CN103193880A - Hcg粗品的制备方法 - Google Patents
Hcg粗品的制备方法 Download PDFInfo
- Publication number
- CN103193880A CN103193880A CN201310120891XA CN201310120891A CN103193880A CN 103193880 A CN103193880 A CN 103193880A CN 201310120891X A CN201310120891X A CN 201310120891XA CN 201310120891 A CN201310120891 A CN 201310120891A CN 103193880 A CN103193880 A CN 103193880A
- Authority
- CN
- China
- Prior art keywords
- concentrated solution
- crude product
- hcg
- acetone
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012043 crude product Substances 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 102000011022 Chorionic Gonadotropin Human genes 0.000 title abstract description 8
- 108010062540 Chorionic Gonadotropin Proteins 0.000 title abstract description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 82
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 59
- 210000002700 urine Anatomy 0.000 claims abstract description 44
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 13
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 238000005406 washing Methods 0.000 claims abstract description 10
- 208000030507 AIDS Diseases 0.000 claims description 15
- 241000700721 Hepatitis B virus Species 0.000 claims description 15
- 241000700605 Viruses Species 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 12
- 239000001110 calcium chloride Substances 0.000 claims description 11
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 238000001556 precipitation Methods 0.000 claims description 11
- 238000001291 vacuum drying Methods 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 9
- 238000001471 micro-filtration Methods 0.000 claims description 9
- 238000002203 pretreatment Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000005057 refrigeration Methods 0.000 claims description 6
- 238000001223 reverse osmosis Methods 0.000 claims description 6
- 230000002000 scavenging effect Effects 0.000 claims description 6
- 238000005304 joining Methods 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract description 12
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 abstract description 8
- 239000004299 sodium benzoate Substances 0.000 abstract description 8
- 235000010234 sodium benzoate Nutrition 0.000 abstract description 8
- 229940084986 human chorionic gonadotropin Drugs 0.000 abstract description 6
- 239000006228 supernatant Substances 0.000 abstract description 4
- 238000006243 chemical reaction Methods 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 2
- 238000001035 drying Methods 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 55
- 238000000034 method Methods 0.000 description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- 210000004379 membrane Anatomy 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 229960004407 chorionic gonadotrophin Drugs 0.000 description 4
- 230000035935 pregnancy Effects 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002594 sorbent Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 230000004720 fertilization Effects 0.000 description 2
- 210000002826 placenta Anatomy 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- SXHWYMWRVLSNAW-UHFFFAOYSA-L C(C)O.[Cl-].[Ca+2].C(C)(=O)[O-].[Na+] Chemical compound C(C)O.[Cl-].[Ca+2].C(C)(=O)[O-].[Na+] SXHWYMWRVLSNAW-UHFFFAOYSA-L 0.000 description 1
- 208000006332 Choriocarcinoma Diseases 0.000 description 1
- 206010011498 Cryptorchism Diseases 0.000 description 1
- 208000008899 Habitual abortion Diseases 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 210000004252 chorionic villi Anatomy 0.000 description 1
- 210000004246 corpus luteum Anatomy 0.000 description 1
