CN100425258C - Compound Chinese medicine composition and its prepn and use - Google Patents
Compound Chinese medicine composition and its prepn and use Download PDFInfo
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- CN100425258C CN100425258C CNB2006100021643A CN200610002164A CN100425258C CN 100425258 C CN100425258 C CN 100425258C CN B2006100021643 A CNB2006100021643 A CN B2006100021643A CN 200610002164 A CN200610002164 A CN 200610002164A CN 100425258 C CN100425258 C CN 100425258C
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
The present invention relates to one kind of compound Chinese medicine and its preparation and use. The compound Chinese medicine is Chinese medicine powder prepared with Chinese goldthread in 2-15 weight portions, skullcap root in 2-30 weight portions, rhubarb in 5-25 weight portions and phellodendron bark in 3-35 weight portions. The present invention also provides the preparation process and use in preventing and treating diseases of aquatic animals of the compound Chinese medicine. The compound Chinese medicine has the features of determined curative effect, less toxic side effect and convenient use.
Description
Technical field
The present invention relates to a kind of traditional Chinese compound medicine composition and method of making the same, and said composition is used to prevent and treat the purposes of diseases such as the explosive hemorrhagic disease, enteritis, gill rot, erythroderma of aquatic animal.
Background technology
The present invention relates to a kind of traditional Chinese compound medicine composition and method of making the same, said composition is used for the aquatic animal disease control.
Compare with the medicine of control livestock and poultry, it is less that approval is used for the medicine of aquatic animal disease control, and major part is the bigger medicine of toxicity.Owing to lack effective medicine, add the abuse medicine, cause the residual incidents of aquatic animal medicine such as chloromycetin, malachite green oxalate frequently to take place, had a strong impact on the export trade of China's aquatic animal product and the reputation of China, endanger public health, destroyed ecological environment.Along with " pollution-free food action plan " propelling in China, Aquatic product with Chinese herbal and crude drugs preparations as a class " triple effect " (efficient, quick-acting, long-acting), " three is little " (toxicity is little, side effect is little, consumption little), harm humans health, the plant source fisheries drug that do not destroy water area ecological environment do not obtain paying close attention in aquatic health is cultured gradually.
Chinese medicine is the most frequently used dosage form with powder on the veterinary clinic, and there is the problem of " thick, big, black " in common Chinese powder.Because common Chinese powder particle diameter is thicker, has reduced its utilization rate, has influenced the performance of drug effect, using dosage is bigger usually.Even carry out purification by liquid extraction, but also have complex process, problems such as investment is big, cost is high, organic solvent pollution, loss of effective components, the wasting of resources.Superfine powder be utilize superfine communication technique break plant cell wall and the granularity that obtains less than 50 microns impalpable powder, be characterized in: powder diameter is little, be evenly distributed, the quality homogeneous, help the release and the absorption of medicine, improve bioavailability of medicament and pharmacodynamics activity, reduce dosage, save medical material, reduce cost.
Press Chinese traditional medicine principle, Rhizoma Coptidis, Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, the Radix Scutellariae heat-clearing and toxic substances removing, hemostasis, the Radix Et Rhizoma Rhei removing pathogenic heat from blood and toxic substance from the body, purging heat and dredging bowels, the compound Chinese medicinal preparation that mixed preparing forms has multiple functions such as anti-inflammation, clearing away heat to stop bleeding, dampness, antiviral; The explosive hemorrhagic disease of suitable control aquatic animal, and diseases such as enteritis, gill rot, erythroderma.
Summary of the invention
The objective of the invention is to, a kind of traditional Chinese compound medicine compositions of control aquatic animal disease of high-efficiency low-toxicity green environmental protection is provided.
Another object of the present invention also is, this traditional Chinese compound medicine preparation of compositions method is provided.
A further object of the present invention is, the purposes of this traditional Chinese compound medicine compositions at preparation control aquatic animal disease medicine is provided.
A kind of traditional Chinese compound medicine compositions provided by the present invention is the powder of being made by certain weight proportion by Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Cortex Phellodendri raw material.
It contains the following weight proportion raw material: Rhizoma Coptidis 2-15 part, Radix Scutellariae 2-30 part, Radix Et Rhizoma Rhei 5-25 part, Cortex Phellodendri 3-35 part.
Preferred raw material weight proportioning is: Rhizoma Coptidis 5-12 part, Radix Scutellariae 10-30 part, Radix Et Rhizoma Rhei 10-20 part, Cortex Phellodendri 10-25 part.
