CN103442767A - 药物活性物质的固体形式 - Google Patents

药物活性物质的固体形式 Download PDF

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Publication number
CN103442767A
CN103442767A CN2012800097909A CN201280009790A CN103442767A CN 103442767 A CN103442767 A CN 103442767A CN 2012800097909 A CN2012800097909 A CN 2012800097909A CN 201280009790 A CN201280009790 A CN 201280009790A CN 103442767 A CN103442767 A CN 103442767A
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CN
China
Prior art keywords
degrees
solid form
ray powder
powder diffraction
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2012800097909A
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English (en)
Chinese (zh)
Inventor
R·迪度恩
K·海因里希
P·N·阿布拉汉姆
S-M·邝
G·C·维索
B·赵
U·施威特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Plexxikon Inc
Original Assignee
F Hoffmann La Roche AG
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Plexxikon Inc filed Critical F Hoffmann La Roche AG
Priority to CN201610829679.4A priority Critical patent/CN106632314A/zh
Publication of CN103442767A publication Critical patent/CN103442767A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2012800097909A 2011-02-21 2012-02-21 药物活性物质的固体形式 Pending CN103442767A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610829679.4A CN106632314A (zh) 2011-02-21 2012-02-21 药物活性物质的固体形式

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161444866P 2011-02-21 2011-02-21
US61/444,866 2011-02-21
PCT/US2012/025965 WO2012161776A1 (en) 2011-02-21 2012-02-21 Solid forms of a pharmaceutically active substance

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610829679.4A Division CN106632314A (zh) 2011-02-21 2012-02-21 药物活性物质的固体形式

Publications (1)

Publication Number Publication Date
CN103442767A true CN103442767A (zh) 2013-12-11

Family

ID=47217568

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201610829679.4A Pending CN106632314A (zh) 2011-02-21 2012-02-21 药物活性物质的固体形式
CN2012800097909A Pending CN103442767A (zh) 2011-02-21 2012-02-21 药物活性物质的固体形式

Family Applications Before (1)

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CN201610829679.4A Pending CN106632314A (zh) 2011-02-21 2012-02-21 药物活性物质的固体形式

Country Status (17)

Country Link
US (1) US8865735B2 (enExample)
EP (2) EP2678075A4 (enExample)
JP (2) JP2014505740A (enExample)
KR (1) KR20140011340A (enExample)
CN (2) CN106632314A (enExample)
AR (1) AR085279A1 (enExample)
AU (1) AU2012259422B2 (enExample)
BR (1) BR112013021103A2 (enExample)
CA (1) CA2827708A1 (enExample)
IL (1) IL227862A0 (enExample)
MX (1) MX2013009558A (enExample)
MY (1) MY163083A (enExample)
RU (1) RU2013143010A (enExample)
SG (1) SG192722A1 (enExample)
TW (1) TWI558702B (enExample)
WO (1) WO2012161776A1 (enExample)
ZA (1) ZA201306237B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115991704A (zh) * 2022-12-16 2023-04-21 深圳市新阳唯康科技有限公司 维莫非尼的新晶型、使用新晶型制备的活性药物和药物组合物

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