CN103554030A - 苯达莫司汀游离碱的新颖形式 - Google Patents
苯达莫司汀游离碱的新颖形式 Download PDFInfo
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- CN103554030A CN103554030A CN201310425128.8A CN201310425128A CN103554030A CN 103554030 A CN103554030 A CN 103554030A CN 201310425128 A CN201310425128 A CN 201310425128A CN 103554030 A CN103554030 A CN 103554030A
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- Prior art keywords
- bendamustine free
- free alkali
- ray powder
- powder diffraction
- crystallized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- Organic Chemistry (AREA)
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- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
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| EP2516404A4 (en) * | 2009-12-23 | 2013-04-17 | Reddys Lab Ltd Dr | PREPARATION OF BENDAMUSTINE AND ITS SALTS |
| PL3158991T3 (pl) | 2010-01-28 | 2021-09-27 | Eagle Pharmaceuticals, Inc. | Preparaty bendamustyny |
| EP2720547A4 (en) * | 2011-06-20 | 2014-11-05 | Hetero Research Foundation | PROCESS FOR BENDAMUSTINE HYDROCHLORIDE |
| US20230241218A1 (en) * | 2012-07-10 | 2023-08-03 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
| EP2827863B1 (en) | 2012-03-20 | 2019-01-16 | Eagle Pharmaceuticals, Inc. | Liquid composition for use in a method of treating bendamustine-responsive conditions in patients requiring reduced volumes for administration |
| JP6250628B2 (ja) | 2012-03-20 | 2017-12-20 | イーグル・ファーマシューティカルズ・インコーポレーテッド | ベンダムスチンの製剤 |
| CA2904143A1 (en) | 2013-03-12 | 2014-10-09 | Cephalon, Inc. | Nanoparticulate and macroparticulate formulations |
| EP4218543A1 (en) | 2013-04-26 | 2023-08-02 | Genentech, Inc. | Contour integration perimetry vision test |
| US20240148696A1 (en) | 2022-10-25 | 2024-05-09 | Softkemo Pharma Inc. | Lyophilized bendamustine-cyclodextrin composition |
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| DE122004000036I1 (de) | 1992-11-13 | 2005-07-07 | Biogen Idec Inc | Therapeutische Verwendung von chimerischen und markierten Antik¦rper gegen menschlichen B Lymphozyt beschr{nkter Differenzierung antigen f}r die Behandlung von B-Zell-Lymphoma. |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
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| US5955504A (en) | 1995-03-13 | 1999-09-21 | Loma Linda University Medical Center | Colorectal chemoprotective composition and method of preventing colorectal cancer |
| DE19529057B4 (de) | 1995-08-08 | 2007-12-13 | Baxter Healthcare S.A. | Ifosfamid-Lyophilisat-Zubereitungen |
| US20040072889A1 (en) | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
| US6034256A (en) | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
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| AU767586B2 (en) | 1998-07-09 | 2003-11-20 | Cephalon, Inc. | Methods and compositions for the treatment of chronic lymphocytic leukemia |
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| US6545034B1 (en) | 1999-07-23 | 2003-04-08 | The Regents Of The University Of California | Use of etodolac for the treatment of chronic lymphocytic leukemia |
| DE10016077A1 (de) | 2000-03-31 | 2001-12-13 | Cellcontrol Biomedical Lab Gmb | Verfahren und Vorrichtung zum automatischen Nachweisen einer Wirkung eines zellbeeinflussenden Mittels auf lebende Zellen |
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| HUP0400683A2 (hu) | 2000-12-11 | 2004-06-28 | Takeda Chemical Industries, Ltd. | HER2 inhibitort tartalmazó fokozott felszívódású gyógyászati készítmény |
| CA2431319A1 (en) | 2000-12-11 | 2002-06-20 | Hiroto Bando | Pharmaceutical composition having an improved water solubility |
| BR0213279A (pt) | 2001-10-15 | 2004-10-26 | Hemoteq Gmbh | Revestimento de stents para impedir a restenose |
| US6613927B1 (en) | 2002-02-08 | 2003-09-02 | American Pharmaceutical Partners, Inc. | Sterile lyophilized ifosfamide and associated methods |
| DE10306724A1 (de) | 2002-02-28 | 2003-09-18 | G O T Therapeutics Gmbh | Vesikuläre Verkapselung von Bendamustin |
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| WO2003086470A2 (en) | 2002-04-17 | 2003-10-23 | Deutsches Krebsforschungszentrum | Smac-peptides as therapeutics against cancer and autoimmune diseases |
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| DE10393060D2 (de) | 2002-05-09 | 2005-05-04 | Hemoteq Gmbh | Reduktion der Schallemission von dünnwadigen Bauteilen in Magnetresonazgeräten |
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| WO2005011688A1 (en) | 2003-07-25 | 2005-02-10 | Wyeth | Cci-779 lyophilized formulations |
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| AU2009302493B2 (en) * | 2008-10-08 | 2015-04-09 | Cephalon Llc | Processes for the preparation of bendamustine |
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2016
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Also Published As
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| KR20110110293A (ko) | 2011-10-06 |
| WO2010083276A1 (en) | 2010-07-22 |
| CA2749101A1 (en) | 2010-07-22 |
| ZA201105099B (en) | 2012-03-28 |
| IL213725A0 (en) | 2011-07-31 |
| AU2016204902A1 (en) | 2016-08-04 |
| EA020767B1 (ru) | 2015-01-30 |
| EA201170934A1 (ru) | 2011-12-30 |
| SG172810A1 (en) | 2011-08-29 |
| JP2012515210A (ja) | 2012-07-05 |
| BRPI1004922A2 (pt) | 2019-09-24 |
| US20100210701A1 (en) | 2010-08-19 |
| EP2387400A1 (en) | 2011-11-23 |
| CN102281877B (zh) | 2014-07-23 |
| US8076366B2 (en) | 2011-12-13 |
| NZ594010A (en) | 2013-08-30 |
| CN102281877A (zh) | 2011-12-14 |
| AU2010204765A1 (en) | 2011-07-28 |
| MX2011007557A (es) | 2011-08-12 |
| UA109109C2 (uk) | 2015-07-27 |
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