RU2013113677A - Визуализирующие апоптоз агенты на основе лантибиотических пептидов - Google Patents
Визуализирующие апоптоз агенты на основе лантибиотических пептидов Download PDFInfo
- Publication number
- RU2013113677A RU2013113677A RU2013113677/04A RU2013113677A RU2013113677A RU 2013113677 A RU2013113677 A RU 2013113677A RU 2013113677/04 A RU2013113677/04 A RU 2013113677/04A RU 2013113677 A RU2013113677 A RU 2013113677A RU 2013113677 A RU2013113677 A RU 2013113677A
- Authority
- RU
- Russia
- Prior art keywords
- group
- cys
- imaging agent
- lbp
- formula
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 5
- 108010062877 Bacteriocins Proteins 0.000 title claims abstract 3
- 230000006907 apoptotic process Effects 0.000 title claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 239000002738 chelating agent Substances 0.000 claims abstract 12
- 239000012216 imaging agent Substances 0.000 claims abstract 12
- 239000002184 metal Substances 0.000 claims abstract 8
- 230000002285 radioactive effect Effects 0.000 claims abstract 6
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract 5
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract 5
- 230000004060 metabolic process Effects 0.000 claims abstract 4
- 150000004696 coordination complex Chemical class 0.000 claims abstract 3
- YYLQUHNPNCGKJQ-NHYDCYSISA-N (3R)-3-hydroxy-L-aspartic acid Chemical compound OC(=O)[C@@H](N)[C@@H](O)C(O)=O YYLQUHNPNCGKJQ-NHYDCYSISA-N 0.000 claims abstract 2
- 150000001413 amino acids Chemical class 0.000 claims abstract 2
- 150000001768 cations Chemical class 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 150000002337 glycosamines Chemical class 0.000 claims abstract 2
- 238000001727 in vivo Methods 0.000 claims abstract 2
- 230000002401 inhibitory effect Effects 0.000 claims abstract 2
- 125000005647 linker group Chemical group 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229940126601 medicinal product Drugs 0.000 claims 3
- 239000012217 radiopharmaceutical Substances 0.000 claims 3
- 229940121896 radiopharmaceutical Drugs 0.000 claims 3
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 238000002600 positron emission tomography Methods 0.000 claims 2
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 2
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- KSSJBGNOJJETTC-UHFFFAOYSA-N COC1=C(C=CC=C1)N(C1=CC=2C3(C4=CC(=CC=C4C=2C=C1)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC(=CC=C1C=1C=CC(=CC=13)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC=C(C=C1)OC Chemical compound COC1=C(C=CC=C1)N(C1=CC=2C3(C4=CC(=CC=C4C=2C=C1)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC(=CC=C1C=1C=CC(=CC=13)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC=C(C=C1)OC KSSJBGNOJJETTC-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000012800 visualization Methods 0.000 claims 1
- 238000007794 visualization technique Methods 0.000 claims 1
- WYVKPHCYMTWUCW-YUPRTTJUSA-N Cys-Thr Chemical compound C[C@@H]([C@@H](C(=O)O)NC(=O)[C@H](CS)N)O WYVKPHCYMTWUCW-YUPRTTJUSA-N 0.000 abstract 2
- FFOKMZOAVHEWET-IMJSIDKUSA-N Ser-Cys Chemical compound OC[C@H](N)C(=O)N[C@@H](CS)C(O)=O FFOKMZOAVHEWET-IMJSIDKUSA-N 0.000 abstract 1
- SBMNPABNWKXNBJ-BQBZGAKWSA-N Ser-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CO SBMNPABNWKXNBJ-BQBZGAKWSA-N 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1016206.3 | 2010-09-27 | ||
| GBGB1016206.3A GB201016206D0 (en) | 2010-09-27 | 2010-09-27 | Apoptosis imaging agents |
| PCT/EP2011/066789 WO2012041862A1 (en) | 2010-09-27 | 2011-09-27 | Apoptosis imaging agents based on lantibiotic peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013113677A true RU2013113677A (ru) | 2014-11-10 |
