CN110742200A - Compound Chinese herbal medicine feed additive for resisting ruminant nematode - Google Patents

Compound Chinese herbal medicine feed additive for resisting ruminant nematode Download PDF

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CN110742200A
CN110742200A CN201911265967.1A CN201911265967A CN110742200A CN 110742200 A CN110742200 A CN 110742200A CN 201911265967 A CN201911265967 A CN 201911265967A CN 110742200 A CN110742200 A CN 110742200A
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herbal medicine
chinese herbal
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ruminant
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钟荣珍
房义
贺志雄
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Northeast Institute of Geography and Agroecology of CAS
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Northeast Institute of Geography and Agroecology of CAS
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/10Feeding-stuffs specially adapted for particular animals for ruminants
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K10/00Animal feeding-stuffs
    • A23K10/30Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87Re-use of by-products of food processing for fodder production

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Abstract

The invention discloses a compound Chinese herbal medicine feed additive for resisting ruminant nematode, which comprises the following components in parts by weight: 4-8 parts of hawthorn, 1-4 parts of bighead atractylodes rhizome, 4-8 parts of medicated leaven, 3-6 parts of orange peel, 1-4 parts of malt, 1-4 parts of allicin, 4-8 parts of pharbitis seed, 2-4 parts of radix stemonae and 1-4 parts of gallnut, and the preparation method comprises the following steps: s1, weighing the hawthorn, the bighead atractylodes rhizome, the medicated leaven, the orange peel, the malt, the allicin, the pharbitidis seed, the radix stemonae and the gallnut in parts by mass, putting into an extraction tank, and adding 4-6 times of water to soak for 48 hours; s2, collecting the extracting solution; the dried powder is a compound Chinese herbal medicine feed additive for resisting ruminant nematode. The compound Chinese herbal medicine feed additive for resisting the ruminant nematodes can inhibit the reproduction of the nematodes in intestinal tracts of the ruminant and kill the nematodes in the intestinal tracts, so that the ruminant is prevented from suffering from chronic and consumptive diseases.

Description

Compound Chinese herbal medicine feed additive for resisting ruminant nematode
Technical Field
The invention relates to the technical field of ruminant nematode resistance, in particular to a compound Chinese herbal medicine feed additive for resisting ruminant nematodes.
Background
Ruminant (ch u) animals are a sub-order of the artiodactyla. Rumination refers to eating and feeding food which is half digested in the stomach and then chewing again in the mouth, and a ruminant is an animal which has a ruminant digestion mode. Usually some herbivores, because the fibres of the plants are relatively indigestible. Ruminants generally eat food in a hurry, and particularly coarse feed is swallowed into rumens without being chewed sufficiently, and after the rumens are soaked and softened for a period of time, the food returns to the oral cavity again through retching, and is chewed again, mixed with saliva again and swallowed into the rumens again. With the exception of camels and vicunas, these animals do not have upper incisors but rather have stiff gums in place to support the lower incisors from biting. When eating, ruminants roughly chew retropharyngeal food (mainly vegetation and twigs) and then lie or sit returning the food back into the mouth for a fine chew.
When nematodes are parasitized in the intestinal tracts of many ruminants, the nematodes have antagonistic action on the rumination capability of the ruminants, and the low rumination capability of the ruminants can cause diseases such as reduction of digestive tract function, food retention in rumen, rumen flatulence and no adverse promotion.
In particular, many species of nematodes parasitize in the digestive tract and intestinal tract of cattle and sheep, and generally present symptoms of chronic and wasting diseases. The sick livestock have rough and disorderly hair, emaciation, anemia, mental retardation and herding. When the infection is serious, the disease is dysentery with mucus and blood, but the disease is rarely caused by the strongylostomosis. And finally death is caused by extreme debilitation. Common symptoms caused by parasitic nematodes in the lung are cough, emaciation, anemia, rough and dull hair, dyspnea in severe cases, dyspnea, and even death from a ventricular rest. Sheep suffering from large pulmonary nematode disease often run nasal discharge, dry around nostrils to form crusts, and sneeze.
The effects of parasitic nematodes in the intestinal tract on ruminant protein and mineral metabolism;
effect on ruminant protein metabolism: the nutritional studies of the physiological metabolism of ruminants by a number of gastrointestinal nematodes have led to a full recognition of the hazards of parasitic infections. Infection of cattle and sheep with parasites mainly results in reduced feed utilization and daily gain, slow tissue deposition and impaired bone development.
