CN1030195C - 降血糖药噻唑烷二酮及其中间体的制备方法 - Google Patents

降血糖药噻唑烷二酮及其中间体的制备方法 Download PDF

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Publication number
CN1030195C
CN1030195C CN92108662A CN92108662A CN1030195C CN 1030195 C CN1030195 C CN 1030195C CN 92108662 A CN92108662 A CN 92108662A CN 92108662 A CN92108662 A CN 92108662A CN 1030195 C CN1030195 C CN 1030195C
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CN
China
Prior art keywords
compound
formula
hours
following formula
phenyl
Prior art date
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Expired - Fee Related
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CN92108662A
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English (en)
Chinese (zh)
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CN1068823A (zh
Inventor
D·A·克拉克
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Pfizer Inc
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Pfizer Inc
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Publication of CN1068823A publication Critical patent/CN1068823A/zh
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Publication of CN1030195C publication Critical patent/CN1030195C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CN92108662A 1991-07-22 1992-07-21 降血糖药噻唑烷二酮及其中间体的制备方法 Expired - Fee Related CN1030195C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73377191A 1991-07-22 1991-07-22
US733,771 1991-07-22

Publications (2)

Publication Number Publication Date
CN1068823A CN1068823A (zh) 1993-02-10
CN1030195C true CN1030195C (zh) 1995-11-01

Family

ID=24949048

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92108662A Expired - Fee Related CN1030195C (zh) 1991-07-22 1992-07-21 降血糖药噻唑烷二酮及其中间体的制备方法

Country Status (19)

Country Link
US (1) US6329408B1 (enExample)
EP (1) EP0641338A1 (enExample)
JP (1) JPH08823B2 (enExample)
CN (1) CN1030195C (enExample)
AU (1) AU665775B2 (enExample)
BR (1) BR9206293A (enExample)
CA (1) CA2111447C (enExample)
CZ (1) CZ282831B6 (enExample)
HU (1) HUT69692A (enExample)
IE (1) IE922357A1 (enExample)
IL (1) IL102573A (enExample)
MX (1) MX9204279A (enExample)
NO (1) NO301226B1 (enExample)
NZ (1) NZ243653A (enExample)
PT (1) PT100711B (enExample)
RU (1) RU2079497C1 (enExample)
TW (1) TW222626B (enExample)
WO (1) WO1993002079A1 (enExample)
ZA (1) ZA925468B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0595868B1 (en) * 1991-07-22 1998-11-25 Pfizer Inc. Process for the preparation of (s)-4-[3-(5-methyl-2-phenyl-4-oxazolyl)- 1-hydroxypropyl]bromobenzene
GB9308487D0 (en) * 1993-04-23 1993-06-09 Smithkline Beecham Plc Novel compounds
EP1671637A3 (en) 1997-06-18 2007-12-19 SmithKline Beecham P.L.C. Treatment of diabetes with thiazolidinedione and sulphonylurea
DZ2937A1 (fr) 1998-11-12 2004-03-15 Smithkline Beecham Plc Compositions nouvelles de sensibilidants à l'insuline.
WO2000028989A1 (en) * 1998-11-12 2000-05-25 Smithkline Beecham P.L.C. Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
HRP20010795A2 (en) * 1999-04-28 2003-02-28 Aventis Pharma Gmbh Di-aryl acid derivatives as ppar receptor ligands
TWI302149B (en) * 1999-09-22 2008-10-21 Bristol Myers Squibb Co Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
CA2390923A1 (en) * 1999-11-10 2001-05-31 Takeda Chemical Industries, Ltd. 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
IL152979A0 (en) * 2000-05-26 2003-06-24 Nippon Shinyaku Co Ltd Heterocyclic compounds
GB0014969D0 (en) 2000-06-19 2000-08-09 Smithkline Beecham Plc Novel method of treatment
JP2003040877A (ja) * 2001-07-24 2003-02-13 Sumika Fine Chemicals Co Ltd ５−［６−（２−フルオロベンジルオキシ）−２−ナフチル］メチル−２，４−チアゾリジンジオンの製造方法及びその精製方法
CN100402026C (zh) * 2002-06-03 2008-07-16 诺瓦提斯公司 取代的氰基吡咯烷和含有它们的组合制剂用于治疗高脂血症和相关疾病的用途
PL374818A1 (en) * 2002-07-03 2005-10-31 F.Hoffmann-La Roche Ag Oxazole derivatives and their use as insulin sensitizers
US8216609B2 (en) 2002-08-05 2012-07-10 Torrent Pharmaceuticals Limited Modified release composition of highly soluble drugs
US8268352B2 (en) 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
JP4661595B2 (ja) * 2003-09-22 2011-03-30 小野薬品工業株式会社 フェニル酢酸誘導体、その製造方法および用途
EP1586573B1 (en) * 2004-04-01 2007-02-07 Sanofi-Aventis Deutschland GmbH Oxadiazolones, processes for their preparation and their use as pharmaceuticals
US20120094959A1 (en) 2010-10-19 2012-04-19 Bonnie Blazer-Yost Treatment of cystic diseases
WO2016071727A1 (en) 2014-11-04 2016-05-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the prevention and the treatment of rapidly progressive glomerulonephritis
CN109867765A (zh) * 2019-02-28 2019-06-11 中山大学惠州研究院 一种长效缓释可降解防污聚氨酯及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
US4342771A (en) 1981-01-02 1982-08-03 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4367234A (en) 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4617312A (en) 1983-01-17 1986-10-14 Pfizer Inc. Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones
CN1003445B (zh) 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
WO1986007056A1 (en) 1985-05-21 1986-12-04 Pfizer Inc. Hypoglycemic thiazolidinediones
FI91869C (fi) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
GB8713861D0 (en) * 1987-06-13 1987-07-15 Beecham Group Plc Compounds
WO1989008651A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US5036079A (en) 1989-12-07 1991-07-30 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US5089514A (en) 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents

Also Published As

Publication number Publication date
EP0641338A1 (en) 1995-03-08
BR9206293A (pt) 1994-11-08
NO940225D0 (no) 1994-01-21
WO1993002079A1 (en) 1993-02-04
AU2297392A (en) 1993-02-23
AU665775B2 (en) 1996-01-18
IL102573A0 (en) 1993-01-14
RU2079497C1 (ru) 1997-05-20
CA2111447A1 (en) 1993-02-04
IL102573A (en) 1997-04-15
CZ12494A3 (en) 1994-07-13
MX9204279A (es) 1994-03-31
IE922357A1 (en) 1993-01-27
NO301226B1 (no) 1997-09-29
TW222626B (enExample) 1994-04-21
NO940225L (no) 1994-01-21
ZA925468B (en) 1994-01-21
JPH07502487A (ja) 1995-03-16
NZ243653A (en) 1995-02-24
HUT69692A (en) 1995-09-28
CZ282831B6 (cs) 1997-10-15
CA2111447C (en) 2002-08-13
PT100711A (pt) 1993-09-30
PT100711B (pt) 1999-07-30
JPH08823B2 (ja) 1996-01-10
CN1068823A (zh) 1993-02-10
US6329408B1 (en) 2001-12-11
HU9400181D0 (en) 1994-05-30

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C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee