CN103339111B - 双环乙酰基-CoA羧化酶抑制剂 - Google Patents
双环乙酰基-CoA羧化酶抑制剂 Download PDFInfo
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- CN103339111B CN103339111B CN201180035809.2A CN201180035809A CN103339111B CN 103339111 B CN103339111 B CN 103339111B CN 201180035809 A CN201180035809 A CN 201180035809A CN 103339111 B CN103339111 B CN 103339111B
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- indole
- methyl
- cyclohexyl
- carbonyl
- phenyl
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- 0 CC1(CCN)C*CC(C*)(C2)C2CC1 Chemical compound CC1(CCN)C*CC(C*)(C2)C2CC1 0.000 description 25
- CTDDYZDCAIAKLZ-UHFFFAOYSA-N CC(C)C(COC)N=C Chemical compound CC(C)C(COC)N=C CTDDYZDCAIAKLZ-UHFFFAOYSA-N 0.000 description 1
- XVHRBZGMWSUSTO-VBHDRNNKSA-N CC(COCC1)N1C([C@H](CC1)CC[C@@H]1NS(c(cc1)cc2c1c(C)c(C1CC1)[n]2C)(=O)=O)=O Chemical compound CC(COCC1)N1C([C@H](CC1)CC[C@@H]1NS(c(cc1)cc2c1c(C)c(C1CC1)[n]2C)(=O)=O)=O XVHRBZGMWSUSTO-VBHDRNNKSA-N 0.000 description 1
- JAHRPDMIKPTMBO-ZKCHVHJHSA-O CC([C@H](CC1)CC[C@@H]1N)=[NH2+] Chemical compound CC([C@H](CC1)CC[C@@H]1N)=[NH2+] JAHRPDMIKPTMBO-ZKCHVHJHSA-O 0.000 description 1
- QRAXZXPSAGQUNP-UHFFFAOYSA-N CNc(cc1)ccc1S(O)(=O)=O Chemical compound CNc(cc1)ccc1S(O)(=O)=O QRAXZXPSAGQUNP-UHFFFAOYSA-N 0.000 description 1
- IBUGGKCVHHNEAE-UHFFFAOYSA-N COCCc(cc1)ccc1C#C Chemical compound COCCc(cc1)ccc1C#C IBUGGKCVHHNEAE-UHFFFAOYSA-N 0.000 description 1
- XFDBMUHMAWUBEM-QMMMGPOBSA-N C[C@@H](CC=N)c(cc1)ccc1F Chemical compound C[C@@H](CC=N)c(cc1)ccc1F XFDBMUHMAWUBEM-QMMMGPOBSA-N 0.000 description 1
- IVQFLYMNDFFXQO-UHFFFAOYSA-N Cc([o]1)nnc1[Re] Chemical compound Cc([o]1)nnc1[Re] IVQFLYMNDFFXQO-UHFFFAOYSA-N 0.000 description 1
- ZKUCVUOHZFWFNV-UHFFFAOYSA-N O=C(C(F)(F)F)N1c(cccc2)c2OCC1 Chemical compound O=C(C(F)(F)F)N1c(cccc2)c2OCC1 ZKUCVUOHZFWFNV-UHFFFAOYSA-N 0.000 description 1
- QRCGFTXRXYMJOS-UHFFFAOYSA-N O=C1Nc(cccc2)c2OC1 Chemical compound O=C1Nc(cccc2)c2OC1 QRCGFTXRXYMJOS-UHFFFAOYSA-N 0.000 description 1
- DXFXNSNBZNELII-UHFFFAOYSA-N O=S(c(cc1)cc(Cl)c1F)(Cl)=O Chemical compound O=S(c(cc1)cc(Cl)c1F)(Cl)=O DXFXNSNBZNELII-UHFFFAOYSA-N 0.000 description 1
- PSKWRGYUMTVZIV-UHFFFAOYSA-N OCC(C(F)(F)F)N1c(cc(cc2)S(Cl)(=O)=O)c2OCC1 Chemical compound OCC(C(F)(F)F)N1c(cc(cc2)S(Cl)(=O)=O)c2OCC1 PSKWRGYUMTVZIV-UHFFFAOYSA-N 0.000 description 1
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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- C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
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| Application Number | Priority Date | Filing Date | Title |
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| US36882010P | 2010-07-29 | 2010-07-29 | |
| US61/368,820 | 2010-07-29 | ||
| PCT/EP2011/062933 WO2012013716A1 (en) | 2010-07-29 | 2011-07-27 | Bicyclic acetyl-coa carboxylase inhibitors |
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| CN103339111B true CN103339111B (zh) | 2015-12-16 |