After slaughtering cattle and sheep infected with nematodes in the gastrointestinal tract, the protein content in the muscle is lower than in uninfected animals 0, probably because after infection with nematodes in the gastrointestinal tract the host preferentially synthesizes plasma proteins using more feed and tissue proteins, repairs the damaged intestinal mucosa and activates various metabolic enzymes, which results in a partial reduction in protein deposition for the tissue. If the host animal feed protein is maintained at a level at which it was not infected, a deficiency in body proteins will result.
Effect on mineral metabolism in ruminants: yu et al applied inter-organ catheter and isotope tracer technology, combined with leucine labeling, and carried out quantitative studies on protein turnover of sheep infected with parasites, and it is believed that not only is the protein demand increased, but also the loss of endogenous protein increases after cattle and sheep are infected with gastrointestinal nematodes. Liu et al found that glutathione levels in blood of sheep after infection with gastrointestinal nematodes were reduced, and it was necessary to investigate the relationship between glutathione nutrition and gastrointestinal nematode resistance in cattle and sheep, since glutathione is involved in animal energy metabolism and immune responses. In fact, many parasitic infections result in the loss of endogenous nitrogen and increased depletion of endogenous glutathione by roundworms infected with animals, so that the daily ration of infected cattle and sheep is increased in a proper amount to increase the protein level, especially the sulfur-containing amino acid level.
At present, chemical medicines are utilized at home and abroad to achieve remarkable effects on prevention and control of gastrointestinal parasitic infection, but cattle and sheep can quickly generate drug resistance, and drug residues damage human health through animal products, so that the development cost of expensive new drugs and the food safety problem promote research and search for new insect expelling methods, and ruminants such as cattle and sheep can generate drug resistance to western medicines, so that the ruminants adopt traditional Chinese medicines to resist insects.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a compound Chinese herbal medicine feed additive for resisting ruminant nematode.
A compound Chinese herbal medicine feed additive for resisting ruminant nematode comprises the following raw materials in parts by weight: 4-8 parts of hawthorn, 1-4 parts of bighead atractylodes rhizome, 4-8 parts of medicated leaven, 3-6 parts of orange peel, 1-4 parts of malt, 1-4 parts of allicin, 4-8 parts of pharbitis seed, 2-4 parts of radix stemonae and 1-4 parts of gallnut.
Further, the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 6-8 parts of hawthorn, 2-4 parts of bighead atractylodes rhizome, 6-8 parts of medicated leaven, 4-6 parts of orange peel, 2-4 parts of malt, 2-4 parts of allicin, 6-8 parts of pharbitis seed, 3-4 parts of radix stemonae and 2-4 parts of gallnut.
Further, the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 6 parts of hawthorn, 3 parts of bighead atractylodes rhizome, 6 parts of medicated leaven, 4 parts of orange peel, 2 parts of malt, 2 parts of allicin, 6 parts of pharbitis seed, 3 parts of radix stemonae and 3 parts of gallnut.
Further, the mass ratio of the allicin to the pharbitidis seed to the stemona root to the gallnut is 1-4:4-8:2-4: 1-4.
Furthermore, the compound Chinese herbal medicine feed additive for resisting ruminant nematode is compound Chinese herbal medicine powder or compound Chinese herbal medicine extract preparation.
A preparation method of a compound Chinese herbal medicine feed additive for resisting ruminant nematodes comprises the following preparation steps:
s1, weighing the hawthorn, the bighead atractylodes rhizome, the medicated leaven, the orange peel, the malt, the allicin, the pharbitidis seed, the radix stemonae and the gallnut in parts by mass, putting the materials into an extraction tank, and adding 4-6 times of water to soak the materials for 48 hours to obtain an extracting solution;
s2, decocting Chinese gall in water twice: adding 8 times of water for the first time, decocting for 1-2 hr, adding 6 times of water for the second time, decocting for 0.5-1.5 hr, filtering to remove residue, and heating and concentrating to obtain Galla chinensis liquid preparation;
s3, collecting the extract, adding Galla chinensis liquid preparation, repeatedly extracting for 3-6 times, adjusting pH to 4.0-6.5, heating and reflux extracting for 1-2 times, each time for 1-2 hr;
s4, filtering the liquid obtained in the step S3 for 2-4 times, combining extracting solutions, concentrating for 2-4 times, and drying to obtain a dry extract;
s5, crushing the dry extract into dry powder, wherein the dry powder is a compound Chinese herbal medicine feed additive for resisting ruminant nematodes, and the parts are parts by weight.
Each bag of the compound Chinese herbal medicine powder is 1000 g; the administration method is mixing.
