CN103463179A - Traditional Chinese medicinal composition for preventing and treating chicken aflatoxicosis - Google Patents
Traditional Chinese medicinal composition for preventing and treating chicken aflatoxicosis Download PDFInfo
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- CN103463179A CN103463179A CN2013101167483A CN201310116748A CN103463179A CN 103463179 A CN103463179 A CN 103463179A CN 2013101167483 A CN2013101167483 A CN 2013101167483A CN 201310116748 A CN201310116748 A CN 201310116748A CN 103463179 A CN103463179 A CN 103463179A
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Abstract
The invention relates to a traditional Chinese medicinal composition for preventing and treating chicken aflatoxicosis. The composition is prepared by using 6-8 parts by weight of honeysuckle flower, 12-14 parts by weight of Radix Puerariae and 9-11 parts by weight of licorice root. The composition can well prevent and treat the chicken aflatoxicosis, improve the liver detoxifying capability, enhance the body immunity, reduce the mortality and improve the production performance.
Description
(1) technical field
The present invention relates to Chinese medicine composition, be specifically related to a kind of Chinese medicine composition of preventing and treating chicken aflatoxicosis disease.
(2) background technology
Aflatoxin is the toxic metabolite product that Aspergillus flavus produces, united state food and agricultural organization and World Health Organization (WHO) regard as the material with strong toxicity and carcinogenecity, its toxicity is 10 times of potassium cyanide, 68 times of arsenicum, being the most stable a kind of in the mycotoxin of finding so far, is also to the maximum a kind of toxin of poultry harm.The chicken aflatoxicosis is one of Amphixenosis, aflatoxin not only reduces the fertility performance of poultry, can also be detrimental to health by polluting the animals and plants derived food, chicken is more responsive to aflatoxin, poisoning after with liver damage, general is hemorrhage, ascites, digestive function obstacle and nervous symptoms etc. are feature, generally are acute poisoning, and mortality rate can reach 100%.Sick chickling diarrhoea, feces is mixed with blood more, ataxia, to present the death of opisthotonus symptom, Adult Chicken mostly is the chronic poisoning symptom, makes hen easily cause fatty liver syndrome, laying rate and egg hatchability reduce, the die of illness liver enlargement of chicken, diffuse hemorrhage and necrosis, the chronic type case for liver volume dwindles, cirrhosis etc.
As can be seen here, it is comparatively serious that the aflatoxicosis disease of chicken is endangered concerning aquaculture, yet in the reality cultivation, also there is no medicine preferably for chicken aflatoxicosis disease, main still to put prevention first, as: add mould inhibitor and reduce feed mold, additive rationality adsorbent is to reduce the absorption of body to mycotoxin.But for the chicken that aflatoxicosis occurs, because it does not have specific antidote, can only adopt and change feedstuff, feed vitamin or trace element, reach and improved the chicken poisoning symptom, yet its fertility performance is not but had to substantial curative effect.Therefore, for aquaculture in the urgent need to developing a medicine that is used for the treatment of chicken aflatoxicosis disease.
(3) summary of the invention
The object of the present invention is to provide a kind of the have liver detoxification of raising ability, enhancing human body immunity power, reduction mortality rate, raising fertility performance, to solve the pure Chinese medicine of chicken aflatoxicosis disease.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
A kind of Chinese medicine composition of preventing and treating chicken aflatoxicosis disease, the formula composition is expressed as by weight:
6～8 parts of Flos Loniceraes, 12～14 parts of Radix Puerariaes, 9～11 parts, Radix Glycyrrhizae.
The preparation method of described Chinese medicine is as follows:
Take each raw material by described weight ratio, decoct with water, filter, merging filtrate, being evaporated to relative density is 1.10～1.30, while being chilled to room temperature, adds the volume that water is settled to 2～4 times of raw materials quality, stirs evenly, and filters, and obtains.
Usage and dosage: mixed drink, chicken, every 100L water is converted above-mentioned Chinese medicine 100ml, freely drinks water.
