CN103055220A - Pure Chinese medicinal composition for treating nematodosis of poultry and preparation method of pure Chinese medicinal composition - Google Patents
Pure Chinese medicinal composition for treating nematodosis of poultry and preparation method of pure Chinese medicinal composition Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicinal composition for treating the nematodosis of poultry. The pure Chinese medicinal composition is characterized in that the pure Chinese medicinal composition is prepared by mixing the following components in part by weight: 15 to 35 parts of pharbitis seed, 15 to 25 parts of almond, 25 to 45 parts of areca catechu, 10 to 20 parts of realgar, 15 to 35 parts of stone-like omphalia, 15 to 35 parts of rhizoma coptidis, 30 to 50 parts of hawthorn, 20 to 40 parts of white paeony root, 25 to 45 parts of dark plum fruit, 25 to 45 parts of sessile stemona root and 25 to 45 parts of Szechwan chinaberry fruit. The invention has the advantages that the pure Chinese medicinal composition is rational in formula, easy to prepare, free of toxic or side effects, medicament residues and medicament resistance and high in superfine grinding degree and bioavailability, can treat both symptoms and root causes and has remarkable curative effects, and clinical results prove that the pure Chinese medicinal composition has a special effect of treating the infectious bursal disease of the poultry.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of livestock nematodiasis and preparation method thereof, belong to the animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to the treatment livestock nematodiasis and preparation method thereof.
Background technology
The domestic animal nematicide mainly contains ascarid, whipworm, nodular worm, ancylostome and bar worm etc., when domestic animal during by parasitism, show as that spirit is relatively poor, food less, become thin, the symptoms such as anemia, dysentery, feces band mucus, during infringement pulmonary, cough, the symptoms such as rapid breathing appear; There is hyperemia, hemorrhage etc. in pulmonary.During the infringement intestinal, vomiting, sleeping ground, intestinal obstruction or enterorrhexis appear.Cut open congested, hemorrhage, the ulcer of the visible intestinal tube mucosa of inspection, include white fraction.The domestic animal mortality rate can reach about 15%, endangers very serious.
This disease almost spreads all over all livestock culturing countries of the world, is widely distributed.The primary disease western medicine mainly uses antiparasitic and antibiosis anti-inflammatory drug, though receive certain effect, because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, clinical practice is very limited or bans use of.At present, treat the most frequently used Chinese medicine of this disease because its prescription is unreasonable or just simple pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine.
Therefore research and develop a kind of pure Chinese medicine composition for the treatment of livestock nematodiasis, micronizing, bioavailability height, the specific medicament for the treatment of both the principal and secondary aspects of a disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simply, micronizing, high, the treating both the principal and secondary aspects of a disease of bioavailability, pure Chinese medicine composition of effective treatment livestock nematodiasis of successful and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of livestock nematodiasis, by following component by weight mixed preparing form: Semen Pharbitidis 15-35 part, Semen Armeniacae Amarum 15-25 part, Semen Arecae 25-45 part, Realgar 10-20 part, Omphalia 15-35 part, Rhizoma Coptidis 15-35 part, Fructus Crataegi 30-50 part, Radix Paeoniae Alba 20-40 part, Fructus Mume 25-45 part, Radix Stemonae 25-45 part, Fructus Toosendan 25-45 part.
Described various component optimum ratio amount is: 25 parts of Semen Pharbitidis, 20 parts in Semen Armeniacae Amarum, 35 parts of Semen Arecaes, 15 parts of Realgars, 25 parts of Omphalias, 25 parts of Rhizoma Coptidis, 40 parts of Fructus Crataegis, 30 parts of the Radix Paeoniae Albas, 35 parts of Fructus Mumes, 35 parts of the Radixs Stemonae, 30 parts of Fructus Toosendans.
