CN102869250A - 作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺衍生物 - Google Patents

作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺衍生物 Download PDF

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Publication number
CN102869250A
CN102869250A CN2011800161510A CN201180016151A CN102869250A CN 102869250 A CN102869250 A CN 102869250A CN 2011800161510 A CN2011800161510 A CN 2011800161510A CN 201180016151 A CN201180016151 A CN 201180016151A CN 102869250 A CN102869250 A CN 102869250A
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compound
formula
contemplates
provides
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Chinese (zh)
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J-M·韦尼耶
玛莎·德拉罗萨
H·陈
J·Z·吴
加里·李·拉尔森
兰·韦恩·切尼
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VALEANT PHARMACEUTICALS INTERNATIONAL
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VALEANT PHARMACEUTICALS INTERNATIONAL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CN2011800161510A 2010-02-01 2011-01-25 作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺衍生物 Pending CN102869250A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/698,070 2010-02-01
US12/698,070 US8993593B2 (en) 2006-08-23 2010-02-01 N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
PCT/US2011/022345 WO2011094186A1 (en) 2010-02-01 2011-01-25 Derivatives of 4-(n-azacycloalkyl) aniilides as potassium channel modulators

Publications (1)

Publication Number Publication Date
CN102869250A true CN102869250A (zh) 2013-01-09

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CN2011800161510A Pending CN102869250A (zh) 2010-02-01 2011-01-25 作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺衍生物

Country Status (12)

Country Link
US (1) US8993593B2 (enExample)
EP (1) EP2531024A4 (enExample)
JP (1) JP5844285B2 (enExample)
KR (1) KR101841989B1 (enExample)
CN (1) CN102869250A (enExample)
AU (1) AU2011209731A1 (enExample)
BR (1) BR112012019199A2 (enExample)
CA (1) CA2788712C (enExample)
EA (1) EA201290748A1 (enExample)
MX (1) MX2012008969A (enExample)
SG (1) SG182799A1 (enExample)
WO (1) WO2011094186A1 (enExample)

Cited By (8)

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CN112384216A (zh) * 2018-05-11 2021-02-19 泽农医药公司 用于增强生物利用度和电压门控钾离子通道开放暴露的方法
CN114786658A (zh) * 2019-12-06 2022-07-22 泽农医药公司 Kv7钾离子通道开放剂治疗疼痛的用途
WO2022174667A1 (zh) * 2021-10-27 2022-08-25 上海挚盟医药科技有限公司 作为钾通道调节剂的化合物及其制备和应用
CN115190874A (zh) * 2019-10-10 2022-10-14 泽农医药公司 一种选择性钾通道调节剂的固态结晶形式
WO2023125935A1 (zh) * 2021-12-31 2023-07-06 上海翰森生物医药科技有限公司 苯并哌啶衍生物调节剂、其制备方法和应用
WO2023143388A1 (zh) * 2022-01-25 2023-08-03 上海挚盟医药科技有限公司 作为钾通道调节剂的酰胺类化合物及其制备和应用
US12319656B2 (en) 2021-10-27 2025-06-03 Shanghai Zhimeng Biopharma, Inc. Compound as potassium channel regulator and preparation and use thereof
WO2025167886A1 (zh) * 2024-02-08 2025-08-14 上海挚盟医药科技有限公司 四氢异喹啉基化合物的晶型及其应用

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US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
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WO2014184682A1 (en) 2013-04-19 2014-11-20 Oslo Universitetssykehus Hf Radiolabeled gnrh antagonists as pet imaging agents
MX2018015251A (es) 2016-06-10 2019-04-25 Scifluor Life Sciences Inc Derivados de 2-amino-4-(amino sustituido)fenil carbamato fluorinado.
CN110511220B (zh) 2018-05-22 2022-04-01 上海挚盟医药科技有限公司 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用
PH12022551110A1 (en) 2019-11-08 2024-02-26 Xenon Pharmaceuticals Inc Methods of treating depressive disorders
US20210213009A1 (en) * 2019-12-13 2021-07-15 Xenon Pharmaceuticals Inc. Methods of treating pain
WO2022173853A1 (en) 2021-02-09 2022-08-18 Xenon Pharmaceuticals Inc. Conjoint therapy for treating seizure disorders
JP2024508660A (ja) 2021-02-09 2024-02-28 ゼノン・ファーマシューティカルズ・インコーポレイテッド 快感消失の治療に使用するための電位依存性カリウムチャネル開口薬
US20240101531A1 (en) 2022-06-08 2024-03-28 Xenon Pharmaceuticals Inc. Pyridinamine derivatives and their use as potassium channel modulators
WO2025179128A1 (en) 2024-02-22 2025-08-28 Xenon Pharmaceuticals Inc. Azetukalner for use in the treatment of depression, anhedonia or a seizure disorder such as epilepsy in pediatric subjects

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CN120549930A (zh) * 2018-05-11 2025-08-29 泽农医药公司 用于增强生物利用度和电压门控钾离子通道开放暴露的方法
CN115190874A (zh) * 2019-10-10 2022-10-14 泽农医药公司 一种选择性钾通道调节剂的固态结晶形式
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WO2022174667A1 (zh) * 2021-10-27 2022-08-25 上海挚盟医药科技有限公司 作为钾通道调节剂的化合物及其制备和应用
US12319656B2 (en) 2021-10-27 2025-06-03 Shanghai Zhimeng Biopharma, Inc. Compound as potassium channel regulator and preparation and use thereof
WO2023125935A1 (zh) * 2021-12-31 2023-07-06 上海翰森生物医药科技有限公司 苯并哌啶衍生物调节剂、其制备方法和应用
WO2023143388A1 (zh) * 2022-01-25 2023-08-03 上海挚盟医药科技有限公司 作为钾通道调节剂的酰胺类化合物及其制备和应用
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AU2011209731A1 (en) 2012-08-23
US8993593B2 (en) 2015-03-31
JP5844285B2 (ja) 2016-01-13
EP2531024A4 (en) 2013-06-19
JP2013518815A (ja) 2013-05-23
EA201290748A1 (ru) 2013-04-30
CA2788712C (en) 2018-09-11
BR112012019199A2 (pt) 2017-01-17
CA2788712A1 (en) 2011-08-04
US20110003850A1 (en) 2011-01-06
MX2012008969A (es) 2012-09-07
EP2531024A1 (en) 2012-12-12
SG182799A1 (en) 2012-09-27

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