CN103476773A - 用作丝氨酸/苏氨酸激酶抑制剂的新的氮杂吲哚基苯基磺酰胺 - Google Patents
用作丝氨酸/苏氨酸激酶抑制剂的新的氮杂吲哚基苯基磺酰胺 Download PDFInfo
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Oncology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
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| EP11153087.9 | 2011-02-02 | ||
| EP11153087 | 2011-02-02 | ||
| EP11181258 | 2011-09-14 | ||
| EP11181258.2 | 2011-09-14 | ||
| PCT/EP2012/051796 WO2012104388A1 (en) | 2011-02-02 | 2012-02-02 | New azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors |
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| CN103476773A true CN103476773A (zh) | 2013-12-25 |
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| EP (1) | EP2670749B1 (enExample) |
| JP (1) | JP5850952B2 (enExample) |
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| CN (1) | CN103476773A (enExample) |
| AU (1) | AU2012213390A1 (enExample) |
| BR (1) | BR112013019714A2 (enExample) |
| CA (1) | CA2825279A1 (enExample) |
| CL (1) | CL2013002063A1 (enExample) |
| EA (1) | EA201300874A1 (enExample) |
| IL (1) | IL227399A0 (enExample) |
| MX (1) | MX2013008868A (enExample) |
| PH (1) | PH12013501618A1 (enExample) |
| UY (1) | UY33890A (enExample) |
| WO (1) | WO2012104388A1 (enExample) |
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| WO2017025064A1 (zh) * | 2015-08-13 | 2017-02-16 | 北京韩美药品有限公司 | Irak4抑制剂及其应用 |
| CN107454899A (zh) * | 2014-10-27 | 2017-12-08 | 大学健康网络 | Ripk2抑制剂及用其治疗癌症的方法 |
| CN110741004A (zh) * | 2016-12-23 | 2020-01-31 | 阿尔维纳斯运营股份有限公司 | 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法 |
| CN111818924A (zh) * | 2017-10-26 | 2020-10-23 | 徐诺药业公司 | B-raf激酶抑制剂的结晶盐 |
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| CL2008001943A1 (es) | 2007-07-02 | 2009-09-11 | Boehringer Ingelheim Int | Compuestos derivados de fenil-triazol, inhibidores de enzimas de señales especificas que participan del control de la proliferacion celular; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, infecciones, enfermedades inflamatorias y autoinmunes. |
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| US8778929B2 (en) | 2008-09-29 | 2014-07-15 | Boehringer Ingelheim International Gmbh | Substituted heteroaryl inhibitors of B-RAF |
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- 2012-01-27 US US13/359,555 patent/US8889684B2/en active Active
- 2012-02-01 UY UY0001033890A patent/UY33890A/es unknown
- 2012-02-02 AU AU2012213390A patent/AU2012213390A1/en not_active Abandoned
- 2012-02-02 JP JP2013552207A patent/JP5850952B2/ja active Active
- 2012-02-02 MX MX2013008868A patent/MX2013008868A/es not_active Application Discontinuation
- 2012-02-02 KR KR1020137022388A patent/KR20140014149A/ko not_active Withdrawn
- 2012-02-02 EP EP12701914.9A patent/EP2670749B1/en active Active
- 2012-02-02 BR BR112013019714A patent/BR112013019714A2/pt not_active IP Right Cessation
- 2012-02-02 CN CN2012800157100A patent/CN103476773A/zh active Pending
- 2012-02-02 CA CA2825279A patent/CA2825279A1/en not_active Abandoned
- 2012-02-02 PH PH1/2013/501618A patent/PH12013501618A1/en unknown
- 2012-02-02 EA EA201300874A patent/EA201300874A1/ru unknown
- 2012-02-02 WO PCT/EP2012/051796 patent/WO2012104388A1/en not_active Ceased
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2013
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- 2013-07-17 CL CL2013002063A patent/CL2013002063A1/es unknown
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| CN107454899A (zh) * | 2014-10-27 | 2017-12-08 | 大学健康网络 | Ripk2抑制剂及用其治疗癌症的方法 |
| CN107454899B (zh) * | 2014-10-27 | 2020-05-29 | 大学健康网络 | Ripk2抑制剂及用其治疗癌症的方法 |
| WO2017025064A1 (zh) * | 2015-08-13 | 2017-02-16 | 北京韩美药品有限公司 | Irak4抑制剂及其应用 |
| US10562902B2 (en) | 2015-08-13 | 2020-02-18 | Beijing Hanmi Pharmaceutical Co., Ltd. | IRAK4 inhibitor and use thereof |
| CN110741004A (zh) * | 2016-12-23 | 2020-01-31 | 阿尔维纳斯运营股份有限公司 | 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法 |
| CN110741004B (zh) * | 2016-12-23 | 2023-10-17 | 阿尔维纳斯运营股份有限公司 | 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法 |
| CN111818924A (zh) * | 2017-10-26 | 2020-10-23 | 徐诺药业公司 | B-raf激酶抑制剂的结晶盐 |
| CN111818924B (zh) * | 2017-10-26 | 2023-08-15 | 徐诺药业公司 | B-raf激酶抑制剂的结晶盐 |
| US11753409B2 (en) | 2017-10-26 | 2023-09-12 | Xynomic Pharmaceuticals, Inc. | Crystalline salts of a B-RAF kinase inhibitor |
| CN116942672A (zh) * | 2017-10-26 | 2023-10-27 | 徐诺药业公司 | B-raf激酶抑制剂的结晶盐 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8889684B2 (en) | 2014-11-18 |
| JP2014504622A (ja) | 2014-02-24 |
| CL2013002063A1 (es) | 2013-12-27 |
| JP5850952B2 (ja) | 2016-02-03 |
| IL227399A0 (en) | 2013-09-30 |
| WO2012104388A1 (en) | 2012-08-09 |
| PH12013501618A1 (en) | 2013-09-30 |
| KR20140014149A (ko) | 2014-02-05 |
| UY33890A (es) | 2012-08-31 |
| US20130029993A1 (en) | 2013-01-31 |
| EP2670749B1 (en) | 2016-01-27 |
| AU2012213390A1 (en) | 2013-08-01 |
| CA2825279A1 (en) | 2012-08-09 |
| MX2013008868A (es) | 2013-08-14 |
| BR112013019714A2 (pt) | 2016-10-18 |
| EA201300874A1 (ru) | 2014-02-28 |
| EP2670749A1 (en) | 2013-12-11 |
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