Family
ID=43128013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013113677/04A RU2013113677A (ru) | 2010-09-27 | 2011-09-27 | Визуализирующие апоптоз агенты на основе лантибиотических пептидов |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20130189186A1 (enExample) |
| EP (1) | EP2621545A1 (enExample) |
| JP (1) | JP2013538819A (enExample) |
| KR (1) | KR20130097780A (enExample) |
| CN (1) | CN103118710A (enExample) |
| AU (1) | AU2011310663A1 (enExample) |
| BR (1) | BR112013006536A2 (enExample) |
| CA (1) | CA2810573A1 (enExample) |
| GB (1) | GB201016206D0 (enExample) |
| MX (1) | MX2013003398A (enExample) |
| RU (1) | RU2013113677A (enExample) |
| SG (1) | SG188464A1 (enExample) |
| WO (1) | WO2012041862A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108144073A (zh) * | 2017-12-28 | 2018-06-12 | 中山大学附属第医院 | 靶向磷脂酰乙醇胺的放射性标记三聚乙二醇修饰耐久霉素多肽药物 |
| GB201804835D0 (en) * | 2018-03-26 | 2018-05-09 | Ge Healthcare As | Formulation and method of preparation |
| EP4057002B1 (en) | 2019-11-12 | 2024-08-07 | Ewha University-Industry Collaboration Foundation | Cell imaging composition and cellular material imaging method using same |
| CN113368264B (zh) * | 2020-03-09 | 2022-09-30 | 南方医科大学南方医院 | 放射性标记肉桂霉素，其制备方法及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0105224D0 (en) * | 2001-03-02 | 2001-04-18 | Nycomed Amersham Plc | Improved peptide-chelate conjugates |
| US7034113B2 (en) * | 2002-02-22 | 2006-04-25 | Paradigm Diagnostics, Llc | Bacteriocin-metal complexes in the detection of pathogens and other biological analytes |
| US7879801B2 (en) | 2002-07-15 | 2011-02-01 | Board Of Regents, The University Of Texas System | Compositions comprising cell-impermeant duramycin derivatives |
| GB0416062D0 (en) * | 2004-07-19 | 2004-08-18 | Amersham Plc | Improved N4 chelator conjugates |
| US20060110323A1 (en) | 2004-11-19 | 2006-05-25 | Ming Zhao | Method of imaging cell death in vivo |
| AU2009223677A1 (en) | 2008-03-10 | 2009-09-17 | Mcw Research Foundation, Inc. | 99mTc-labeled 19 amino acid containing peptide for use as phosphatidylethanolamine binding molecular probe and radiopharmaceutical |
-
2010
- 2010-09-27 GB GBGB1016206.3A patent/GB201016206D0/en not_active Ceased
-
2011
- 2011-09-27 CN CN2011800462575A patent/CN103118710A/zh active Pending
- 2011-09-27 BR BR112013006536A patent/BR112013006536A2/pt not_active Application Discontinuation
- 2011-09-27 RU RU2013113677/04A patent/RU2013113677A/ru not_active Application Discontinuation
- 2011-09-27 MX MX2013003398A patent/MX2013003398A/es unknown
- 2011-09-27 WO PCT/EP2011/066789 patent/WO2012041862A1/en not_active Ceased
- 2011-09-27 AU AU2011310663A patent/AU2011310663A1/en not_active Abandoned
- 2011-09-27 US US13/876,187 patent/US20130189186A1/en not_active Abandoned
- 2011-09-27 CA CA2810573A patent/CA2810573A1/en not_active Abandoned
- 2011-09-27 JP JP2013529674A patent/JP2013538819A/ja not_active Withdrawn
- 2011-09-27 EP EP11761385.1A patent/EP2621545A1/en not_active Withdrawn
- 2011-09-27 KR KR1020137010727A patent/KR20130097780A/ko not_active Withdrawn
- 2011-09-27 SG SG2013017306A patent/SG188464A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG188464A1 (en) | 2013-04-30 |
| US20130189186A1 (en) | 2013-07-25 |
| JP2013538819A (ja) | 2013-10-17 |
| MX2013003398A (es) | 2013-05-30 |
| KR20130097780A (ko) | 2013-09-03 |
| BR112013006536A2 (pt) | 2016-05-31 |
| AU2011310663A1 (en) | 2013-03-28 |
| EP2621545A1 (en) | 2013-08-07 |
| GB201016206D0 (en) | 2010-11-10 |
| WO2012041862A1 (en) | 2012-04-05 |
| CA2810573A1 (en) | 2012-04-05 |
| CN103118710A (zh) | 2013-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20140929 |