BRPI0510396A - vacina compreendendo um pestivìrus atenuado - Google Patents
vacina compreendendo um pestivìrus atenuadoInfo
- Publication number
- BRPI0510396A BRPI0510396A BRPI0510396-7A BRPI0510396A BRPI0510396A BR PI0510396 A BRPI0510396 A BR PI0510396A BR PI0510396 A BRPI0510396 A BR PI0510396A BR PI0510396 A BRPI0510396 A BR PI0510396A
- Authority
- BR
- Brazil
- Prior art keywords
- bvdv
- pestiviruses
- attenuated
- mutation
- residing
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/15—Reoviridae, e.g. calf diarrhea virus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24361—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
VACINA COMPREENDENDO UM PESTIVìRUS ATENUADO. A presente invenção refere-se aos pestivírus atenuados, em particular ao BVDV atenuado, em que pelo menos uma mutação está na seqüência de codificação para glicoproteína Erns e pelo menos outra mutação na seqüência de codificação para Npro que preferivelmente leva à inativação combinada da atividade de RNase que reside na glicoproteína Erns além da inativação da atividade imunomoduladora (sob hipótese) que reside na Npro. A invenção também relaciona-se aos métodos para atenuar pestivírus como BVDV, ácidos nucléicos que codificam os ditos pestivírus, em particular BVDV, composições e vacinas compreendendo os pestivírus atenuados, em particular BVDV da invenção.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004025452.4 | 2004-05-19 | ||
| DE102004025452A DE102004025452A1 (de) | 2004-05-19 | 2004-05-19 | Vakzine enthaltend BVDV |
| PCT/EP2005/005377 WO2005111201A1 (en) | 2004-05-19 | 2005-05-18 | Vaccine comprising an attenuated pestivirus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0510396A true BRPI0510396A (pt) | 2007-11-13 |
| BRPI0510396B1 BRPI0510396B1 (pt) | 2020-08-18 |
Family
ID=34967522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0510396-7A BRPI0510396B1 (pt) | 2004-05-19 | 2005-05-18 | Pestivírus atenuado e seu uso, composição, molécula de ácido nucléico e método para atenuar pestivírus |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1751276B9 (pt) |
| JP (2) | JP5006782B2 (pt) |
| KR (1) | KR100908798B1 (pt) |
| CN (2) | CN1989240B (pt) |
| AR (2) | AR049176A1 (pt) |
| AT (1) | ATE420949T1 (pt) |
| AU (1) | AU2005243488B2 (pt) |
| BR (1) | BRPI0510396B1 (pt) |
| CA (1) | CA2561719C (pt) |
| CY (4) | CY1109036T1 (pt) |
| DE (2) | DE102004025452A1 (pt) |
| DK (1) | DK1751276T5 (pt) |
| ES (1) | ES2321210T3 (pt) |
| HU (2) | HUS1500033I1 (pt) |
| LU (3) | LU92747I2 (pt) |
| ME (1) | ME01119B (pt) |
| MX (1) | MXPA06013298A (pt) |
| NL (3) | NL300744I1 (pt) |
| NZ (1) | NZ552088A (pt) |
| PL (1) | PL1751276T3 (pt) |
| PT (1) | PT1751276E (pt) |
| RS (1) | RS50753B9 (pt) |
| SI (1) | SI1751276T1 (pt) |
| UY (1) | UY28905A1 (pt) |
| WO (1) | WO2005111201A1 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7179473B2 (en) | 1998-06-05 | 2007-02-20 | Boehringer Ingelheim Vetmedica Gmbh | Attenuated pestiviruses |
| US7135561B2 (en) | 2001-09-06 | 2006-11-14 | Boehringer Ingelheim Vetmedica Gmbh | Infectious bovine viral diarrhea virus clone |
| UY29915A1 (es) | 2005-11-15 | 2007-06-29 | Boehringer Ingelheim Vetmed | Vacuna combinada que comprende un virus atenuado de la diarrea viral bovina |
| AR062917A1 (es) * | 2006-09-22 | 2008-12-17 | Intervet Int Bv | Nuevo mutante de pestivirus para uso en una vacuna. |
| AR069087A1 (es) | 2007-10-29 | 2009-12-30 | Boehringer Ingelheim Vetmed | Cepa bacteriana de m. bovis atenuada avirulenta obtenida por pases, vacuna de micoplasma boris y metodos de uso de la misma |
| UY31930A (es) | 2008-06-25 | 2010-01-29 | Boheringer Ingelheim Pharma Kg | Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante |
| SG10201506597RA (en) | 2008-10-31 | 2015-10-29 | Boehringer Ingelheim Vetmed | Use Of Various Antigens Including Antigens From Mycoplasma Bovis In Multivalent Vaccine Composition |
| US8846054B2 (en) | 2009-01-09 | 2014-09-30 | Boehringer Ingelheim Vetmedica, Inc. | Method of treating pregnant cows and/or heifers |
| UY32570A (es) | 2009-04-24 | 2010-11-30 | Boehringer Ingelheim Vetmed | Vacuna viva modificada de mycoplasma bovis mejorada |
