CN103534255B - 作为葡萄糖脑苷脂酶激活剂的取代的吡唑并嘧啶 - Google Patents

作为葡萄糖脑苷脂酶激活剂的取代的吡唑并嘧啶 Download PDF

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CN103534255B
CN103534255B CN201180066859.7A CN201180066859A CN103534255B CN 103534255 B CN103534255 B CN 103534255B CN 201180066859 A CN201180066859 A CN 201180066859A CN 103534255 B CN103534255 B CN 103534255B
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pyrimidine
carboxamide
alkyl
difluoromethyl
phenyl
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CN103534255A (zh
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胡安·乔斯·马鲁甘
诺埃尔·索撒尔
埃胡德·戈尔金
伟·郑
S·帕特奈克
艾伦·西德兰斯基
奥米德·莫塔巴尔
文迪·韦斯特布鲁克
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US Department of Health and Human Services
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201180066859.7A 2010-12-08 2011-12-08 作为葡萄糖脑苷脂酶激活剂的取代的吡唑并嘧啶 Active CN103534255B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42094610P 2010-12-08 2010-12-08
US61/420,946 2010-12-08
PCT/US2011/063928 WO2012078855A1 (en) 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators

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CN103534255A CN103534255A (zh) 2014-01-22
CN103534255B true CN103534255B (zh) 2016-12-21

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US10925874B2 (en) 2021-02-23
ES2681218T3 (es) 2018-09-12
US20140249145A1 (en) 2014-09-04
JP6154746B2 (ja) 2017-06-28
CA2820362C (en) 2020-03-24
RU2013126094A (ru) 2015-01-20
WO2012078855A1 (en) 2012-06-14
EP2649075A1 (en) 2013-10-16
JP2013544893A (ja) 2013-12-19
ES2912284T3 (es) 2022-05-25
MX2013006462A (es) 2013-10-01
EP3366688B1 (en) 2022-02-09
IL226767B (en) 2018-06-28
CA2820362A1 (en) 2012-06-14
HRP20220512T1 (hr) 2022-05-27
IL259648A (en) 2018-07-31
ZA201304215B (en) 2014-03-26
AU2011338377A1 (en) 2013-07-04
PL2649075T3 (pl) 2018-09-28
DK3366688T3 (da) 2022-05-02
HUE038635T2 (hu) 2018-11-28
KR101931224B1 (ko) 2018-12-20
CY1125186T1 (el) 2024-12-13
US20180263988A1 (en) 2018-09-20
TR201810523T4 (tr) 2018-08-27
PT2649075T (pt) 2018-07-30
RS63320B1 (sr) 2022-07-29
EP2649075B1 (en) 2018-04-25
BR112013014242B1 (pt) 2022-02-22
LT3366688T (lt) 2022-05-25
US20160346284A1 (en) 2016-12-01
AU2011338377B2 (en) 2016-08-04
RU2603637C2 (ru) 2016-11-27
SI2649075T1 (sl) 2018-10-30
PT3366688T (pt) 2022-05-11
US9974789B2 (en) 2018-05-22
PL3366688T3 (pl) 2022-05-23
KR20140010012A (ko) 2014-01-23
CN103534255A (zh) 2014-01-22
EP3366688A1 (en) 2018-08-29
BR112013014242A2 (pt) 2018-06-26
IL259648B (en) 2021-03-25
US9353117B2 (en) 2016-05-31
AU2011338377A8 (en) 2015-10-29
MX385600B (es) 2025-03-18
DK2649075T3 (en) 2018-07-30
MX354506B (es) 2018-01-16
SI3366688T1 (sl) 2022-07-29

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