CN103239544A - Fishery Chinese and western compound medicine composition as well as premix compound, batch mixture and application thereof - Google Patents
Fishery Chinese and western compound medicine composition as well as premix compound, batch mixture and application thereof Download PDFInfo
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Abstract
The invention relates to a fishery Chinese and western compound medicine composition as well as a premix compound, batch mixture and application thereof and discloses a fishery Chinese and western compound medicine composition. The fishery Chinese and western compound medicine composition comprises the following components, namely, rheum officinale, golden cypress, scutellaria baicalensis, coptis chinensis, radix bupleuri, liquorice, gypsum and enrofloxacin. The fishery Chinese and western compound medicine composition has remarkable curative effects and takes quick effects on common bacterial diseases, such as bacterial septicemia, gill rot and red skin disease of aquatic livestock. The fishery Chinese and western compound medicine composition is stable in quality, convenient to use and low in cost, has the advantages of small toxic and side effects, efficient broad-spectrum, safety, environmental friendliness and the like and can be used for effectively ensuring the health and safety of the aquaculture animals.
Description
Technical field
The present invention relates to a kind of fishing and can be used for preventing and treating bacterial diseasees such as aquatic animal bacterial septicemia, gill rot, erythroderma, enteritis with Chinese and Western compound medicament composition and premix material, batch and application said composition, belong to field of veterinary and field of fodder.
Background technology
China is aquaculture big country, and cultured output accounts for 70% of whole world aquaculture.But China also is aquatic animal disease big country simultaneously, and every year is direct above 10,000,000,000 yuan because of the loss that disease causes.Fish diseases has become the restriction principal element of domestic Aquatic product aquaculture development gradually, and wherein bacterial disease accounts for more than 50%.Along with the intensive progressively propelling of aquaculture, water body environment takes place more frequent with ecological going from bad to worse, fish diseases, brings heavy losses to fish production in recent years.It is reported that the loss that Ctenopharyngodon idellus gill rot, bacterial septicemia, enteritis, four kinds of bacterial diseasees of red skin in 2006 cause just reaches 800,000,000 yuan, the loss that the Cyprinus carpio bacterial disease causes also reaches 100,000,000 yuan.
China's cultured fishes disease takes place frequently, cultured fishes losses serious situation, but the exploitation of fisheries drug and use be scarcely out of swaddling-clothes, and seriously lags behind the breed level.Fisheries drug derives from poultry medicine and pesticide mostly, uses frequently that easily to produce drug resistance and medicine residual, some even the destruction of directly water quality being caused irreversibility.In addition, some fisheries drug are bigger to the toxic and side effects of Fish, and residual period is oversize, directly influence the quality of aquatic products, and infringement consumer is healthy.Chinese herbal medicine is a kind of desirable natural, environment-friendly medicine, have efficient, toxic and side effects is little, safe, residual plurality of advantages such as few, and the source is wide, cost is low.Advocating healthy aquaculture under the new situation at present comprehensively, using the herbal control fish diseases and have broad prospects.But Chinese herbal medicine also has the shortcoming that waits slowly such as taking effect, and when fish diseases was broken out on a large scale, poor effect was often felt in a large amount of uses in a short time.
Summary of the invention
In order to address the above problem, the invention provides a kind of fishing Chinese and Western compound medicament composition and its preparation method and application.
At first, the invention provides a kind of fishing Chinese and Western compound medicament composition, it is made by following component: Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae, Gypsum Fibrosum and enrofloxacin.
In specific embodiment of the present invention, described fishing Chinese and Western compound medicament composition is made by following components by part by weight: Radix Et Rhizoma Rhei 1-60 part, Cortex Phellodendri 1-60 part, Radix Scutellariae 1-60 part, Rhizoma Coptidis 1-60 part, Radix Bupleuri 1-50, Radix Glycyrrhizae 1-50, Gypsum Fibrosum 1-50, enrofloxacin 1-50 part.
