UY28905A1 - Pestivirus atenuados con al menos una mutación en las secuencias codificadoras de glicoproteína erns y de npro, preparación y composiciones - Google Patents

Pestivirus atenuados con al menos una mutación en las secuencias codificadoras de glicoproteína erns y de npro, preparación y composiciones

Info

Publication number
UY28905A1
UY28905A1 UY28905A UY28905A UY28905A1 UY 28905 A1 UY28905 A1 UY 28905A1 UY 28905 A UY28905 A UY 28905A UY 28905 A UY28905 A UY 28905A UY 28905 A1 UY28905 A1 UY 28905A1
Authority
UY
Uruguay
Prior art keywords
mutation
npro
erns
compositions
vdvb
Prior art date
Application number
UY28905A
Other languages
English (en)
Inventor
Gregor Meyers
Andreas Ege
Christiane Meyer
Martina Von Freyburg
Original Assignee
Boehringer Ingelheim Vetmed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34967522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY28905(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Vetmed filed Critical Boehringer Ingelheim Vetmed
Publication of UY28905A1 publication Critical patent/UY28905A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24361—Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Pestivirus atenuados, en particular a VDVB atenuado, donde al menos una mutación está en la secuencia codificadora de la glicoproteína Erns y al menos otra mutación está en la secuencia codificadora de la glicoproteína Erns y al menos otra mutación esta en la secuencia codificadora de Npro, que preferiblemente conduce a una inactivación combinada de la actividad de Rnasa que reside en la glicoproteína Erns, además de la inactivación de la actividad inmunomoduladora (en hipótesis) que reside en Npro. Métodos para atenuar pestivirus como VDVB, ácidos nucleicos que codifican dichos pestivirus, en particular VDVB. Composiciones Y vacunas que comprenden los pestivirus atenuados, en particular el VDVB de la invención.
UY28905A 2004-05-19 2005-05-18 Pestivirus atenuados con al menos una mutación en las secuencias codificadoras de glicoproteína erns y de npro, preparación y composiciones UY28905A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004025452A DE102004025452A1 (de) 2004-05-19 2004-05-19 Vakzine enthaltend BVDV

Publications (1)

Publication Number Publication Date
UY28905A1 true UY28905A1 (es) 2005-12-30

Family

ID=34967522

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28905A UY28905A1 (es) 2004-05-19 2005-05-18 Pestivirus atenuados con al menos una mutación en las secuencias codificadoras de glicoproteína erns y de npro, preparación y composiciones

Country Status (25)

Country Link
EP (1) EP1751276B9 (es)
JP (2) JP5006782B2 (es)
KR (1) KR100908798B1 (es)
CN (2) CN1989240B (es)
AR (2) AR049176A1 (es)
AT (1) ATE420949T1 (es)
AU (1) AU2005243488B2 (es)
BR (1) BRPI0510396B1 (es)
CA (1) CA2561719C (es)
CY (4) CY1109036T1 (es)
DE (2) DE102004025452A1 (es)
DK (1) DK1751276T5 (es)
ES (1) ES2321210T3 (es)
HU (2) HUS1500033I1 (es)
LU (3) LU92747I2 (es)
ME (1) ME01119B (es)
MX (1) MXPA06013298A (es)
NL (3) NL300744I1 (es)
NZ (1) NZ552088A (es)
PL (1) PL1751276T3 (es)
PT (1) PT1751276E (es)
RS (1) RS50753B9 (es)
SI (1) SI1751276T1 (es)
UY (1) UY28905A1 (es)
WO (1) WO2005111201A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179473B2 (en) 1998-06-05 2007-02-20 Boehringer Ingelheim Vetmedica Gmbh Attenuated pestiviruses
US7135561B2 (en) 2001-09-06 2006-11-14 Boehringer Ingelheim Vetmedica Gmbh Infectious bovine viral diarrhea virus clone
UY29915A1 (es) 2005-11-15 2007-06-29 Boehringer Ingelheim Vetmed Vacuna combinada que comprende un virus atenuado de la diarrea viral bovina
AR062917A1 (es) * 2006-09-22 2008-12-17 Intervet Int Bv Nuevo mutante de pestivirus para uso en una vacuna.
AR069087A1 (es) 2007-10-29 2009-12-30 Boehringer Ingelheim Vetmed Cepa bacteriana de m. bovis atenuada avirulenta obtenida por pases, vacuna de micoplasma boris y metodos de uso de la misma
UY31930A (es) 2008-06-25 2010-01-29 Boheringer Ingelheim Pharma Kg Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante
SG10201506597RA (en) 2008-10-31 2015-10-29 Boehringer Ingelheim Vetmed Use Of Various Antigens Including Antigens From Mycoplasma Bovis In Multivalent Vaccine Composition
US8846054B2 (en) 2009-01-09 2014-09-30 Boehringer Ingelheim Vetmedica, Inc. Method of treating pregnant cows and/or heifers
UY32570A (es) 2009-04-24 2010-11-30 Boehringer Ingelheim Vetmed Vacuna viva modificada de mycoplasma bovis mejorada
EP2618841B1 (en) 2010-09-21 2016-10-19 Intervet International B.V. Bvdv vaccine
JP6589159B2 (ja) * 2014-04-01 2019-10-16 共立製薬株式会社 新規ネコモルビリウイルス株、不活化ワクチン製剤、並びにネコモルビリウイルス感染症予防方法
WO2015177369A1 (en) * 2014-05-23 2015-11-26 Boehringer Ingelheim Vetmedica Gmbh Recombinant classical swine fever virus (csfv) comprising substitution in the tav epitope of the e2 protein
CN105779499B (zh) * 2016-03-23 2019-11-19 江苏科技大学 重组杆状病毒和其应用及构建该重组杆状病毒的载体
CN107823639B (zh) * 2017-11-10 2020-10-02 齐鲁动物保健品有限公司 牛病毒性腹泻病毒灭活疫苗及其制备方法
CN108707190B (zh) * 2018-04-18 2021-07-13 中国科学院武汉病毒研究所 猪瘟病毒ns5b蛋白保真度突变体及其应用
CN114853912B (zh) * 2022-05-24 2023-06-13 中国农业科学院兰州兽医研究所 一种牛病毒性腹泻病毒e2-e0融合蛋白、制备方法及应用
CN115960847B (zh) * 2023-01-11 2024-06-14 青岛大学 小分子依赖的内含肽自剪接系统在制备减毒活疫苗中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6168942B1 (en) * 1998-11-10 2001-01-02 Pfizer Inc. Attenuated forms of bovine viral diarrhea virus
EP1104676A1 (en) * 1999-11-30 2001-06-06 Boehringer Ingelheim Vetmedica Gmbh Safe attenuated bovine viral diarrhea viruses for use in pregnant cows
CA2363493C (en) * 2000-11-22 2006-06-06 Xuemei Cao Attenuated forms of bovine viral diarrhea virus
DE10143813A1 (de) * 2001-09-06 2003-04-10 Boehringer Ingelheim Vetmed Infektiöser Rindervirusdiarrhoe-Virusklon

