CN103108631B - 用于治疗疼痛的联合药物 - Google Patents

用于治疗疼痛的联合药物 Download PDF

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Publication number
CN103108631B
CN103108631B CN201180029405.2A CN201180029405A CN103108631B CN 103108631 B CN103108631 B CN 103108631B CN 201180029405 A CN201180029405 A CN 201180029405A CN 103108631 B CN103108631 B CN 103108631B
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CN
China
Prior art keywords
pain
combination
dimethylamino
methyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180029405.2A
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English (en)
Chinese (zh)
Other versions
CN103108631A (zh
Inventor
K.席内
P.布隆斯芬克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42395008&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN103108631(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of CN103108631A publication Critical patent/CN103108631A/zh
Application granted granted Critical
Publication of CN103108631B publication Critical patent/CN103108631B/zh
Expired - Fee Related legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201180029405.2A 2010-06-15 2011-06-14 用于治疗疼痛的联合药物 Expired - Fee Related CN103108631B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10006202 2010-06-15
EP10006202.5 2010-06-15
PCT/EP2011/002905 WO2011157391A1 (en) 2010-06-15 2011-06-14 Pharmaceutical combination for the treatment of pain

Publications (2)

Publication Number Publication Date
CN103108631A CN103108631A (zh) 2013-05-15
CN103108631B true CN103108631B (zh) 2015-08-26

Family

ID=42395008

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180029405.2A Expired - Fee Related CN103108631B (zh) 2010-06-15 2011-06-14 用于治疗疼痛的联合药物

Country Status (29)

Country Link
US (3) US8846765B2 (https=)
EP (2) EP2992877A1 (https=)
JP (3) JP6133772B2 (https=)
KR (1) KR101831616B1 (https=)
CN (1) CN103108631B (https=)
AR (1) AR081931A1 (https=)
AU (2) AU2011267474B2 (https=)
BR (1) BR112012031836A2 (https=)
CA (1) CA2796774C (https=)
CL (1) CL2012002551A1 (https=)
CO (1) CO6602157A2 (https=)
CY (1) CY1117118T1 (https=)
DK (1) DK2582366T3 (https=)
EC (2) ECSP12012217A (https=)
ES (1) ES2560676T3 (https=)
HK (1) HK1215787A1 (https=)
HR (1) HRP20151327T1 (https=)
HU (1) HUE026619T2 (https=)
IL (1) IL221926A (https=)
MX (1) MX2012014482A (https=)
NZ (1) NZ602625A (https=)
PE (2) PE20130243A1 (https=)
PL (1) PL2582366T3 (https=)
PT (1) PT2582366E (https=)
RS (1) RS54439B1 (https=)
RU (2) RU2589692C2 (https=)
SI (1) SI2582366T1 (https=)
WO (1) WO2011157391A1 (https=)
ZA (1) ZA201208646B (https=)

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US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
WO2013138322A1 (en) * 2012-03-12 2013-09-19 Janssen Pharmaceutica Nv Esketamine for the treatment of treatment-refractory or treatment-resistant depression
PT3598971T (pt) 2013-01-22 2024-06-20 Vistagen Therapeutics Inc ¿formas de dosagem e utilizações terapêuticas de l-4 cloroquinurenina
US20140274981A1 (en) 2013-03-15 2014-09-18 Janssen Pharmaceutica Nv Pharmaceutical composition of s-ketamine hydrochloride
CN103655523A (zh) * 2013-12-24 2014-03-26 南京艾德凯腾生物医药有限责任公司 他喷他多组合物
KR20170013890A (ko) * 2014-05-06 2017-02-07 노쓰웨스턴유니버시티 Nmdar 조절 화합물의 조합물
KR20170040800A (ko) 2014-08-13 2017-04-13 얀센 파마슈티카 엔.브이. 우울증 치료 방법
AU2015318123A1 (en) 2014-09-15 2017-03-30 Janssen Pharmaceutica Nv Val66Met (SNP rs6265) genotype specific dosing regimens and methods for the treatment of depression
US20160332962A1 (en) 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
CN107847469A (zh) 2015-06-27 2018-03-27 美国神农制药责任有限公司 氯胺酮透皮递送系统
US20200009081A1 (en) 2017-09-13 2020-01-09 Janssen Pharmaceutica N.V. Delivery Of Esketamine For The Treatment Of Depression
KR20240011237A (ko) 2017-12-22 2024-01-25 얀센 파마슈티카 엔브이 우울증 치료를 위한 에스케타민
JP7532718B2 (ja) * 2018-04-12 2024-08-14 アナベックス ライフ サイエンス コーポレイション 物質のａ２－７３結晶多形組成物およびそれらの使用方法
JP2022524008A (ja) 2019-03-05 2022-04-27 ヤンセン ファーマシューティカルズ，インコーポレーテッド うつ病の治療のためのエスケタミン