Preferred raw material weight proportioning is: Rhizoma Coptidis 8-10 part, Radix Scutellariae 25-30 part, Radix Et Rhizoma Rhei 15-20 part, Cortex Phellodendri 15-20 part.
This traditional Chinese compound medicine preparation of compositions method is as follows:
(1) taking by weighing the following traditional Chinese medicines material is raw material: Rhizoma Coptidis 2-15 part, Radix Scutellariae 2-30 part, Radix Et Rhizoma Rhei 5-25 part, Cortex Phellodendri 3-35 part.
(2) each component is cleaned oven dry, after micronizing,, stir and make powder promptly in required ratio combination.
(3) the traditional Chinese compound medicine compositions particle diameter of being made by this method is below 50 microns.
Advantage of the present invention and good effect are:
(1) the present invention brings into play the combined effect treatment disease of compound Chinese medicinal preparation, determined curative effect, and instant effect is used to prevent and treat the explosive hemorrhagic disease of aquatic animal, and diseases such as enteritis, gill rot, erythroderma.
(2) the present invention adopts superfine communication technique, increases the surface area of drug particles, strengthens the stripping and the absorption of medicine, thereby improves curative effect of medication.Compare with the powder of common breaking method preparation, drug use dosage reduces, and saves herb resource.
(3) the present invention is a pure Chinese medicinal preparation, the drug residue that toxic and side effects is little, can not produce harm humans health, be difficult for producing drug resistance, free from environmental pollution, do not cause drug-induced disease.
(4) in control aquatic animal disease process, except having medicine and trophism concurrently, also has the effect that improves aquatic animal fertility performance and efficiency of feed utilization.
Description of drawings
The present invention is described in further detail below in conjunction with the drawings and specific embodiments.
Fig. 1 is the volume distributed median curve of SIHUANGFEN ultra micro powder particle diameter.
The specific embodiment
Embodiment 1
9 parts of Rhizoma Coptidis, 27 parts of Radix Scutellariaes, 18 parts of Radix Et Rhizoma Rhei, 18 parts of Cortex Phellodendris, oven dry, micronizing is sieved, and in required ratio combination, stirs and makes powder promptly, and diameter of aspirin particle is controlled at below 50 microns.
Embodiment 2
2 parts of Rhizoma Coptidis, 2 parts of Radix Scutellariaes, 5 parts of Radix Et Rhizoma Rhei, 3 parts of Cortex Phellodendris, oven dry, micronizing is sieved, and in required ratio combination, stirs and makes powder promptly, and diameter of aspirin particle is controlled at below 50 microns.
Embodiment 3
8 parts of Rhizoma Coptidis, 16 parts of Radix Scutellariaes, 15 parts of Radix Et Rhizoma Rhei, 19 parts of Cortex Phellodendris, oven dry, micronizing is sieved, and in required ratio combination, stirs and makes powder promptly, and diameter of aspirin particle is controlled at below 50 microns.
Embodiment 4
15 parts of Rhizoma Coptidis, 30 parts of Radix Scutellariaes, 25 parts of Radix Et Rhizoma Rhei, 35 parts of Cortex Phellodendris, oven dry, micronizing is sieved, and in required ratio combination, stirs and makes powder promptly, and diameter of aspirin particle is controlled at below 50 microns.
Embodiment 5
This traditional Chinese compound medicine compositions is prepared as follows and obtains:
(1) taking by weighing the following traditional Chinese medicines material is raw material: 9 parts of Rhizoma Coptidis, 27 parts of Radix Scutellariaes, 18 parts of Radix Et Rhizoma Rhei, 18 parts of Cortex Phellodendris.
(2) each component is cleaned oven dry, after micronizing,, stir and make powder promptly in required ratio combination.
(3) diameter of aspirin particle is controlled at below 50 microns.
Observe example
Observe example 1
Adopt the observation of 1 pair of Penaeus vannamei growth-promoting effect of the embodiment of the invention
12 mouthfuls of the glass jars of 150cm * 80cm * 80cm, every mouthful of cylinder is adorned water 800L, and covers with window screen cloth, prevents that shrimp from jumping out.The duration of test water temperature is 20～28 ℃, and whole breeding process is with the continuous oxygenation of inflator pump.Before the test indoor environment, glass jar, instrument are carried out thorough disinfection.