(4) specific embodiment:
Following examples are in order to further illustrate the present invention.
Embodiment 1:
The Chinese medicine of control chicken aflatoxicosis disease, form weight ratio by formula and take Flos Lonicerae 70g, Radix Puerariae 140g, Radix Glycyrrhizae 110g, pack in Chinese medicine extracting tank, to the water that adds 4320ml in tank, heated and boiled 1.5 hours, emit extracting solution in basin, then add the water of 3840ml, heated and boiled 1.0 hours, emit extracting solution, and secondary raffinate is merged, filter, being evaporated to relative density is 1.20, while being chilled to 25 ℃, adding water and be settled to 1000ml, after mix homogeneously, filter, obtain medicinal liquid 1.
Form weight ratio by formula and take Flos Lonicerae 70g, Radix Puerariae 130g, Radix Glycyrrhizae 100g, pack in Chinese medicine extracting tank, to the water that adds 3600ml in tank, heated and boiled 1.5 hours, emit extracting solution in basin, the water that adds again 3600ml, heated and boiled 1.5 hours, emit extracting solution in basin, then add the water of 3600ml, heated and boiled 1.5 hours, emit extracting solution, and three extracting solution are merged, filter, being evaporated to relative density is 1.18, while being chilled to 30 ℃, adding water and be settled to 1000ml, after mix homogeneously, filter, obtain medicinal liquid 2.
Take respectively Flos Lonicerae, Radix Puerariae, Radix Glycyrrhizae three flavor Chinese medicines, do not follow this formula and form the weight ratio relation, arbitrarily carry out prescription, prescription is Flos Lonicerae 150g, Radix Puerariae 150g, Radix Glycyrrhizae 75g, pack in Chinese medicine extracting tank, to the water that adds 4500ml in tank, heated and boiled 1.5 hours, emit extracting solution in basin, the water that adds again 4500ml, heated and boiled 1.0 hours, emit extracting solution, and secondary raffinate is merged, filter, being evaporated to relative density is 1.20, while being chilled to 25 ℃, add water and be settled to 1000ml, after mix homogeneously, filter, obtain medicinal liquid 3.
Take respectively Flos Lonicerae, Radix Puerariae, Radix Glycyrrhizae three flavor Chinese medicines, do not follow this formula and form the weight ratio relation, arbitrarily carry out prescription, prescription is Flos Lonicerae 120g, Radix Puerariae 120g, Radix Glycyrrhizae 120g, pack in Chinese medicine extracting tank, to the water that adds 4200ml in tank, heated and boiled 1.5 hours, emit extracting solution in basin, the water that adds again 4200ml, heated and boiled 1.0 hours, emit extracting solution, and secondary raffinate is merged, filter, being evaporated to relative density is 1.22, while being chilled to 25 ℃, add water and be settled to 1000ml, after mix homogeneously, filter, obtain medicinal liquid 4.
Take respectively Flos Lonicerae, Radix Puerariae, Radix Glycyrrhizae three flavor Chinese medicines, do not follow this formula and form the weight ratio relation, arbitrarily carry out prescription, prescription is Flos Lonicerae 90g, Radix Puerariae 110g, Radix Glycyrrhizae 120g, pack in Chinese medicine extracting tank, to the water that adds 4000ml in tank, heated and boiled 1.5 hours, emit extracting solution in basin, the water that adds again 4000ml, heated and boiled 1.0 hours, emit extracting solution, and secondary raffinate is merged, filter, being evaporated to relative density is 1.21, while being chilled to 25 ℃, add water and be settled to 1000ml, after mix homogeneously, filter, obtain medicinal liquid 5.
Above-mentioned Chinese medicine has been carried out to Piglet s colibacillosis at laboratory, and concrete grammar is as follows:
For trying place: Shunyi, Beijing broiler is put field in a suitable place to breed.
For trying the chicken group: Ai Wei mattress commercial broiler flocks, 5 ages in days, 18526.