A kind of preparation method for the treatment of the pure Chinese medicine composition of livestock nematodiasis, carry out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Semen Pharbitidis 15-35 part, Semen Armeniacae Amarum 15-25 part, Semen Arecae 25-45 part, Realgar 10-20 part, Omphalia 15-35 part, Rhizoma Coptidis 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Fructus Crataegi 30-50 part, Radix Paeoniae Alba 20-40 part, Fructus Mume 25-45 part, Radix Stemonae 25-45 part, Fructus Toosendan 25-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
The medicinal property of each component is as follows:
Semen Pharbitidis: bitter, hot, cold, return lung, kidney, large intestine, small intestine meridian, have the diuretic relieving constipation, eliminate the phlegm by the function of drink, eliminating stagnated food and killing intestinal worms; Curing mainly edema, ascites, dyspepsia malnutrition due to parasitic infestation, swollen ulcer drug, QI rising in reverse order breathes with cough etc.
Semen Armeniacae Amarum: bitter, tepor, return lung, large intestine channel, have the function of relieving cough and asthma, loosening bowel to relieve constipation; Cure mainly cough and asthma, dryness of the intestine constipation etc.
The Radix Stemonae: sweet, bitter, return lung meridian, have the function of nourishing the lung to arrest cough, parasite killing; Cure mainly cough, enterobiasis, ascariasis, scabies, body louse etc.
Realgar: hot, temperature, poisonous, return liver, large intestine channel, have the function of detoxifcation parasite killing, removing dampness and eliminating phlegm; Cure mainly carbuncle sore tumefacting virus, abdominal pain due to worm stagnation, infantile convulsion, scabies etc.
Omphalia: bitter, cold, return stomach, large intestine channel, have the function of eliminating stagnated food and killing intestinal worms; Cure mainly cestode, ancylostome, ascariasis, abdominal pain due to worm stagnation, edema, ascites, dyspepsia malnutrition due to parasitic infestation etc.
Rhizoma Coptidis: bitter, cold, return spleen, stomach, large intestine, gallbladder, heart channel, have the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.
Fructus Crataegi: sour, sweet, tepor, return stomach, spleen, Liver Channel, have the function of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis; Cure mainly dyspeptic abdominal flatulence, dyspepsia, prolonged lochia etc.
The Radix Paeoniae Alba: bitter, acid, be slightly cold, return liver, spleen channel, have the suppressing the hyperactive liver pain relieving, a function of the yin fluid astringing that nourishes blood; Cure mainly deficiecny of liver-YIN, deficiency-heat, dysentery stomachache, spasm of the limbs etc.
Fructus Mume: sour, puckery, warm, return large intestine channel, have the function of relieving diarrhea with astringents, hemostasis, anthelmintic; Cure mainly dysentery, have blood in stool, proctoptosis, malnutrition due to parasitic infestation etc.
Semen Arecae: bitter, hot, warm, return stomach, large intestine channel, have the function of anthelmintic, removing food stagnancy, circulation of qi promoting, diuretic; Cure mainly taeniasis, the impaction of rumen, dyspeptic abdominal distention, constipation, edema etc.
Fructus Toosendan: bitter, cold, return liver, small intestinal, urinary bladder channel, have the function of soothing liver-QI, circulation of qi promoting, pain relieving, anthelmintic; Cure mainly abdominal distention, abdominal pain due to worm stagnation etc.