Also Published As

Publication number Publication date
MXPA06013298A (es) 2007-05-07
NL300743I2 (es) 2016-01-26
SI1751276T1 (sl) 2009-06-30
EP1751276B9 (en) 2020-05-27
CY1109036T1 (el) 2014-07-02
JP5562316B2 (ja) 2014-07-30
RS50753B9 (sr) 2020-08-31
NZ552088A (en) 2009-10-30
LU92749I2 (fr) 2015-11-02
LU92747I2 (fr) 2015-11-02
CY2015023I1 (el) 2020-05-29
CY2015022I2 (el) 2024-02-16
DK1751276T5 (da) 2020-07-20
ES2321210T9 (es) 2020-11-04
CY2015021I1 (el) 2020-05-29
ATE420949T1 (de) 2009-01-15
NL300744I2 (es) 2016-01-26
LU92748I2 (fr) 2015-11-02
BRPI0510396A (pt) 2007-11-13
AU2005243488B2 (en) 2011-07-07
PL1751276T3 (pl) 2009-06-30
ME01119B (me) 2013-03-20
EP1751276A1 (en) 2007-02-14
DK1751276T3 (da) 2009-05-18
DE602005012381D1 (de) 2009-03-05
CN1989240A (zh) 2007-06-27
PT1751276E (pt) 2009-02-24
NL300745I1 (es) 2016-01-26
CY2015021I2 (el) 2023-11-15
JP5006782B2 (ja) 2012-08-22
JP2012061001A (ja) 2012-03-29
CA2561719A1 (en) 2005-11-24
CN103352030A (zh) 2013-10-16
ES2321210T3 (es) 2009-06-03
RS50753B (sr) 2010-08-31
CA2561719C (en) 2015-01-27
NL300744I1 (es) 2016-01-26
AU2005243488A1 (en) 2005-11-24
HUS1500031I1 (hu) 2019-11-28
CN103352030B (zh) 2018-08-10
AR049176A1 (es) 2006-07-05
NL300745I2 (es) 2016-01-26
WO2005111201A1 (en) 2005-11-24
DE102004025452A1 (de) 2006-01-19
CY2015022I1 (el) 2020-05-29
EP1751276B1 (en) 2009-01-14
CN1989240B (zh) 2013-07-31
JP2007537740A (ja) 2007-12-27
HUS1500033I1 (hu) 2015-07-28
AR104448A2 (es) 2017-07-19
BRPI0510396B1 (pt) 2020-08-18
KR100908798B1 (ko) 2009-07-22
KR20070012862A (ko) 2007-01-29
NL300743I1 (es) 2016-01-26
CY2015023I2 (el) 2024-02-16

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