NZ602141A - Inhibitors of semicarabazide-sensitive amine oxidase - Google Patents
Inhibitors of semicarabazide-sensitive amine oxidaseInfo
- Publication number
- NZ602141A NZ602141A NZ602141A NZ60214111A NZ602141A NZ 602141 A NZ602141 A NZ 602141A NZ 602141 A NZ602141 A NZ 602141A NZ 60214111 A NZ60214111 A NZ 60214111A NZ 602141 A NZ602141 A NZ 602141A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pyrrolo
- chlorophenyl
- pyridin
- piperidin
- methyl
- Prior art date
Links
- 102000004316 Oxidoreductases Human genes 0.000 title 1
- 108090000854 Oxidoreductases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- ZNGWEEUXTBNKFR-UHFFFAOYSA-N 1,4-oxazepane Chemical compound C1CNCCOC1 ZNGWEEUXTBNKFR-UHFFFAOYSA-N 0.000 abstract 1
- FZFSUNWMWPGDQM-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)pyrrolo[2,3-c]pyridine Chemical compound C1=CC(Cl)=CC=C1N1C2=CN=CC=C2C(C=2CCNCC=2)=C1 FZFSUNWMWPGDQM-UHFFFAOYSA-N 0.000 abstract 1
- AZIUJAOZSXAHOD-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(oxan-4-yl)pyrrolo[2,3-c]pyridine Chemical compound C1=CC(Cl)=CC=C1N1C2=CN=CC=C2C(C2CCOCC2)=C1 AZIUJAOZSXAHOD-UHFFFAOYSA-N 0.000 abstract 1
- FUESDKXSKZBKIW-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(piperazin-1-ylmethyl)pyrrolo[2,3-c]pyridine Chemical compound C1=CC(Cl)=CC=C1N1C2=CN=CC=C2C(CN2CCNCC2)=C1 FUESDKXSKZBKIW-UHFFFAOYSA-N 0.000 abstract 1
- AHTLZZSSNIMDDX-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-[(4-methylpiperazin-1-yl)methyl]pyrrolo[2,3-c]pyridine Chemical compound C1CN(C)CCN1CC(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 AHTLZZSSNIMDDX-UHFFFAOYSA-N 0.000 abstract 1
- UXBOPANQZQDGFP-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-[1-(1h-pyrazol-5-ylmethyl)piperidin-4-yl]pyrrolo[2,3-c]pyridine Chemical compound C1=CC(Cl)=CC=C1N1C2=CN=CC=C2C(C2CCN(CC3=NNC=C3)CC2)=C1 UXBOPANQZQDGFP-UHFFFAOYSA-N 0.000 abstract 1
- ICTHLQAYBCVJAA-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-[1-[(1-methylpyrazol-4-yl)methyl]piperidin-4-yl]pyrrolo[2,3-c]pyridine Chemical compound C1=NN(C)C=C1CN1CCC(C=2C3=CC=NC=C3N(C=3C=CC(Cl)=CC=3)C=2)CC1 ICTHLQAYBCVJAA-UHFFFAOYSA-N 0.000 abstract 1
- SNTSYBHIFUFMNR-UHFFFAOYSA-N 1-(4-methylphenyl)-3-(oxan-4-yl)pyrrolo[2,3-c]pyridine Chemical compound C1=CC(C)=CC=C1N1C2=CN=CC=C2C(C2CCOCC2)=C1 SNTSYBHIFUFMNR-UHFFFAOYSA-N 0.000 abstract 1
- KUKHQQQVBFTSPF-UHFFFAOYSA-N 1-(5-chloropyridin-2-yl)-3-(oxan-4-yl)pyrrolo[2,3-c]pyridine Chemical compound N1=CC(Cl)=CC=C1N1C2=CN=CC=C2C(C2CCOCC2)=C1 KUKHQQQVBFTSPF-UHFFFAOYSA-N 0.000 abstract 1
- BCTZJRGISGITFZ-UHFFFAOYSA-N 1-[4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl]-2-(dimethylamino)ethanone Chemical compound C1CN(C(=O)CN(C)C)CCC1C(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 BCTZJRGISGITFZ-UHFFFAOYSA-N 0.000 abstract 1
- VIUQFKJKEZNIOV-UHFFFAOYSA-N 1-[4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl]-2-hydroxyethanone Chemical compound C1CN(C(=O)CO)CCC1C(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 VIUQFKJKEZNIOV-UHFFFAOYSA-N 0.000 abstract 1
- PVKFTMXILNTSOY-UHFFFAOYSA-N 1-[[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]methyl]piperidin-4-ol Chemical compound C1CC(O)CCN1CC(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 PVKFTMXILNTSOY-UHFFFAOYSA-N 0.000 abstract 1
- AGOLRJPOKXWUNE-UHFFFAOYSA-N 2-[1-[[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]methyl]piperidin-4-yl]ethanol Chemical compound C1CC(CCO)CCN1CC(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 AGOLRJPOKXWUNE-UHFFFAOYSA-N 0.000 abstract 1
