CN103339111B - 双环乙酰基-CoA羧化酶抑制剂 - Google Patents
双环乙酰基-CoA羧化酶抑制剂 Download PDFInfo
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- CN103339111B CN103339111B CN201180035809.2A CN201180035809A CN103339111B CN 103339111 B CN103339111 B CN 103339111B CN 201180035809 A CN201180035809 A CN 201180035809A CN 103339111 B CN103339111 B CN 103339111B
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- indole
- methyl
- cyclohexyl
- carbonyl
- phenyl
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- 0 CC1(CCN)C*CC(C*)(C2)C2CC1 Chemical compound CC1(CCN)C*CC(C*)(C2)C2CC1 0.000 description 25
- CTDDYZDCAIAKLZ-UHFFFAOYSA-N CC(C)C(COC)N=C Chemical compound CC(C)C(COC)N=C CTDDYZDCAIAKLZ-UHFFFAOYSA-N 0.000 description 1
- XVHRBZGMWSUSTO-VBHDRNNKSA-N CC(COCC1)N1C([C@H](CC1)CC[C@@H]1NS(c(cc1)cc2c1c(C)c(C1CC1)[n]2C)(=O)=O)=O Chemical compound CC(COCC1)N1C([C@H](CC1)CC[C@@H]1NS(c(cc1)cc2c1c(C)c(C1CC1)[n]2C)(=O)=O)=O XVHRBZGMWSUSTO-VBHDRNNKSA-N 0.000 description 1
- JAHRPDMIKPTMBO-ZKCHVHJHSA-O CC([C@H](CC1)CC[C@@H]1N)=[NH2+] Chemical compound CC([C@H](CC1)CC[C@@H]1N)=[NH2+] JAHRPDMIKPTMBO-ZKCHVHJHSA-O 0.000 description 1
- QRAXZXPSAGQUNP-UHFFFAOYSA-N CNc(cc1)ccc1S(O)(=O)=O Chemical compound CNc(cc1)ccc1S(O)(=O)=O QRAXZXPSAGQUNP-UHFFFAOYSA-N 0.000 description 1
- IBUGGKCVHHNEAE-UHFFFAOYSA-N COCCc(cc1)ccc1C#C Chemical compound COCCc(cc1)ccc1C#C IBUGGKCVHHNEAE-UHFFFAOYSA-N 0.000 description 1
- XFDBMUHMAWUBEM-QMMMGPOBSA-N C[C@@H](CC=N)c(cc1)ccc1F Chemical compound C[C@@H](CC=N)c(cc1)ccc1F XFDBMUHMAWUBEM-QMMMGPOBSA-N 0.000 description 1
- IVQFLYMNDFFXQO-UHFFFAOYSA-N Cc([o]1)nnc1[Re] Chemical compound Cc([o]1)nnc1[Re] IVQFLYMNDFFXQO-UHFFFAOYSA-N 0.000 description 1
- ZKUCVUOHZFWFNV-UHFFFAOYSA-N O=C(C(F)(F)F)N1c(cccc2)c2OCC1 Chemical compound O=C(C(F)(F)F)N1c(cccc2)c2OCC1 ZKUCVUOHZFWFNV-UHFFFAOYSA-N 0.000 description 1
- QRCGFTXRXYMJOS-UHFFFAOYSA-N O=C1Nc(cccc2)c2OC1 Chemical compound O=C1Nc(cccc2)c2OC1 QRCGFTXRXYMJOS-UHFFFAOYSA-N 0.000 description 1
- DXFXNSNBZNELII-UHFFFAOYSA-N O=S(c(cc1)cc(Cl)c1F)(Cl)=O Chemical compound O=S(c(cc1)cc(Cl)c1F)(Cl)=O DXFXNSNBZNELII-UHFFFAOYSA-N 0.000 description 1
- PSKWRGYUMTVZIV-UHFFFAOYSA-N OCC(C(F)(F)F)N1c(cc(cc2)S(Cl)(=O)=O)c2OCC1 Chemical compound OCC(C(F)(F)F)N1c(cc(cc2)S(Cl)(=O)=O)c2OCC1 PSKWRGYUMTVZIV-UHFFFAOYSA-N 0.000 description 1
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
- C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
- C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36882010P | 2010-07-29 | 2010-07-29 | |
| US61/368,820 | 2010-07-29 | ||
| PCT/EP2011/062933 WO2012013716A1 (en) | 2010-07-29 | 2011-07-27 | Bicyclic acetyl-coa carboxylase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103339111A CN103339111A (zh) | 2013-10-02 |
| CN103339111B true CN103339111B (zh) | 2015-12-16 |
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| Country | Link |
|---|---|
| US (2) | US8697739B2 (https=) |
| EP (1) | EP2598486B1 (https=) |
| JP (1) | JP5998133B2 (https=) |
| CN (1) | CN103339111B (https=) |
| AR (1) | AR082391A1 (https=) |
| ES (1) | ES2641833T3 (https=) |
| TW (1) | TW201206907A (https=) |
| UY (1) | UY33536A (https=) |
| WO (1) | WO2012013716A1 (https=) |
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| JPWO2013061962A1 (ja) * | 2011-10-24 | 2015-04-02 | 武田薬品工業株式会社 | 二環性化合物 |
| MX2015015422A (es) * | 2013-05-10 | 2016-06-21 | Nimbus Apollo Inc | Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos. |
| AU2014262547A1 (en) | 2013-05-10 | 2015-11-26 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