Preferably, described fishing Chinese and Western compound medicament composition is made by following components by part by weight: Radix Et Rhizoma Rhei 5-50 part, Cortex Phellodendri 5-50 part, Radix Scutellariae 5-50 part, Rhizoma Coptidis 10-50 part, Radix Bupleuri 5-40, Radix Glycyrrhizae 5-40, Gypsum Fibrosum 3-40, enrofloxacin 3-40 part.
Preferred, described fishing Chinese and Western compound medicament composition is made by following components by part by weight: Radix Et Rhizoma Rhei 10-40 part, Cortex Phellodendri 10-40 part, Radix Scutellariae 10-40 part, Rhizoma Coptidis 15-40 part, Radix Bupleuri 10-35, Radix Glycyrrhizae 10-35, Gypsum Fibrosum 5-35, enrofloxacin 5-30 part.
In specific embodiment of the present invention, described fishing is powder with the Chinese and Western compound medicament composition.
The present invention also provides the preparation method of described fishing with the Chinese and Western compound medicament composition, and it comprises the steps:
Take by weighing each component by weight, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 5-15 times of water gaging, decoct backflow 1-3h, filter; Filtering residue adds 5-15 times of water gaging, decocts backflow 1-3h, filters, and repeats 1-3 time, and merging filtrate adds 1-5 and doubly measures dehydrated alcohol and staticly settle 1-5h, dry grinding powdered again, and the adding enrofloxacin, mixing is namely.
Further, fishing of the present invention can be hybridly prepared into premix material with other premix material component with the Chinese and Western compound medicament composition, and therefore, the present invention also provides and contains the premix material that the Chinese and Western compound medicament composition is used in described fishing.
Further, fishing of the present invention can be added in the batch with conventional amount used with the Chinese and Western compound medicament composition, perhaps add in the batch with the premix material of Chinese and Western compound medicament composition containing described fishing, therefore, the present invention also provides and contains the batch that the Chinese and Western compound medicament composition is used in described fishing.
Further, the present invention also provides the described fishing medicinal application of Chinese and Western compound medicament composition aspect preparation control bacteriosis of aquatic livestock.
Wherein, described bacterial disease is bacterial septicemia, gill rot, erythroderma or enteritis.
The present invention adopts the Chinese and Western combination, at present common fish bacterial disease, select Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis Chinese crude drug for use, extract its effective ingredient, reduce its toxic and side effects, improve bactericidal effect, add the fishing Chinese and Western compound medicine that enrofloxacin is mixed with wide spectrum, efficient, safety, environmental protection simultaneously.Both can improve that single Chinese herbal medicine takes effect slowly, the problem of drug effect difference, and can improve chemicals again and easily produce drug resistance and the residual problem of medicine.Fishing of the present invention is with the obvious advantage with the Chinese and Western compound medicine, this medicine fungicidal spectrum is wide, determined curative effect, easy to use, medicine is easy to even dispersion, toxic and side effects is little, be difficult for to produce drug resistance, free from environmental pollution, do not cause drug-induced disease, can effectively ensure the healthy and safe and food safety of aquatic animal.
Fishing of the present invention is to control under the guidance of principle in the dialectical opinion of Chinese veterinarian's prescription with each drug component in the compound medicine of Chinese and Western and consumption thereof, gets by repeatedly practising in a large number, and advantage of the present invention and good effect are:
1) fishing of the present invention is wide with Chinese and Western compound medicine fungicidal spectrum, can effectively kill common pathogenic bacterias such as Aeromonas hydrophila, pseudomonas fluorescens, vibrio;
2) fishing of the present invention has the efficient sterilizing effect with the Chinese and Western compound medicine.Bactericidal effect to common pathogenic bacterias such as Aeromonas hydrophila, pseudomonas fluorescens, vibrios is better than single enrofloxacin;
3) fishing of the present invention is the Chinese and Western compound medicine with the Chinese and Western compound medicine, has overcome single chemical medicine and has easily produced drug resistance and the residual problem of medicine, ensures when cultivated animals is healthy and safe, also helps food safety;
4) fishing of the present invention is beneficial to absorbing of medicine with Chinese medicine ingredients in the compound medicine of Chinese and Western through extracting purification, has significantly increased drug effect, reduces toxic and side effects.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
60 parts of Radix Et Rhizoma Rhei, 60 parts of Cortex Phellodendris, 60 parts of Radix Scutellariaes, 60 parts of Rhizoma Coptidis, 60 parts of Radix Bupleuri, 50 parts in Radix Glycyrrhizae, 50 parts in Gypsum Fibrosum, 50 parts of enrofloxacins.
