NZ594010A - Novel forms of bendamustine free base - Google Patents

Novel forms of bendamustine free base

Info

Publication number
NZ594010A
NZ594010A NZ594010A NZ59401010A NZ594010A NZ 594010 A NZ594010 A NZ 594010A NZ 594010 A NZ594010 A NZ 594010A NZ 59401010 A NZ59401010 A NZ 59401010A NZ 594010 A NZ594010 A NZ 594010A
Authority
NZ
New Zealand
Prior art keywords
free base
bendamustine free
forms
novel forms
bendamustine
Prior art date
Application number
NZ594010A
Other languages
English (en)
Inventor
Mark Eddleston
Curtis R Haltiwanger
Laurent D Courvoisier
Robert E Mckean
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42008533&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ594010(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cephalon Inc filed Critical Cephalon Inc
Publication of NZ594010A publication Critical patent/NZ594010A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NZ594010A 2009-01-15 2010-01-14 Novel forms of bendamustine free base NZ594010A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14484309P 2009-01-15 2009-01-15
PCT/US2010/020992 WO2010083276A1 (en) 2009-01-15 2010-01-14 Novel forms of bendamustine free base

Publications (1)

Publication Number Publication Date
NZ594010A true NZ594010A (en) 2013-08-30

Family

ID=42008533

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ594010A NZ594010A (en) 2009-01-15 2010-01-14 Novel forms of bendamustine free base

Country Status (16)

Country Link
US (1) US8076366B2 (enExample)
EP (1) EP2387400A1 (enExample)
JP (1) JP2012515210A (enExample)
KR (1) KR20110110293A (enExample)
CN (2) CN102281877B (enExample)
AU (2) AU2010204765A1 (enExample)
BR (1) BRPI1004922A2 (enExample)
CA (1) CA2749101A1 (enExample)
EA (1) EA020767B1 (enExample)
IL (1) IL213725A0 (enExample)
MX (1) MX2011007557A (enExample)
NZ (1) NZ594010A (enExample)
SG (1) SG172810A1 (enExample)
UA (1) UA109109C2 (enExample)
WO (1) WO2010083276A1 (enExample)
ZA (1) ZA201105099B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9376394B2 (en) * 2009-12-23 2016-06-28 Dr. Reddy's Laboratories Ltd. Preparation of bendamustine and its salts
PL3158991T3 (pl) 2010-01-28 2021-09-27 Eagle Pharmaceuticals, Inc. Preparaty bendamustyny
EP2720547A4 (en) * 2011-06-20 2014-11-05 Hetero Research Foundation PROCESS FOR BENDAMUSTINE HYDROCHLORIDE
EP4360621A3 (en) 2012-03-20 2024-05-22 Eagle Pharmaceuticals, Inc. Formulations of bendamustine
PT3533447T (pt) 2012-03-20 2023-05-17 Eagle Pharmaceuticals Inc Composições líquidas de bendamustina para utilização num método de tratamento de condições com resposta a bendamustina em pacientes que requerem volumes reduzidos para administração
US20230241218A1 (en) * 2012-07-10 2023-08-03 Eagle Pharmaceuticals, Inc. Formulations of bendamustine
US9598377B2 (en) * 2013-03-12 2017-03-21 Cephalon, Inc. Nanoparticulate and macroparticulate formulations
EP2988655B1 (en) 2013-04-26 2023-04-12 Genentech, Inc. Contour integration perimetry vision test
US20240148696A1 (en) 2022-10-25 2024-05-09 Softkemo Pharma Inc. Lyophilized bendamustine-cyclodextrin composition