The compound Chinese herbal medicine feed additive for resisting the ruminant nematodes can inhibit the reproduction of the nematodes in intestinal tracts of the ruminant and kill the nematodes in the intestinal tracts, so that the ruminant is prevented from suffering from chronic and consumptive diseases, the digestive disorder of the ruminant is eliminated, the effect is more obvious, the onset time is faster, the cure rate is higher, the compound Chinese herbal medicine feed additive can help the ruminant reduce blood pressure and protect cardiovascular health, and the compound Chinese herbal medicine feed additive is good in curative effect, safe and reliable, non-toxic, harmless, free of residue, simple in process, low in cost and strong in practicability. Can be used in the field of prevention and treatment of ruminant breeding industry.
The technical scheme of the invention is that the compound Chinese herbal medicine extract preparation is prepared from the following raw materials: hawthorn, largehead atractylodes rhizome, medicated leaven, orange peel, malt, allicin, pharbitis seed, radix stemonae and gallnut.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
The first embodiment is as follows:
a compound Chinese herbal medicine feed additive for resisting ruminant nematode comprises the following raw materials in parts by weight: 4 parts of hawthorn, 1 part of bighead atractylodes rhizome, 4 parts of medicated leaven, 3 parts of orange peel, 1 part of malt, 1 part of allicin, 4 parts of pharbitis seed, 2 parts of radix stemonae and 1 part of gallnut.
The specific preparation method comprises the following steps:
s1, weighing the hawthorn, the bighead atractylodes rhizome, the medicated leaven, the orange peel, the malt, the allicin, the pharbitidis seed, the radix stemonae and the gallnut in parts by mass, putting the weighed materials into an extraction tank, and adding 4 times of water to soak the materials for 48 hours to obtain an extracting solution;
s2, decocting Chinese gall in water twice: adding 8 times of water for the first time, decocting for 1 hr, adding 6 times of water for the second time, decocting for 0.5 hr, filtering to remove residue, and heating and concentrating to obtain Galla chinensis liquid preparation;
s3, collecting the extract, adding the gallnut liquid preparation, repeatedly extracting for 3 times, adjusting the pH value to 4.0, heating and refluxing for extraction for 1 time, and extracting for 1 hour each time;
s4, filtering the liquid obtained in the step S3 by 2 times, combining extracting solutions, concentrating for 2 times, and drying to obtain a dry extract;
s5, crushing the dry extract into dry powder, wherein the dry powder is a compound Chinese herbal medicine feed additive for resisting ruminant nematodes, and the parts are parts by weight.
The compound Chinese herbal medicine powder is 1000 g per bag, and the taking method is mixing materials.
Example two:
a compound Chinese herbal medicine feed additive for resisting ruminant nematode comprises the following raw materials in parts by weight: 6 parts of hawthorn, 3 parts of bighead atractylodes rhizome, 6 parts of medicated leaven, 4 parts of orange peel, 2 parts of malt, 2 parts of allicin, 6 parts of pharbitis seed, 3 parts of radix stemonae and 3 parts of gallnut.
The specific preparation method comprises the following steps:
s1, weighing the hawthorn, the bighead atractylodes rhizome, the medicated leaven, the orange peel, the malt, the allicin, the pharbitidis seed, the radix stemonae and the gallnut in parts by mass, putting the materials into an extraction tank, and adding 5 times of water to soak the materials for 48 hours to obtain an extracting solution;
s2, decocting Chinese gall in water twice: adding 8 times of water for the first time, decocting for 1.5 hr, adding 6 times of water for the second time, decocting for 1 hr, filtering to remove residue, and heating and concentrating to obtain Galla chinensis liquid preparation;
s3, collecting the extract, adding the gallnut liquid preparation, repeatedly extracting for 4 times, adjusting the pH value to 5, and heating and refluxing for extraction for 1 time, wherein each time lasts for 2 hours;
s4, filtering the liquid obtained in the step S3 by 3 times, combining extracting solutions, concentrating for 3 times, and drying to obtain a dry extract;
s5, crushing the dry extract into dry powder, wherein the dry powder is a compound Chinese herbal medicine feed additive for resisting ruminant nematodes, and the parts are parts by weight.
The compound Chinese herbal medicine powder is 1000 g per bag, and the taking method is mixing materials.
Example three:
a compound Chinese herbal medicine feed additive for resisting ruminant nematode comprises the following raw materials in parts by weight: 8 parts of hawthorn, 4 parts of bighead atractylodes rhizome, 8 parts of medicated leaven, 6 parts of orange peel, 4 parts of malt, 4 parts of allicin, 8 parts of pharbitis seed, 4 parts of radix stemonae and 4 parts of gallnut.