Take by weighing each raw material by weight ratio, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 5 times of water gagings, decoct backflow 2h, filter; Filtering residue by preceding method reflux, extract,, repeats 3 times again, and merging filtrate adds 5 times of amount dehydrated alcohol and staticly settles 5h, and the dry powdered that grinds adds enrofloxacin again, and mixing namely.
Embodiment 2
1 part of Radix Et Rhizoma Rhei, 1 part of Cortex Phellodendri, 1 part of Radix Scutellariae, 1 part of Rhizoma Coptidis, 1 part of Radix Bupleuri, 1 part in Radix Glycyrrhizae, 1 part in Gypsum Fibrosum, 1 part of enrofloxacin.
Take by weighing each raw material by weight ratio, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 15 times of water gagings, decoct backflow 1h, filter; Filtering residue by preceding method reflux, extract,, repeats 1 time again, and merging filtrate adds 1 times of amount dehydrated alcohol and staticly settles 1h, and the dry powdered that grinds adds enrofloxacin again, and mixing namely.
Embodiment 3
5 parts of Radix Et Rhizoma Rhei, 5 parts of Cortex Phellodendris, 5 parts of Radix Scutellariaes, 10 parts of Rhizoma Coptidis, 5 parts of Radix Bupleuri, 5 parts in Radix Glycyrrhizae, 3 parts in Gypsum Fibrosum, 3 parts of enrofloxacins.
Take by weighing each raw material by weight ratio, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 10 times of water gagings, decoct backflow 3h, filter; Filtering residue by preceding method reflux, extract,, repeats 2 times again, and merging filtrate adds 5 times of amount dehydrated alcohol and staticly settles 5h, and the dry powdered that grinds adds enrofloxacin again, and mixing namely.
Embodiment 4
50 parts of Radix Et Rhizoma Rhei, 50 parts of Cortex Phellodendris, 50 parts of Radix Scutellariaes, 50 parts of Rhizoma Coptidis, 40 parts of Radix Bupleuri, 40 parts in Radix Glycyrrhizae, 40 parts in Gypsum Fibrosum, 40 parts of enrofloxacins.
Take by weighing each raw material by weight ratio, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 10 times of water gagings, decoct backflow 1h, filter; Filtering residue by preceding method reflux, extract,, repeats 3 times again, and merging filtrate adds 5 times of amount dehydrated alcohol and staticly settles 5h, and the dry powdered that grinds adds enrofloxacin again, and mixing namely.
Embodiment 5
10 parts of Radix Et Rhizoma Rhei, 10 parts of Cortex Phellodendris, 10 parts of Radix Scutellariaes, 15 parts of Rhizoma Coptidis, 10 parts of Radix Bupleuri, 10 parts in Radix Glycyrrhizae, 10 parts in Gypsum Fibrosum, 5 parts of enrofloxacins.
Take by weighing each raw material by weight ratio, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 10 times of water gagings, decoct backflow 1h, filter; Filtering residue by preceding method reflux, extract,, repeats 3 times again, and merging filtrate adds 5 times of amount dehydrated alcohol and staticly settles 5h, and the dry powdered that grinds adds enrofloxacin again, and mixing namely.
