CN103118710A - 基于羊毛硫抗生素肽的凋亡成像剂 - Google Patents

基于羊毛硫抗生素肽的凋亡成像剂 Download PDF

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Publication number
CN103118710A
CN103118710A CN2011800462575A CN201180046257A CN103118710A CN 103118710 A CN103118710 A CN 103118710A CN 2011800462575 A CN2011800462575 A CN 2011800462575A CN 201180046257 A CN201180046257 A CN 201180046257A CN 103118710 A CN103118710 A CN 103118710A
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CN
China
Prior art keywords
preparation
conjugate
group
lbp
chelator
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Pending
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CN2011800462575A
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English (en)
Chinese (zh)
Inventor
B.因德雷沃尔
D.希斯科克
B.E.阿尔博
R.布哈拉
M.E.格拉泽
G.W.麦克罗比
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GE Healthcare Ltd
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GE Healthcare Ltd
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Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN103118710A publication Critical patent/CN103118710A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN2011800462575A 2010-09-27 2011-09-27 基于羊毛硫抗生素肽的凋亡成像剂 Pending CN103118710A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1016206.3 2010-09-27
GBGB1016206.3A GB201016206D0 (en) 2010-09-27 2010-09-27 Apoptosis imaging agents
PCT/EP2011/066789 WO2012041862A1 (en) 2010-09-27 2011-09-27 Apoptosis imaging agents based on lantibiotic peptides

Publications (1)

Publication Number Publication Date
CN103118710A true CN103118710A (zh) 2013-05-22

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ID=43128013

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800462575A Pending CN103118710A (zh) 2010-09-27 2011-09-27 基于羊毛硫抗生素肽的凋亡成像剂

Country Status (13)

Country Link
US (1) US20130189186A1 (enExample)
EP (1) EP2621545A1 (enExample)
JP (1) JP2013538819A (enExample)
KR (1) KR20130097780A (enExample)
CN (1) CN103118710A (enExample)
AU (1) AU2011310663A1 (enExample)
BR (1) BR112013006536A2 (enExample)
CA (1) CA2810573A1 (enExample)
GB (1) GB201016206D0 (enExample)
MX (1) MX2013003398A (enExample)
RU (1) RU2013113677A (enExample)
SG (1) SG188464A1 (enExample)
WO (1) WO2012041862A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108144073A (zh) * 2017-12-28 2018-06-12 中山大学附属第医院 靶向磷脂酰乙醇胺的放射性标记三聚乙二醇修饰耐久霉素多肽药物
CN112203698A (zh) * 2018-03-26 2021-01-08 通用电气医疗集团股份有限公司 制剂及制备方法
CN113368264A (zh) * 2020-03-09 2021-09-10 南方医科大学南方医院 放射性标记肉桂霉素，其制备方法及其用途
CN114729927A (zh) * 2019-11-12 2022-07-08 梨花女子大学校产学协力团 细胞成像组合物及使用其的细胞物质成像方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101128219A (zh) * 2004-07-19 2008-02-20 通用电气健康护理有限公司 改进的n4螯合剂缀合物
WO2009114549A2 (en) * 2008-03-10 2009-09-17 Mcw Research Foundation, Inc. 99mtc-labeled 19 amino acid containing peptide for use as phosphatidylethanolamine binding molecular probe and radiopharmaceutical

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0105224D0 (en) * 2001-03-02 2001-04-18 Nycomed Amersham Plc Improved peptide-chelate conjugates
US7034113B2 (en) * 2002-02-22 2006-04-25 Paradigm Diagnostics, Llc Bacteriocin-metal complexes in the detection of pathogens and other biological analytes
US7879801B2 (en) 2002-07-15 2011-02-01 Board Of Regents, The University Of Texas System Compositions comprising cell-impermeant duramycin derivatives
WO2006055855A2 (en) 2004-11-19 2006-05-26 Mcw Research Foundation, Inc. Method of imaging cell death in vivo

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101128219A (zh) * 2004-07-19 2008-02-20 通用电气健康护理有限公司 改进的n4螯合剂缀合物
WO2009114549A2 (en) * 2008-03-10 2009-09-17 Mcw Research Foundation, Inc. 99mtc-labeled 19 amino acid containing peptide for use as phosphatidylethanolamine binding molecular probe and radiopharmaceutical

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108144073A (zh) * 2017-12-28 2018-06-12 中山大学附属第医院 靶向磷脂酰乙醇胺的放射性标记三聚乙二醇修饰耐久霉素多肽药物
CN112203698A (zh) * 2018-03-26 2021-01-08 通用电气医疗集团股份有限公司 制剂及制备方法
CN114729927A (zh) * 2019-11-12 2022-07-08 梨花女子大学校产学协力团 细胞成像组合物及使用其的细胞物质成像方法
US12181409B2 (en) 2019-11-12 2024-12-31 Ewha University-Industry Collaboration Foundation Cell imaging composition and cellular material imaging method using same
CN113368264A (zh) * 2020-03-09 2021-09-10 南方医科大学南方医院 放射性标记肉桂霉素，其制备方法及其用途
CN113368264B (zh) * 2020-03-09 2022-09-30 南方医科大学南方医院 放射性标记肉桂霉素，其制备方法及其用途

Also Published As

Publication number Publication date
GB201016206D0 (en) 2010-11-10
CA2810573A1 (en) 2012-04-05
SG188464A1 (en) 2013-04-30
MX2013003398A (es) 2013-05-30
JP2013538819A (ja) 2013-10-17
KR20130097780A (ko) 2013-09-03
WO2012041862A1 (en) 2012-04-05
RU2013113677A (ru) 2014-11-10
AU2011310663A1 (en) 2013-03-28
US20130189186A1 (en) 2013-07-25
EP2621545A1 (en) 2013-08-07
BR112013006536A2 (pt) 2016-05-31

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Application publication date: 20130522