The specific preparation method comprises the following steps:
s1, weighing the hawthorn, the bighead atractylodes rhizome, the medicated leaven, the orange peel, the malt, the allicin, the pharbitidis seed, the radix stemonae and the gallnut in parts by mass, putting the materials into an extraction tank, and adding 6 times of water to soak the materials for 48 hours to obtain an extracting solution;
s2, decocting Chinese gall in water twice: adding 8 times of water for the first time, decocting for 2 hr, adding 6 times of water for the second time, decocting for 1.5 hr, filtering to remove residue, and heating and concentrating to obtain Galla chinensis liquid preparation;
s3, collecting the extract, adding the gallnut liquid preparation, repeatedly extracting for 6 times, adjusting the pH value to 6.5, heating and refluxing for 2 times, and extracting for 2 hours each time;
s4, filtering the liquid obtained in the step S3 by 4 times, combining extracting solutions, concentrating for 4 times, and drying to obtain a dry extract;
s5, crushing the dry extract into dry powder, wherein the dry powder is a compound Chinese herbal medicine feed additive for resisting ruminant nematodes, and the parts are parts by weight.
The compound Chinese herbal medicine powder is 1000 g per bag, and the taking method is mixing materials.
Referring to the first to third embodiments, 10000 cows are present in a farmer, 400 cows are checked to have nematodes in their intestines, and 400 cows are averagely divided into A, B, C, D groups, wherein group A is application example 1, group B is application example 2, group C is application example 3, and group D is blank control; A. b, C the feed additive is added into feed for preventing ruminant nematode. After three months, the following results were obtained by examination:
Figure DEST_PATH_IMAGE002
as a result: the compound Chinese herbal medicine feed additive for resisting ruminant nematode is added into the feed for the milk cows in the A, B, C group, after three months, the milk cows in the A, B, C, D groups are checked, the number of the remaining nematodes in the intestinal tracts of the group A accounts for 7% of the number of the original nematodes, the number of the remaining nematodes in the intestinal tracts of the group B accounts for 6% of the number of the original nematodes, the number of the remaining nematodes in the intestinal tracts of the group C accounts for 3% of the number of the original nematodes, and the number of the remaining nematodes in the intestinal tracts of the group D accounts for 98% of the number of the original nematodes, so the compound Chinese herbal medicine feed additive for resisting ruminant nematode is effective in killing ruminant intestinal nematodes.
Wherein, the pharmacological basis of the technical proposal is as follows: the hawthorn can improve the activity of pepsin and promote the digestion of protein; the hawthorn is sour in taste, stimulates gastric mucosa and promotes gastric secretion; the hawthorn contains lipase, which can promote the digestion of fat; the hawthorn contains vitamin C and other ingredients, and can promote appetite by oral administration; the hawthorn has a regulating effect on gastrointestinal motility, has an inhibiting effect on spastic gastrointestinal smooth muscle, has an exciting effect on relaxed smooth muscle, and also has the effects of reducing blood fat, resisting atherosclerosis, and having strong antibacterial effects on Shigella, Proteus, Escherichia coli, Staphylococcus aureus and the like; in addition, when the intestinal canal is excited by acetylcholine, the white atractylodes rhizome has inhibitory effect; when the intestinal canal is in an inhibition state under the action of adrenaline, the bighead atractylodes rhizome plays an exciting role, so that the movement of the intestinal canal can be restored to a level close to normal, the function of regulating gastrointestinal movement is realized, and the repair of gastrointestinal mucosal injury is facilitated; medicated leaven has effects of promoting digestion and stimulating appetite; the orange peel has the functions of protecting the cardiovascular system, reducing blood pressure, resisting inflammation, resisting ulcer, promoting the circulation of qi, relieving pain, strengthening the spleen and promoting digestion; the malt can be used for treating dyspepsia, abdominal pain, spleen deficiency, anorexia, milk stagnation, breast pain, breast weaning, hypochondriac pain due to stagnation of liver-qi, and pain of liver and stomach; invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, and tranquilizing; allicin has antibacterial effect on various gram positive and negative bacteria, and has inhibiting and killing effects on Bacillus (dysentery bacillus, typhoid bacillus, Escherichia coli, Bordetella pertussis bacillus), fungi (Candida