More than all herbal medicines according to the theoretical compatible combination of Chinese veterinarian, for paathogenic factor and clinical symptoms and the pathological change of livestock nematodiasis, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition, treating both the principal and secondary aspects of a disease, cost is low, and it is wide to draw materials, micronizing, bioavailability height, curative effect highly significant.The present invention is theoretical according to Chinese veterinarian, optimizes this ten medicine simply, and they are formed according to optimum ratio, and clinical practice proves that the treatment livestock nematodiasis is had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of livestock nematodiasis and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 150 parts of Semen Pharbitidis, 150 parts in Semen Armeniacae Amarum, 250 parts of Semen Arecaes, 100 parts of Realgars, 150 parts of Omphalias, 150 parts of Rhizoma Coptidis, mix 5-10 minute to even;
(3) take by weighing by weight 300 parts of Fructus Crataegis, 200 parts of the Radix Paeoniae Albas, 250 parts of Fructus Mumes, 250 parts of the Radixs Stemonae, 250 parts of Fructus Toosendans, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of livestock nematodiasis and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of Semen Pharbitidis, 200 parts in Semen Armeniacae Amarum, 350 parts of Semen Arecaes, 150 parts of Realgars, 250 parts of Omphalias, 250 parts of Rhizoma Coptidis, mix 5-10 minute to even;
(3) take by weighing by weight 400 parts of Fructus Crataegis, 300 parts of the Radix Paeoniae Albas, 350 parts of Fructus Mumes, 350 parts of the Radixs Stemonae, 350 parts of Fructus Toosendans, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 3
A kind of pure Chinese medicine Chinese medicine composition for the treatment of livestock nematodiasis and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 350 parts of Semen Pharbitidis, 250 parts in Semen Armeniacae Amarum, 450 parts of Semen Arecaes, 200 parts of Realgars, 350 parts of Omphalias, 350 parts of Rhizoma Coptidis, mix 5-10 minute to even;
(3) take by weighing by weight 500 parts of Fructus Crataegis, 400 parts of the Radix Paeoniae Albas, 450 parts of Fructus Mumes, 450 parts of the Radixs Stemonae, 450 parts of Fructus Toosendans, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Clinical trial:
It is the ill pig of ascaris suum disease at 50kg-51kg, Laboratory Diagnosed that the clinical experiment animal is selected 90 ages in days, body weight, and the complete feed of feeding is raised separately in ill pig isolation, and be divided at random 3 groups, every group 30,3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " anthelmintic is loose " by specification; Present composition group can be for oral administration with product of the present invention (embodiment of the invention 1 prepared compositions), admixes feedstuff in 1.5% ratio, every day 2-3 time, is used in conjunction 3-5 days; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.5 days excrement check ovum 1 time after the medication, identify and counting.Calculate the clean rate of driving of medicine and count deworming rates with smart, and carry out statistical analysis.Computational methods: drive clean rate=complete anthelmintic number of animals/experimental animal number * 100%, worm's ovum number * 100% before smart meter deworming rates=(worm's ovum number after the front worm's ovum number-administration of administration)/administration.Result's (testing the 5th day) when following table is the experiment end.
Table 1 is the applicable cases contrast of the present invention and other medicines treatment ascaris suum disease:
| Numbering | Group | Drive clean rate % | Smart meter deworming rates % |
| I | The blank group | 10 | 62.1 |
| II | The loose group of anthelmintic | 80 | 87.9 |
| III | Chinese medicine composition group of the present invention | 86.7 | 97.7 |
This clinical effectiveness statistical analysis, the loose group of present composition treatment group and anthelmintic are compared difference all significantly (P＜0.05) aspect clean rate, the smart meter deworming rates two driving.
It is the ill pig of Gaster Sus domestica nematicide at 55kg-60kg, Laboratory Diagnosed that the clinical experiment animal is selected 100-110 age in days, body weight.Ill pig isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, 30 every group, 3 groups of feeding environments are identical, experimental period 7 days; The blank group is left intact, and the medicine matched group uses treatment with " the loose group of anthelmintic " by specification; Present composition group is with product of the present invention (embodiment of the invention 1 prepared compositions) the ill pig of feeding, and a day dose is: per 100 restrain 200 kilograms of present composition spices feeds every day 1 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.5 days excrement check ovum 1 time after the medication, identify and counting.Calculate the clean rate of driving of medicine and count deworming rates with smart, and carry out statistical analysis.Computational methods: drive clean rate=complete anthelmintic number of animals/experimental animal number * 100%, worm's ovum number * 100% before smart meter deworming rates=(worm's ovum number after the front worm's ovum number-administration of administration)/administration.Result's (testing the 5th day) when following table is the experiment end.
