WO2011104723A3 - Acid addition salts of ivabradine and preparation method thereof - Google Patents

Acid addition salts of ivabradine and preparation method thereof Download PDF

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Publication number
WO2011104723A3
WO2011104723A3 PCT/IN2011/000103 IN2011000103W WO2011104723A3 WO 2011104723 A3 WO2011104723 A3 WO 2011104723A3 IN 2011000103 W IN2011000103 W IN 2011000103W WO 2011104723 A3 WO2011104723 A3 WO 2011104723A3
Authority
WO
WIPO (PCT)
Prior art keywords
ivabradine
acid addition
addition salts
preparation
solvates
Prior art date
Application number
PCT/IN2011/000103
Other languages
French (fr)
Other versions
WO2011104723A2 (en
Inventor
Gajendra Singh
Satyendra Pal Singh
Lalit Wadhwa
Original Assignee
Ind-Swift Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind-Swift Laboratories Limited filed Critical Ind-Swift Laboratories Limited
Publication of WO2011104723A2 publication Critical patent/WO2011104723A2/en
Publication of WO2011104723A3 publication Critical patent/WO2011104723A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Provided are the novel acid addition salts of ivabradine of formula I including their hydrates, solvates, anhydrous form, and non-solvated form, all in amorphous or crystalline forms.
PCT/IN2011/000103 2010-02-23 2011-02-21 Acid addition salts of ivabradine and preparation thereof WO2011104723A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN395DE2010 2010-02-23
IN395/DEL/2010 2010-02-23

Publications (2)

Publication Number Publication Date
WO2011104723A2 WO2011104723A2 (en) 2011-09-01
WO2011104723A3 true WO2011104723A3 (en) 2011-11-03

Family

ID=44507315

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000103 WO2011104723A2 (en) 2010-02-23 2011-02-21 Acid addition salts of ivabradine and preparation thereof

Country Status (1)

Country Link
WO (1) WO2011104723A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013093753A1 (en) * 2011-12-24 2013-06-27 Alembic Pharmaceuticals Limited Ivabradine hydrochloride premix
US9409913B2 (en) * 2012-11-21 2016-08-09 Enaltec Labs Private Limited Polymorphic forms of alcaftadine
WO2014114341A1 (en) 2013-01-24 2014-07-31 Synthon Bv Process for making ivabradine
CZ305096B6 (en) * 2013-10-02 2015-04-29 Zentiva, K.S. Ivabradine hydrochloride and (S)-mandelic acid solid form and pharmaceutical composition thereof
FR3020810B1 (en) * 2014-05-06 2016-05-06 Servier Lab NEW SALT OF IVABRADINE AND PROCESS FOR PREPARING SAME
CZ305436B6 (en) * 2014-07-10 2015-09-16 Zentiva, K.S. Solid form of ivabradine hydrochloride and (R)-mandelic acid and pharmaceutical composition thereof
GB201621771D0 (en) * 2016-12-20 2017-02-01 Biogena (A P I) Ltd New salts of compounds and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1683341A (en) * 2004-04-13 2005-10-19 瑟维尔实验室 New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
CN101607939A (en) * 2008-06-20 2009-12-23 瑟维尔实验室 Method for synthesizing 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzoaza-2-ketone and its application

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1683341A (en) * 2004-04-13 2005-10-19 瑟维尔实验室 New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
CN101607939A (en) * 2008-06-20 2009-12-23 瑟维尔实验室 Method for synthesizing 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzoaza-2-ketone and its application

Also Published As

Publication number Publication date
WO2011104723A2 (en) 2011-09-01

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