| HK1217448A1 (zh) | 2013-09-12 | 2017-01-13 | 辉瑞大药厂 | 乙酰辅酶a羧化酶抑制剂用於治疗寻常痤疮的用途 |
| MA41179A (fr) | 2014-12-19 | 2017-10-24 | Cancer Research Tech Ltd | Composés inhibiteurs de parg |
| AU2016215228A1 (en) * | 2015-02-05 | 2017-08-10 | Dermira Inc. | Synthetic process for preparing 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-tetradecyloxy)furan-2-carboxylate |
| EP3287441B1 (en) | 2015-04-20 | 2021-06-09 | Takeda Pharmaceutical Company Limited | Acylated 4-aminopiperidines as inhibitors of serine palmitoyltransferase |
| DK3330259T3 (da) | 2015-07-27 | 2020-08-10 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazolamidderivativ-forbindelse som histondeacetylase-6-inhibitor og farmaceutisk sammensætning indeholdende denne |
| ES2774510T3 (es) | 2015-07-27 | 2020-07-21 | Chong Kun Dang Pharmaceutical Corp | Derivados de 1,3,4-oxadiazol sulfamida como inhibidores de histona desacetilasa 6 y composición farmacéutica que comprende los mismos |
| FI3328843T3 (fi) * | 2015-07-27 | 2023-01-31 | 1,3,4-oksadiatsolisulfonamidijohdannaisyhdisteitä histonideasetylaasi-6:n inhibiittoreina ja samaa käsittävä farmaseuttinen koostumus | |
| RU2709207C2 (ru) | 2015-08-04 | 2019-12-17 | Чонг Кун Данг Фармасьютикал Корп. | 1,3,4-оксадиазольные производные соединения в качестве ингибитора гистондеацетилазы 6 и фармацевтическая композиция, содержащая их |
| CN105130893B (zh) * | 2015-09-08 | 2018-04-10 | 大连理工大学 | 一种1‑苄基‑6‑甲氧羰甲基四氢异喹啉衍生物、制备方法及其抗血小板聚集的应用 |
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| JP2019510820A (ja) * | 2016-03-21 | 2019-04-18 | ワインスタイン,デイビッド | 創傷治癒及び瘢痕予防のための方法 |
| EA202191466A1 (ru) | 2016-04-11 | 2021-12-31 | Женфит | Способы лечения холестатических и фибротических заболеваний |
| US10653678B2 (en) | 2016-04-11 | 2020-05-19 | Genfit | Methods of treatment for cholestatic and fibrotic diseases |
| WO2018074461A1 (ja) | 2016-10-18 | 2018-04-26 | 武田薬品工業株式会社 | 複素環化合物 |
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| KR102316234B1 (ko) | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
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| CN109836385B (zh) * | 2019-04-04 | 2021-12-17 | 上海翰森生物医药科技有限公司 | 四氢喹啉类n-氧化衍生物及其制备方法和应用 |
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- 2011-07-27 AR ARP110102709A patent/AR082391A1/es unknown
- 2011-07-27 EP EP11741554.7A patent/EP2598486B1/en not_active Not-in-force
- 2011-07-27 JP JP2013521136A patent/JP5998133B2/ja not_active Expired - Fee Related
- 2011-07-27 WO PCT/EP2011/062933 patent/WO2012013716A1/en not_active Ceased
- 2011-07-27 CN CN201180035809.2A patent/CN103339111B/zh not_active Expired - Fee Related
- 2011-07-27 ES ES11741554.7T patent/ES2641833T3/es active Active
- 2011-07-28 UY UY0001033536A patent/UY33536A/es not_active Application Discontinuation
- 2011-07-28 TW TW100126860A patent/TW201206907A/zh unknown
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Also Published As
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| CN103339111A (zh) | 2013-10-02 |
| US20120028969A1 (en) | 2012-02-02 |
| AR082391A1 (es) | 2012-12-05 |
| US20140171363A1 (en) | 2014-06-19 |
| UY33536A (es) | 2012-02-29 |
| EP2598486B1 (en) | 2017-06-28 |
| EP2598486A1 (en) | 2013-06-05 |
| WO2012013716A1 (en) | 2012-02-02 |
| ES2641833T3 (es) | 2017-11-14 |
| JP5998133B2 (ja) | 2016-09-28 |
| US9789118B2 (en) | 2017-10-17 |
| JP2013533279A (ja) | 2013-08-22 |
| US8697739B2 (en) | 2014-04-15 |
| TW201206907A (en) | 2012-02-16 |
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