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| Country | Link |
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| US (2) | US8697739B2 (enExample) |
| EP (1) | EP2598486B1 (enExample) |
| JP (1) | JP5998133B2 (enExample) |
| CN (1) | CN103339111B (enExample) |
| AR (1) | AR082391A1 (enExample) |
| ES (1) | ES2641833T3 (enExample) |
| TW (1) | TW201206907A (enExample) |
| UY (1) | UY33536A (enExample) |
| WO (1) | WO2012013716A1 (enExample) |
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| US7745629B2 (en) * | 2005-05-16 | 2010-06-29 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of ion channels |
| TW201300358A (zh) * | 2011-03-14 | 2013-01-01 | 大正製藥股份有限公司 | 含氮縮合雜環化合物 |
| EP2772485A4 (en) * | 2011-10-24 | 2015-06-10 | Takeda Pharmaceutical | BICYCLIC CONNECTION |
| BR112015028152A2 (pt) | 2013-05-10 | 2017-07-25 | Nimbus Apollo Inc | inibidores de acc e usos dos mesmos |
| EA201591962A1 (ru) | 2013-05-10 | 2016-06-30 | Нимбус Аполло, Инк. | Ингибиторы акк и их применение |
| CN105530940A (zh) | 2013-09-12 | 2016-04-27 | 辉瑞大药厂 | 乙酰辅酶a羧化酶抑制剂用于治疗寻常痤疮的用途 |
| MA41179A (fr) | 2014-12-19 | 2017-10-24 | Cancer Research Tech Ltd | Composés inhibiteurs de parg |
| HK1243706A1 (zh) * | 2015-02-05 | 2018-07-20 | Dermira, Inc. | 用於制备(5-十四烷氧基)呋喃-2-甲酸2-((2-乙氧基-2-氧代乙基)(甲基)氨基)-2-氧代乙酯的合成方法 |
| US10189785B2 (en) | 2015-04-20 | 2019-01-29 | Takeda Pharmaceuticals Company Limited | Heterocyclic compound |
| HRP20201304T1 (hr) | 2015-07-27 | 2020-11-27 | Chong Kun Dang Pharmaceutical Corp. | Spoj derivata 1,3,4-oksadiazol-amida koji služi kao inhibitor histonske deacetilaze 6 i farmaceutski pripravak koji sadrži taj spoj |
| CN107980040B (zh) | 2015-07-27 | 2021-11-26 | 株式会社钟根堂 | 作为组蛋白去乙酰酶6抑制剂的1,3,4-噁二唑磺酰胺衍生物及含其的医药组合物 |
| FI3328843T3 (fi) * | 2015-07-27 | 2023-01-31 | 1,3,4-oksadiatsolisulfonamidijohdannaisyhdisteitä histonideasetylaasi-6:n inhibiittoreina ja samaa käsittävä farmaseuttinen koostumus | |
| DK3331864T3 (da) | 2015-08-04 | 2021-12-13 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-Oxadiazolderivat-forbindelser som histon-deacetylase-6-hæmmer, og den farmaceutiske sammensætning omfattende disse |
| CN105130893B (zh) * | 2015-09-08 | 2018-04-10 | 大连理工大学 | 一种1‑苄基‑6‑甲氧羰甲基四氢异喹啉衍生物、制备方法及其抗血小板聚集的应用 |
| MY196174A (en) | 2015-10-12 | 2023-03-20 | Chong Kun Dang Pharmaceutical Corp | Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the Same |
| WO2017165119A1 (en) * | 2016-03-21 | 2017-09-28 | David Weinstein | Methods for wound healing and scar prevention |
| US10653678B2 (en) | 2016-04-11 | 2020-05-19 | Genfit | Methods of treatment for cholestatic and fibrotic diseases |
| SG11201808402RA (en) | 2016-04-11 | 2018-10-30 | Genfit | Methods of treatment for cholestatic and fibrotic diseases |
| CA3041266A1 (en) | 2016-10-18 | 2018-04-26 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US11572347B2 (en) | 2017-10-20 | 2023-02-07 | The Regents Of The University Of California | Orally available sEH/PDE4 dual inhibitors |