Purchase average weight for (0.98 ± 0.25) g Penaeus vannamei, support after 7 days temporarily, discard little, weak individuality, the shrimp of size specification basically identical (average weight be (1.0 ± 0.17) g) is used for testing; The foundation bait of throwing something and feeding during supporting temporarily.Randomly draw 30 tails for every group and measure body weight, and with its initial weight as the test shrimp.Every mouthful of cylinder is put 150 of Penaeus vannameis in a suitable place to breed.
If four groups of A, B, C, D, every group establish again 3 parallel.A, B, C are respectively basic, normal, high drug dose groups, and with the traditional Chinese compound medicine compositions bait feeding of 1g/kg, 2g/kg, 4g/kg, every two weeks was thrown something and fed seven days continuously respectively, all the other times normal feedstuff of throwing something and feeding; D organizes negative matched group, the normal feedstuff of throwing something and feeding.Duration of test writes down water temperature and growth, death condition every day, removes water-bed residual bait, feces and dead individual, and looks the water quality situation and change water 1/3～1/2.Each organizes the corresponding bait twice of throwing something and feeding every day, at 9 o'clock in the morning and afternoon 4 o'clock each once, daily ration, feeding quantity is as the criterion to eat up substantially in 2 hours.Growth test has carried out 60 days.
Through 60 days breed, when growth test finished, the growth promoting function of matched group and each traditional Chinese compound medicine compositions test group Penaeus vannamei the results are shown in Table 1.
Table 1 traditional Chinese compound medicine compositions pharmaceutical chemistry is to the growth of Penaeus vannamei and the facilitation of survival rate
| Group | Average initial body weight (g) | Average whole opisthosoma heavy (g) | Daily gain rate (%) | Survival rate (%) |
| The A group | 0.99 | 2.31 | 0.01423 | 85.2 |
| The B group | 1.01 | 2.69 | 0.01645 | 95.7 |
| The C group | 1.00 | 2.65 | 0.01637 | 97.5 |
| The D group | 1.01 | 2.23 | 0.01328 | 74.3 |
Test data is carried out statistical disposition, and through the ANOVA analytical control, on daily gain rate, two indexs of survival rate, A, B, C organize apparently higher than matched group.There were significant differences with matched group for the A group, P＜0.05; B, C group has utmost point significant difference, P＜0.01 with matched group; There were significant differences with the A group for B, C group, P＜0.05.The daily gain rate of B group is organized a little more than C, and survival rate is organized a little less than C, but does not have significant difference between these two groups, P＞0.05.
Observe example 2
Therapeutic effect to aeromonas hydrophila disease is observed
Adopt the embodiment of the invention 2 traditional Chinese compound medicine combination treatment Cyprinus carpio enteritis, embodiment 2 traditional Chinese compound medicine composition medicines are made the treatment of throwing something and feeding of pharmaceutical chemistry material according to 1g/kg, 2.5g/kg, 5g/kg, 7.5g/kg, 10g/kg concentration, and powder 1g/kg, 2.5g/kg, 5g/kg, 7.5g/kg, the 10g/kg concentration pharmaceutical chemistry of the same composition made from conventional method compare.Result of the test shows that in 360 hours the cure rate of compound Chinese medicinal preparation of the present invention is respectively 85%, 100%, 100%, 100%, 100%, and the cure rate of the preparation that conventional method is made is respectively 49%, 62%, 83%, 94% and 100%.Therefore, the effective using dosage of compound Chinese medicinal preparation in feedstuff that the present invention makes is 0.25%, than what conventional method was made Cyprinus carpio enteritis shown better therapeutical effect.
Observe example 3
Adopt 3 pairs of the embodiment of the invention to improve Trionyx sinensis (Wiegmann) fertility performance observation on effect
Area 180m
2For five in examination Trionyx sinensis Wiegmann pond, numbering A, B, C, D, E.Every about 250 grams of Trionyx sinensis Wiegmann, totally 5000, to divide and support in five Trionyx sinensis Wiegmann ponds, every pond is put 1000 in a suitable place to breed; Randomly draw 50 before putting in a suitable place to breed and measure body weight.Plant regularly sterilizes.
The negative matched group in A pond, the normal feedstuff of always throwing something and feeding; B pond and C pond are the low-dose drugs group, press the traditional Chinese compound medicine compositions bait feeding of 2g/kg, D pond and E pond are the high dose medicament group, throw something and feed respectively by the traditional Chinese compound medicine compositions pharmaceutical chemistry of 4g/kg, every two weeks was thrown something and fed seven days continuously, all the other times normal feedstuff of throwing something and feeding; The bait feeding amount in each pond is consistent.Duration of test regularly detects water quality, sterilizes and use each ponds of operation such as biological preparation all to be consistent.Test has been carried out 90 days altogether.