Table 2 is situation contrasts of the present invention and other medicines treatment Gaster Sus domestica nematicide:
| Numbering | Group | Drive clean rate % | Smart meter deworming rates % |
| I | The blank group | 10 | 55.8 |
| II | The loose group of anthelmintic | 73.3 | 85.6 |
| III | Chinese medicine composition group of the present invention | 83.3 | 98.9 |
This clinical effectiveness statistical analysis, the loose group of present composition group and anthelmintic are compared difference all extremely remarkable (P＜0.01) aspect clean rate and the smart meter deworming rates two driving.
Safety testing:
Choose 10 of 70 age in days health pig, 5 times of spices according to the embodiment of the invention 1 made compositions recommended dose were fed 10 days, during the medication, health pig is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment livestock nematodiasis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. pure Chinese medicine composition for the treatment of livestock nematodiasis, it is characterized in that by following component by weight mixed preparing form: Semen Pharbitidis 15-35 part, Semen Armeniacae Amarum 15-25 part, Semen Arecae 25-45 part, Realgar 10-20 part, Omphalia 15-35 part, Rhizoma Coptidis 15-35 part, Fructus Crataegi 30-50 part, Radix Paeoniae Alba 20-40 part, Fructus Mume 25-45 part, Radix Stemonae 25-45 part, Fructus Toosendan 25-45 part.
2. the pure Chinese medicine composition for the treatment of livestock nematodiasis according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of Semen Pharbitidis, 20 parts in Semen Armeniacae Amarum, 35 parts of Semen Arecaes, 15 parts of Realgars, 25 parts of Omphalias, 25 parts of Rhizoma Coptidis, 40 parts of Fructus Crataegis, 30 parts of the Radix Paeoniae Albas, 35 parts of Fructus Mumes, 35 parts of the Radixs Stemonae, 30 parts of Fructus Toosendans.
3. the preparation method of the pure Chinese medicine composition of a treatment livestock nematodiasis according to claim 1 and 2 is characterized in that carrying out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Semen Pharbitidis 15-35 part, Semen Armeniacae Amarum 15-25 part, Semen Arecae 25-45 part, Realgar 10-20 part, Omphalia 15-35 part, Rhizoma Coptidis 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Fructus Crataegi 30-50 part, Radix Paeoniae Alba 20-40 part, Fructus Mume 25-45 part, Radix Stemonae 25-45 part, Fructus Toosendan 25-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110074270A (en) * | 2019-06-05 | 2019-08-02 | 四川农业大学 | A kind of feed for sheep for adding expelling parasite Chinese herbal medicine |
| CN110742200A (en) * | 2019-12-11 | 2020-02-04 | 中国科学院东北地理与农业生态研究所 | Compound Chinese herbal medicine feed additive for resisting ruminant nematode |
| CN112933172A (en) * | 2021-04-13 | 2021-06-11 | 四川省畜牧科学研究院 | Traditional Chinese medicine compound extract for treating intestinal coccidiosis of rabbits and application thereof |
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- 2012-12-09 CN CN201210549158.5A patent/CN103055220B/en not_active Expired - Fee Related
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| CN85104477A (en) * | 1985-06-08 | 1986-12-03 | 宋远忠 | The compound method of compounded pills of Darkplum-Buplear-Realgar |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110074270A (en) * | 2019-06-05 | 2019-08-02 | 四川农业大学 | A kind of feed for sheep for adding expelling parasite Chinese herbal medicine |
| CN110742200A (en) * | 2019-12-11 | 2020-02-04 | 中国科学院东北地理与农业生态研究所 | Compound Chinese herbal medicine feed additive for resisting ruminant nematode |
| CN112933172A (en) * | 2021-04-13 | 2021-06-11 | 四川省畜牧科学研究院 | Traditional Chinese medicine compound extract for treating intestinal coccidiosis of rabbits and application thereof |
| CN112933172B (en) * | 2021-04-13 | 2022-05-06 | 四川省畜牧科学研究院 | Traditional Chinese medicine compound extract for treating intestinal coccidiosis of rabbits and application thereof |
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