albicans, Cryptococcus, Aspergillus fumigatus), virus (cytomegalovirus), amoeba, vaginal infusorium, enterobiasis, etc., especially has strong effect on intestinal bacteria such as Escherichia coli, dysentery bacillus, etc. Clinical research shows that the Chinese medicinal composition has obvious effect of preventing and treating cytomegalovirus infection of bone marrow transplanters. It also has effects in reducing blood cholesterol, triglyceride and lipoprotein, resisting platelet aggregation, and resisting tumor; semen Pharbitidis can be used for treating constipation, eliminating phlegm, and killing parasites. Can be used for treating edema, constipation, phlegm and fluid accumulation, asthma, cough, and abdominal pain due to parasitic infestation; the stemona root can be used as a medicine for external use for killing insects, relieving itching and killing lice; the oral administration has the effects of moistening lung, relieving cough and eliminating phlegm; galla chinensis has inhibitory effect on various strains. The bacillus subtilis comprises staphylococcus aureus, typhoid bacillus, pseudomonas aeruginosa, shigella dysenteriae, pneumococcus, bacillus anthracis, escherichia coli, several pathogenic vibrios (vibrio anguillarum, vibrio alginolyticus, vibrio parahaemolyticus, vibrio harveyi) and the like. The cleaning effect on the biological membrane is pseudomonas aeruginosa. The antibacterial function is realized by the fact that protein is easy to precipitate and solidify through tanning, and the leather part is the distribution part of the main antibacterial component.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (6)

1. The compound Chinese herbal medicine feed additive for resisting ruminant nematode is characterized by comprising the following components in parts by weight: 4-8 parts of hawthorn, 1-4 parts of bighead atractylodes rhizome, 4-8 parts of medicated leaven, 3-6 parts of orange peel, 1-4 parts of malt, 1-4 parts of allicin, 4-8 parts of pharbitis seed, 2-4 parts of radix stemonae and 1-4 parts of gallnut.
2. The compound Chinese herbal medicine feed additive for resisting ruminant nematode as claimed in claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 6-8 parts of hawthorn, 2-4 parts of bighead atractylodes rhizome, 6-8 parts of medicated leaven, 4-6 parts of orange peel, 2-4 parts of malt, 2-4 parts of allicin, 6-8 parts of pharbitis seed, 3-4 parts of radix stemonae and 2-4 parts of gallnut.
3. The compound Chinese herbal medicine feed additive for resisting ruminant nematode as claimed in claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 6 parts of hawthorn, 3 parts of bighead atractylodes rhizome, 6 parts of medicated leaven, 4 parts of orange peel, 2 parts of malt, 2 parts of allicin, 6 parts of pharbitis seed, 3 parts of radix stemonae and 3 parts of gallnut.
4. The compound Chinese herbal medicine feed additive for resisting ruminant nematode as claimed in claim 1, wherein the mass ratio of allicin, pharbitidis seed, stemona root and gallnut is 1-4:4-8:2-4: 1-4.
5. The compound Chinese herbal medicine feed additive for resisting ruminant nematode as claimed in claim 1, wherein the compound Chinese herbal medicine feed additive for resisting ruminant nematode is compound Chinese herbal medicine powder.
6. A preparation method of a compound Chinese herbal medicine feed additive for resisting ruminant nematodes is characterized by comprising the following preparation steps:
s1, weighing the hawthorn, the bighead atractylodes rhizome, the medicated leaven, the orange peel, the malt, the allicin, the pharbitidis seed, the radix stemonae and the gallnut in parts by mass, putting the materials into an extraction tank, and adding 4-6 times of water to soak the materials for 48 hours to obtain an extracting solution;
s2, decocting Chinese gall in water twice: adding 8 times of water for the first time, decocting for 1-2 hr, adding 6 times of water for the second time, decocting for 0.5-1.5 hr, filtering to remove residue, and heating and concentrating to obtain Galla chinensis liquid preparation;
s3, collecting the extract, adding Galla chinensis liquid preparation, repeatedly extracting for 3-6 times, adjusting pH to 4.0-6.5, heating and reflux extracting for 1-2 times, each time for 1-2 hr;
s4, filtering the liquid obtained in the step S3 for 2-4 times, combining extracting solutions, concentrating for 2-4 times, and drying to obtain a dry extract;
s5, crushing the dry extract into dry powder, wherein the dry powder is a compound Chinese herbal medicine feed additive for resisting ruminant nematodes, and the parts are parts by weight.
CN201911265967.1A 2019-12-11 2019-12-11 Compound Chinese herbal medicine feed additive for resisting ruminant nematode Pending CN110742200A (en)

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Application publication date: 20200204