Through 90 days raising, the Trionyx sinensis Wiegmann in each pond risen catch, to randomly draw 50 and weigh, result of the test sees Table 2.
Table 2 traditional Chinese compound medicine compositions pharmaceutical chemistry is to the growth of Trionyx sinensis (Wiegmann) and the facilitation of premunition
| Pond number | Average initial body weight (g) | Average whole opisthosoma heavy (g) | Daily gain rate (%) | Survival rate (%) |
| A | 261±29 | 526±47 | 0.00782 | 75.6 |
| B | 253±30 | 558±49 | 0.00883 | 91.5 |
| C | 267±18 | 586±53 | 0.00879 | 90.7 |
| D | 258±23 | 566±41 | 0.00876 | 92.4 |
| E | 263±25 | 575±39 | 0.00872 | 91.8 |
Through the ANOVA analytical control, on daily gain rate, two indexs of survival rate, there is utmost point significant difference in B, C, D, E pond apparently higher than the A pond, P＜0.01; And there is not significant difference, P＞0.05 between B, C, D, the E pond.
Observe example 4
Adopt 4 pairs of Ctenopharyngodon idellus common bacterials of embodiment of the invention prevention and treatment of diseases effect research
Enteritis disease, erythroderma, gill rot, bacterial septicemia are bacterial disease common in the Ctenopharyngodon idellus breeding process.
Geographic masters such as Xinzhou, picked at random Hubei, Xiaogan, Qichun, Wuxue City, Flos Jasmini Nudiflori, Jing Zhou, XIANTAO, Jiangxia support the fishing breeding pond of Ctenopharyngodon idellus, and area is 2～30 mu not to be waited, and the depth of water is 1～2 meter; The Ctenopharyngodon idellus commodity bait of throwing something and feeding.The pond of selecting to have taken place in various degree bacterial diseasees such as enteritis disease, erythroderma, gill rot, bacterial septicemia totally 105 mouthfuls carry out therapeutic test.Carry out disease treatment with throw something and feed continuously 6 days, the method for throwing something and feeding continuously 4 days with the ciprofloxacin powder pharmaceutical chemistry of 1.5g/kg of embodiment 4 traditional Chinese compound medicine compositionss, the 2g/kg Chinese medicine compound compositions coarse powder pharmaceutical chemistry of 2g/kg respectively.Write down breed situation and incidence every day.
For the pond of having broken out diseases such as enteritis disease, erythroderma, gill rot, bacterial septicemia in various degree, therapeutic effect sees table 3 for details.
Table 3 medicine is to the therapeutic outcome of Ctenopharyngodon idellus bacterial disease
Table 3 is the result show, embodiment 4 Chinese medicine compound compositionss have significant prevention and therapeutical effect to aquatic animal common bacterial diseases such as enteritis, red skin, gill rot, bacterial septicemiaes, and its treatment effective percentage is significantly better than Chinese medicine compound compositions coarse powder and ciprofloxacin.
Observe example 5
Detect through laser particle size detector (MALVERN VALIDATION INITIATIVE), the particle diameter of Chinese medicine compound compositions wherein has 50% (volume parts) to reach below 12.30 microns below 50 microns, has 90% to reach below 27.26 microns.The results are shown in Figure 1, table 4.
The particle size distribution of table 4 SIHUANGFEN ultra micro powder
Annotate: what volume (%) hurdle was represented is the volume parts of contained ultra micro powder in this particle size range
Claims (6)
1, a kind of traditional Chinese compound medicine compositions of preventing and treating aquatic animal disease is characterized in that being combined by Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, 4 kinds of raw material of Chinese medicine of Cortex Phellodendri, and weight proportion is: Rhizoma Coptidis 2-15 part, Radix Scutellariae 2-30 part, Radix Et Rhizoma Rhei 5-25 part, Cortex Phellodendri 3-35 part.
2, the traditional Chinese compound medicine compositions of the described control aquatic animal disease of claim 1 is characterized in that weight proportion is: Rhizoma Coptidis 5-12 part, Radix Scutellariae 10-30 part, Radix Et Rhizoma Rhei 10-20 part, Cortex Phellodendri 10-25 part.
