CN103459395A - 作为磷酸二酯酶抑制剂的(1,2,4)三唑并[4,3-a]喹喔啉衍生物 - Google Patents

作为磷酸二酯酶抑制剂的(1,2,4)三唑并[4,3-a]喹喔啉衍生物 Download PDF

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Publication number
CN103459395A
CN103459395A CN2012800157168A CN201280015716A CN103459395A CN 103459395 A CN103459395 A CN 103459395A CN 2012800157168 A CN2012800157168 A CN 2012800157168A CN 201280015716 A CN201280015716 A CN 201280015716A CN 103459395 A CN103459395 A CN 103459395A
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methyl
compound
triazolo
quinoxaline
alkyl
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CN2012800157168A
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Chinese (zh)
Inventor
H.J.兰考
B.兰根
C.格伦瓦尔德
N.霍夫根
H.斯坦格
R.多斯特
U.埃格兰德
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Ophthalmology & Optometry (AREA)
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CN2012800157168A 2011-01-31 2012-01-31 作为磷酸二酯酶抑制剂的(1,2,4)三唑并[4,3-a]喹喔啉衍生物 Pending CN103459395A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161437848P 2011-01-31 2011-01-31
US61/437,848 2011-01-31
PCT/EP2012/051546 WO2012104293A1 (en) 2011-01-31 2012-01-31 (1,2,4)triazolo[4,3-a]quinoxaline derivatives as inhibitors of phosphodiesterases

Publications (1)

Publication Number Publication Date
CN103459395A true CN103459395A (zh) 2013-12-18

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CN2012800157168A Pending CN103459395A (zh) 2011-01-31 2012-01-31 作为磷酸二酯酶抑制剂的(1,2,4)三唑并[4,3-a]喹喔啉衍生物

Country Status (25)

Country Link
US (1) US9540379B2 (https=)
EP (1) EP2670754B1 (https=)
JP (1) JP6027547B2 (https=)
KR (1) KR20140019342A (https=)
CN (1) CN103459395A (https=)
AR (1) AR085099A1 (https=)
AU (1) AU2012213471B2 (https=)
BR (1) BR112013019354A2 (https=)
CA (1) CA2824929A1 (https=)
CL (1) CL2013002003A1 (https=)
CO (1) CO6811848A2 (https=)
EA (1) EA023792B1 (https=)
EC (1) ECSP13012824A (https=)
GE (1) GEP20156333B (https=)
IL (1) IL226826A (https=)
MA (1) MA34844B1 (https=)
MX (1) MX2013008667A (https=)
PE (1) PE20141023A1 (https=)
PH (1) PH12013501355A1 (https=)
SG (1) SG192210A1 (https=)
TN (1) TN2013000325A1 (https=)
TW (1) TWI535718B (https=)
UA (1) UA111963C2 (https=)
UY (1) UY33888A (https=)
WO (1) WO2012104293A1 (https=)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN106212487A (zh) * 2016-07-28 2016-12-14 浙江工业大学 一种含甲氧基苯并吡嗪结构的1,2,4‑三唑衍生物作为杀菌剂的应用
CN116903569A (zh) * 2023-07-06 2023-10-20 常州大学 作为磷酸二酯酶2抑制剂的香豆素-查尔酮杂合类衍生物及其应用

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US20140045856A1 (en) 2012-07-31 2014-02-13 Boehringer Ingelheim International Gmbh 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
WO2014139983A1 (en) 2013-03-13 2014-09-18 H. Lundbeck A/S [1,2,4]triazolo[4,3-a]quinoxalines as dual pde2/pde10 inhibitors
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BR112013033375B1 (pt) 2011-06-27 2022-05-10 Janssen Pharmaceutica N.V Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
WO2013034758A1 (en) 2011-09-09 2013-03-14 H. Lundbeck A/S Substituted triazolopyrazines and uses thereof
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