CN103180732B - 检测抗he4抗体的方法以及诊断和/或预后与he4表达细胞相关的病症的方法 - Google Patents

检测抗he4抗体的方法以及诊断和/或预后与he4表达细胞相关的病症的方法 Download PDF

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Publication number
CN103180732B
CN103180732B CN201180051336.5A CN201180051336A CN103180732B CN 103180732 B CN103180732 B CN 103180732B CN 201180051336 A CN201180051336 A CN 201180051336A CN 103180732 B CN103180732 B CN 103180732B
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seq
antibody
biological sample
antibodies
cancer
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CN103180732A (zh
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卡尔·埃里克·赫尔斯特罗姆
因格戈尔德·赫尔斯特罗姆
刘璞
嘉德·贾法尔
伊丽莎白·思惟舍尔
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University of Washington Center for Commercialization
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57545—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201180051336.5A 2010-08-26 2011-08-26 检测抗he4抗体的方法以及诊断和/或预后与he4表达细胞相关的病症的方法 Active CN103180732B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37738710P 2010-08-26 2010-08-26
US61/377,387 2010-08-26
PCT/US2011/049274 WO2012027631A2 (en) 2010-08-26 2011-08-26 Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells

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Publication Number Publication Date
CN103180732A CN103180732A (zh) 2013-06-26
CN103180732B true CN103180732B (zh) 2017-09-08

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US (2) US20130224772A1 (https=)
EP (1) EP2609429B1 (https=)
JP (1) JP6097688B2 (https=)
CN (1) CN103180732B (https=)
AU (1) AU2011293217A1 (https=)
BR (1) BR112013004458A2 (https=)
CA (1) CA2809368C (https=)
MX (1) MX2013002268A (https=)
RU (1) RU2600891C2 (https=)
WO (1) WO2012027631A2 (https=)

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US7270960B2 (en) * 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
RU2650778C2 (ru) * 2011-02-17 2018-04-17 Фуджиребио Диагностикс, Инк Композиции и способы применения для определения не4а
CN103424551B (zh) * 2013-08-06 2015-08-26 江苏福隆生物技术有限公司 人附睾上皮分泌蛋白4定量测定试剂盒及其检测方法
US10267802B2 (en) * 2015-09-23 2019-04-23 The Board Of Trustees Of The Leland Stanford Junior University Methods of prognosis and diagnosis of ovarian cancer
ES2792055T3 (es) * 2015-12-17 2020-11-06 Hoffmann La Roche Métodos de detección de una recidiva de un adenocarcinoma de pulmón basándose en la proteína 4 del epidídimo humano (HE 4) marcadora y usos relacionados
CN109280084B (zh) * 2018-03-09 2022-04-29 河南大学 一种胶体硒标记的抗he4抗体、试剂盒及其制备方法
CN109480771B (zh) * 2018-10-17 2021-09-07 江西惠肽生物科技有限公司 一种卵巢肿块良恶的确定方法及确定装置
CN110895279B (zh) * 2019-11-27 2023-02-28 普健生物（武汉）科技有限公司 一种检测人附睾分泌蛋白4的化学发光试剂盒
TW202300916A (zh) * 2021-03-22 2023-01-01 美商治療股份有限公司 使用唾液或鼻腔檢體之免疫評估
CN113045663B (zh) * 2021-04-18 2022-04-01 深圳市国创纳米抗体技术有限公司 一种抗he4的纳米抗体1a8及其应用
CN117487018B (zh) * 2023-09-27 2024-05-17 武汉爱博泰克生物科技有限公司 抗人附睾分泌蛋白4的兔单克隆抗体及其应用

Citations (4)

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US20020182619A1 (en) * 2000-11-08 2002-12-05 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer
CN1813188A (zh) * 2001-08-29 2006-08-02 太平洋西北研究院 癌的诊断
CN101473041A (zh) * 2006-01-04 2009-07-01 富士瑞必欧美国公司 He4与其它生化标记物在评估子宫内膜癌和子宫癌中的应用
CN101525614A (zh) * 2009-04-13 2009-09-09 大连美亿德生物科技有限公司 人卵巢癌肿瘤标志物he4酶联免疫诊断试剂盒

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US5017342A (en) * 1988-06-01 1991-05-21 Ortho Diagnostic Systems Inc. Device for immunoassay determinations
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
CA2622332A1 (en) * 2005-09-15 2007-03-22 Val-Chum, S.E.C. Methods of diagnosing ovarian cancer and kits therefor
JP5495159B2 (ja) * 2006-09-13 2014-05-21 オンクイミューン リミテッド 改善されたイムノアッセイ法
BRPI0808655A2 (en) * 2007-03-09 2018-10-23 Tripath Imaging, Inc. he4 monoclonal antibodies and methods for their use.
US8455189B2 (en) * 2007-03-29 2013-06-04 Jeffrey W. Allard Use of HE4 for assessment of breast cancers
WO2010061393A1 (en) * 2008-11-30 2010-06-03 Compugen Ltd. He4 variant nucleotide and amino acid sequences, and methods of use thereof

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US20020182619A1 (en) * 2000-11-08 2002-12-05 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer
CN1813188A (zh) * 2001-08-29 2006-08-02 太平洋西北研究院 癌的诊断
CN101473041A (zh) * 2006-01-04 2009-07-01 富士瑞必欧美国公司 He4与其它生化标记物在评估子宫内膜癌和子宫癌中的应用
CN101525614A (zh) * 2009-04-13 2009-09-09 大连美亿德生物科技有限公司 人卵巢癌肿瘤标志物he4酶联免疫诊断试剂盒

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The HE4 (WFDC2) Protein Is a Biomarker for Ovarian Carcinoma;Ingegerd Hellstrom et al;《CANCER RESEARCH》;20030701;第63卷;3695-3700 *
人附睾上皮分泌蛋白4在卵巢癌诊治中的应用价值;卢仁泉等;《中华检验医学杂志》;20091231;第32卷(第12期);1379-1383 *

Also Published As

Publication number Publication date
WO2012027631A3 (en) 2012-07-19
JP2013536442A (ja) 2013-09-19
EP2609429A4 (en) 2014-03-19
AU2011293217A1 (en) 2013-04-11
MX2013002268A (es) 2014-02-03
CA2809368C (en) 2021-08-24
JP6097688B2 (ja) 2017-03-15
CN103180732A (zh) 2013-06-26
EP2609429A2 (en) 2013-07-03
EP2609429B1 (en) 2017-09-20
CA2809368A1 (en) 2012-03-01
RU2013113314A (ru) 2014-10-10
RU2600891C2 (ru) 2016-10-27
US20180217158A1 (en) 2018-08-02
BR112013004458A2 (pt) 2016-06-07
US20130224772A1 (en) 2013-08-29
WO2012027631A2 (en) 2012-03-01

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