3, the traditional Chinese compound medicine compositions of the described control aquatic animal disease of claim 2 is characterized in that weight proportion is: Rhizoma Coptidis 8-10 part, Radix Scutellariae 25-30 part, Radix Et Rhizoma Rhei 15-20 part, Cortex Phellodendri 15-20 part.
4, the traditional Chinese compound medicine compositions of each described control aquatic animal disease of claim 1-3 is characterized in that it is a kind of powder.
5, the traditional Chinese compound medicine compositions of the described control aquatic animal disease of claim 4 is characterized in that the powder particle diameter is below 50 microns.
6, as the traditional Chinese compound medicine preparation of compositions method of each described control aquatic animal disease of claim 1-5, it is characterized in that comprising the steps:
(1) taking by weighing the following traditional Chinese medicines material is raw material: Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Cortex Phellodendri;
(2) each component is cleaned oven dry, after micronizing,, stir and make powder promptly in required ratio combination.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100021643A CN100425258C (en) | 2006-01-19 | 2006-01-19 | Compound Chinese medicine composition and its prepn and use |
| PCT/CN2006/002365 WO2007082425A1 (en) | 2006-01-19 | 2006-09-12 | A chinese medicine composition and its process and use |
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| CNB2006100021643A CN100425258C (en) | 2006-01-19 | 2006-01-19 | Compound Chinese medicine composition and its prepn and use |
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| CN100425258C true CN100425258C (en) | 2008-10-15 |
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| WO (1) | WO2007082425A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101653150B (en) * | 2008-08-19 | 2011-08-17 | 天津瑞贝特科技发展有限公司 | Chinese medicinal disinfectant for preventing and controlling aquaculture obstinate bacteria and virus, and preparation method and application thereof |
| CN103127263A (en) * | 2013-02-28 | 2013-06-05 | 张丽香 | Drug for treating oyster perkinsus disease |
| CN103239544A (en) * | 2013-05-29 | 2013-08-14 | 北京大北农动物保健科技有限责任公司 | Fishery Chinese and western compound medicine composition as well as premix compound, batch mixture and application thereof |
| CN103610808A (en) * | 2013-11-13 | 2014-03-05 | 赵林斌 | Traditional Chinese medicine composition for treating turtle enteritis and preparation method thereof |
| CN105816637A (en) * | 2016-03-22 | 2016-08-03 | 五河县金塘水产养殖有限公司金贸园分公司 | Medicament composition for treating bighead sinergsilus |
| CN105816639A (en) * | 2016-04-25 | 2016-08-03 | 固镇县益民养殖专业合作社 | Medicament used for preventing and controlling sinergasilus on aristichthys nobilis |
| CN106620099A (en) * | 2016-10-26 | 2017-05-10 | 临湘市东昇生物科技有限公司 | Inflammation-diminishing and antibacterial Chinese herbal medicine for aquatic animals and preparation method of Chinese herbal medicine |
| CN108077331A (en) * | 2017-12-07 | 2018-05-29 | 湛江市海科生物科技有限公司 | A kind of preparation method and applications of synthesis detoxicating liquid used for aquiculture |
| CN108815281A (en) * | 2018-08-13 | 2018-11-16 | 成都通威三新药业有限公司 | A kind of aquatic products Sanhuang San and preparation method thereof |
| CN109010497A (en) * | 2018-10-29 | 2018-12-18 | 河南后羿实业集团有限公司 | It is a kind of for treating the drug and preparation method thereof of fish bacterial septicemia and enteritis |
| CN111066957A (en) * | 2019-12-19 | 2020-04-28 | 无锡三智生物科技有限公司 | High-efficiency natural plant feed additive for repairing intestinal injury of aquatic animals |
| CN114159547A (en) * | 2021-11-04 | 2022-03-11 | 河南惠康动物药业有限公司 | Doxycycline hydrochloride powder for aquatic products, use method and preparation method thereof |
| CN114246901A (en) * | 2021-12-29 | 2022-03-29 | 江西阳际峰生态农业有限公司 | Medicine for treating stone frog skin disease and its production method |
| CN114468185B (en) * | 2022-03-02 | 2023-11-21 | 中国水产科学研究院长江水产研究所 | Doxycycline slow-release medicinal bait for aquatic products and preparation method thereof |
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- 2006-09-12 WO PCT/CN2006/002365 patent/WO2007082425A1/en active Application Filing
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| CN1887322A (en) | 2007-01-03 |
| WO2007082425A1 (en) | 2007-07-26 |
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