- SNUPNVCHYSJETG-UHFFFAOYSA-N 2-[4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl]ethanol Chemical compound C1CN(CCO)CCC1C(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 SNUPNVCHYSJETG-UHFFFAOYSA-N 0.000 abstract 1
- ZZPKYLOQWXZCBX-UHFFFAOYSA-N 2-[[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]methylamino]ethanol Chemical compound C12=CN=CC=C2C(CNCCO)=CN1C1=CC=C(Cl)C=C1 ZZPKYLOQWXZCBX-UHFFFAOYSA-N 0.000 abstract 1
- WDTBPWKPLTZJPQ-UHFFFAOYSA-N 2-amino-1-[4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl]ethanone Chemical compound C1CN(C(=O)CN)CCC1C(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 WDTBPWKPLTZJPQ-UHFFFAOYSA-N 0.000 abstract 1
- RLAZHPPTTCCHPL-UHFFFAOYSA-N 2-aminoethyl 4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OCCN)CCC1C(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 RLAZHPPTTCCHPL-UHFFFAOYSA-N 0.000 abstract 1
- GIYVZZSXUQYABS-UHFFFAOYSA-N 3-(3,6-dihydro-2h-pyran-4-yl)-2-methyl-1-(4-methylphenyl)pyrrolo[2,3-c]pyridine Chemical compound C12=CC=NC=C2N(C=2C=CC(C)=CC=2)C(C)=C1C1=CCOCC1 GIYVZZSXUQYABS-UHFFFAOYSA-N 0.000 abstract 1
- PAIVUCFYABFSFP-UHFFFAOYSA-N 3-[4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl]propanenitrile Chemical compound C1=CC(Cl)=CC=C1N1C2=CN=CC=C2C(C2CCN(CCC#N)CC2)=C1 PAIVUCFYABFSFP-UHFFFAOYSA-N 0.000 abstract 1
- SXONDVGUWVLMQZ-UHFFFAOYSA-N 3-amino-1-[4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl]propan-1-one Chemical compound C1CN(C(=O)CCN)CCC1C(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 SXONDVGUWVLMQZ-UHFFFAOYSA-N 0.000 abstract 1
- ZSMAHLWYKQUKJJ-UHFFFAOYSA-N 4-[1-(4-chloro-2-methylphenyl)pyrrolo[2,3-c]pyridin-3-yl]cyclohexan-1-amine Chemical compound CC1=CC(Cl)=CC=C1N1C2=CN=CC=C2C(C2CCC(N)CC2)=C1 ZSMAHLWYKQUKJJ-UHFFFAOYSA-N 0.000 abstract 1
- AOHGNGRSRMZXLI-UHFFFAOYSA-N 4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]cyclohexan-1-amine Chemical compound C1CC(N)CCC1C(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 AOHGNGRSRMZXLI-UHFFFAOYSA-N 0.000 abstract 1
- VPNRBAOCCZTCJQ-UHFFFAOYSA-N 4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]morpholine Chemical compound C1=CC(Cl)=CC=C1N1C2=CN=CC=C2C(N2CCOCC2)=C1 VPNRBAOCCZTCJQ-UHFFFAOYSA-N 0.000 abstract 1
- SFUCPNXUZHQVCG-UHFFFAOYSA-N 4-[4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl]butanenitrile Chemical compound C1=CC(Cl)=CC=C1N1C2=CN=CC=C2C(C2CCN(CCCC#N)CC2)=C1 SFUCPNXUZHQVCG-UHFFFAOYSA-N 0.000 abstract 1
- FGYKHVGONVOUOE-UHFFFAOYSA-N 4-[[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]methyl]morpholine Chemical compound C1=CC(Cl)=CC=C1N1C2=CN=CC=C2C(CN2CCOCC2)=C1 FGYKHVGONVOUOE-UHFFFAOYSA-N 0.000 abstract 1
- GWESHTVIEYBLRM-UHFFFAOYSA-N 4-amino-1-[4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl]butan-1-one Chemical compound C1CN(C(=O)CCCN)CCC1C(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 GWESHTVIEYBLRM-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- QKXXUOISKVZSIE-UHFFFAOYSA-N [1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]methanol Chemical compound C12=CN=CC=C2C(CO)=CN1C1=CC=C(Cl)C=C1 QKXXUOISKVZSIE-UHFFFAOYSA-N 0.000 abstract 1
- ACDAWIRIJKZIBF-UHFFFAOYSA-N [1-[[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]methyl]piperidin-4-yl]methanol Chemical compound C1CC(CO)CCN1CC(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 ACDAWIRIJKZIBF-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- NROZPPILISSGRK-UHFFFAOYSA-N tert-butyl 4-[1-(4-chlorophenyl)pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1C(C1=CC=NC=C11)=CN1C1=CC=C(Cl)C=C1 NROZPPILISSGRK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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| PCT/EP2011/053818 WO2011113798A2 (en) | 2010-03-15 | 2011-03-14 | New enzyme inhibitor compounds |
