JP5868862B2 - 双性イオンポリマーバイオコンジュゲートおよび関連する方法 - Google Patents

双性イオンポリマーバイオコンジュゲートおよび関連する方法 Download PDF

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JP5868862B2
JP5868862B2 JP2012538070A JP2012538070A JP5868862B2 JP 5868862 B2 JP5868862 B2 JP 5868862B2 JP 2012538070 A JP2012538070 A JP 2012538070A JP 2012538070 A JP2012538070 A JP 2012538070A JP 5868862 B2 JP5868862 B2 JP 5868862B2
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polymer
conjugate
pcb
biomolecule
protein
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JP2013510181A (ja
JP2013510181A5 (enExample
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ジャング、シャオイ
キーフェ、アンドリュー
シュ、ホン
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ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21001—Chymotrypsin (3.4.21.1)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
JP2012538070A 2009-11-06 2010-11-08 双性イオンポリマーバイオコンジュゲートおよび関連する方法 Expired - Fee Related JP5868862B2 (ja)

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US25908809P 2009-11-06 2009-11-06
US61/259,088 2009-11-06
PCT/US2010/055886 WO2011057224A2 (en) 2009-11-06 2010-11-08 Zwitterionic polymer bioconjugates and related methods

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JP2013510181A JP2013510181A (ja) 2013-03-21
JP2013510181A5 JP2013510181A5 (enExample) 2013-12-26
JP5868862B2 true JP5868862B2 (ja) 2016-02-24

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US (3) US8877172B2 (enExample)
EP (1) EP2496267A4 (enExample)
JP (1) JP5868862B2 (enExample)
CN (1) CN102905730A (enExample)
WO (1) WO2011057224A2 (enExample)

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WO2013013220A2 (en) 2011-07-20 2013-01-24 University Of Washington Through Its Center For Commercialization Photonic blood typing
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
TWI481442B (zh) * 2013-11-14 2015-04-21 中原大學 雙離子電荷偏差型血球篩選用材料
CN106999270B (zh) 2014-09-09 2021-01-01 华盛顿大学 官能化的两性离子和混合电荷聚合物、相关的水凝胶及它们的使用方法
WO2016149851A1 (zh) * 2015-03-20 2016-09-29 中原大学 双离子电荷偏差型血球筛选用材料及从血液样品中移除白血球的方法
CA3027856A1 (en) 2016-06-13 2017-12-21 Massachusetts Institute Of Technology Surface-coated continuous glucose monitors
US20190365907A1 (en) * 2017-01-17 2019-12-05 Wayne State University Zwitterionic polymer-insulin compositions and related methods
DE102017101057A1 (de) * 2017-01-20 2018-07-26 Fraunhofer-Institut für Angewandte Polymerforschung IAP Zwitterionische Nanopartikel
BR112020001290A2 (pt) * 2017-07-24 2020-07-28 Union Carbide Corporation composição, método de produção do polímero de carga mista, e, polímero de carga mista
CN111032845A (zh) * 2017-07-24 2020-04-17 联合碳化公司 使用乙酸根阴离子的不含氯化物的阳离子聚合物
BR112020000981A2 (pt) * 2017-07-24 2020-07-14 Union Carbide Corporation método para produzir um polímero catiônico, e, polímero catiônico.
US12194103B2 (en) 2018-03-23 2025-01-14 University Of Washington Immunosuppressive materials and related methods
WO2021022198A1 (en) * 2019-08-01 2021-02-04 Carnegie Mellon University (CMU) Tuning protein solubility by polymer surface modification
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CN114605577B (zh) * 2022-03-21 2023-05-26 长春中医药大学 一种抗肿瘤两性聚合物及其制备方法与应用

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Publication number Publication date
CN102905730A (zh) 2013-01-30
JP2013510181A (ja) 2013-03-21
US8877172B2 (en) 2014-11-04
US20150157732A1 (en) 2015-06-11
EP2496267A4 (en) 2016-02-17
US20190070300A1 (en) 2019-03-07
WO2011057224A3 (en) 2011-09-15
US20120315239A1 (en) 2012-12-13
WO2011057224A2 (en) 2011-05-12
EP2496267A2 (en) 2012-09-12
US10130716B2 (en) 2018-11-20

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