Embodiment 6
40 parts of Radix Et Rhizoma Rhei, 40 parts of Cortex Phellodendris, 40 parts of Radix Scutellariaes, 40 parts of Rhizoma Coptidis, 35 parts of Radix Bupleuri, 35 parts in Radix Glycyrrhizae, 30 parts in Gypsum Fibrosum, 30 parts of enrofloxacins.
Take by weighing each raw material by weight ratio, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 10 times of water gagings, decoct backflow 1h, filter; Filtering residue by preceding method reflux, extract,, repeats 3 times again, and merging filtrate adds 5 times of amount dehydrated alcohol and staticly settles 5h, and the dry powdered that grinds adds enrofloxacin again, and mixing namely.
Embodiment 7
55 parts of Radix Et Rhizoma Rhei, 55 parts of Cortex Phellodendris, 55 parts of Radix Scutellariaes, 55 parts of Rhizoma Coptidis, 45 parts of Radix Bupleuri, 45 parts in Radix Glycyrrhizae, 45 parts in Gypsum Fibrosum, 45 parts of enrofloxacins.
Take by weighing each raw material by weight ratio, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 10 times of water gagings, decoct backflow 1h, filter; Filtering residue by preceding method reflux, extract,, repeats 3 times again, and merging filtrate adds 5 times of amount dehydrated alcohol and staticly settles 5h, and the dry powdered that grinds adds enrofloxacin again, and mixing namely.
Embodiment 8
45 parts of Radix Et Rhizoma Rhei, 45 parts of Cortex Phellodendris, 45 parts of Radix Scutellariaes, 45 parts of Rhizoma Coptidis, 35 parts of Radix Bupleuri, 35 parts in Radix Glycyrrhizae, 35 parts in Gypsum Fibrosum, 35 parts of enrofloxacins.
Take by weighing each raw material by weight ratio, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 10 times of water gagings, decoct backflow 1h, filter; Filtering residue by preceding method reflux, extract,, repeats 3 times again, and merging filtrate adds 5 times of amount dehydrated alcohol and staticly settles 5h, and the dry powdered that grinds adds enrofloxacin again, and mixing namely.
Embodiment 9
30 parts of Radix Et Rhizoma Rhei, 30 parts of Cortex Phellodendris, 30 parts of Radix Scutellariaes, 30 parts of Rhizoma Coptidis, 20 parts of Radix Bupleuri, 20 parts in Radix Glycyrrhizae, 10 parts in Gypsum Fibrosum, 10 parts of enrofloxacins.
Take by weighing each raw material by weight ratio, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 10 times of water gagings, decoct backflow 1h, filter; Filtering residue by preceding method reflux, extract,, repeats 3 times again, and merging filtrate adds 5 times of amount dehydrated alcohol and staticly settles 5h, and the dry powdered that grinds adds enrofloxacin again, and mixing namely.
Embodiment 10
40 parts of Radix Et Rhizoma Rhei, 40 parts of Cortex Phellodendris, 40 parts of Radix Scutellariaes, 30 parts of Rhizoma Coptidis, 30 parts of Radix Bupleuri, 30 parts in Radix Glycyrrhizae, 10 parts in Gypsum Fibrosum, 5 parts of enrofloxacins.
Take by weighing each raw material by weight ratio, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 10 times of water gagings, decoct backflow 1h, filter; Filtering residue by preceding method reflux, extract,, repeats 3 times again, and merging filtrate adds 5 times of amount dehydrated alcohol and staticly settles 5h, and the dry powdered that grinds adds enrofloxacin again, and mixing namely.
Observe example 1
Adopt the embodiment of the invention 1 bactericidal experimental observation
Test is carried out in big northern agricultural Microbiological Lab.Experimental strain is the bent oar bacillus (gill rot pathogen) of column, pseudomonas fluorescens (erythroderma cause of disease), Aeromonas hydrophila (various bacterial disease pathogen) and visible peristalsis visible intestinal peristalsis point-like Aeromonas (enteritis disease pathogen bacterium), and being the Ministry of Agriculture of Shanghai Aquatic Products Univ. 9CN) fishery animals and plants cause of disease storehouse provides.The experiment medicine is the embodiment of the invention 1 fishing Chinese and Western compound medicament composition and enrofloxacin.