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| NZ602141A true NZ602141A (en) | 2014-09-26 |
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| GB201115853D0 (en) * | 2011-09-14 | 2011-10-26 | Proximagen Ltd | New enzyme inhibitor compounds |
| EA201490451A1 (ru) | 2011-09-14 | 2014-12-30 | Проксимаген Лимитед | Новые соединения - ингибиторы ферментов |
| US9273056B2 (en) | 2011-10-03 | 2016-03-01 | The University Of North Carolina At Chapel Hill | Pyrrolopyrimidine compounds for the treatment of cancer |
| CA3086105A1 (en) | 2012-05-02 | 2013-11-07 | Boehringer Ingelheim International Gmbh | Substituted 3-haloallylamine inhibitors of ssao and uses thereof |
| KR20150018789A (ko) | 2012-05-22 | 2015-02-24 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 암의 치료를 위한 피리미딘 화합물 |
| WO2014026330A1 (en) * | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| US9562047B2 (en) | 2012-10-17 | 2017-02-07 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| WO2014085225A1 (en) | 2012-11-27 | 2014-06-05 | The University Of North Carolina At Chapel Hill | Pyrimidine compounds for the treatment of cancer |
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| GB201304527D0 (en) * | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
| AU2014279863A1 (en) | 2013-06-12 | 2016-01-28 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
| US20150291609A1 (en) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Mertk-specific pyrimidine compounds |
| WO2015188368A1 (en) | 2014-06-13 | 2015-12-17 | Merck Sharp & Dohme Corp. | Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles |
| GB201416446D0 (en) | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New enzyme inhibitor compounds |
| GB201416444D0 (en) * | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New compounds |
| KR102412146B1 (ko) * | 2015-02-11 | 2022-06-22 | 주식회사 아이엔테라퓨틱스 | 소디움 채널 차단제 |
| GB201507031D0 (en) * | 2015-04-24 | 2015-06-10 | Proximagen Ltd | New pharmaceutical salt forms |
| US20180360808A1 (en) | 2015-12-07 | 2018-12-20 | Benevolentai Cambridge Limited | Vap-1 inhibitors for treating pain |
| US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
| CN106045876B (zh) * | 2016-06-07 | 2018-02-09 | 四川福思达生物技术开发有限责任公司 | 一种对氯苯肼盐酸盐的合成方法 |
| CA3036987A1 (en) * | 2016-09-16 | 2018-03-22 | Vitae Pharmaceuticals, Inc. | Inhibitors of the menin-mll interaction |
| UY38144A (es) | 2018-03-12 | 2019-10-31 | Abbvie Inc | Inhibidores de la señalización mediada por tirosina cinasa |
| PE20242359A1 (es) | 2021-06-01 | 2024-12-16 | Janssen Pharmaceutica Nv | Derivados de fenil-1h-pirrolo[2,3-c]piridina sustituidos |
| EP4397655A4 (en) * | 2021-10-01 | 2025-08-06 | Yuhan Corp | BICYCLIC FUSED RING DERIVATIVE OR SALT THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING IT |
| JP2024541508A (ja) * | 2021-11-24 | 2024-11-08 | ジェネンテック， インコーポレイテッド | 治療用インダゾール化合物およびがんの治療における使用方法 |
| EP4436969A2 (en) | 2021-11-24 | 2024-10-02 | Genentech, Inc. | Bicyclic therapeutic compounds and methods of use in the treatment of cancer |
| WO2023193790A1 (en) * | 2022-04-08 | 2023-10-12 | Janssen Pharmaceutica Nv | Crystalline forms of an inhibitor of the menin/mll interaction |
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| AU8712191A (en) * | 1990-10-15 | 1992-05-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New diazines |
| US6143749A (en) | 1995-06-07 | 2000-11-07 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
| DE19649460A1 (de) | 1996-11-26 | 1998-05-28 | Bayer Ag | Neue substituierte Pyrazolderivate |
