CN103180319A - 氨基脲敏感性胺氧化酶抑制剂 - Google Patents

氨基脲敏感性胺氧化酶抑制剂 Download PDF

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Publication number
CN103180319A
CN103180319A CN2011800140213A CN201180014021A CN103180319A CN 103180319 A CN103180319 A CN 103180319A CN 2011800140213 A CN2011800140213 A CN 2011800140213A CN 201180014021 A CN201180014021 A CN 201180014021A CN 103180319 A CN103180319 A CN 103180319A
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alkyl
compound
amino
pyridin
mmol
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CN2011800140213A
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Chinese (zh)
Inventor
大卫·埃文斯
阿莉森·卡利
阿莉森·斯图尔特
迈克尔·希金博特姆
爱德华·萨沃里
伊恩·辛普森
玛丽安娜·尼尔森
马丁·哈拉尔德松
埃里克·努德林
托比亚斯·科尔迈斯特
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BenevolentAI Cambridge Ltd
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Proximagen Ltd
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Publication of CN103180319A publication Critical patent/CN103180319A/zh
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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CN2011800140213A 2010-03-15 2011-03-14 氨基脲敏感性胺氧化酶抑制剂 Pending CN103180319A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1004311.5 2010-03-15
GBGB1004311.5A GB201004311D0 (en) 2010-03-15 2010-03-15 New enzyme inhibitor compounds
PCT/EP2011/053818 WO2011113798A2 (en) 2010-03-15 2011-03-14 New enzyme inhibitor compounds

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CN103180319A true CN103180319A (zh) 2013-06-26

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CN2011800140213A Pending CN103180319A (zh) 2010-03-15 2011-03-14 氨基脲敏感性胺氧化酶抑制剂

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US (1) US9227967B2 (enExample)
EP (2) EP2547677B1 (enExample)
JP (2) JP5643347B2 (enExample)
KR (1) KR20130057971A (enExample)
CN (1) CN103180319A (enExample)
AU (1) AU2011229267B2 (enExample)
BR (1) BR112012023315A2 (enExample)
CA (1) CA2793125A1 (enExample)
DK (1) DK2547677T3 (enExample)
EA (1) EA023038B1 (enExample)
ES (1) ES2538526T3 (enExample)
GB (1) GB201004311D0 (enExample)
MX (1) MX2012010292A (enExample)
NZ (1) NZ602141A (enExample)
SG (1) SG183936A1 (enExample)
WO (1) WO2011113798A2 (enExample)
ZA (1) ZA201206424B (enExample)

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CN106045876A (zh) * 2016-06-07 2016-10-26 四川福思达生物技术开发有限责任公司 一种对氯苯肼盐酸盐的合成方法
CN107074854A (zh) * 2014-09-17 2017-08-18 普罗克斯马根有限公司 咪唑并[4，5‑c]吡啶衍生的SSAO抑制剂
CN107074853A (zh) * 2014-09-17 2017-08-18 普罗克斯马根有限公司 咪唑并[4,5‑c]吡啶衍生的SSAO抑制剂
CN110325533A (zh) * 2016-09-16 2019-10-11 生命医药有限责任公司 Menin-mll相互作用的抑制剂

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GB201115853D0 (en) * 2011-09-14 2011-10-26 Proximagen Ltd New enzyme inhibitor compounds
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US9273056B2 (en) 2011-10-03 2016-03-01 The University Of North Carolina At Chapel Hill Pyrrolopyrimidine compounds for the treatment of cancer
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WO2014026330A1 (en) * 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
US9562047B2 (en) 2012-10-17 2017-02-07 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
WO2014085225A1 (en) 2012-11-27 2014-06-05 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
GB201304526D0 (en) * 2013-03-13 2013-04-24 Proximagen Ltd New compounds
GB201304527D0 (en) * 2013-03-13 2013-04-24 Proximagen Ltd New compounds
AU2014279863A1 (en) 2013-06-12 2016-01-28 Proximagen Limited New therapeutic uses of enzyme inhibitors
US20150291609A1 (en) 2014-04-11 2015-10-15 The University Of North Carolina At Chapel Hill Mertk-specific pyrimidine compounds
WO2015188368A1 (en) 2014-06-13 2015-12-17 Merck Sharp & Dohme Corp. Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles
KR102412146B1 (ko) * 2015-02-11 2022-06-22 주식회사 아이엔테라퓨틱스 소디움 채널 차단제
GB201507031D0 (en) * 2015-04-24 2015-06-10 Proximagen Ltd New pharmaceutical salt forms
US20180360808A1 (en) 2015-12-07 2018-12-20 Benevolentai Cambridge Limited Vap-1 inhibitors for treating pain
US10709708B2 (en) 2016-03-17 2020-07-14 The University Of North Carolina At Chapel Hill Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor
UY38144A (es) 2018-03-12 2019-10-31 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa
PE20242359A1 (es) 2021-06-01 2024-12-16 Janssen Pharmaceutica Nv Derivados de fenil-1h-pirrolo[2,3-c]piridina sustituidos
EP4397655A4 (en) * 2021-10-01 2025-08-06 Yuhan Corp BICYCLIC FUSED RING DERIVATIVE OR SALT THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING IT
JP2024541508A (ja) * 2021-11-24 2024-11-08 ジェネンテック， インコーポレイテッド 治療用インダゾール化合物およびがんの治療における使用方法
EP4436969A2 (en) 2021-11-24 2024-10-02 Genentech, Inc. Bicyclic therapeutic compounds and methods of use in the treatment of cancer
WO2023193790A1 (en) * 2022-04-08 2023-10-12 Janssen Pharmaceutica Nv Crystalline forms of an inhibitor of the menin/mll interaction

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