CN103352030B - 含有减毒瘟病毒的疫苗 - Google Patents

含有减毒瘟病毒的疫苗 Download PDF

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Publication number
CN103352030B
CN103352030B CN201310269097.1A CN201310269097A CN103352030B CN 103352030 B CN103352030 B CN 103352030B CN 201310269097 A CN201310269097 A CN 201310269097A CN 103352030 B CN103352030 B CN 103352030B
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China
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term
pro
mutation
bvdv
pestivirus
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Expired - Lifetime
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CN201310269097.1A
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English (en)
Chinese (zh)
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CN103352030A (zh
Inventor
格雷戈尔.迈耶斯
安德烈亚斯.埃格
克里斯琴.费策尔
马蒂纳.冯弗赖伯格
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Boehringer Ingelheim Vetmedica GmbH
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Boehringer Ingelheim Vetmedica GmbH
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Application filed by Boehringer Ingelheim Vetmedica GmbH filed Critical Boehringer Ingelheim Vetmedica GmbH
Publication of CN103352030A publication Critical patent/CN103352030A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24361—Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201310269097.1A 2004-05-19 2005-05-18 含有减毒瘟病毒的疫苗 Expired - Lifetime CN103352030B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004025452.4 2004-05-19
DE102004025452A DE102004025452A1 (de) 2004-05-19 2004-05-19 Vakzine enthaltend BVDV
CN200580024345XA CN1989240B (zh) 2004-05-19 2005-05-18 含有减毒瘟病毒的疫苗

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200580024345XA Division CN1989240B (zh) 2004-05-19 2005-05-18 含有减毒瘟病毒的疫苗

Publications (2)

Publication Number Publication Date
CN103352030A CN103352030A (zh) 2013-10-16
CN103352030B true CN103352030B (zh) 2018-08-10

Family

ID=34967522

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201310269097.1A Expired - Lifetime CN103352030B (zh) 2004-05-19 2005-05-18 含有减毒瘟病毒的疫苗
CN200580024345XA Expired - Lifetime CN1989240B (zh) 2004-05-19 2005-05-18 含有减毒瘟病毒的疫苗

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200580024345XA Expired - Lifetime CN1989240B (zh) 2004-05-19 2005-05-18 含有减毒瘟病毒的疫苗

Country Status (26)

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EP (1) EP1751276B9 (enExample)
JP (2) JP5006782B2 (enExample)
KR (1) KR100908798B1 (enExample)
CN (2) CN103352030B (enExample)
AR (2) AR049176A1 (enExample)
AT (1) ATE420949T1 (enExample)
AU (1) AU2005243488B2 (enExample)
BR (1) BRPI0510396B1 (enExample)
CA (1) CA2561719C (enExample)
CY (4) CY1109036T1 (enExample)
DE (2) DE102004025452A1 (enExample)
DK (1) DK1751276T5 (enExample)
ES (1) ES2321210T3 (enExample)
FR (3) FR15C0044I2 (enExample)
HU (2) HUS1500033I1 (enExample)
LU (3) LU92749I2 (enExample)
ME (1) ME01119B (enExample)
MX (1) MXPA06013298A (enExample)
NL (3) NL300743I1 (enExample)
NZ (1) NZ552088A (enExample)
PL (1) PL1751276T3 (enExample)
PT (1) PT1751276E (enExample)
RS (1) RS50753B9 (enExample)
SI (1) SI1751276T1 (enExample)
UY (1) UY28905A1 (enExample)
WO (1) WO2005111201A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179473B2 (en) 1998-06-05 2007-02-20 Boehringer Ingelheim Vetmedica Gmbh Attenuated pestiviruses
US7135561B2 (en) 2001-09-06 2006-11-14 Boehringer Ingelheim Vetmedica Gmbh Infectious bovine viral diarrhea virus clone
US20090068223A1 (en) 2005-11-15 2009-03-12 Boehringer Ingelheim Vetmedica, Inc. Combination vaccine comprising an attenuated bovine viral diarrhea virus
CL2007002704A1 (es) 2006-09-22 2008-05-30 Intervet Int Bv Mutante de un pestivirus de una cepa citopatogenica con deleciones en la region codificante de la proteina npro del virus; vacuna que la comprende; y su uso para proteger al ganado vacuno contra la infeccion con un pestivirus tipo silvestre.
CL2008003202A1 (es) 2007-10-29 2009-11-27 Boehringer Ingelheim Vetmedica Inc Composicion inmunogenica que comprende bacterias vivas de mycoplasma bovis atenuada avirulenta.
UY31930A (es) * 2008-06-25 2010-01-29 Boheringer Ingelheim Pharma Kg Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante
SG10201506597RA (en) 2008-10-31 2015-10-29 Boehringer Ingelheim Vetmed Use Of Various Antigens Including Antigens From Mycoplasma Bovis In Multivalent Vaccine Composition
US8846054B2 (en) 2009-01-09 2014-09-30 Boehringer Ingelheim Vetmedica, Inc. Method of treating pregnant cows and/or heifers
UY32570A (es) 2009-04-24 2010-11-30 Boehringer Ingelheim Vetmed Vacuna viva modificada de mycoplasma bovis mejorada
BR112013006515B1 (pt) 2010-09-21 2020-04-28 Intervet Int Bv vacina de combinação, e, método para a fabricação de uma vacina de combinação
JP6589159B2 (ja) * 2014-04-01 2019-10-16 共立製薬株式会社 新規ネコモルビリウイルス株、不活化ワクチン製剤、並びにネコモルビリウイルス感染症予防方法
ES2757927T3 (es) * 2014-05-23 2020-04-30 Boehringer Ingelheim Vetmedica Gmbh Virus de la peste porcina clásica (VPPC) recombinante que comprende sustituciones en el epítopo TAV de la proteína E2
CN105779499B (zh) * 2016-03-23 2019-11-19 江苏科技大学 重组杆状病毒和其应用及构建该重组杆状病毒的载体
CN107823639B (zh) * 2017-11-10 2020-10-02 齐鲁动物保健品有限公司 牛病毒性腹泻病毒灭活疫苗及其制备方法
CN108707190B (zh) * 2018-04-18 2021-07-13 中国科学院武汉病毒研究所 猪瘟病毒ns5b蛋白保真度突变体及其应用
CN114853912B (zh) * 2022-05-24 2023-06-13 中国农业科学院兰州兽医研究所 一种牛病毒性腹泻病毒e2-e0融合蛋白、制备方法及应用
CN115960847B (zh) * 2023-01-11 2024-06-14 青岛大学 小分子依赖的内含肽自剪接系统在制备减毒活疫苗中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6168942B1 (en) * 1998-11-10 2001-01-02 Pfizer Inc. Attenuated forms of bovine viral diarrhea virus
EP1104676A1 (en) * 1999-11-30 2001-06-06 Boehringer Ingelheim Vetmedica Gmbh Safe attenuated bovine viral diarrhea viruses for use in pregnant cows
CA2363493C (en) * 2000-11-22 2006-06-06 Xuemei Cao Attenuated forms of bovine viral diarrhea virus
DE10143813A1 (de) * 2001-09-06 2003-04-10 Boehringer Ingelheim Vetmed Infektiöser Rindervirusdiarrhoe-Virusklon