| ATE247110T1 (de) * | 1999-09-14 | 2003-08-15 | Aventis Pharma Inc | Benzisoxazolyl-, pyridoisoxazolyl- und benzthienyl-phenoxy derivate als d4 antagonisten |
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| US6982286B2 (en) | 2001-07-12 | 2006-01-03 | Biotie Therapies Corp. | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
| EP1432714B1 (en) | 2001-10-02 | 2008-08-06 | Smithkline Beecham Corporation | Chemical compounds |
| TWI317360B (en) | 2001-11-07 | 2009-11-21 | Schering Corp | Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1 |
| US7456169B2 (en) | 2003-02-27 | 2008-11-25 | Abbott Laboratories Inc. | Heterocyclic kinase inhibitors |
| WO2005014530A2 (en) | 2003-08-08 | 2005-02-17 | La Jolla Pharmaceutical Co. | Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment of diseases |
| JP5069907B2 (ja) | 2003-09-17 | 2012-11-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 縮合複素環式化合物 |
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| ATE524467T1 (de) * | 2005-04-25 | 2011-09-15 | Merck Patent Gmbh | Neuartige aza-heterozyklen als kinase-inhibitoren |
| EA017278B9 (ru) | 2005-06-22 | 2013-01-30 | Кемосентрикс, Инк. | Соединения азаиндазола и способы применения |
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| BRPI0710527B8 (pt) | 2006-04-04 | 2021-05-25 | Fibrogen Inc | compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende |
| GB0610242D0 (en) | 2006-05-23 | 2006-07-05 | Novartis Ag | Organic compounds |
| PE20080928A1 (es) | 2006-10-31 | 2008-08-15 | Schering Corp | Derivados de anilinopiperazina como inhibidores de proteina quinasa |
| CA2671990A1 (en) | 2006-12-06 | 2008-06-12 | Boehringer Ingelheim International Gmbh | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| WO2008088744A1 (en) | 2007-01-17 | 2008-07-24 | Merck & Co., Inc. | Decahydroquinoline analogs as cb2 receptor modulators |
| JP2010525032A (ja) | 2007-05-02 | 2010-07-22 | ノバルティス アーゲー | ヘテロ環化合物及び殺有害生物剤としてのそれらの使用 |
| GB0725103D0 (en) | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Novel compounds |
| CA2712701A1 (en) | 2008-01-31 | 2009-08-06 | Henning Steinhagen | Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals |
| WO2009108551A2 (en) * | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
| EP2334672B1 (en) | 2008-09-16 | 2013-11-20 | Proximagen Limited | 4,5,6,7-Tetrahydroimidazo[4,5-c]pyridine compounds as inhibitors of SSAO |
| WO2010031791A1 (en) | 2008-09-16 | 2010-03-25 | Biovitrum Ab (Publ) | New compounds ii |
| ES2403633T3 (es) | 2008-12-04 | 2013-05-20 | Proximagen Limited | Compuestos de imidazopiridina |
| JP2012211085A (ja) | 2009-08-12 | 2012-11-01 | Kyowa Hakko Kirin Co Ltd | ヘッジホッグシグナル阻害剤 |
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| US9227967B2 (en) | 2016-01-05 |
| EP2547677A2 (en) | 2013-01-23 |
| CA2793125A1 (en) | 2011-09-22 |
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| GB201004311D0 (en) | 2010-04-28 |
| US20130102587A1 (en) | 2013-04-25 |
| CN103180319A (zh) | 2013-06-26 |
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| EP2547677B1 (en) | 2015-05-06 |
| SG183936A1 (en) | 2012-10-30 |
| MX2012010292A (es) | 2013-03-12 |
| KR20130057971A (ko) | 2013-06-03 |
| ZA201206424B (en) | 2013-06-26 |
| EP2927233A1 (en) | 2015-10-07 |
| JP2015017141A (ja) | 2015-01-29 |
| EA023038B1 (ru) | 2016-04-29 |
| JP2013529179A (ja) | 2013-07-18 |
| JP5643347B2 (ja) | 2014-12-17 |
| AU2011229267B2 (en) | 2013-07-18 |
| AU2011229267A1 (en) | 2012-09-20 |
| WO2011113798A2 (en) | 2011-09-22 |
| ES2538526T3 (es) | 2015-06-22 |
| BR112012023315A2 (pt) | 2016-05-24 |
| EA201290880A1 (ru) | 2013-03-29 |
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