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE293808C (enExample)
DE80967C (enExample)
DE159877C (enExample)
DD159289A1 (de) 1981-06-01 1983-03-02 Uwe Olthoff Verfahren zur herstellung stabiler injektionsloesungen von n-lostverbindungen
DD159877A1 (de) * 1981-06-12 1983-04-13 Wolfgang Krueger Verfahren zur herstellung von 4-[1-methyl-5-bis(2-chloraethyl)amino-benzimidazolyl-2]-buttersaeure
US5204335A (en) * 1986-10-31 1993-04-20 Asta Pharma Aktiengesellschaft Ifosfamide lyophilisate and process for its preparation
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
RU2139731C1 (ru) * 1992-11-13 1999-10-20 Айдек Фармасьютикалс Корпорейшн (US Способ лечения, антитела, гибридома
US5595721A (en) * 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
CN1060042C (zh) * 1993-10-27 2001-01-03 法玛西雅厄普约翰美国公司 稳定的前列腺素e1
US5561121A (en) 1993-11-09 1996-10-01 American Cyanamid Company Stable lyophilized thiotepa composition
US5955504A (en) * 1995-03-13 1999-09-21 Loma Linda University Medical Center Colorectal chemoprotective composition and method of preventing colorectal cancer
DE19529057B4 (de) * 1995-08-08 2007-12-13 Baxter Healthcare S.A. Ifosfamid-Lyophilisat-Zubereitungen
US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
US6034256A (en) * 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
AU767586B2 (en) * 1998-07-09 2003-11-20 Cephalon, Inc. Methods and compositions for the treatment of chronic lymphocytic leukemia
US5972912A (en) * 1998-12-17 1999-10-26 S.P. Pharmaceuticals Method for lyophilizing ifosfamide
US6569402B1 (en) * 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6380210B1 (en) * 1999-04-02 2002-04-30 Neurogen Corporation Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6545034B1 (en) * 1999-07-23 2003-04-08 The Regents Of The University Of California Use of etodolac for the treatment of chronic lymphocytic leukemia
DE10016077A1 (de) 2000-03-31 2001-12-13 Cellcontrol Biomedical Lab Gmb Verfahren und Vorrichtung zum automatischen Nachweisen einer Wirkung eines zellbeeinflussenden Mittels auf lebende Zellen
US20040152672A1 (en) * 2000-08-09 2004-08-05 Carson Dennis A. Indole compounds useful for the treatment of cancer
KR20040025880A (ko) * 2000-12-11 2004-03-26 다케다 야쿠힌 고교 가부시키가이샤 수용해성이 개선된 의약 조성물
AU2002221115A1 (en) * 2000-12-11 2002-06-24 Takeda Chemical Industries Ltd. Medicinal compositions having improved absorbability
CA2462723C (en) * 2001-10-15 2012-05-01 Hemoteq Gmbh Coated stents for preventing restenosis
US6613927B1 (en) 2002-02-08 2003-09-02 American Pharmaceutical Partners, Inc. Sterile lyophilized ifosfamide and associated methods
DE10306724A1 (de) 2002-02-28 2003-09-18 G O T Therapeutics Gmbh Vesikuläre Verkapselung von Bendamustin
WO2003081238A2 (en) 2002-03-22 2003-10-02 Ludwig Maximilians Universität Cytocapacity test
EP1354952A1 (en) 2002-04-17 2003-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-peptides as therapeutics against cancer and autoimmune diseases
EP1495124A2 (en) 2002-04-17 2005-01-12 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Smac-peptides as therapeutics against cancer and autoimmune diseases
WO2003094990A1 (de) 2002-05-09 2003-11-20 Hemoteq Gmbh Verbindungen und verfahren zur hemokompatiblen beschichtung von oberflächen
AU2003258061A1 (en) * 2002-08-02 2004-02-23 Salmedix, Inc. Therapeutic inhibitionof protein kinases in cancer cells
DE10304403A1 (de) 2003-01-28 2004-08-05 Röhm GmbH & Co. KG Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung
EP1444989A1 (en) 2003-02-07 2004-08-11 Giorgio Dr. Stassi Sensitizing cells for apoptosis by selectively blocking cytokines
WO2004074325A2 (en) * 2003-02-14 2004-09-02 Salmedix, Inc Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers
MXPA05013865A (es) * 2003-07-25 2006-02-28 Wyeth Corp Formulaciones liofilizadas de cci-779.
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
JP5773874B2 (ja) * 2008-10-08 2015-09-02 セファロン、インク． ベンダムスチンの調製方法