The chicken group state of an illness: part chickling lethargy, inappetence, and find, on bedding and padding, many white loose stools to be arranged and doubt as Pullorum Disease, once with the antibiotic medicine treatment, all do not feel any better, to dead 240 altogether of 5 ages in days, mortality rate reaches 2.04%.Find that after testing its chicken feed of feeding makes moist because crossing water, aflatoxin B in feedstuff
1content>80 μ g/kg, therefore be defined as aflatoxicosis disease, changes the feedstuff that goes mouldy, and grouping is simultaneously tested, and detect each group and deliver for sale heavily.
The test grouping: 1000 of matched groups, do not give any medicine, free choice feeding and drinking-water.
Test 1 group 3500, with above-mentioned medicinal liquid 1, every 100L water adds medicinal liquid 100ml, freely drinks water, and is used in conjunction 5 days.
Test 2 groups 3526, with above-mentioned medicinal liquid 2, every 100L water adds medicinal liquid 100ml, freely drinks water, and is used in conjunction 5 days.
Test 3 groups 3500, with above-mentioned medicinal liquid 3, every 100L water adds medicinal liquid 100ml, freely drinks water, and is used in conjunction 5 days.
Test 4 groups 3440, with above-mentioned medicinal liquid 4, every 100L water adds medicinal liquid 100ml, freely drinks water, and is used in conjunction 5 days.
Test 5 groups 3560, with above-mentioned medicinal liquid 5, every 100L water adds medicinal liquid 100ml, freely drinks water, and is used in conjunction 5 days.
Result of the test sees the following form:
Annotate: the different significant differences (P<0.05) that mean of lower case; The different difference extremely significantly (P<0.01) that means of capitalization.
As seen from the above table: give the drinking-water administration of aflatoxicosis disease chickling above-mentioned medicinal liquid 1,2, all can significantly reduce the mortality rate of test group chicken, improve the cure rate of test group chicken, and improve delivering for sale heavily of test group chicken, with the poor heteropole of matched group remarkable (P<0.01); And drinking-water administration above-mentioned medicinal liquid 3,4,5 can reduce the mortality rate of test group chicken, improve cure rate and deliver for sale heavily, but with matched group comparing difference not significantly (P>0.05).
On therapeutic effect for chickling aflatoxicosis disease, medicinal liquid 1 and medicinal liquid 2 effects are best, with medicinal liquid 3,4,5 poor heteropoles significantly (P<0.01), illustrate that this invents prepared Chinese medicine composition and can well treat chicken aflatoxicosis disease.
Claims (3)
1. a Chinese medicine composition of preventing and treating chicken aflatoxicosis disease, formula forms and is expressed as by weight:
6～8 parts of Flos Loniceraes, 12～14 parts of Radix Puerariaes, 9～11 parts, Radix Glycyrrhizae.
2. the Chinese medicine composition of control chicken aflatoxicosis disease according to claim 1, is characterized in that, the preparation method of described Chinese medicine is as follows:
Take each raw material by described weight ratio, decoct with water, filter, merging filtrate, being evaporated to relative density is 1.10～1.30, while being chilled to room temperature, adds the volume that water is settled to 2～4 times of raw materials quality, stirs evenly, and filters, and obtains.
