CN103491955B - 磷脂酰肌醇-3-激酶(pi3k)抑制剂及mtor抑制剂的组合 - Google Patents

磷脂酰肌醇-3-激酶(pi3k)抑制剂及mtor抑制剂的组合 Download PDF

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Publication number
CN103491955B
CN103491955B CN201280020528.4A CN201280020528A CN103491955B CN 103491955 B CN103491955 B CN 103491955B CN 201280020528 A CN201280020528 A CN 201280020528A CN 103491955 B CN103491955 B CN 103491955B
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compound
rad001
everolimus
combination
mtor
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CN103491955A (zh
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C·弗里特什
C·加西亚-爱切维拉
X·黄
S-M·玛拉
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Novartis AG
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Novartis AG
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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CN201280020528.4A 2011-04-25 2012-04-23 磷脂酰肌醇-3-激酶(pi3k)抑制剂及mtor抑制剂的组合 Expired - Fee Related CN103491955B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161478572P 2011-04-25 2011-04-25
US61/478,572 2011-04-25
PCT/US2012/034647 WO2012148846A1 (en) 2011-04-25 2012-04-23 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

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CN103491955A CN103491955A (zh) 2014-01-01
CN103491955B true CN103491955B (zh) 2015-12-23

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CN201280020528.4A Expired - Fee Related CN103491955B (zh) 2011-04-25 2012-04-23 磷脂酰肌醇-3-激酶(pi3k)抑制剂及mtor抑制剂的组合

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US (3) US20140066474A1 (https=)
EP (1) EP2701703A1 (https=)
JP (2) JP6086902B2 (https=)
KR (1) KR101925656B1 (https=)
CN (1) CN103491955B (https=)
AR (1) AR086481A1 (https=)
AU (2) AU2012250010A1 (https=)
BR (1) BR112013027486A2 (https=)
CA (1) CA2833962A1 (https=)
CL (1) CL2013003078A1 (https=)
CO (1) CO6801759A2 (https=)
EA (1) EA025948B1 (https=)
EC (1) ECSP13012994A (https=)
GT (1) GT201300263A (https=)
IL (1) IL229008A (https=)
MA (1) MA35038B1 (https=)
MX (1) MX2013012385A (https=)
NZ (1) NZ615593A (https=)
PE (1) PE20140601A1 (https=)
PH (1) PH12013502077A1 (https=)
SG (1) SG193919A1 (https=)
TN (1) TN2013000392A1 (https=)
TW (1) TWI602567B (https=)
UA (1) UA110961C2 (https=)
WO (1) WO2012148846A1 (https=)
ZA (1) ZA201306973B (https=)

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EP2968340A4 (en) * 2013-03-15 2016-08-10 Intellikine Llc COMBINING KINASE INHIBITORS AND USES THEREOF
CN105899232A (zh) * 2013-11-13 2016-08-24 诺华股份有限公司 用于增强免疫应答的mTOR抑制剂
RU2016135413A (ru) * 2014-02-11 2018-03-14 Новартис Аг Фармацевтические комбинации, включающие ингибитор pi3k, для лечения рака
WO2015148626A1 (en) * 2014-03-26 2015-10-01 Millennium Pharmaceuticals, Inc. Treatment of fibrotic disorders
RU2690685C2 (ru) * 2014-10-03 2019-06-05 Новартис Аг Фармацевтические композиции, содержащие алпелисиб
US20160339030A1 (en) 2015-05-19 2016-11-24 University Of Maryland, Baltimore Treatment agents for inhibiting hiv and cancer in hiv infected patients
JP6691337B2 (ja) * 2016-02-29 2020-04-28 学校法人北里研究所 膀胱癌患者の予後を予測するための方法
GB202010627D0 (en) * 2020-07-10 2020-08-26 Qbd (Qs-Ip) Ltd Blocking method

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JP2014513097A (ja) 2014-05-29
US20180085362A1 (en) 2018-03-29
GT201300263A (es) 2015-11-24
US20140066474A1 (en) 2014-03-06
UA110961C2 (uk) 2016-03-10
IL229008A (en) 2017-11-30
PE20140601A1 (es) 2014-05-24
JP2017061527A (ja) 2017-03-30
ECSP13012994A (es) 2013-12-31
KR20140012147A (ko) 2014-01-29
KR101925656B1 (ko) 2018-12-05
AU2012250010A1 (en) 2013-10-10
AR086481A1 (es) 2013-12-18
JP6086902B2 (ja) 2017-03-01
TN2013000392A1 (en) 2015-01-20
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US20170095463A1 (en) 2017-04-06
CA2833962A1 (en) 2012-11-01
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WO2012148846A1 (en) 2012-11-01
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CO6801759A2 (es) 2013-11-29
TWI602567B (zh) 2017-10-21
EA025948B1 (ru) 2017-02-28
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IL229008A0 (en) 2013-12-31
MA35038B1 (fr) 2014-04-03
BR112013027486A2 (pt) 2017-02-14
PH12013502077A1 (en) 2013-12-16
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AU2016202372A1 (en) 2016-05-05

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