Also Published As

Publication number Publication date
AU2016204902A1 (en) 2016-08-04
MX2011007557A (es) 2011-08-12
AU2010204765A1 (en) 2011-07-28
WO2010083276A1 (en) 2010-07-22
ZA201105099B (en) 2012-03-28
US8076366B2 (en) 2011-12-13
CA2749101A1 (en) 2010-07-22
US20100210701A1 (en) 2010-08-19
SG172810A1 (en) 2011-08-29
CN102281877B (zh) 2014-07-23
CN102281877A (zh) 2011-12-14
KR20110110293A (ko) 2011-10-06
UA109109C2 (uk) 2015-07-27
JP2012515210A (ja) 2012-07-05
CN103554030A (zh) 2014-02-05
EA020767B1 (ru) 2015-01-30
EA201170934A1 (ru) 2011-12-30
EP2387400A1 (en) 2011-11-23
IL213725A0 (en) 2011-07-31
BRPI1004922A2 (pt) 2019-09-24

Similar Documents

Publication Publication Date Title
NZ594010A (en) Novel forms of bendamustine free base
MX339878B (es) Nuevas formas solidas de clorhidrato de bendamustina.
HUE036085T2 (hu) Nagy tisztaságú és kristályos dimetil-fumarát elõállítására szolgáló eljárás
ZA200908231B (en) Stevioside polymorphic and amorphous forms,methods for their formulation,and uses
PL3061760T3 (pl) Deuterowane pochodne benzochinoliny jako inhibitory pęcherzykowego transportera monoamin 2
MY185130A (en) Romidepsin solid forms and uses thereof
PL2247582T3 (pl) Postać krystaliczna bezwodna dimetoksydocetakselu i sposoby jej wytwarzania
MY158257A (en) Forms of rifaximin and uses thereof
MX338327B (es) Inhibidores de cdk.
EP2480079A4 (en) PYRIDO- (3,4-B-) INDOLE AND USE METHOD THEREFOR
WO2007136510A3 (en) Polymorphic forms of imatinib mesylate and processes for their preparation as well as of amorphous imatinib mesylate and form alpha
MX2015003124A (es) Formas polimorficas de enzalutamida y su preparacion.
JO2887B1 (en) Spiro-pyridine compounds as ORL-1 receptor antagonists
SI2963024T1 (sl) Kristalinični hidrati metiltioninijevega klorida-del 2
UA99787C2 (en) Lactams as beta secretase inhibitors
MY165234A (en) A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
PH12015500733A1 (en) Method of weight management
IL214421A0 (en) Methods for producing human amniotic cell lines
IL221461A0 (en) Crystalline forms of the tri-mesylate salt of perphenazine-gaba and process of producing the same
UA105767C2 (uk) Аморфна форма протіоконазолу, бактерицидна композиція на її основі, способи їх одержання
MX343234B (es) Formas cristalinas de 6-(1h-imidazol-1-il)-2-fenilquinazolina.
IL215965A0 (en) Solvate crystals and methods of producing the same
EP2386592A4 (en) MANUFACTURING METHOD FOR MASTERBATCH, MASTERBATCH AND USE
IN2012DN02698A (enExample)
HUP0900130A3 (en) Novel crystalline hydrate, amorphous and polymorphic forms of dihydro-benzoxazole-6-yl-acetamide derivative and processes for their preparation

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 14 JAN 2017 BY DENNEMEYER SA

Effective date: 20131218

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 14 JAN 2023 BY DENNEMEYER + CO

Effective date: 20140829

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 14 JAN 2020 BY DENNEMEYER + CO

Effective date: 20140828

Free format text: PATENT RENEWED FOR 7 YEARS UNTIL 14 JAN 2030 BY DENNEMEYER + CO

Effective date: 20140829