Test is carried out with reference to the requirement of the external medicament sensitivity test technical operation of " pharmacological testing methodology " third edition (Xu Shuyun etc., 2003).The test strain that adopts dull and stereotyped diffusion method will cultivate 18h is diluted to 10 with sterilized water
7The bacteria suspension of cfu/ml pipettes 50 μ L bacteria suspensions to gravy peptone solid medium, and sample pusher pushes away even, dried slightly back tweezer susceptibility sheet pastes the plate media surface that is put in inoculation overtesting bacterial strain, every tablet of medicine that drips 100 μ g, behind 28 ℃ of constant temperature culture 24h, the vernier caliper measurement antibacterial circle diameter.
Result of the test sees Table 1.From table 1 result as can be seen, each bacterial strain is had nothing in common with each other to the sensitivity of medicine.Column bend four kinds of common Aquatic product pathogenic bacterium such as distaff bacterium, pseudomonas fluorescens and Aeromonas hydrophila to the sensitivity of the embodiment of the invention 1 medicine significantly better than enrofloxacin, and equal stronger sensitivity of performance; Aeromonas hydrophila and visible peristalsis visible intestinal peristalsis point-like Aeromonas all show sensitivity preferably to medicine.
The inhibition zone of 1 pair of several frequently seen Aquatic product pathogenic bacterium of table 1 embodiment of the invention is measured
Observe example 2
The therapeutic effect of 2 pairs of fish enteritis diseases of the embodiment of the invention is observed
Test is carried out at big northern agricultural zoopery center.Experiment grouping is divided into drug study group, positive experimental group and negative experimental group, and wherein the drug study group is divided into three groups of F, E and Z again.Establish three repetitions, specifically see Table 2 for every group.Experiment is at indoor aquarium (1 * 0.55 * 0.60M
3) in carry out, experimental period every other day feeding volume is 4% of fish body weight; The experiment water body keeps the dissolved oxygen abundance, and water quality is good.Drug study group and positive experimental group Cyprinus carpio at first carry out the pathogenic experiment of artificial challenge.Mode of infection takes artificial lumbar injection pathogen mode to carry out, and the every tail fish injection of infected group visible peristalsis visible intestinal peristalsis point-like Aeromonas bacterium liquid 0.1mL(bacterial concentration is 2 * 10
8CFU/mL), the every endnote of matched group is penetrated normal saline 0.1mL.The corresponding bait of throwing something and feeding after the infection, F group are thrown something and fed and are added the embodiment of the invention 2 fishing with Chinese and Western compound medicament composition (addition 1g/kg feedstuff); The E group is thrown something and fed and is added enrofloxacin (addition 1g/kg feedstuff); Z organizes the medicine (addition 1g/kg feedstuff) of the embodiment of the invention 2 of the enrofloxacin of throwing something and feeding; Positive controls is thrown something and fed and is not added the feedstuff of medicine; Negative experimental group does not carry out the pathogenic experiment of artificial challenge, the contrast bait of always throwing something and feeding.Observe 15d continuously, record experiment Cyprinus carpio M ﹠ M.
The grouping situation of table 2 bacterial enteritis control experiment
Experimental session, negative experimental group Cyprinus carpio movable and ingest all normal, not morbidity and dead; Positive experimental group cumulative life-incidence reaches 100%, and the average accumulated mortality rate reaches 81.11%; In the drug test group F group M ﹠ M be respectively 100.00% and 17.78%, E group M ﹠ M be respectively 100.00% and 32.22%, Z group M ﹠ M be respectively 100.00% and 40.00%.Concrete condition sees Table 3.