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WO2009094563A2 (en) * 2008-01-25 2009-07-30 Xenoport, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use
WO2010025931A2 (en) * 2008-09-05 2010-03-11 Grünenthal GmbH Pharmaceutical combination

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1125221A (zh) * 1994-07-23 1996-06-26 格吕伦塔尔有限公司 具有药理效果的1-苯基-3-二甲氨基丙烷化合物
US6248789B1 (en) * 1996-08-29 2001-06-19 Stuart L. Weg Administration of ketamine to manage pain and to reduce drug dependency
CN1607947A (zh) * 2001-10-24 2005-04-20 格吕伦塔尔有限公司 包含3－(3－二甲基氨基－1－乙基－2－甲基－丙基)苯酚并能提供活性成分的延迟释放的药物
WO2003053427A1 (de) * 2001-12-21 2003-07-03 Grünenthal GmbH Verwendung von (+)-(1s,2s)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol als antiemetikum
WO2009094563A2 (en) * 2008-01-25 2009-07-30 Xenoport, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use
WO2010025931A2 (en) * 2008-09-05 2010-03-11 Grünenthal GmbH Pharmaceutical combination

Also Published As

Publication number Publication date
US20110306674A1 (en) 2011-12-15
US20170333369A1 (en) 2017-11-23
RU2675261C2 (ru) 2018-12-18
WO2011157391A1 (en) 2011-12-22
CA2796774A1 (en) 2011-12-22
AU2016219643A1 (en) 2016-09-15
HK1215787A1 (en) 2016-09-15
HK1184370A1 (zh) 2014-01-24
SI2582366T1 (sl) 2016-02-29
KR101831616B1 (ko) 2018-04-04
NZ602625A (en) 2014-03-28
JP6133772B2 (ja) 2017-05-24
PT2582366E (pt) 2016-01-26
US8846765B2 (en) 2014-09-30
JP6423036B2 (ja) 2018-11-14
JP2015232015A (ja) 2015-12-24
CO6602157A2 (es) 2013-01-18
US10813890B2 (en) 2020-10-27
CA2796774C (en) 2020-06-02
MX2012014482A (es) 2013-02-21
JP2013528629A (ja) 2013-07-11
AU2016219643B2 (en) 2018-04-12
RU2016119041A (ru) 2017-11-20
RU2589692C2 (ru) 2016-07-10
EP2582366B1 (en) 2015-10-28
AU2011267474B2 (en) 2016-05-26
DK2582366T3 (en) 2015-12-07
EP2582366A1 (en) 2013-04-24
ZA201208646B (en) 2013-09-25
ES2560676T3 (es) 2016-02-22
ECSP19047259A (es) 2019-07-31
US20140309311A1 (en) 2014-10-16
AR081931A1 (es) 2012-10-31
HUE026619T2 (en) 2016-06-28
AU2011267474A1 (en) 2013-01-10
PL2582366T3 (pl) 2016-04-29
RS54439B1 (sr) 2016-06-30
CN103108631A (zh) 2013-05-15
HRP20151327T1 (hr) 2016-01-01
JP2017141277A (ja) 2017-08-17
BR112012031836A2 (pt) 2016-11-08
RU2013101515A (ru) 2014-07-20
JP6197007B2 (ja) 2017-09-13
PE20160531A1 (es) 2016-06-05
IL221926A (en) 2015-08-31
ECSP12012217A (es) 2012-11-30
EP2992877A1 (en) 2016-03-09
PE20130243A1 (es) 2013-03-22
KR20130111945A (ko) 2013-10-11
CY1117118T1 (el) 2017-04-05
CL2012002551A1 (es) 2012-11-09

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