CN103282034A - 造血生长因子模拟物的用途 - Google Patents

造血生长因子模拟物的用途 Download PDF

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CN103282034A
CN103282034A CN2011800627578A CN201180062757A CN103282034A CN 103282034 A CN103282034 A CN 103282034A CN 2011800627578 A CN2011800627578 A CN 2011800627578A CN 201180062757 A CN201180062757 A CN 201180062757A CN 103282034 A CN103282034 A CN 103282034A
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optionally substituted
group
alkyl
aryl
heteroaryl
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里德·P·比索尼特
安德鲁·R·赫德森
基思·B·马斯克
蒂帕·兰格塔
智林
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Ligand Pharmaceuticals Inc
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105916841A (zh) * 2013-11-25 2016-08-31 诺沃根公司 作为抗癌药物的功能化的和取代的吲哚
CN112321513A (zh) * 2020-11-06 2021-02-05 中国药科大学 杂环类化合物及其制备方法和用途
CN113924146A (zh) * 2019-05-29 2022-01-11 加拉帕戈斯股份有限公司 用于治疗疾病的新化合物及其药物组合物
WO2022166482A1 (zh) * 2021-02-04 2022-08-11 清药同创(北京)药物研发中心有限公司 一种苯并咪唑类enl蛋白抑制剂及其制备方法和用途

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102766135B (zh) * 2012-07-09 2017-05-03 云南大学 二氢呋喃并茚烷‑咪唑盐类化合物及其制备方法
AU2013305759C1 (en) 2012-08-23 2018-01-18 Janssen Biopharma, Inc. Compounds for the treatment of paramoxyvirus viral infections
DK3054936T5 (da) 2013-10-10 2024-03-18 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino) benzensulfonamid derivater som 12-lipoxygenase inhibitorer
PE20170247A1 (es) 2014-05-15 2017-03-29 Iteos Therapeutics Derivados de pirrolidina-2,5-diona, composiciones farmaceuticas y metodos para usar como inhibidores ido1
KR102412146B1 (ko) 2015-02-11 2022-06-22 주식회사 아이엔테라퓨틱스 소디움 채널 차단제
WO2016147144A1 (en) 2015-03-17 2016-09-22 Pfizer Inc. Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use
EP3334733A1 (en) 2015-08-10 2018-06-20 Pfizer Inc 3-indol substituted derivatives, pharmaceutical compositions and methods for use
WO2017039318A1 (en) * 2015-09-01 2017-03-09 Kainos Medicine, Inc. Benzimidazole derivatives for dna methylation inhibitors
EP3365340B1 (en) 2015-10-19 2022-08-10 Incyte Corporation Heterocyclic compounds as immunomodulators
US20170145025A1 (en) 2015-11-19 2017-05-25 Incyte Corporation Heterocyclic compounds as immunomodulators
ES2916874T3 (es) 2015-12-17 2022-07-06 Incyte Corp Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1
AU2016379372A1 (en) 2015-12-22 2018-08-02 Incyte Corporation Heterocyclic compounds as immunomodulators
CN107176951A (zh) * 2016-03-11 2017-09-19 恩瑞生物医药科技（上海）有限公司 一种脲类化合物、其制备方法及其医药用途
US10844052B2 (en) 2016-04-04 2020-11-24 The Regents Of The University Of California LLS compounds for treatment of cancer
ES2906460T3 (es) 2016-05-06 2022-04-18 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
ES2905980T3 (es) 2016-05-26 2022-04-12 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
BR112018076534A2 (pt) 2016-06-20 2019-04-02 Incyte Corporation compostos heterocíclicos como imunomoduladores
MA45669A (fr) 2016-07-14 2019-05-22 Incyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
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ES2899402T3 (es) 2016-12-22 2022-03-11 Incyte Corp Derivados de piridina como inmunomoduladores
WO2018119286A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Bicyclic heteroaromatic compounds as immunomodulators
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AU2017382870B2 (en) 2016-12-22 2022-03-24 Incyte Corporation Benzooxazole derivatives as immunomodulators
WO2019100106A1 (en) * 2017-11-24 2019-05-31 The University Of Sydney Antibacterial compounds and methods of use thereof
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CR20200520A (es) 2018-03-30 2021-03-09 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017958A1 (en) * 1995-11-13 1997-05-22 Smithkline Beecham Corporation Hemoregulatory compounds
WO2009155362A1 (en) * 2008-06-19 2009-12-23 Ligand Pharmaceuticals Inc. Small molecule hematopoietic growth factor mimetic compounds and their uses
WO2010029300A1 (en) * 2008-09-12 2010-03-18 Biolipox Ab Bis aromatic compounds for use in the treatment of inflammation
WO2010103278A1 (en) * 2009-03-12 2010-09-16 Biolipox Ab Bis aromatic compounds for use as ltc4 synthase inhibitors
CN102656141A (zh) * 2009-10-13 2012-09-05 利亘制药公司 模拟造血生长因子的小分子化合物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0126036D0 (en) 2001-10-30 2001-12-19 Amedis Pharm Ltd Silicon compounds
WO2011151618A2 (en) * 2010-06-01 2011-12-08 Summit Corporation Plc Compounds for the treatment of clostridium difficile-associated disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017958A1 (en) * 1995-11-13 1997-05-22 Smithkline Beecham Corporation Hemoregulatory compounds
WO2009155362A1 (en) * 2008-06-19 2009-12-23 Ligand Pharmaceuticals Inc. Small molecule hematopoietic growth factor mimetic compounds and their uses
WO2010029300A1 (en) * 2008-09-12 2010-03-18 Biolipox Ab Bis aromatic compounds for use in the treatment of inflammation
WO2010103278A1 (en) * 2009-03-12 2010-09-16 Biolipox Ab Bis aromatic compounds for use as ltc4 synthase inhibitors
CN102656141A (zh) * 2009-10-13 2012-09-05 利亘制药公司 模拟造血生长因子的小分子化合物及其用途

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105916841A (zh) * 2013-11-25 2016-08-31 诺沃根公司 作为抗癌药物的功能化的和取代的吲哚
CN113924146A (zh) * 2019-05-29 2022-01-11 加拉帕戈斯股份有限公司 用于治疗疾病的新化合物及其药物组合物
CN112321513A (zh) * 2020-11-06 2021-02-05 中国药科大学 杂环类化合物及其制备方法和用途
WO2022095569A1 (zh) * 2020-11-06 2022-05-12 药康众拓(江苏)医药科技有限公司 杂环类化合物及其制备方法和用途
WO2022166482A1 (zh) * 2021-02-04 2022-08-11 清药同创(北京)药物研发中心有限公司 一种苯并咪唑类enl蛋白抑制剂及其制备方法和用途

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