Table 3 bacterial enteritis therapeutic effect experiment information slip
Utilize SPSS13.0 software to carry out one factor analysis of variance to above data.Found that aspect mortality rate, positive experimental group and F group (P＜0.01), E group (P＜0.01) and Z group (P＜0.01) all have utmost point significant difference; The F group is organized with E, there were significant differences for the Z group; Show that three kinds of medicines of F, E and Z play certain therapeutic effect to the Cyprinus carpio bacterial enteritis, wherein the embodiment of the invention 2 fishing significantly are better than other two medicines with Chinese and Western compound medicament composition therapeutic effect.
Observe example 3
The therapeutic effect of 3 pairs of Fish gill rots of the embodiment of the invention is observed
On May 9th, (1) 2011, Tianjin Wuqing District raiser cultures the phenomenon that the pond finds that a small amount of dead fish, fish do not eat food.This fishpond has more than 30 mu, about 1.5 meters of the depth of water, and main foster Cyprinus carpio mixes and takes a small amount of Ctenopharyngodon idellus.Be judged to be bacterial gill rot disease through field diagnostic.Began medication the same day, first " bodyguard " disinfectant sterilization water body of producing with Shaoshan Da Bei farming animal Pharmaceutical, spice is thrown something and fed the fishing of adding the embodiment of the invention 3 with the feedstuff (adding with the 1.5kg/ ton) of Chinese and Western compound medicament composition simultaneously, is used in conjunction 5 days.Second day, continue to find dead fish, but fish begins normal food, dead fish phenomenon stops after 4 days, and the fish food is normal.
(2) the breed pond of more than the 50 mu of water surface of Tianjin Wuqing District Gong surname raiser, main foster Cyprinus carpio, silver carp, flathead, grass etc. have been put in collocation in a suitable place to breed.On August 5th, 2011, discovery had the death of a few tail fish, sharply increased to about 30 tails after 2 days.Field observation on August 7 is found, finds tens of tails near the water surface in the following air port of pool mouth, move about slow, dyspnea, body colour blackout.The fish food is undesired, and appetite lowers, and pick up the dying fish of several tails and observe, the perforation of gill portion, the gill filament turns white and sticks a large amount of mud, and abdominal part has ascites, is diagnosed as bacterial gill rot disease." bodyguard " disinfectant sterilization water body that full pool spilling head Shaoshan Da Bei farming on same day animal Pharmaceutical is produced, spice is thrown something and fed the fishing of adding the embodiment of the invention 3 with the feedstuff (adding with the 1.5kg/ ton) of Chinese and Western compound medicament composition simultaneously, is used in conjunction 5 days.Second day, the fish food increased, and the phenomena of mortality reduce to some extent; Fish death reduces to below ten tails after 3 days, after 5 days, does not have the dead generation of fish substantially, Fish food, movable normal.
(3) 15 mu of intensive fish ponds of Nan County, Hunan Province surnamed Zhang raiser, the main Ctenopharyngodon idellus of supporting, silver carp, flathead have been put in collocation in a suitable place to breed.Found that the part fish is slow in action on August 6th, 2011, ingest and weaken that food ration descends, indivedual fishes peel off, and pull indivedual frank fishes out, check to be diagnosed as bacterial gill rot disease." bodyguard " disinfectant sterilization water body that full pool spilling head Shaoshan on the 7th Da Bei farming in August animal Pharmaceutical is produced, spice is thrown something and fed the fishing of adding the embodiment of the invention 3 with the feedstuff (adding with the 1.5kg/ ton) of Chinese and Western compound medicine simultaneously, is used in conjunction 5 days.The fish food ration rose in the 3rd day, and the morbidity fish reduces, and basic recovery is normal after 4 days.
