CN106153916A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504439.7A Withdrawn CN106198977A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610504850.4A Pending CN105891480A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610503246.XA Pending CN106053809A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
CN201610497173.8A Withdrawn CN106153914A (zh) | 2015-11-29 | 2015-11-29 | 一种用于胃病检测的试剂盒 |
Country Status (1)
Country | Link |
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CN (14) | CN105891478A (zh) |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004040306A1 (en) * | 2002-10-31 | 2004-05-13 | Labrea Holding S.A. | Diagnostic device and kit |
FI20065542A0 (fi) * | 2006-09-01 | 2006-09-01 | Biohit Oyj | Menetelmä ja näytteenottopakkaus vatsan limakalvon tilan arvioimiseksi |
EP2203745A4 (en) * | 2007-10-26 | 2010-12-08 | Biohit Oyj | METHODS AND PRODUCTS FOR DIAGNOSING AUTOIMMUNE DISEASES AND GASTRIC CANCER RELATED TO ATROPHIC GASTRITIS |
US20130217046A1 (en) * | 2010-06-23 | 2013-08-22 | The Board of Trustees of the Univer. of Illinois | Method for determining predisposition to esophageal-related disorders |
CN102839181B (zh) * | 2011-06-23 | 2014-05-14 | 复旦大学附属华山医院 | 一种胃癌细胞的核酸适配体序列及用途 |
CN102426236A (zh) * | 2011-08-31 | 2012-04-25 | 内蒙古科慧生物科技有限责任公司 | 胃蛋白酶原ii(pgii)定量测定试剂盒及其检测方法 |
CN103305521B (zh) * | 2012-03-06 | 2016-06-08 | 复旦大学附属华山医院 | 一种胃癌细胞的核酸适配体的序列及应用 |
CN102645537B (zh) * | 2012-04-26 | 2014-07-30 | 北京美康生物技术研究中心 | 用于诊断胃病或胃癌的胶乳增强免疫比浊试剂盒及其制备方法和应用 |
CN103320445B (zh) * | 2013-07-11 | 2017-07-28 | 重庆市肿瘤研究所 | 特异性识别胃癌细胞的dna适配子gca‑5及其应用 |
CN104418937B (zh) * | 2013-08-22 | 2018-01-02 | 朱建安 | 人pgii抗原表位肽、抗原、抗体、用途及试剂盒 |
CN103627701B (zh) * | 2013-12-04 | 2015-07-15 | 武汉大学 | 特异性靶向胃癌细胞的适配子的筛选及筛选得到的适配子 |
CN104818278A (zh) * | 2015-04-17 | 2015-08-05 | 刘红卫 | 能够特异性结合胃癌细胞中的ts/mdep蛋白的适配子 |
CN104830867A (zh) * | 2015-06-07 | 2015-08-12 | 杨洋 | 一种能够特异性结合癌细胞中的dkk1蛋白的适配子 |
-
2015
- 2015-11-29 CN CN201610503444.6A patent/CN105891478A/zh active Pending
- 2015-11-29 CN CN201610504437.8A patent/CN105929160A/zh active Pending
- 2015-11-29 CN CN201610504404.3A patent/CN106405083A/zh not_active Withdrawn
- 2015-11-29 CN CN201610505390.7A patent/CN105929161A/zh active Pending
- 2015-11-29 CN CN201610504436.3A patent/CN106153915A/zh not_active Withdrawn
- 2015-11-29 CN CN201610503443.1A patent/CN106198975A/zh not_active Withdrawn
- 2015-11-29 CN CN201610504405.8A patent/CN105891479A/zh active Pending
- 2015-11-29 CN CN201610504868.4A patent/CN105911280A/zh active Pending
- 2015-11-29 CN CN201610505427.6A patent/CN106153916A/zh not_active Withdrawn
- 2015-11-29 CN CN201610504439.7A patent/CN106198977A/zh not_active Withdrawn
- 2015-11-29 CN CN201610504850.4A patent/CN105891480A/zh active Pending
- 2015-11-29 CN CN201610503246.XA patent/CN106053809A/zh active Pending
- 2015-11-29 CN CN201610497173.8A patent/CN106153914A/zh not_active Withdrawn
- 2015-11-29 CN CN201510849189.6A patent/CN105277698B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN106153916A (zh) | 2016-11-23 |
CN106405083A (zh) | 2017-02-15 |
CN106198977A (zh) | 2016-12-07 |
CN105891478A (zh) | 2016-08-24 |
CN105911280A (zh) | 2016-08-31 |
CN106153914A (zh) | 2016-11-23 |
CN106198975A (zh) | 2016-12-07 |
CN105891480A (zh) | 2016-08-24 |
CN105277698A (zh) | 2016-01-27 |
CN105929161A (zh) | 2016-09-07 |
CN106153915A (zh) | 2016-11-23 |
CN106053809A (zh) | 2016-10-26 |
CN105929160A (zh) | 2016-09-07 |
CN105891479A (zh) | 2016-08-24 |
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Inventor after: Ling Zisong Inventor before: Lu Meizhen |
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Effective date of registration: 20160822 Address after: 510095, Guangzhou, Guangdong, Yuexiu District Lu Lu Hua Yue Street, No. 41, building 8, building 3, B306 room (only office use) Applicant after: Guangzhou Hongxin Biological Technology Co., Ltd. Address before: 3 unit 4, building 488, 336000 Yuan Yuan Xi Road, Nanchang, Jiangxi, Xihu District Applicant before: Lu Meizhen |
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