- 201000000160 cryptorchidism Diseases 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 210000003785 decidua Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 231100000545 luteal phase defect Toxicity 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000010999 medical injection Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000009597 pregnancy test Methods 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 229960004249 sodium acetate Drugs 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310120891.XA CN103193880B (zh) | 2013-04-09 | 2013-04-09 | Hcg粗品的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310120891.XA CN103193880B (zh) | 2013-04-09 | 2013-04-09 | Hcg粗品的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN103193880A true CN103193880A (zh) | 2013-07-10 |
CN103193880B CN103193880B (zh) | 2015-04-15 |
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Family Applications (1)
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CN201310120891.XA Active CN103193880B (zh) | 2013-04-09 | 2013-04-09 | Hcg粗品的制备方法 |
Country Status (1)
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CN (1) | CN103193880B (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104479005A (zh) * | 2014-09-05 | 2015-04-01 | 上海丽珠制药有限公司 | 一种促性腺激素纯化的方法 |
CN105085660A (zh) * | 2015-08-21 | 2015-11-25 | 江西浩然生物医药有限公司 | 一种基于超滤浓缩从大体积孕妇尿液中提取绒促性素粗品的方法 |
CN107312081A (zh) * | 2017-08-02 | 2017-11-03 | 临沂华业生物制品有限公司 | 一种hmg粗品的制备方法 |
CN114313347A (zh) * | 2022-03-02 | 2022-04-12 | 山东滨渤生物制品有限公司 | 一种hcg粗品原料的智能化快速收集系统 |
CN114736285A (zh) * | 2022-05-18 | 2022-07-12 | 江苏尤里卡生物科技有限公司 | 一种人绒毛膜促性腺激素的制备装置及制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1302818A (zh) * | 2000-12-12 | 2001-07-11 | 上海惠海生化制品厂 | 一种人绒毛膜促性腺激素及其制备方法 |
-
2013
- 2013-04-09 CN CN201310120891.XA patent/CN103193880B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1302818A (zh) * | 2000-12-12 | 2001-07-11 | 上海惠海生化制品厂 | 一种人绒毛膜促性腺激素及其制备方法 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104479005A (zh) * | 2014-09-05 | 2015-04-01 | 上海丽珠制药有限公司 | 一种促性腺激素纯化的方法 |
CN105085660A (zh) * | 2015-08-21 | 2015-11-25 | 江西浩然生物医药有限公司 | 一种基于超滤浓缩从大体积孕妇尿液中提取绒促性素粗品的方法 |
CN107312081A (zh) * | 2017-08-02 | 2017-11-03 | 临沂华业生物制品有限公司 | 一种hmg粗品的制备方法 |
CN114313347A (zh) * | 2022-03-02 | 2022-04-12 | 山东滨渤生物制品有限公司 | 一种hcg粗品原料的智能化快速收集系统 |
CN114313347B (zh) * | 2022-03-02 | 2022-07-15 | 山东滨渤生物制品有限公司 | 一种hcg粗品原料的智能化快速收集系统 |
CN114736285A (zh) * | 2022-05-18 | 2022-07-12 | 江苏尤里卡生物科技有限公司 | 一种人绒毛膜促性腺激素的制备装置及制备方法 |
CN114736285B (zh) * | 2022-05-18 | 2023-11-03 | 江苏尤里卡生物科技有限公司 | 一种人绒毛膜促性腺激素的制备装置及制备方法 |
Also Published As
Publication number | Publication date |
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CN103193880B (zh) | 2015-04-15 |
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C06 | Publication | ||
PB01 | Publication | ||
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SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHANDONG BINBO BIOLOGICAL PRODUCT CO., LTD. Free format text: FORMER OWNER: ZOUPING COUNTY BINBO BIOLOGY SCIENCE + TECHNOLOGY CO., LTD. Effective date: 20150512 |
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C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Chen Guang Inventor after: Liu Aihong Inventor before: Liu Aihong Inventor before: Chen Fangshan |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LIU AIHONG CHEN FANGSHAN TO: CHEN GUANG LIU AIHONG Free format text: CORRECT: ADDRESS; FROM: 256200 BINZHOU, SHANDONG PROVINCE TO: 272200 JINING, SHANDONG PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20150512 Address after: 272200, No. 88 Jin Yuan Road, fish town, Jinxiang County, Shandong, Jining Patentee after: Shandong Bohai Biological Products Co., Ltd. Address before: 256200 Yang Dicun, Mount Huangshan office, Zouping County, Binzhou, Shandong Patentee before: Zouping County Binbo Biological Science & Technology Co., Ltd. |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation of crude HCG Effective date of registration: 20210625 Granted publication date: 20150415 Pledgee: Jinxiang County sub branch of Postal Savings Bank of China Ltd. Pledgor: Shandong Bohai Biological Products Co.,Ltd. Registration number: Y2021980005330 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |