CN103524447A - 一种利伐沙班中间体4-(4-氨基苯基)-3-吗啉酮的合成方法 - Google Patents
一种利伐沙班中间体4-(4-氨基苯基)-3-吗啉酮的合成方法 Download PDFInfo
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- CN103524447A CN103524447A CN201310504464.1A CN201310504464A CN103524447A CN 103524447 A CN103524447 A CN 103524447A CN 201310504464 A CN201310504464 A CN 201310504464A CN 103524447 A CN103524447 A CN 103524447A
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- ethanol
- aminophenyl
- morpholinone
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- nitro
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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CN201310504464.1A CN103524447B (zh) | 2013-10-24 | 2013-10-24 | 一种利伐沙班中间体4-(4-氨基苯基)-3-吗啉酮的合成方法 |
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CN201310504464.1A CN103524447B (zh) | 2013-10-24 | 2013-10-24 | 一种利伐沙班中间体4-(4-氨基苯基)-3-吗啉酮的合成方法 |
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CN103524447A true CN103524447A (zh) | 2014-01-22 |
CN103524447B CN103524447B (zh) | 2015-04-22 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103965184A (zh) * | 2014-04-18 | 2014-08-06 | 上海方楠生物科技有限公司 | 一种利伐沙班中间体的合成方法 |
CN104478820A (zh) * | 2014-12-22 | 2015-04-01 | 杭州瀚康生物医药科技有限公司 | 一种利伐沙班中间体的制备方法 |
CN104829551A (zh) * | 2015-05-12 | 2015-08-12 | 浙江天顺生物科技有限公司 | 一种利伐沙班中间体4-(4-氨基苯基)-3-吗啉酮的制备方法 |
CN104974105A (zh) * | 2014-04-14 | 2015-10-14 | 北大方正集团有限公司 | 一种制备4-(4-氨基苯基)-3-吗啉酮的方法 |
CN105085431A (zh) * | 2014-04-22 | 2015-11-25 | 北大方正集团有限公司 | 4-(4-甲氨烯基苯基)-3-吗啉酮及其制备方法 |
CN109384738A (zh) * | 2017-08-04 | 2019-02-26 | 新发药业有限公司 | 一种高纯度4-(4-氨基苯基)吗啡啉-3-酮的制备方法 |
CN114014820A (zh) * | 2021-12-18 | 2022-02-08 | 南京焕然生物科技有限公司 | 一种4-(4-氨基苯基)-3-吗啉酮的制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070149522A1 (en) * | 2003-01-07 | 2007-06-28 | Bayer Healthcare Ag | Method for producing 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide |
WO2010047919A1 (en) * | 2008-10-20 | 2010-04-29 | Nova Chemicals Inc. | Locking tie and insulating concrete form |
-
2013
- 2013-10-24 CN CN201310504464.1A patent/CN103524447B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070149522A1 (en) * | 2003-01-07 | 2007-06-28 | Bayer Healthcare Ag | Method for producing 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide |
WO2010047919A1 (en) * | 2008-10-20 | 2010-04-29 | Nova Chemicals Inc. | Locking tie and insulating concrete form |
Non-Patent Citations (3)
Title |
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KIMURA, MAKOTO ET AL.: "Antioxidative activities of novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》, vol. 14, no. 16, 31 December 2004 (2004-12-31), pages 4287 - 4290 * |
李连连 等.: "3-氯-4-(3-氟苄氧基)苯胺的合成", 《中国现代应用药学》, vol. 28, no. 3, 28 March 2011 (2011-03-28), pages 245 - 246 * |
罗玲艳 等.: "4-(4-氨基苯基)-3-吗啉酮的合成", 《中国医药工业杂质》, vol. 42, no. 2, 10 February 2011 (2011-02-10), pages 93 - 95 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104974105A (zh) * | 2014-04-14 | 2015-10-14 | 北大方正集团有限公司 | 一种制备4-(4-氨基苯基)-3-吗啉酮的方法 |
CN104974105B (zh) * | 2014-04-14 | 2017-06-16 | 北大方正集团有限公司 | 一种制备4‑(4‑氨基苯基)‑3‑吗啉酮的方法 |
CN103965184A (zh) * | 2014-04-18 | 2014-08-06 | 上海方楠生物科技有限公司 | 一种利伐沙班中间体的合成方法 |
CN105085431A (zh) * | 2014-04-22 | 2015-11-25 | 北大方正集团有限公司 | 4-(4-甲氨烯基苯基)-3-吗啉酮及其制备方法 |
CN105085431B (zh) * | 2014-04-22 | 2017-03-29 | 北大方正集团有限公司 | 4‑(4‑甲氨烯基苯基)‑3‑吗啉酮及其制备方法 |
CN104478820A (zh) * | 2014-12-22 | 2015-04-01 | 杭州瀚康生物医药科技有限公司 | 一种利伐沙班中间体的制备方法 |
CN104478820B (zh) * | 2014-12-22 | 2016-08-31 | 杭州瀚康生物医药科技有限公司 | 一种利伐沙班中间体的制备方法 |
CN104829551A (zh) * | 2015-05-12 | 2015-08-12 | 浙江天顺生物科技有限公司 | 一种利伐沙班中间体4-(4-氨基苯基)-3-吗啉酮的制备方法 |
CN109384738A (zh) * | 2017-08-04 | 2019-02-26 | 新发药业有限公司 | 一种高纯度4-(4-氨基苯基)吗啡啉-3-酮的制备方法 |
CN109384738B (zh) * | 2017-08-04 | 2020-10-02 | 新发药业有限公司 | 一种4-(4-氨基苯基)吗啡啉-3-酮的制备方法 |
CN114014820A (zh) * | 2021-12-18 | 2022-02-08 | 南京焕然生物科技有限公司 | 一种4-(4-氨基苯基)-3-吗啉酮的制备方法 |
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CN103524447B (zh) | 2015-04-22 |
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Denomination of invention: A synthetic method of rivaroxaban Intermediate 4 - (4-aminophenyl) - 3-morpholinone Effective date of registration: 20211207 Granted publication date: 20150422 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan science and technology innovation center sub branch Pledgor: SHANDONG BOYUAN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980014223 |
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Address after: 251400 No. 12, Taixing East Street, Jibei Economic Development Zone, Jiyang District, Jinan City, Shandong Province Patentee after: Shandong Baoyuan Pharmaceutical Co.,Ltd. Address before: Strong in Jiyang County of Ji'nan City, 251400 North Street, Shandong Province Economic Development Zone Patentee before: SHANDONG BOYUAN PHARMACEUTICAL Co.,Ltd. |
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