CN102985437B - 通过下调ldh和pdhk表达降低乳酸水平和增加多肽生产 - Google Patents

通过下调ldh和pdhk表达降低乳酸水平和增加多肽生产 Download PDF

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CN102985437B
CN102985437B CN201180026517.2A CN201180026517A CN102985437B CN 102985437 B CN102985437 B CN 102985437B CN 201180026517 A CN201180026517 A CN 201180026517A CN 102985437 B CN102985437 B CN 102985437B
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cell
nucleic acid
acid sequence
sirna
heterologous nucleic
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CN102985437A (zh
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M·周
B·R·斯奈德克尔
C·K·D·恩格
A·沈
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F Hoffmann La Roche AG
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CN201180026517.2A 2010-05-28 2011-05-26 通过下调ldh和pdhk表达降低乳酸水平和增加多肽生产 Active CN102985437B (zh)

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US34972710P 2010-05-28 2010-05-28
US61/349,727 2010-05-28
PCT/US2011/038191 WO2011150241A2 (en) 2010-05-28 2011-05-26 Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase

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CN102985437A CN102985437A (zh) 2013-03-20
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KR (3) KR20190067277A (cg-RX-API-DMAC7.html)
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