3. according to the Chinese medicine composition of the arbitrary control chicken aflatoxicosis disease of stating of claim 1～2, it is characterized in that take that above-mentioned Chinese medicine composition is prepared into oral liquid, powder, granule as raw material.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288548A (en) * | 2014-09-25 | 2015-01-21 | 陆凤琪 | Traditional Chinese medicine composition for reducing aflatoxin M1 in cow milk |
| EP3342416A1 (en) * | 2016-12-28 | 2018-07-04 | Erber Aktiengesellschaft | Use of at least one glycyrrhiza plant preparation, an antidote containing same and use of the antidote |
| CN109125478A (en) * | 2018-11-01 | 2019-01-04 | 衡阳市武顺循环农牧绿色生态科技有限公司 | A kind of drug and preparation method thereof of prevention and treatment chicken aspergillin poisoning |
| CN111671792A (en) * | 2020-06-28 | 2020-09-18 | 瑞普（天津）生物药业有限公司 | Traditional Chinese medicine composition for preventing and treating liver injury and preparation method thereof |
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| CN1385192A (en) * | 2002-06-10 | 2002-12-18 | 陈中夫 | Oral health care products using extreated mung bean juice as mother liquor and preparation method thereof |
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| 赵辉等: "《方便易得的畜禽良药》", 《中国畜牧兽医报》 * |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288548A (en) * | 2014-09-25 | 2015-01-21 | 陆凤琪 | Traditional Chinese medicine composition for reducing aflatoxin M1 in cow milk |
| CN104288548B (en) * | 2014-09-25 | 2017-07-04 | 安徽牧春堂天然药物研究开发有限公司 | One kind is for reducing aflatoxin M in dairy cow milk1Chinese medicine composition |
| EP3342416A1 (en) * | 2016-12-28 | 2018-07-04 | Erber Aktiengesellschaft | Use of at least one glycyrrhiza plant preparation, an antidote containing same and use of the antidote |
| WO2018121881A1 (en) * | 2016-12-28 | 2018-07-05 | Erber Aktiengesellschaft | Use of at least one glycyrrhiza plant-based preparation, an antidote made from same, and the use of said antidote |
| CN108245550A (en) * | 2016-12-28 | 2018-07-06 | 爱尔伯股份公司 | At least one Radix Glycyrrhizae galenical, antidote and application thereof |
| RU2747191C2 (en) * | 2016-12-28 | 2021-04-29 | Эрбер Акциенгезелльшафт | Use of at least one drug based on licorice, antidote obtained from it, and application of specified antidote |
| US11096980B2 (en) | 2016-12-28 | 2021-08-24 | Erber Aktiengesellschaft | Method of using glycyrrhiza plant-based preparation to reduce toxic effect of polypeptide fungitoxin |
| CN108245550B (en) * | 2016-12-28 | 2021-11-26 | 爱尔伯股份公司 | At least one licorice galenical, antidote and use thereof |
| AU2017389373B2 (en) * | 2016-12-28 | 2023-02-02 | Erber Aktiengesellschaft | Use of at least one glycyrrhiza plant-based preparation, an antidote made from same, and the use of said antidote |
| CN109125478A (en) * | 2018-11-01 | 2019-01-04 | 衡阳市武顺循环农牧绿色生态科技有限公司 | A kind of drug and preparation method thereof of prevention and treatment chicken aspergillin poisoning |
| CN111671792A (en) * | 2020-06-28 | 2020-09-18 | 瑞普（天津）生物药业有限公司 | Traditional Chinese medicine composition for preventing and treating liver injury and preparation method thereof |
| CN111671792B (en) * | 2020-06-28 | 2022-05-17 | 瑞普（天津）生物药业有限公司 | Traditional Chinese medicine composition for preventing and treating liver injury and preparation method thereof |
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| CN103463179B (en) | 2015-07-22 |
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Address after: 102206, Changping District science and Technology Park, Beijing, No. 9, block B, 2354 Patentee after: BEIJING CENTRE BIOLOGY CO., LTD. Address before: 102206, Changping District science and Technology Park, Beijing, No. 9, block B, 2354 Patentee before: Beijing Centre Biology Co., Ltd. |
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Effective date of registration: 20170704 Address after: 102600, Beijing Zhongguancun Daxing District science and Technology Park, Daxing pharmaceutical industry base, No. 44 permanent road Patentee after: Beijing hi bird Pharmaceutical Co., Ltd. Address before: 102206, Changping District science and Technology Park, Beijing, No. 9, block B, 2354 Patentee before: BEIJING CENTRE BIOLOGY CO., LTD. |