CA2809368C - Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells - Google Patents

Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells Download PDF

Info

Publication number
CA2809368C
CA2809368C CA2809368A CA2809368A CA2809368C CA 2809368 C CA2809368 C CA 2809368C CA 2809368 A CA2809368 A CA 2809368A CA 2809368 A CA2809368 A CA 2809368A CA 2809368 C CA2809368 C CA 2809368C
Authority
CA
Canada
Prior art keywords
antibodies
amount
serum
plasma sample
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2809368A
Other languages
English (en)
French (fr)
Other versions
CA2809368A1 (en
Inventor
Karl Erik Hellstrom
Ingegerd Hellstrom
Pu Liu
Jade Jaffar
Elizabeth Swisher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington Center for Commercialization
Original Assignee
University of Washington Center for Commercialization
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington Center for Commercialization filed Critical University of Washington Center for Commercialization
Publication of CA2809368A1 publication Critical patent/CA2809368A1/en
Application granted granted Critical
Publication of CA2809368C publication Critical patent/CA2809368C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57545—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2809368A 2010-08-26 2011-08-26 Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells Active CA2809368C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37738710P 2010-08-26 2010-08-26
US61/377,387 2010-08-26
PCT/US2011/049274 WO2012027631A2 (en) 2010-08-26 2011-08-26 Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells

Publications (2)

Publication Number Publication Date
CA2809368A1 CA2809368A1 (en) 2012-03-01
CA2809368C true CA2809368C (en) 2021-08-24

Family

ID=45724080

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2809368A Active CA2809368C (en) 2010-08-26 2011-08-26 Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells

Country Status (10)

Country Link
US (2) US20130224772A1 (https=)
EP (1) EP2609429B1 (https=)
JP (1) JP6097688B2 (https=)
CN (1) CN103180732B (https=)
AU (1) AU2011293217A1 (https=)
BR (1) BR112013004458A2 (https=)
CA (1) CA2809368C (https=)
MX (1) MX2013002268A (https=)
RU (1) RU2600891C2 (https=)
WO (1) WO2012027631A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270960B2 (en) * 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
JP5887364B2 (ja) 2011-02-17 2016-03-16 フジレビオ ダイアグノスティックス インコーポレイテッド ＨＥ４ａの測定のための組成物および使用方法
CN103424551B (zh) * 2013-08-06 2015-08-26 江苏福隆生物技术有限公司 人附睾上皮分泌蛋白4定量测定试剂盒及其检测方法
US10267802B2 (en) * 2015-09-23 2019-04-23 The Board Of Trustees Of The Leland Stanford Junior University Methods of prognosis and diagnosis of ovarian cancer
WO2017103034A1 (en) * 2015-12-17 2017-06-22 Roche Diagnostics Gmbh Methods of detecting a relapse of a lung adenocarcinoma based on marker human epididymis protein 4 (he 4) and related uses
CN109280084B (zh) * 2018-03-09 2022-04-29 河南大学 一种胶体硒标记的抗he4抗体、试剂盒及其制备方法
CN109480771B (zh) * 2018-10-17 2021-09-07 江西惠肽生物科技有限公司 一种卵巢肿块良恶的确定方法及确定装置
CN110895279B (zh) * 2019-11-27 2023-02-28 普健生物（武汉）科技有限公司 一种检测人附睾分泌蛋白4的化学发光试剂盒
WO2022204017A1 (en) * 2021-03-22 2022-09-29 Curative Inc. Immunization assessments using saliva or nasal specimen
CN113045663B (zh) * 2021-04-18 2022-04-01 深圳市国创纳米抗体技术有限公司 一种抗he4的纳米抗体1a8及其应用
CN117487018B (zh) * 2023-09-27 2024-05-17 武汉爱博泰克生物科技有限公司 抗人附睾分泌蛋白4的兔单克隆抗体及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017342A (en) * 1988-06-01 1991-05-21 Ortho Diagnostic Systems Inc. Device for immunoassay determinations
WO2002046765A2 (en) * 2000-11-08 2002-06-13 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer
US7270960B2 (en) * 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
DE602006021038D1 (de) * 2005-09-15 2011-05-12 Univ Mcgill Verfahren zur diagnose eines ovarialkarzinoms
CN101473041B (zh) * 2006-01-04 2017-11-14 富士瑞必欧美国公司 He4与其它生化标记物在评估子宫内膜癌和子宫癌中的应用
WO2008032084A1 (en) * 2006-09-13 2008-03-20 Oncimmune Ltd Improved immunoassay methods
CN101802014A (zh) * 2007-03-09 2010-08-11 三路影像公司 He4单克隆抗体和它们的使用方法
JP5144742B2 (ja) * 2007-03-29 2013-02-13 フジレビオ ダイアグノスティックス インコーポレイテッド 乳がんの評価のためのｈｅ４の使用
WO2010061393A1 (en) * 2008-11-30 2010-06-03 Compugen Ltd. He4 variant nucleotide and amino acid sequences, and methods of use thereof
CN101525614A (zh) * 2009-04-13 2009-09-09 大连美亿德生物科技有限公司 人卵巢癌肿瘤标志物he4酶联免疫诊断试剂盒

Also Published As

Publication number Publication date
WO2012027631A2 (en) 2012-03-01
MX2013002268A (es) 2014-02-03
US20180217158A1 (en) 2018-08-02
EP2609429B1 (en) 2017-09-20
EP2609429A4 (en) 2014-03-19
AU2011293217A1 (en) 2013-04-11
CN103180732B (zh) 2017-09-08
RU2600891C2 (ru) 2016-10-27
RU2013113314A (ru) 2014-10-10
CN103180732A (zh) 2013-06-26
US20130224772A1 (en) 2013-08-29
WO2012027631A3 (en) 2012-07-19
JP6097688B2 (ja) 2017-03-15
JP2013536442A (ja) 2013-09-19
EP2609429A2 (en) 2013-07-03
BR112013004458A2 (pt) 2016-06-07
CA2809368A1 (en) 2012-03-01

Similar Documents

Publication Publication Date Title
CA2809368C (en) Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells
US7846692B2 (en) HE4 monoclonal antibodies and methods for their use
EP3026119B1 (en) Use of he4 and other biochemical markers for assessment of ovarian cancers
US20100227335A1 (en) Matrix metalloproteinase-7 (mmp-7) monoclonal antibodies and methods for their use in the detection of ovarian cancer
US8252904B2 (en) Glycodelin monoclonal antibodies and methods for their use in the detection of ovarian cancer
US20090042224A1 (en) Methods for diagnosis and/or prognosis of ovarian cancer
JP6729917B2 (ja) ＥｐｈＡ２ Ｎ末端フラグメント抗体
HK1187100B (en) Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells
HK1187100A (en) Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells
CN115873117B (zh) 一种pd-l1单克隆抗体或其抗原结合片段及检测试剂盒
HK1225411B (en) Use of he4 and other biochemical markers for assessment of ovarian cancers
HK1225411A1 (en) Use of he4 and other biochemical markers for assessment of ovarian cancers
HK1225411A (en) Use of he4 and other biochemical markers for assessment of ovarian cancers

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160819

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 13TH ANNIV.) - STANDARD

Year of fee payment: 13

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240822

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20241021

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20241021

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 14TH ANNIV.) - STANDARD

Year of fee payment: 14

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250819

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250819