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| CN110041253B (zh) * | 2018-01-17 | 2022-03-29 | 上海翰森生物医药科技有限公司 | 吡啶类n-氧化衍生物及其制备方法和应用 |
| KR102316234B1 (ko) | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| CN113056266A (zh) * | 2018-09-18 | 2021-06-29 | 梅塔科林公司 | 用于治疗疾病的法尼醇x受体激动剂 |
| WO2020097398A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| PL3947360T3 (pl) | 2019-03-28 | 2024-11-04 | Zoetis Services Llc | Związki hamujące receptor serotoninowy 5-HT2B |
| CN109836385B (zh) * | 2019-04-04 | 2021-12-17 | 上海翰森生物医药科技有限公司 | 四氢喹啉类n-氧化衍生物及其制备方法和应用 |
| CN113874369B (zh) | 2019-05-31 | 2024-08-27 | 株式会社钟根堂 | 作为组蛋白脱乙酰酶6抑制剂的1,3,4-噁二唑高邻苯二甲酰亚胺衍生化合物及包含其的药物组合物 |
| WO2021087077A1 (en) * | 2019-10-29 | 2021-05-06 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of autophagy and histone deactylases and uses thereof |
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| CN112370455A (zh) * | 2020-10-19 | 2021-02-19 | 济南大学 | 一种磺酰胺衍生物作为α-葡萄糖苷酶抑制剂及其应用 |
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| WO2022140527A1 (en) | 2020-12-23 | 2022-06-30 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| TW202325289A (zh) | 2021-11-09 | 2023-07-01 | 美商雅捷可斯治療公司 | Jak2抑制劑之形式及組合物 |
| CN116354903B (zh) * | 2021-12-28 | 2025-09-09 | 南京药石科技股份有限公司 | 一种6-苯并噻唑磺酰氯的制备方法 |
| CN114469952B (zh) * | 2022-03-02 | 2023-09-19 | 中南大学湘雅三医院 | 特拉匹韦在制备malt1抑制剂、抗malt1依赖性肿瘤的药物中的应用及抗肿瘤药物 |
| KR20240165402A (ko) | 2022-03-23 | 2024-11-22 | 아이디어야 바이오사이언시스 인코포레이티드 | Parg의 억제제로서의 피페라진 치환된 인다졸 화합물 |
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- 2011-07-27 AR ARP110102709A patent/AR082391A1/es unknown
- 2011-07-27 CN CN201180035809.2A patent/CN103339111B/zh not_active Expired - Fee Related
- 2011-07-27 EP EP11741554.7A patent/EP2598486B1/en not_active Not-in-force
- 2011-07-27 JP JP2013521136A patent/JP5998133B2/ja not_active Expired - Fee Related
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- 2011-07-27 WO PCT/EP2011/062933 patent/WO2012013716A1/en not_active Ceased
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- 2011-07-28 UY UY0001033536A patent/UY33536A/es not_active Application Discontinuation
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| JPH08183759A (ja) * | 1994-12-28 | 1996-07-16 | Fujirebio Inc | アミド誘導体 |
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Also Published As
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| UY33536A (es) | 2012-02-29 |
| JP2013533279A (ja) | 2013-08-22 |
| CN103339111A (zh) | 2013-10-02 |
| ES2641833T3 (es) | 2017-11-14 |
| JP5998133B2 (ja) | 2016-09-28 |
| EP2598486A1 (en) | 2013-06-05 |
| WO2012013716A1 (en) | 2012-02-02 |
| TW201206907A (en) | 2012-02-16 |
| EP2598486B1 (en) | 2017-06-28 |
| AR082391A1 (es) | 2012-12-05 |
| US20140171363A1 (en) | 2014-06-19 |
| US20120028969A1 (en) | 2012-02-02 |
| US8697739B2 (en) | 2014-04-15 |
| US9789118B2 (en) | 2017-10-17 |
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