CN102905730A - 两性离子聚合物生物缀合物以及相关的方法 - Google Patents

两性离子聚合物生物缀合物以及相关的方法 Download PDF

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Publication number
CN102905730A
CN102905730A CN2010800559646A CN201080055964A CN102905730A CN 102905730 A CN102905730 A CN 102905730A CN 2010800559646 A CN2010800559646 A CN 2010800559646A CN 201080055964 A CN201080055964 A CN 201080055964A CN 102905730 A CN102905730 A CN 102905730A
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China
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conjugate
biomolecule
polymer
alkyl
pcb
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CN2010800559646A
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English (en)
Chinese (zh)
Inventor
S·江
A·克弗
H·薛
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University of Washington Center for Commercialization
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University of Washington Center for Commercialization
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21001—Chymotrypsin (3.4.21.1)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
CN2010800559646A 2009-11-06 2010-11-08 两性离子聚合物生物缀合物以及相关的方法 Pending CN102905730A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25908809P 2009-11-06 2009-11-06
US61/259,088 2009-11-06
PCT/US2010/055886 WO2011057224A2 (en) 2009-11-06 2010-11-08 Zwitterionic polymer bioconjugates and related methods

Publications (1)

Publication Number Publication Date
CN102905730A true CN102905730A (zh) 2013-01-30

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CN2010800559646A Pending CN102905730A (zh) 2009-11-06 2010-11-08 两性离子聚合物生物缀合物以及相关的方法

Country Status (5)

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US (3) US8877172B2 (enExample)
EP (1) EP2496267A4 (enExample)
JP (1) JP5868862B2 (enExample)
CN (1) CN102905730A (enExample)
WO (1) WO2011057224A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI481442B (zh) * 2013-11-14 2015-04-21 中原大學 雙離子電荷偏差型血球篩選用材料
WO2016149851A1 (zh) * 2015-03-20 2016-09-29 中原大学 双离子电荷偏差型血球筛选用材料及从血液样品中移除白血球的方法
CN114605577A (zh) * 2022-03-21 2022-06-10 长春中医药大学 一种新型抗肿瘤两性聚合物及其制备方法与应用

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US9533006B2 (en) 2007-11-19 2017-01-03 University Of Washington Marine coatings
CN102905730A (zh) * 2009-11-06 2013-01-30 华盛顿大学商业中心 两性离子聚合物生物缀合物以及相关的方法
CA2872378C (en) 2011-07-20 2016-01-12 University Of Washington Through Its Center For Commercialization Photonic blood typing
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
US10272180B2 (en) 2014-09-09 2019-04-30 University Of Washington Functionalized zwitterionic and mixed charge polymers, related hydrogels, and methods for their use
AU2017283463A1 (en) 2016-06-13 2019-01-17 Massachusetts Institute Of Technology Biocompatible zwitterionic polymer coatings and hydrogels for reducing foreign body response and fibrosis
WO2018136505A1 (en) * 2017-01-17 2018-07-26 Wayne State University Zwitterionic polymer-insulin compositions and related methods
DE102017101057A1 (de) * 2017-01-20 2018-07-26 Fraunhofer-Institut für Angewandte Polymerforschung IAP Zwitterionische Nanopartikel
US11230616B2 (en) * 2017-07-24 2022-01-25 Rohm And Haas Company Chloride-free cationic polymers using acetate anions
JP2020528475A (ja) * 2017-07-24 2020-09-24 ユニオン カーバイド コーポレーション アセテートアニオンを使用する塩化物を含まないカチオン性ポリマー
US20200216592A1 (en) * 2017-07-24 2020-07-09 Rohm And Haas Company Monomeric counterion pairs and mixed-charge polymers made therefrom
WO2019183637A1 (en) * 2018-03-23 2019-09-26 University Of Washington Immunosuppressive materials and related methods
WO2021022198A1 (en) * 2019-08-01 2021-02-04 Carnegie Mellon University (CMU) Tuning protein solubility by polymer surface modification
CN114901303A (zh) * 2019-10-11 2022-08-12 华盛顿大学 修饰的核酸内切酶和相关方法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI481442B (zh) * 2013-11-14 2015-04-21 中原大學 雙離子電荷偏差型血球篩選用材料
WO2016149851A1 (zh) * 2015-03-20 2016-09-29 中原大学 双离子电荷偏差型血球筛选用材料及从血液样品中移除白血球的方法
CN114605577A (zh) * 2022-03-21 2022-06-10 长春中医药大学 一种新型抗肿瘤两性聚合物及其制备方法与应用

Also Published As

Publication number Publication date
JP2013510181A (ja) 2013-03-21
EP2496267A4 (en) 2016-02-17
US8877172B2 (en) 2014-11-04
EP2496267A2 (en) 2012-09-12
WO2011057224A2 (en) 2011-05-12
US10130716B2 (en) 2018-11-20
JP5868862B2 (ja) 2016-02-24
WO2011057224A3 (en) 2011-09-15
US20150157732A1 (en) 2015-06-11
US20190070300A1 (en) 2019-03-07
US20120315239A1 (en) 2012-12-13

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Application publication date: 20130130