CN103068789B - 选择性间位氯化烷基苯胺的方法 - Google Patents

选择性间位氯化烷基苯胺的方法 Download PDF

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Publication number
CN103068789B
CN103068789B CN201180040323.8A CN201180040323A CN103068789B CN 103068789 B CN103068789 B CN 103068789B CN 201180040323 A CN201180040323 A CN 201180040323A CN 103068789 B CN103068789 B CN 103068789B
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CN
China
Prior art keywords
reaction
diethylaniline
sulfuric acid
mixture
chlorination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201180040323.8A
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English (en)
Chinese (zh)
Other versions
CN103068789A (zh
Inventor
尼古拉斯·比勒尔
斯特凡·埃林格尔
马丁纳·富勒
维克托·拉德尼亚克
康斯坦策·米勒
莱奥·施密德
科尔内利娅·祖尔塔西勒
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Lonza AG
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Lonza AG
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Publication of CN103068789A publication Critical patent/CN103068789A/zh
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Publication of CN103068789B publication Critical patent/CN103068789B/zh
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C07C211/64—Quaternary ammonium compounds having quaternised nitrogen atoms bound to carbon atoms of six-membered aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201180040323.8A 2010-08-20 2011-08-16 选择性间位氯化烷基苯胺的方法 Expired - Fee Related CN103068789B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10173496.0 2010-08-20
EP10173496 2010-08-20
PCT/EP2011/004099 WO2012022460A1 (en) 2010-08-20 2011-08-16 Process for the selective meta-chlorination of alkylanilines

Publications (2)

Publication Number Publication Date
CN103068789A CN103068789A (zh) 2013-04-24
CN103068789B true CN103068789B (zh) 2015-11-25

Family

ID=43430640

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180040323.8A Expired - Fee Related CN103068789B (zh) 2010-08-20 2011-08-16 选择性间位氯化烷基苯胺的方法

Country Status (8)

Country Link
US (1) US9193667B2 (https=)
EP (1) EP2606028A1 (https=)
JP (1) JP5917514B2 (https=)
KR (1) KR20130099929A (https=)
CN (1) CN103068789B (https=)
BR (1) BR112013003937A2 (https=)
CA (1) CA2808258A1 (https=)
WO (1) WO2012022460A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9340487B2 (en) * 2010-10-14 2016-05-17 Lonza Ltd. Halogenated diethyltoluenediamines

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962336A (en) * 1973-04-18 1976-06-08 Hoechst Aktiengesellschaft Process for the preparation of 5-chloro-2-toluidine
GB1521136A (en) * 1974-10-16 1978-08-16 Hoechst Ag Chlorination of aromatic amines and their derivatives
US4401833A (en) * 1980-11-15 1983-08-30 Bayer Aktiengesellschaft Process for the preparation of 4-chloro-2,6-dialkylanilines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE499591C (de) * 1926-10-07 1930-06-10 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Chlorsubstitutionsprodukten des 1-Amino-2, 4-dimethylbenzols
JPS4910938B1 (https=) * 1970-02-05 1974-03-13
US3890388A (en) * 1974-03-04 1975-06-17 Du Pont Ring chlorination of ortho-toluidine
FR2487823A1 (fr) * 1980-08-01 1982-02-05 Rhone Poulenc Agrochimie Procede de preparation selective d'anilines metachlorees
DE3042242A1 (de) * 1980-11-08 1982-06-09 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von m-halogensubstituierten anilinen
FR2532305A1 (fr) * 1982-08-24 1984-03-02 Rhone Poulenc Agrochimie Procede de preparation d'anilines metachlorees
JPS62178548A (ja) * 1986-01-31 1987-08-05 Mitsui Toatsu Chem Inc ３−クロロ−４−イソプロピルアニリンの製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962336A (en) * 1973-04-18 1976-06-08 Hoechst Aktiengesellschaft Process for the preparation of 5-chloro-2-toluidine
GB1521136A (en) * 1974-10-16 1978-08-16 Hoechst Ag Chlorination of aromatic amines and their derivatives
US4401833A (en) * 1980-11-15 1983-08-30 Bayer Aktiengesellschaft Process for the preparation of 4-chloro-2,6-dialkylanilines

Also Published As

Publication number Publication date
JP5917514B2 (ja) 2016-05-18
JP2013538201A (ja) 2013-10-10
WO2012022460A1 (en) 2012-02-23
US20130338400A1 (en) 2013-12-19
EP2606028A1 (en) 2013-06-26
US9193667B2 (en) 2015-11-24
KR20130099929A (ko) 2013-09-06
CN103068789A (zh) 2013-04-24
CA2808258A1 (en) 2012-02-23
BR112013003937A2 (pt) 2016-07-12

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Granted publication date: 20151125

Termination date: 20170816