Also Published As

Publication number Publication date
JP5562316B2 (ja) 2014-07-30
FR15C0043I1 (fr) 2015-07-24
AU2005243488B2 (en) 2011-07-07
WO2005111201A1 (en) 2005-11-24
CA2561719A1 (en) 2005-11-24
CN1989240A (zh) 2007-06-27
CA2561719C (en) 2015-01-27
UY28905A1 (es) 2005-12-30
FR15C0042I1 (fr) 2015-07-24
NL300743I2 (enExample) 2016-01-26
ME01119B (me) 2013-03-20
LU92749I2 (fr) 2015-11-02
AU2005243488A1 (en) 2005-11-24
EP1751276B9 (en) 2020-05-27
DK1751276T3 (da) 2009-05-18
RS50753B9 (sr) 2020-08-31
BRPI0510396A (pt) 2007-11-13
CY2015023I2 (el) 2024-02-16
EP1751276B1 (en) 2009-01-14
MXPA06013298A (es) 2007-05-07
PT1751276E (pt) 2009-02-24
AR104448A2 (es) 2017-07-19
DK1751276T5 (da) 2020-07-20
BRPI0510396B1 (pt) 2020-08-18
AR049176A1 (es) 2006-07-05
DE602005012381D1 (de) 2009-03-05
NL300744I1 (enExample) 2016-01-26
LU92747I2 (fr) 2015-11-02
KR100908798B1 (ko) 2009-07-22
LU92748I2 (fr) 2015-11-02
FR15C0043I2 (fr) 2016-05-27
HUS1500033I1 (hu) 2015-07-28
NL300744I2 (enExample) 2016-01-26
CY2015021I2 (el) 2023-11-15
CY2015022I1 (el) 2020-05-29
CY1109036T1 (el) 2014-07-02
NZ552088A (en) 2009-10-30
FR15C0042I2 (fr) 2018-11-16
CY2015021I1 (el) 2020-05-29
ATE420949T1 (de) 2009-01-15
NL300745I2 (enExample) 2016-01-26
SI1751276T1 (sl) 2009-06-30
JP5006782B2 (ja) 2012-08-22
CN103352030A (zh) 2013-10-16
CN1989240B (zh) 2013-07-31
CY2015022I2 (el) 2024-02-16
JP2012061001A (ja) 2012-03-29
ES2321210T3 (es) 2009-06-03
FR15C0044I2 (fr) 2016-05-27
CY2015023I1 (el) 2020-05-29
RS50753B (sr) 2010-08-31
DE102004025452A1 (de) 2006-01-19
KR20070012862A (ko) 2007-01-29
NL300743I1 (enExample) 2016-01-26
PL1751276T3 (pl) 2009-06-30
EP1751276A1 (en) 2007-02-14
ES2321210T9 (es) 2020-11-04
JP2007537740A (ja) 2007-12-27
NL300745I1 (enExample) 2016-01-26
FR15C0044I1 (fr) 2015-07-24
HUS1500031I1 (hu) 2019-11-28

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