Observe example 4
The therapeutic effect of 8 pairs of cultured fishes bacterial septicemiaes of the embodiment of the invention is observed
In June, (1) 2011 is Huaian, Jiangsu surnamed Zhang raiser, 25 mu in fishpond, and 1.8 meters of the depth of waters are mainly supported Carassius auratus, and Cyprinus carpio, silver carp, Aristichthys nobilis are put in collocation in a suitable place to breed.Found to have part fish food undesired, slow in action on June 5, food ration descends, and pulls indivedual frank fishes out, checks that discovery body surface and fin ray base portion, the gill cover are congested in a large number, and tentative diagnosis is the bacterial septicemia disease.Afternoon on the same day, spice was thrown something and fed the embodiment of the invention 8 fishing with the feedstuff (adding with the 1.5kg/ ton) of Chinese and Western compound medicine, connected and fed 3 days, simultaneously " bodyguard " full pool spilling head of producing with Shaoshan Da Bei farming animal Pharmaceutical.Second day discovery Fish ingests and obviously strengthens after the medication, and food ration increases.Substantially recover normally not see only swimming fish class that peels off to the 4th day Fish.
A left side, Lianyun Harbour, Jiangsu in May, (2) 2012 surname raiser, 10 mu in fishpond, intensive culture Misgurni anguillicaudati.May 11, find to have indivedual Misgurni anguillicaudati death, whole food ration reduces.More than 20 death occurred, and be bacterial septicemia through field diagnostic in second day.The same day, the spice embodiment of the invention 8 fishing of throwing something and feeding added the Aquatic product multidimensional with the feedstuff of Chinese and Western compound medicine (adding with the 1.5kg/ ton), connected and fed 3 days; " bodyguard " full pool spilling head of producing with Shaoshan Da Bei farming animal Pharmaceutical is used in conjunction 2 times simultaneously.Culture the fish food ration next day and rise, the morbidity fish reduces, and basic recovery is normal after 3 days.
(3) 13 mu of intensive fish ponds of Anxiang, Hunan Province Li raiser, the main Ctenopharyngodon idellus of supporting, silver carp, flathead have been put in collocation in a suitable place to breed.Found that the part fish is slow in action on July 11st, 2011, ingest and weaken that food ration descends, indivedual fishes peel off, and pull indivedual frank fishes out, check to be diagnosed as bacterial septicemia." bodyguard " disinfectant sterilization water body that full pool spilling head Shaoshan Da Bei farming on same day animal Pharmaceutical is produced, spice is thrown something and fed the fishing of adding the embodiment of the invention 8 with the feedstuff (adding with the 1.5kg/ ton) of Chinese and Western compound medicine simultaneously, is used in conjunction 5 days.The fish food ration rose in the 3rd day, did not see dead fish, the basic recovery normally after 4 days.
Observe example 5
9 pairs of cultured fishes erythroderma of embodiment of the invention therapeutic effect is observed
In May, 2011, the pond is cultured in 13 mu of intensive cultures of the surname raiser of Xiangyin County, Hunan Province Tang, the main Ctenopharyngodon idellus of supporting, and silver carp, flathead etc. have been put in collocation in a suitable place to breed.Finding after three days to keep to the edge, do not eat food in the pool under May 10 fingerling, pulls frank fish out and check and find that sick fish body surface festers that scale comes off, and dissects and finds that intestinal has ascites.Be erythroderma after diagnosing." bodyguard " disinfectant sterilization water body that full pool spilling head Shaoshan Da Bei farming on same day animal Pharmaceutical is produced, the spice fishing of adding the embodiment of the invention 9 feedstuff (adding with the 1.5kg/ ton) with the Chinese and Western compound medicine of throwing something and feeding simultaneously.The Fish food is normal gradually after the medication.Medication one week back rehabilitation, the no abnormality seen situation.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. a fishing Chinese and Western compound medicament composition is characterized in that it is made by following component: Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae, Gypsum Fibrosum and enrofloxacin.
2. fishing as claimed in claim 1 Chinese and Western compound medicament composition, it is characterized in that, made by following components by part by weight: Radix Et Rhizoma Rhei 1-60 part, Cortex Phellodendri 1-60 part, Radix Scutellariae 1-60 part, Rhizoma Coptidis 1-60 part, Radix Bupleuri 1-50, Radix Glycyrrhizae 1-50, Gypsum Fibrosum 1-50, enrofloxacin 1-50 part.