| EP2618841B1 (en) | 2010-09-21 | 2016-10-19 | Intervet International B.V. | Bvdv vaccine |
| JP6589159B2 (ja) * | 2014-04-01 | 2019-10-16 | 共立製薬株式会社 | 新規ネコモルビリウイルス株、不活化ワクチン製剤、並びにネコモルビリウイルス感染症予防方法 |
| WO2015177369A1 (en) * | 2014-05-23 | 2015-11-26 | Boehringer Ingelheim Vetmedica Gmbh | Recombinant classical swine fever virus (csfv) comprising substitution in the tav epitope of the e2 protein |
| CN105779499B (zh) * | 2016-03-23 | 2019-11-19 | 江苏科技大学 | 重组杆状病毒和其应用及构建该重组杆状病毒的载体 |
| CN107823639B (zh) * | 2017-11-10 | 2020-10-02 | 齐鲁动物保健品有限公司 | 牛病毒性腹泻病毒灭活疫苗及其制备方法 |
| CN108707190B (zh) * | 2018-04-18 | 2021-07-13 | 中国科学院武汉病毒研究所 | 猪瘟病毒ns5b蛋白保真度突变体及其应用 |
| CN114853912B (zh) * | 2022-05-24 | 2023-06-13 | 中国农业科学院兰州兽医研究所 | 一种牛病毒性腹泻病毒e2-e0融合蛋白、制备方法及应用 |
| CN115960847B (zh) * | 2023-01-11 | 2024-06-14 | 青岛大学 | 小分子依赖的内含肽自剪接系统在制备减毒活疫苗中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6168942B1 (en) * | 1998-11-10 | 2001-01-02 | Pfizer Inc. | Attenuated forms of bovine viral diarrhea virus |
| EP1104676A1 (en) * | 1999-11-30 | 2001-06-06 | Boehringer Ingelheim Vetmedica Gmbh | Safe attenuated bovine viral diarrhea viruses for use in pregnant cows |
| CA2363493C (en) * | 2000-11-22 | 2006-06-06 | Xuemei Cao | Attenuated forms of bovine viral diarrhea virus |
| DE10143813A1 (de) * | 2001-09-06 | 2003-04-10 | Boehringer Ingelheim Vetmed | Infektiöser Rindervirusdiarrhoe-Virusklon |
-
2004
- 2004-05-19 DE DE102004025452A patent/DE102004025452A1/de not_active Withdrawn
-
2005
- 2005-05-18 CA CA2561719A patent/CA2561719C/en active Active
- 2005-05-18 NZ NZ552088A patent/NZ552088A/en unknown
- 2005-05-18 RS RS20090106A patent/RS50753B9/sr unknown
- 2005-05-18 AT AT05741681T patent/ATE420949T1/de active
- 2005-05-18 CN CN200580024345XA patent/CN1989240B/zh active Active
- 2005-05-18 AU AU2005243488A patent/AU2005243488B2/en active Active
- 2005-05-18 MX MXPA06013298A patent/MXPA06013298A/es active IP Right Grant
- 2005-05-18 WO PCT/EP2005/005377 patent/WO2005111201A1/en active Application Filing
- 2005-05-18 KR KR1020067026800A patent/KR100908798B1/ko active IP Right Grant
- 2005-05-18 PL PL05741681T patent/PL1751276T3/pl unknown
- 2005-05-18 UY UY28905A patent/UY28905A1/es active IP Right Grant
- 2005-05-18 ES ES05741681T patent/ES2321210T3/es active Active
- 2005-05-18 PT PT05741681T patent/PT1751276E/pt unknown
- 2005-05-18 DE DE602005012381T patent/DE602005012381D1/de active Active
- 2005-05-18 CN CN201310269097.1A patent/CN103352030B/zh active Active
- 2005-05-18 JP JP2007517077A patent/JP5006782B2/ja active Active
- 2005-05-18 AR ARP050102032A patent/AR049176A1/es active Pending
- 2005-05-18 BR BRPI0510396-7A patent/BRPI0510396B1/pt active IP Right Grant
- 2005-05-18 DK DK05741681.0T patent/DK1751276T5/da active
- 2005-05-18 ME MEP-2009-56A patent/ME01119B/me unknown
- 2005-05-18 SI SI200530619T patent/SI1751276T1/sl unknown
- 2005-05-18 EP EP05741681.0A patent/EP1751276B9/en active Active
-
2009
- 2009-04-10 CY CY20091100429T patent/CY1109036T1/el unknown
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2011
- 2011-11-11 JP JP2011247652A patent/JP5562316B2/ja active Active
-
2015
- 2015-06-16 NL NL300744C patent/NL300744I1/nl unknown
- 2015-06-16 NL NL300745C patent/NL300745I2/nl unknown
- 2015-06-16 NL NL300743C patent/NL300743I1/nl unknown
- 2015-06-19 CY CY2015021C patent/CY2015021I2/el unknown
- 2015-06-19 LU LU92747C patent/LU92747I2/xx unknown
- 2015-06-19 LU LU92749C patent/LU92749I2/xx unknown
- 2015-06-19 CY CY2015022C patent/CY2015022I2/el unknown
- 2015-06-19 HU HUS1500033C patent/HUS1500033I1/hu unknown
- 2015-06-19 LU LU92748C patent/LU92748I2/xx unknown
- 2015-06-19 CY CY2015023C patent/CY2015023I2/el unknown
- 2015-06-19 HU HUS1500031 patent/HUS1500031I1/hu unknown
-
2016
- 2016-04-28 AR ARP160101219A patent/AR104448A2/es not_active Application Discontinuation
Also Published As
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Legal Events
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| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B09W | Correction of the decision to grant [chapter 9.1.4 patent gazette] |
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| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 18/08/2020, OBSERVADAS AS CONDICOES LEGAIS. |