3. fishing as claimed in claim 2 Chinese and Western compound medicament composition, it is characterized in that, made by following components by part by weight: Radix Et Rhizoma Rhei 5-50 part, Cortex Phellodendri 5-50 part, Radix Scutellariae 5-50 part, Rhizoma Coptidis 10-50 part, Radix Bupleuri 5-40, Radix Glycyrrhizae 5-40, Gypsum Fibrosum 3-40, enrofloxacin 3-40 part.
4. fishing as claimed in claim 3 Chinese and Western compound medicament composition, it is characterized in that, made by following components by part by weight: Radix Et Rhizoma Rhei 10-40 part, Cortex Phellodendri 10-40 part, Radix Scutellariae 10-40 part, Rhizoma Coptidis 15-40 part, Radix Bupleuri 10-35, Radix Glycyrrhizae 10-35, Gypsum Fibrosum 5-35, enrofloxacin 5-30 part.
5. as each described fishing Chinese and Western compound medicament composition of claim 1～4, it is characterized in that it is powder.
6. one kind prepares the method that the Chinese and Western compound medicament composition is used in each described fishing of claim 1～5, and it comprises the steps:
Take by weighing each component by weight, Radix Et Rhizoma Rhei, Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Radix Bupleuri, Radix Glycyrrhizae and Gypsum Fibrosum are added 5-15 times of water gaging, decoct backflow 1-3h, filter; Filtering residue adds 5-15 times of water gaging, decocts backflow 1-3h, filters, and repeats 1-3 time, and merging filtrate adds 1-5 and doubly measures dehydrated alcohol and staticly settle 1-5h, dry grinding powdered again, and the adding enrofloxacin, mixing is namely.
7. contain each described fishing of claim 1～5 premix material of Chinese and Western compound medicament composition.
8. contain each described fishing of claim 1～5 batch of Chinese and Western compound medicament composition.
9. each described fishing of claim 1～5 medicinal application of Chinese and Western compound medicament composition aspect preparation control bacteriosis of aquatic livestock.
10. application as claimed in claim 9 is characterized in that, described bacterial disease is bacterial septicemia, gill rot, erythroderma or enteritis.
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| CN105168667A (en) * | 2015-10-27 | 2015-12-23 | 上海海洋大学 | Application of Chinese herbal medicament to delaying of bacterial drug resistance |
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| CN105233278A (en) * | 2015-08-31 | 2016-01-13 | 闽南师范大学 | Compound drug for treating bacillary enteritis in freshwater grass carp and its preparation method and application |
| CN105250565A (en) * | 2015-10-26 | 2016-01-20 | 张庆霞 | Chinese and Western compound medicine composition, preparation method thereof and application thereof |
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| CN105214078A (en) * | 2015-08-31 | 2016-01-06 | 闽南师范大学 | A kind ofly prevent and treat pharmaceutical composition of aquatic animal Aeromonas hydrophila disease and its preparation method and application |
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| CN105250565A (en) * | 2015-10-26 | 2016-01-20 | 张庆霞 | Chinese and Western compound medicine composition, preparation method thereof and application thereof |
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| CN107714793A (en) * | 2017-11-24 | 2018-02-23 | 广西吉朋投资有限公司 | A kind of medicament for treating fresh water fish bacterial septicemia |
| CN108619247A (en) * | 2018-08-09 | 2018-10-09 | 集美大学 | A kind of composition and its preparation method and application being combined treatment grouper vibrio alginolyticus disease using Chinese and Western medicine |
| CN108619293A (en) * | 2018-08-09 | 2018-10-09 | 集美大学 | A kind of composition and its preparation method and application being combined treatment grouper vibrio fluvialis disease using Chinese and Western medicine |
| CN108635446A (en) * | 2018-08-09 | 2018-10-12 | 集美大学 | It is a kind of to be combined the composition and its preparation method and application that treatment grouper deforms pseudomonad disease using Chinese and Western medicine |
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Application publication date: 20130814 |